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1Academic Journal
المؤلفون: Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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2Academic Journal
المؤلفون: Xiaoting Li, Hao Chang, Jara Bouma, Laura V. de Paus, Partha Mukhopadhyay, Janos Paloczi, Mohammed Mustafa, Cas van der Horst, Sanjay Sunil Kumar, Lijie Wu, Yanan Yu, Richard J. B. H. N. van den Berg, Antonius P. A. Janssen, Aron Lichtman, Zhi-Jie Liu, Pal Pacher, Mario van der Stelt, Laura H. Heitman, Tian Hua
المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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3Academic Journal
المؤلفون: Alexander T. Bakker (14312845), Ioli Kotsogianni (9930187), Liza Mirenda (14312848), Verena M. Straub (6713687), Mariana Avalos (14312851), Richard J. B. H. N. van den Berg (14312854), Bogdan I. Florea (1330800), Gilles P. van Wezel (7838948), Antonius P. A. Janssen (7449809), Nathaniel I. Martin (847378), Mario van der Stelt (222751)
مصطلحات موضوعية: Biochemistry, Pharmacology, Sociology, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, target interaction landscape, revealed several cysteine, resistant staphylococcus aureus, novel antibacterial chemotype, identify novel antibiotics, high antibacterial potency, comparative chemical proteomics, mrsa phenotypic screening, data showcase oxadiazolones, phenotypic screen, targets responsible, situ competitive, serine hydrolases, resistance studies, relevant targets, powerful approach, polypharmacological mode, ones identified, often challenging, central role, based probe, adhe play
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المؤلفون: Alexander T. Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M. Straub, Mariana Avalos, Richard J. B. H. N. van den Berg, Bogdan I. Florea, Gilles P. van Wezel, Antonius P. A. Janssen, Nathaniel I. Martin, Mario van der Stelt
المصدر: Journal of the American Chemical Society, 145(2), 1136-1143. American Chemical Society (ACS)
مصطلحات موضوعية: Colloid and Surface Chemistry, General Chemistry, Biochemistry, Catalysis
وصف الملف: application/pdf
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المؤلفون: Na Zhu, Antonius P. A. Janssen, Mario van der Stelt
المصدر: Israel Journal of Chemistry. 63
مصطلحات موضوعية: General Chemistry
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المؤلفون: Mario van der Stelt, Olivier J. M. Béquignon, Gerard J. P. van Westen, Jacob M. A. van Hengst, Hui Deng, Antonius P A Janssen
المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 62(17), 7910-7922مصطلحات موضوعية: Diacylglycerol lipase, Stereochemistry, Triazole, Molecular Dynamics Simulation, 01 natural sciences, Article, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Heterocyclic Compounds, Drug Discovery, Humans, Structure–activity relationship, Enzyme Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Leaving group, Serine hydrolase, 3. Good health, 0104 chemical sciences, Kinetics, Lipoprotein Lipase, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Covalent bond, biology.protein, Molecular Medicine
وصف الملف: application/pdf
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المؤلفون: Can Araman, Mikkel H. S. Marqvorsen, René E. M. Toes, Marcel Camps, George M.C. Janssen, Ferry Ossendorp, Clarissa R. Nascimento, Gerard J. P. van Westen, Willemijn van der Wulp, G. J. Mirjam Groenewold, Arieke S. B. Kampstra, Thomas Bakkum, Tyrza van Leeuwen, Antonius P A Janssen, Herman S. Overkleeft, Peter A. van Veelen, Sander I. van Kasteren, Bogdan I. Florea, Linda Pieper Pournara
المصدر: RSC Chemical Biology, 2(3), 855-862. Royal Society of Chemistry ({RSC})
Rsc Chemical Biology
