نتائج البحث - "Askwith, Trevor"

1

Academic Journal

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

المؤلفون: Gong, Grace Q., Bilanges, Benoit, Allsop, Ben, Masson, Glenn R., Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R., Conduit, Sarah E., Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H., Chan, A. W. Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E., Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A., Bunney, Tom D., Stephens, Len R., Hawkins, Phillip T., Katan, Matilda, Yellon, Derek M., Davidson, Sean M., Smith, David M., Phillips, James B., Angell, Richard, Williams, Roger L., Vanhaesebroeck, Bart

المصدر: Gong , G Q , Bilanges , B , Allsop , B , Masson , G R , Roberton , V , Askwith , T , Oxenford , S , Madsen , R R , Conduit , S E , Bellini , D , Fitzek , M , Collier , M , Najam , O , He , Z , Wahab , B , McLaughlin , S H , Chan , A W E , Feierberg , I , Madin , A , Morelli , D , Bhamra , A , Vinciauskaite , V , Anderson , K E ....

مصطلحات موضوعية: Cell signalling, Drug discovery, Kinases, X-ray crystallography, /dk/atira/pure/subjectarea/asjc/1000, name=General

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/ecb2d398-f5df-47cc-8fd6-537759cc5e07
https://doi.org/10.1038/s41586-023-05972-2
https://discovery.dundee.ac.uk/ws/files/103607439/409738_4_merged_1678279284.pdf
http://www.scopus.com/inward/record.url?scp=85160229754&partnerID=8YFLogxK

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2

Academic Journal

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

المؤلفون: Gong, Grace Q, Bilanges, Benoit, Allsop, Ben, Masson, Glenn R, Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R, Conduit, Sarah E, Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H, Chan, AW Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E, Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A, Bunney, Tom D, Stephens, Len R, Hawkins, Phillip T, Katan, Matilda, Yellon, Derek M, Davidson, Sean M, Smith, David M, Phillips, James B, Angell, Richard, Williams, Roger L, Vanhaesebroeck, Bart

المصدر: Nature , 618 pp. 159-168. (2023)

مصطلحات موضوعية: Cell signalling, Drug discovery, Kinases, X-ray crystallography

وصف الملف: text

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10170780/15/Nature_manuscript_RPS.pdf
https://discovery.ucl.ac.uk/id/eprint/10170780/12/SI%20Guide%20with%20tables%20and%20figures_new_upload.pdf
https://discovery.ucl.ac.uk/id/eprint/10170780/8/Supplementary%20Table%201.xlsx
https://discovery.ucl.ac.uk/id/eprint/10170780/2/Supplementary%20Table%204.xls
https://discovery.ucl.ac.uk/id/eprint/10170780/4/Supplementary%20Table%205.xls
https://discovery.ucl.ac.uk/id/eprint/10170780/5/Supplementary%20Table%206.xls
https://discovery.ucl.ac.uk/id/eprint/10170780/11/Supplementary%20Table%207.xlsx
https://discovery.ucl.ac.uk/id/eprint/10170780/6/Supplementary%20Table%208.xlsx
https://discovery.ucl.ac.uk/id/eprint/10170780/7/Supplementary%20Table%209.xlsx
https://discovery.ucl.ac.uk/id/eprint/10170780/9/Suppl%20Video%201_Activation_mechanisms.mp4

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3

Dissertation/ Thesis

Taurine depletion and Schwann cell dysfunction in diabetic neuropathy

المؤلفون: Askwith, Trevor

مصطلحات موضوعية: 616.8, RC Internal medicine

الاتاحة: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.524828

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4

Academic Journal

Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity

المؤلفون: Dora, Nova O., Blackburn, Edith, Boles, Jessica E., Williams, George T., White, Lisa J., Turner, Scarlett E.G., Hothersall, J. Daniel, Askwith, Trevor, Doolan, Jack A., Mulvihill, Daniel P., Garrett, Michelle D., Hiscock, Jennifer

وصف الملف: text

Relation: https://eprints.soton.ac.uk/474153/1/d1ra02281d.pdf; Dora, Nova O., Blackburn, Edith, Boles, Jessica E., Williams, George T., White, Lisa J., Turner, Scarlett E.G., Hothersall, J. Daniel, Askwith, Trevor, Doolan, Jack A., Mulvihill, Daniel P., Garrett, Michelle D. and Hiscock, Jennifer (2021) Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity. RSC Advances, 2021 (11), 14213-14217. (doi:10.1039/D1RA02281D ).

