المؤلفون: Johanna Vappiani, Terezinha de Souza, Theo M. de Kok, Luke Coyle, Julio Saez-Rodriguez, Danyel Jennen, Daniel C. Sévin, D. F. Rodrigues, Seung-Wook Chung, Matteo Di Piazza, Bram Herpers, Attila Gábor, Mian Zhang, Anthony M. Lynch, Jos C. S. Kleinjans, Sofia Ferreira

المساهمون: Toxicogenomics, RS: GROW - R1 - Prevention, RS: FSE MaCSBio, RS: FPN MaCSBio, RS: FHML MaCSBio

المصدر: Archives of Toxicology
Archives of Toxicology, 95(8), 2691-2718. Springer

مصطلحات موضوعية: 0301 basic medicine, Male, PHARMACOKINETICS, Health, Toxicology and Mutagenesis, Cell, Apoptosis, Toxicology, Toxicogenomics and Omics Technologies, COLORECTAL-CANCER, Transcriptome, 0302 clinical medicine, Intestine, Small, E2F1, TISSUE DISTRIBUTION, GENE-EXPRESSION, Cell Cycle, General Medicine, Cell cycle, STEM, 5-FU toxicity, 3. Good health, Cell biology, Organoids, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Antimetabolites, Antineoplastic, Cell Survival, Colon, Human organoid models, Biology, HIGH-THROUGHPUT, Models, Biological, 03 medical and health sciences, Metabolomics, Organoid, Metabolome, medicine, Humans, Transcriptomics, MUCOSAL INJURY, Transcription factor, Dose-Response Relationship, Drug, Molecular mechanisms, IN-VITRO, FLUOROURACIL, MODEL, Oxidative Stress, 030104 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac9c066722eb245b2e70fe09b71ed5
https://doi.org/10.1007/s00204-021-03092-2

المؤلفون: John W. Wills, Ruby Buckley, Catherine A. Thornton, Claire M. Barnes, Paul Rees, George E. Johnson, Julia Kenny, Rachel E. Hewitt, Danielle S.G. Harte, Anne E. Carpenter, James G. Cronin, Minh Doan, Huw D. Summers, Andrew Filby, Benjamin J. Rees, Rachel E. Barnes, Jatin R. Verma, Qiellor Haxhiraj, Matthew A. Rodrigues, Anthony M. Lynch

المساهمون: Wills, John W. [0000-0002-4347-5394], Apollo - University of Cambridge Repository, Wills, John W [0000-0002-4347-5394]

المصدر: Archives of Toxicology

مصطلحات موضوعية: 0301 basic medicine, Imaging flow cytometry, Computer science, Health, Toxicology and Mutagenesis, Genotoxicity and Carcinogenicity, Image analysis, Toxicology, Cell Line, 03 medical and health sciences, Deep Learning, 0302 clinical medicine, Micronucleus test, Machine learning, High throughput, Humans, Inter-laboratory, Safety testing, Cytokinesis, Automation, Laboratory, Micronucleus Tests, Dose-Response Relationship, Drug, Contextual image classification, business.industry, Deep learning, Pattern recognition, General Medicine, Flow Cytometry, Methyl Methanesulfonate, Automation, Compound screening, 030104 developmental biology, 030220 oncology & carcinogenesis, Benzimidazoles, Genetic toxicology, Carbamates, Artificial intelligence, business, Micronucleus, DNA Damage, Mutagens

وصف الملف: application/pdf; text/xml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f8413ddfcd3455a7d89fcc779c1196
https://doi.org/10.1007/s00204-021-03113-0

المؤلفون: Sheroy Minocherhomji, George E. Johnson, Véronique Thybaud, B. Bhaskar Gollapudi, Krista L. Dobo, James Harvey, Julia Kenny, Andreas Zeller, Michelle O. Kenyon, Ryan P Wheeldon, John Nicolette, Anthony M. Lynch

المصدر: Environmental and Molecular Mutagenesis. 62:293-305

مصطلحات موضوعية: Male, Nitrosamines, Acceptable daily intake, Epidemiology, Guanine, DNA repair, Health, Toxicology and Mutagenesis, 010501 environmental sciences, Pharmacology, medicine.disease_cause, 01 natural sciences, DNA Adducts, 03 medical and health sciences, chemistry.chemical_compound, medicine, Animals, Bioassay, Genetics (clinical), Carcinogen, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, Mutation, Environmental Exposure, Rats, chemistry, Nitrosamine, Carcinogens, Female, Carcinogenesis, Water Pollutants, Chemical