RSC Chemical Biology, 2(3), 855-862. ROYAL SOC CHEMISTRY
RSC Chemical Biologyمصطلحات موضوعية: Proteolysis, 010402 general chemistry, 01 natural sciences, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, 03 medical and health sciences, Immune system, Antigen, medicine, Molecular Biology, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, biology, Chemistry, Antigen processing, Citrullination, Acquired immune system, 3. Good health, 0104 chemical sciences, Cell biology, Ovalbumin, Chemistry (miscellaneous), biology.protein, Bioorthogonal chemistry
وصف الملف: application/pdf
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المؤلفون: Ozge Gunduz-Cinar, Laura I. Castillo, Antonius P A Janssen, Helma van den Hurk, Marjolein Soethoudt, Andrew Holmes, Resat Cinar, Cristina Miliano, Annelot C. M. van Esbroeck, Colleen M Donovan, Pal Pacher, Elliot D. Mock, Aron H. Lichtman, Alexander T Bakker, Jesse Wat, Matthew W. Buczynski, Anouk M F van der Gracht, Tom van der Wel, Ioli Kotsogianni, Vasudev Kantae, Tiemen J Wendel, Xinyu Di, Thomas Hankemeier, Matthias B. Wittwer, Matthew N. Hill, János Pálóczi, Gavin N. Petrie, Uwe Grether, Joshua K. Park, Andrea Martella, Zoltán Varga, Ming Jiang, Daisuke Ogasawara, Giulia Donvito, Benjamin F. Cravatt, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Mohammed A. Mustafa
المصدر: Nature Chemical Biology, 16(6), 667-675
Nat Chem Biolمصطلحات موضوعية: Male, Cannabinoid receptor, Nape, medicine.medical_treatment, Drug Evaluation, Preclinical, Article, Amidohydrolases, 03 medical and health sciences, chemistry.chemical_compound, Mice, Fatty acid amide hydrolase, Cell Line, Tumor, Lipidomics, medicine, Phospholipase D, Animals, Humans, Enzyme Inhibitors, Receptors, Cannabinoid, Molecular Biology, Cannabinoid Receptor Antagonists, 030304 developmental biology, 0303 health sciences, Behavior, Animal, Molecular Structure, Chemistry, Phosphatidylethanolamines, 030302 biochemistry & molecular biology, Brain, Cell Biology, Anandamide, Blood Proteins, Fear, Lipid Metabolism, Endocannabinoid system, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, lipids (amino acids, peptides, and proteins), Cannabinoid, Signal Transduction
وصف الملف: application/pdf
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المؤلفون: Antonius P A Janssen, Ferdinando Scavizzi, Hans den Dulk, Barbara Barboni, Nicola Bernabò, Marcello Raspa, Hermen S. Overkleeft, Bogdan I. Florea, Marc P. Baggelaar, Mario van der Stelt, Mauro Maccarrone, Domenico Fazio
المصدر: ACS Chemical Biology
ACS Chemical Biology, 14(10), 2295-2304مصطلحات موضوعية: 0301 basic medicine, Male, Pyrrolidines, Hydrolases, Acrosome reaction, 01 natural sciences, Biochemistry, Small Molecule Libraries, 03 medical and health sciences, Structure-Activity Relationship, Piperidines, Cell Line, Tumor, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Fluorescent Dyes, Molecular Structure, 010405 organic chemistry, Chemistry, Acrosome Reaction, HEK 293 cells, Activity-based proteomics, Serine hydrolase, Articles, General Medicine, 3. Good health, 0104 chemical sciences, Addition/Correction, Mice, Inbred C57BL, 030104 developmental biology, HEK293 Cells, Cell culture, Proteome, Lipase inhibitors, Molecular Medicine, Acrosome
وصف الملف: application/pdf
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المؤلفون: Roy M. Kreekel, Mario van der Stelt, Hans den Dulk, Thomas Hansen, Eva J. van Rooden, Annelot C. M. van Esbroeck, Antonius P A Janssen, Jeroen D. C. Codée, Richard J. B. H. N. van den Berg
المساهمون: Chemistry and Pharmaceutical Sciences
المصدر: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, 16, 5250-5253. Royal Society of Chemistry ({RSC})