الاتاحة: https://eprints.soton.ac.uk/474153/
https://eprints.soton.ac.uk/474153/1/d1ra02281d.pdf

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5

Academic Journal

Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity

المؤلفون: Dora, Nova Olympia, Blackburn, Edith, Boles, Jessica E., Williams, George T., White, Lisa J., Turner, Scarlett, Hothersall, Trevor, Askwith, Trevor, Doolan, Jack, Mulvihill, Daniel P., Garrett, Michelle D., Hiscock, Jennifer R.

مصطلحات موضوعية: Q Science, QD Chemistry, QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids

وصف الملف: application/pdf

Relation: https://kar.kent.ac.uk/87520/13/d1ra02281d.pdf; https://kar.kent.ac.uk/87520/2/revised%20supplementary%20information.pdf; https://kar.kent.ac.uk/87520/1/RSC%20advances_revised.pdf; Dora, Nova Olympia, Blackburn, Edith, Boles, Jessica E., Williams, George T., White, Lisa J., Turner, Scarlett, Hothersall, Trevor, Askwith, Trevor, Doolan, Jack, Mulvihill, Daniel P., and others. Garrett, Michelle D., and Hiscock, Jennifer R. (hide) (2021) Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity. RSC Advances, 11 . pp. 14213-14217. ISSN 2046-2069. (doi:10.1039/D1RA02281D ) (KAR id:87520 )

الاتاحة: https://kar.kent.ac.uk/87520/
https://kar.kent.ac.uk/87520/13/d1ra02281d.pdf
https://kar.kent.ac.uk/87520/2/revised%20supplementary%20information.pdf
https://kar.kent.ac.uk/87520/1/RSC%20advances_revised.pdf
https://doi.org/10.1039/D1RA02281D

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6

Academic Journal

Mast Cells: A Unique Source of Renin

المؤلفون: Silver, Randi B., Reid, Alicia C., Mackins, Christina J., Askwith, Trevor, Schaefer, Ulrich, Herzlinger, Doris, Levi, Roberto, Ignarro, Louis J.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2004 Sep . 101(37), 13607-13612.

URL الوصول: https://www.jstor.org/stable/3373358

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7

Academic Journal

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

المؤلفون: Liu, Yang, Bunney, Tom D., Khosa, Sakshi, Macé, Kévin, Beckenbauer, Katharina, Askwith, Trevor, Maslen, Sarah, Stubbs, Christopher, de Oliveira, Taiana M., Sader, Kasim, Skehel, Mark, Gavin Perrin, Anne-Claude, Phillips, Christopher, Katan, Matilda

المصدر: ISSN: 2352-3964 ; EBioMedicine, vol. 51 (2020) 102607.

مصطلحات موضوعية: info:eu-repo/classification/ddc/612

Relation: info:eu-repo/semantics/altIdentifier/pmid/31918402; https://archive-ouverte.unige.ch/unige:152698; unige:152698

الاتاحة: https://archive-ouverte.unige.ch/unige:152698

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8

Academic Journal

African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase

المؤلفون: West, Ryan A, O'Doherty, Oran G, Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E, Rao, Srinivasa P S, Williams, Gareth, Ward, Simon E

مصطلحات موضوعية: QD0241 Organic chemistry

وصف الملف: application/pdf

Relation: http://sro.sussex.ac.uk/id/eprint/71807/1/__smbhome.uscs.susx.ac.uk_lep20_Desktop_1-s2.0-S022352341730781X-main.pdf; West, Ryan A, O'Doherty, Oran G, Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E, Rao, Srinivasa P S, Williams, Gareth and Ward, Simon E (2017) African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European Journal of Medicinal Chemistry, 141. pp. 676-689. ISSN 0223-5234