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b609d720dd59c323257a79208045cc8a
https://doi.org/10.1002/em.22446

المؤلفون: Francesco Marchetti, Renato Cardoso, Connie L. Chen, George R. Douglas, Joanne Elloway, Patricia A. Escobar, Tod Harper Jr, Robert H. Heflich, Darren Kidd, Anthony M. Lynch, Meagan B. Myers, Barbara L. Parsons, Jesse J. Salk, Raja S. Settivari, Stephanie L. Smith-Roe, Kristine L. Witt, Carole Yauk, Robert R. Young, Shaofei Zhang, Sheroy Minocherhomji

المصدر: Nature Reviews Drug Discovery. 22:165-166

مصطلحات موضوعية: Pharmacology, Drug Discovery, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0999889d4ce03b2372e3772a32b4bdb2
https://doi.org/10.1038/d41573-023-00014-y

المؤلفون: Rachel E. Hewitt, Matthew A. Rodrigues, Danielle S.G. Harte, Q. Haxhiraj, Anne E. Carpenter, R. Buckley, James G. Cronin, Paul Rees, Andrew Filby, Benjamin J. Rees, Catherine A. Thornton, Anthony M. Lynch, Rachel E. Barnes, Jatin R. Verma, Huw D. Summers, Minh Doan, Claire M. Barnes, George E. Johnson, Julia Kenny, John W. Wills

مصطلحات موضوعية: Imaging flow cytometry, Contextual image classification, business.industry, Computer science, Deep learning, Micronucleus test, Frequency data, Pattern recognition, Artificial intelligence, Inter-laboratory, business, Micronucleus, Automation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::61b7a45c53da1a3d22d324a92e689aee
https://doi.org/10.1101/2021.05.05.442619

المؤلفون: Anthony M. Lynch, Douglas C. Bauer

المصدر: Current Topics in Nonclinical Drug Development ISBN: 9780429027536
Current Topics in Nonclinical Drug Development

مصطلحات موضوعية: Environmental science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::74dec42cfef2c8e1a2245f6a6d14634e
https://doi.org/10.1201/9780429027536-7

المؤلفون: Anthony M. Lynch, Sharon A. Robinson, Phil Wilcox, Mark D. Smith, Mark Kleinman, Kaina Jiang, W. Rees, Genetic Toxicology, Glaxosmithkline R, Hertfordshire Sg Dp

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mutage.oxfordjournals.org/content/23/2/111.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.567.1393; http://mutage.oxfordjournals.org/content/23/2/111.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.567.1393
http://mutage.oxfordjournals.org/content/23/2/111.full.pdf

المؤلفون: James S. Harvey, Jonathan R. Howe, Anthony M. Lynch

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mutage.oxfordjournals.org/content/20/1/51.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.548.900; http://mutage.oxfordjournals.org/content/20/1/51.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.548.900
http://mutage.oxfordjournals.org/content/20/1/51.full.pdf

المؤلفون: Kenichi Masumura, Roland Froetschl, Azeddine Elhajouji, Francesco Marchetti, Micheline Kirsch-Volders, David A. Eastmond, David Tweats, Francesca Pacchierotti, Maik Schuler, Anthony M. Lynch

المساهمون: Biology

مصطلحات موضوعية: 0301 basic medicine, Mutagenicity Tests/methods, Health, Toxicology and Mutagenesis, Aneuploidy, Disease, Bioinformatics, medicine.disease_cause, Microtubules, Chromosomes/drug effects, 0302 clinical medicine, Nondisjunction, Genetic, Genes, Reporter, Chromosome Segregation, Neoplasms, Adverse Outcome Pathway, Aurora Kinase B, Risk Management/legislation & jurisprudence, Micronucleus Tests, Aurora Kinase B/antagonists & inhibitors, Tubulin Modulators/toxicity, Tubulin Modulators, Mutagens/analysis, 030220 oncology & carcinogenesis, Aneugen, Mitosis/drug effects, Chromosome Segregation/drug effects, mice, Mitosis, Chromosome Aberrations/chemically induced, Chromosomes, Tubulin binding, 03 medical and health sciences, Genetics, medicine, Animals, Humans, Workgroup, Germ Cells/drug effects, Chromosome Aberrations, Risk Management, Adverse Outcome Pathways, business.industry, Mutagenicity Tests, Genetic Diseases, Inborn/chemically induced, Genetic Diseases, Inborn, Nondisjunction, Genetic/drug effects, medicine.disease, 030104 developmental biology, Germ Cells, Hereditary Diseases, Neoplasms/chemically induced, Carcinogens, Microtubules/drug effects, Carcinogenesis, business, Carcinogens/toxicity, Mutagens