Organic and Biomolecular Chemistry, 16(29), 5250-5253. Royal Society of Chemistry
Van Rooden, E J, Kreekel, R, Hansen, T, Janssen, A P A, Van Esbroeck, A C M, Den Dulk, H, Van Den Berg, R J B H N, Codée, J D C & Van Der Stelt, M 2018, ' Two-step activity-based protein profiling of diacylglycerol lipase ', Organic and Biomolecular Chemistry, vol. 16, no. 29, pp. 5250-5253 . https://doi.org/10.1039/c8ob01499jمصطلحات موضوعية: 0301 basic medicine, Diacylglycerol lipase, Proteome, Triazole, Endogeny, 010402 general chemistry, 01 natural sciences, Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Animals, Humans, Urea, Physical and Theoretical Chemistry, Density Functional Theory, Diacylglycerol kinase, Cycloaddition Reaction, biology, Organic Chemistry, Activity-based proteomics, Brain, Triazoles, Norbornanes, Endocannabinoid system, Recombinant Proteins, 0104 chemical sciences, Lipoprotein Lipase, 030104 developmental biology, chemistry, Cell culture, Molecular Probes, biology.protein, Selectivity, Endocannabinoids
وصف الملف: application/pdf
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المؤلفون: A.C.M. van Esbroeck, Hermen S. Overkleeft, Roy M. Kreekel, M. van der Stelt, R.J.B.H.N. van den Berg, M.J.J. Kohsiek, Antonius P A Janssen, A.M.C.H. van den Nieuwendijk, E.J. van Rooden
المصدر: Chemistry-An Asian Journal, 13(22), 3491-3500
Chemistry-An Asian Journalمصطلحات موضوعية: Diacylglycerol lipase, enzymes, 010402 general chemistry, quenched activity-based probes, 01 natural sciences, Biochemistry, Catalysis, chemistry.chemical_compound, Mice, Biosynthesis, fluorescent probes, Cell Line, Tumor, Hydrolase, Animals, Humans, Diacylglycerol kinase, activity-based protein profiling, Fluorescent Dyes, chemistry.chemical_classification, Aniline Compounds, biology, Cycloaddition Reaction, 010405 organic chemistry, Chemistry, Organic Chemistry, Activity-based proteomics, Brain, Serine hydrolase, General Chemistry, endocannabinoid, Triazoles, ABHD6, Monoacylglycerol Lipases, 0104 chemical sciences, Lipoprotein Lipase, Enzyme, Drug Design, biology.protein, Heterocyclic Compounds, 3-Ring, Copper
وصف الملف: application/pdf
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المؤلفون: Giuseppe Campiani, Antonius P A Janssen, Stefania Butini, Daan van der Vliet, Sebastian H. Grimm, Mario van der Stelt, Ming Jiang, Alexander T Bakker
المصدر: ACS Chemical Biology, 13(9), 2406-2413
ACS Chemical Biologyمصطلحات موضوعية: 0301 basic medicine, Boron Compounds, Serine Proteinase Inhibitors, Halogenation, Proteome, Drug Evaluation, Preclinical, Organophosphonates, Biochemistry, Serine, 03 medical and health sciences, Mice, Hydrolase, Drug Discovery, Animals, Enzyme Assays, Fluorescent Dyes, Chemistry, Drug discovery, Serine Endopeptidases, Activity-based proteomics, Brain, Serine hydrolase, General Medicine, Endocannabinoid system, 030104 developmental biology, Molecular Medicine, Fluorescent tag, Endocannabinoids
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المؤلفون: Mario van der Stelt, Ruud H. Wijdeven, Sebastian H. Grimm, Eelke B. Lenselink, Gerard J. P. van Westen, Constant A. A. van Boeckel, Jacques Neefjes, Antonius P A Janssen
المصدر: Journal of Chemical Information and Modeling, 59(3), 1221-1229