الاتاحة: http://sro.sussex.ac.uk/id/eprint/71807/
http://sro.sussex.ac.uk/id/eprint/71807/1/__smbhome.uscs.susx.ac.uk_lep20_Desktop_1-s2.0-S022352341730781X-main.pdf
https://doi.org/10.1016/j.ejmech.2017.09.067

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9

Academic Journal

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

المؤلفون: Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W, Oliver, Antony W

وصف الملف: application/pdf

Relation: http://sro.sussex.ac.uk/id/eprint/60620/1/BJ_Horynak_et_al_Merged.pdf; http://sro.sussex.ac.uk/id/eprint/60620/6/1869.full.pdf; Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W and Oliver, Antony W (2016) Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal, 473 (13). pp. 1869-1879. ISSN 0264-6021

الاتاحة: http://sro.sussex.ac.uk/id/eprint/60620/
http://sro.sussex.ac.uk/id/eprint/60620/1/BJ_Horynak_et_al_Merged.pdf
http://sro.sussex.ac.uk/id/eprint/60620/6/1869.full.pdf
https://doi.org/10.1042/BCJ20160180

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10

Academic Journal

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors

المؤلفون: Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A., Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H., Pearl, Laurence H., Oliver, Antony W., El-Khamisy, Sherif, Ward, Simon, Atack, John R.

وصف الملف: application/pdf

Relation: https://orca.cardiff.ac.uk/id/eprint/105856/1/1-s2.0-S0003269714000931-main.pdf; Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A., Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H., Pearl, Laurence H., Oliver, Antony W., El-Khamisy, Sherif, Ward, Simon https://orca.cardiff.ac.uk/view/cardiffauthors/A2342916Z.html orcid:0000-0002-8745-8377 orcid:0000-0002-8745-8377 and Atack, John R. https://orca.cardiff.ac.uk/view/cardiffauthors/A2342532W.html orcid:0000-0002-3410-791X orcid:0000-0002-3410-791X 2014. Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry 454 , pp. 17-22. 10.1016/j.ab.2014.03.004 https://doi.org/10.1016/j.ab.2014.03.004 file https://orca.cardiff.ac.uk/id/eprint/105856/1/1-s2.0-S0003269714000931-main.pdf

الاتاحة: https://orca.cardiff.ac.uk/id/eprint/105856/
https://doi.org/10.1016/j.ab.2014.03.004
https://orca.cardiff.ac.uk/id/eprint/105856/1/1-s2.0-S0003269714000931-main.pdf

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11

Academic Journal

SAT-374-Interleukin 35 exerts its suppressive function in chronic liver failure through the induction of an immunosuppressive HLA-G+CD4+ regulatory T -cell population

المؤلفون: Khamri, Wafa, Gudd, Cathrin, Krasniqi, Marigona, Nathwani, Rooshi, Singanayagam, Arjuna, Azam, Sofia, Liu, Tong, Lebosse, Fanny, Kumar, Naveenta, Seoane, Rocio Castro, Barbera, Thomas, Askwith, Trevor, Weston, Christopher, Thursz, Mark, Antoniades, Charalambos

المصدر: Journal of Hepatology ; volume 70, issue 1, page e800 ; ISSN 0168-8278

الاتاحة: http://dx.doi.org/10.1016/s0618-8278(19)31594-4
https://api.elsevier.com/content/article/PII:S0618827819315944?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0618827819315944?httpAccept=text/plain

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12

Book

Taurine Treatment for Complications of Diabetes

المؤلفون: Askwith, Trevor

المصدر: Oxidative Stress in Applied Basic Research and Clinical Practice ; Studies in Diabetes ; page 173-187 ; ISSN 2197-7224 2197-7232 ; ISBN 9781489980342 9781489980359

الاتاحة: http://dx.doi.org/10.1007/978-1-4899-8035-9_10
http://link.springer.com/content/pdf/10.1007/978-1-4899-8035-9_10

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