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1beb47e5cb23d9b121a5188fc38813
https://doi.org/10.1016/j.mrgentox.2019.02.006

المؤلفون: Azeddine Elhajouji, Zhanna Sobol, Véronique Thybaud, Jennifer Y. Tanir, Peter Kasper, Anthony M. Lynch, Andreas Sutter, Melanie Guérard, Mick D. Fellows

المصدر: Mutagenesis. 31:375-384

مصطلحات موضوعية: 0301 basic medicine, Health, Toxicology and Mutagenesis, Guidelines as Topic, Peptide, Toxicology, medicine.disease_cause, Genotoxicity testing, 03 medical and health sciences, In vivo, Genetics, medicine, Animals, Humans, Genetics (clinical), chemistry.chemical_classification, Mutagenicity Tests, Chemistry, Small molecule, Amino acid, 030104 developmental biology, Biochemistry, Peptides, Linker, Genotoxicity, Mutagens, Genetic Toxicology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6793f3bc0169d69bbf2ed73b7eb410bb
https://doi.org/10.1093/mutage/gew013

المؤلفون: Maik Schuler, Roland Froetschl, Francesca Pacchierotti, Anthony M. Lynch, David Tweats, Kenichi Masumura, Francesco Marchetti, Micheline Kirsch-Volders, David A. Eastmond, Azeddine Elhajouji

المساهمون: Pacchierotti, F., Masumura, K., Eastmond, D. A., Elhajouji, A., Froetschl, R., Kirsch-Volders, M., Lynch, A., Schuler, M., Tweats, D., Marchetti, F., Biology

مصطلحات موضوعية: 0301 basic medicine, Somatic cell, Health, Toxicology and Mutagenesis, Genetic Diseases, Inborn/pathology, Population, Aneuploidy, 010501 environmental sciences, Biology, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, Genetics, medicine, Animals, Humans, risk factors, Aneugens/toxicity, education, Germ Cells/drug effects, Carcinogen, 0105 earth and related environmental sciences, education.field_of_study, Genetic Diseases, Inborn, Aneugens, medicine.disease, Oocyte, Germ Cells, 030104 developmental biology, medicine.anatomical_structure, Hereditary Diseases, Cancer research, Carcinogenesis, carcinogenesis, Germ cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11647076242f23bbd6e3f7aa3790db73
http://hdl.handle.net/20.500.12079/51187

المؤلفون: Francesca Pacchierotti, Kenichi Masumura, Roland Froetschl, Azeddine Elhajouji, David Tweats, Micheline Kirsch-Volders, David A. Eastmond, Anthony M. Lynch, Maik Schuler, Francesco Marchetti

المساهمون: Biology, Tweats, D., Eastmond, D. A., Lynch, A. M., Elhajouji, A., Froetschl, R., Kirsch-Volders, M., Marchetti, F., Masumura, K., Pacchierotti, F., Schuler, M.

المصدر: Mutation research. Genetic toxicology and environmental mutagenesis. 847

مصطلحات موضوعية: Mutagenicity Tests/methods, 0301 basic medicine, Carcinogenesis, Health, Toxicology and Mutagenesis, Aneuploidy, Chromosome Disorders, 010501 environmental sciences, medicine.disease_cause, Chromosomes/drug effects, 01 natural sciences, Mice, Chromosome Disorders/genetics, Chromosome instability, Neoplasms, Spindle Apparatus/drug effects, Neoplasms, Second Primary/chemically induced, Down Syndrome/complications, Tubulin Modulators/toxicity, Neoplasms, Second Primary, Tubulin Modulators, Models, Animal, Down syndrome, Spindle Apparatus, Chromosomes, 03 medical and health sciences, Chromosomal Instability, Genetics, medicine, Animals, Humans, Genetic Predisposition to Disease, Mutagens/toxicity, Epigenetics, Carcinogen, 0105 earth and related environmental sciences, Centrosome, business.industry, Mutagenicity Tests, Cancer, medicine.disease, 030104 developmental biology, Neoplasms/chemically induced, Cancer research, Carcinogens, Carcinogenesis/genetics, Down Syndrome, business, Trisomy, Carcinogens/toxicity, Mutagens