Journal of Chemical Information and Modelingمصطلحات موضوعية: Models, Molecular, Protein family, Computer science, Protein Conformation, General Chemical Engineering, Library and Information Sciences, Machine learning, computer.software_genre, 01 natural sciences, Article, Machine Learning, 0103 physical sciences, Drug Discovery, Kinome, Independent data, Protein Kinase Inhibitors, 010304 chemical physics, Drug discovery, business.industry, Kinase Family, General Chemistry, computer.file_format, 0104 chemical sciences, Computer Science Applications, Visualization, 010404 medicinal & biomolecular chemistry, fms-Like Tyrosine Kinase 3, Tyrosine Kinase 3, Artificial intelligence, Executable, business, computer, Protein Kinases, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Erwin R. van Rijssel, Gijsbert A. van der Marel, Alexandra Males, Antonius P A Janssen, Herman S. Overkleeft, Gideon J. Davies, Jeroen D. C. Codée
المصدر: ChemBioChem, 18(13), 1297-1304
ChemBioChemمصطلحات موضوعية: Models, Molecular, Mannosidase, Conformational change, Stereochemistry, Carboxylic acid, Cyclohexane conformation, Carboxylic Acids, Oxocarbenium, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Biochemistry, Caulobacter, chemistry.chemical_compound, Bacterial Proteins, Amide, Mannosidases, Hydrolase, Carbohydrate Conformation, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Aza Compounds, 010405 organic chemistry, Hexuronic Acids, Organic Chemistry, Esters, Hydrogen-Ion Concentration, Imino Sugars, 0104 chemical sciences, Carbohydrate Sequence, chemistry, Molecular Medicine
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المؤلفون: Marjolein Soethoudt, Filomena Fezza, Tom van der Wel, Mauro Maccarrone, Annelot C. M. van Esbroeck, Marc P. Baggelaar, Chris I. De Zeeuw, Giel Hendriks, Guy Shpak, Bogdan I. Florea, Luciano De Petrocellis, Mario van der Stelt, Ilse L. Baak, Hui Deng, Daisuke Ogasawara, Marco Allarà, Vincenzo Di Marzo, Hans den Dulk, Elliot D. Mock, Zhanmin Lin, Armand B. Cognetta, Steven A. Kushner, Thomas Hankemeier, Benjamin F. Cravatt, Femke M.S. de Vrij, Mark van der Kroeg, Vasudev Kantae, Antonius P A Janssen, Herman S. Overkleeft
المساهمون: Psychiatry, Neurosciences, Netherlands Institute for Neuroscience (NIN)
المصدر: Science (N. Y., N.Y.) 356 (2017): 1084–1087. doi:10.1126/science.aaf7497
info:cnr-pdr/source/autori:van Esbroeck, Annelot C. M.; Janssen, Antonius P. A.; Cognetta, Armand B., III; Ogasawara, Daisuke; Shpak, Guy; van der Kroeg, Mark; Kantae, Vasudev; Baggelaar, Marc P.; de Vrij, Femke M. S.; Deng, Hui; Allara, Marco; Fezza, Filomena; Lin, Zhanmin; van der Wel, Tom; Soethoudt, Marjolein; Mock, Elliot D.; den Dulk, Hans; Baak, Ilse L.; Florea, Bogdan I.; Hendriks, Giel; de Petrocellis, Luciano; Overkleeft, Herman S.; Hankemeier, Thomas; De Zeeuw, Chris I.; Di Marzo, Vincenzo; Maccarrone, Mauro; Cravatt, Benjamin F.; Kushner, Steven A.; van der Stelt, Mario/titolo:Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474/doi:10.1126%2Fscience.aaf7497/rivista:Science (N. Y., N.Y.)/anno:2017/pagina_da:1084/pagina_a:1087/intervallo_pagine:1084–1087/volume:356
Science, 356(6342), 1084-1087. American Association for the Advancement of Science
Science, 356(6342), 1084-1087. American Association for the Advancement of Science (AAAS)
SCIENCE, 356(6342), 1084-1087
SCIENCEمصطلحات موضوعية: 0301 basic medicine, Nervous system, Drug, BIA 10-2474, Pyridines, media_common.quotation_subject, Biology, Pharmacology, Phase I as Topic, Cross Reactions, Amidohydrolases, Cell Line, Cyclic N-Oxides, 03 medical and health sciences, Fatty acid amide hydrolase, Cell Line, Tumor, medicine, Journal Article, Humans, Urea, Clinical Trials, FAAH, Protein Interaction Maps, Settore BIO/10, media_common, Neurons, Analgesics, Multidisciplinary, Tumor, Clinical Trials, Phase I as Topic, TRP channels, Activity-based proteomics, Neurotoxicity, Anti-Anxiety Agents, Pyridazines, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, nervous system, Cell culture, Lipase inhibitors
وصف الملف: application/pdf
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