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf0943ba6e018b2c1d6fdf3a5b0cf26
https://pubmed.ncbi.nlm.nih.gov/31699349

المؤلفون: Matthew Cleveland, Anthony M. Lynch, Umesh Kumar, Jens Wuerthner, Robert Stubbs, Rabinder Kumar Prinjha

المصدر: Toxicology Research. 4:1333-1343

مصطلحات موضوعية: Neurite, medicine.drug_class, Health, Toxicology and Mutagenesis, Ozanezumab, Biology, Pharmacology, Toxicology, medicine.disease, Monoclonal antibody, In vitro, Epitope, Immunization, In vivo, medicine, Amyotrophic lateral sclerosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3dce600bc41fe8c54cbf8168c175122a
https://doi.org/10.1039/c5tx00179j

المؤلفون: Benjamin J, Rees, Matthew, Tate, Anthony M, Lynch, Catherine A, Thornton, Gareth J, Jenkins, Richard M, Walmsley, George E, Johnson

المصدر: Mutagenesis

مصطلحات موضوعية: Mutagenicity Tests, Mutation, Humans, Membrane Proteins, Original Manuscripts, Cell Line

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::50b719c0df9f2119aecfed3c59090382
https://pubmed.ncbi.nlm.nih.gov/28057708

المؤلفون: Joachim Kreysa, Mara Ceridono, Eckhard Heisler, Valérie Zuang, João Barroso, Anthony M. Lynch, Mick D. Fellows, David Jones, Catherine Robles, J. Frank Nash, Jacqueline K Akunda, Neil K. Gibbs, Peter Kasper, Cyrille Krul, Abigail Jacobs, Hans Werner Vohr, Dagmar Jírová, Helena Kandarova, Kazuichi Nakamura, Douglas C. Bauer, Nathalie Alépée, Femke M. van de Water, Uwe Pfannenbecker, Olivier Wattrelos, Ann De Smedt, Wolfgang Muster, Gareth Phillips, Douglas B. Learn, Vera Rogiers, Ulla Wändel Liminga, Julie A. Woods, Raffaella Corvi, Manfred Liebsch, Phil Wilcox, Pär Tellner

المصدر: Regulatory Toxicology and Pharmacology, June, 3, 63, 480-488

مصطلحات موضوعية: Drug Industry, Operations research, RAPID - Risk Analysis for Products in Development, Cosmetics, Phototoxicology, Animal Testing Alternatives, Toxicology, Mice, Life, Brainstorming, Toxicity Tests, Animals, Food and Nutrition, Medicine, Nutrition, Pharmaceutical industry, Medical education, Photosensitizing Agents, business.industry, Usability, 3T3 Cells, General Medicine, Guideline, Test (assessment), Positive response, Consumer Product Safety, Neutral Red, Biological Assay, EELS - Earth, Environmental and Life Sciences, Reactive Oxygen Species, business, Phototoxicity, Healthy Living, Dermatitis, Phototoxic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde2d79382eca0cc4dde682c044b1043
https://doi.org/10.1016/j.yrtph.2012.06.001

المؤلفون: K.P. Ahmedi, Anthony M. Lynch, Daniel J. Smart, James Harvey

المصدر: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 715:25-31

مصطلحات موضوعية: Nitrosourea, DNA damage, Health, Toxicology and Mutagenesis, DMBA, Biology, medicine.disease_cause, Chromosome aberration, Flow cytometry, Histones, Mice, chemistry.chemical_compound, Genetics, medicine, Animals, DNA Breaks, Double-Stranded, Leukemia L5178, Cytotoxicity, Molecular Biology, medicine.diagnostic_test, Mutagenicity Tests, Flow Cytometry, Molecular biology, In vitro, chemistry, Biomarkers, Genotoxicity, Mutagens

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4367ea173e93b59489239da3e401c8f0
https://doi.org/10.1016/j.mrfmmm.2011.07.001

المؤلفون: William C. Gunther, Ann Schuermans, John Nicolette, Fabrice Nesslany, Ronald D. Fiedler, Stephen D. Dertinger, Céline Defrain, Laura Custer, Thomas J. Shutsky, Catherine J. Thiffeault, Robert H. Heflich, Paul Sonders, Amanda Giddings, Ljubica Krsmanovic, Javed A. Bhalli, Eleanor C. Wilde, Anthony M. Lynch, James T. MacGregor, Kevin Sweder, Osamu Tajima, Takafumi Kimoto, Andrew Henwood, Jing Shi, Terry Van Doninck, Souk Phonethepswath, Carol Gleason, Bas-jan M. van der Leede, Hans-Werner Vohr, Daniel J. Roberts, Pamela Weller, Azeddine Elhajouji, Yoshie Hiwata, Leon F. Stankowski, Joel Murray, Julia Kenny, Kentaro Tanaka

المصدر: Environmental and Molecular Mutagenesis. 52:690-698

مصطلحات موضوعية: Erythrocytes, Reticulocytes, Time Factors, Endpoint Determination, Epidemiology, International Cooperation, Health, Toxicology and Mutagenesis, Transferability, CD59 Antigens, Pig a gene, Mutagen, Gene mutation, Biology, medicine.disease_cause, Risk Assessment, Flow cytometry, Rats, Sprague-Dawley, Andrology, medicine, Animals, Rats, Wistar, Genetics (clinical), Genetics, Reproducibility, medicine.diagnostic_test, Mutagenicity Tests, Membrane Proteins, Reproducibility of Results, Reference Standards, Flow Cytometry, Rats, Inbred F344, Rats, Data Interpretation, Statistical, Ethylnitrosourea, Calibration, Mutation, Mutation (genetic algorithm), Laboratories, Genotoxicity, Mutagens

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f313510d8a658754853218a9f4fc7a2
https://doi.org/10.1002/em.20672

المؤلفون: Dan D. Levy, Mick D. Fellows, Marilyn J. Aardema, Takeshi Morita, Robert H. Heflich, Elisabeth Lorge, David Kirkland, Maik Schuler, Anthony M. Lynch, Daniel Marzin, David A. Eastmond, Günter Speit, Sheila M. Galloway

المصدر: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 723:77-83

مصطلحات موضوعية: Genetics, Proliferation index, Cell growth, Health, Toxicology and Mutagenesis, Cell, Biology, Pharmacology, medicine.disease_cause, Chromosome aberration, medicine.anatomical_structure, Toxicity, medicine, Cytotoxicity, Micronucleus, Genotoxicity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e935bb8d6d6e649e4fd803ab3b13be45
https://doi.org/10.1016/j.mrgentox.2011.01.003

المؤلفون: Phillip Wilcox, Anthony M. Lynch

المصدر: Experimental and Toxicologic Pathology. 63:209-214

مصطلحات موضوعية: BALB 3T3 Cells, Drug Industry, Drug-Related Side Effects and Adverse Reactions, Ultraviolet Rays, Drug Evaluation, Preclinical, Toxicology, Pathology and Forensic Medicine, Mice, Predictive Value of Tests, Toxicity Tests, Animals, Humans, Medicine, Drug industry, Pharmaceutical industry, business.industry, Guidance documents, Cell Biology, General Medicine, Photochemical Processes, Biotechnology, Pharmaceutical Preparations, Drug development, Neutral Red, Phototoxicity, business, Dermatitis, Phototoxic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef004d103fd4c810588390da4edaa57
https://doi.org/10.1016/j.etp.2009.12.001

المؤلفون: Svetlana L. Avlasevich, Stephen D. Dertinger, Anthony M. Lynch, Azeddine Elhajouji, Steven M. Bryce, Marlies De Boeck, John Nicolette, Freddy Van Goethem, Jing Shi

المصدر: Mutagenesis. 26:147-152

مصطلحات موضوعية: Genetics, Micronucleus Tests, medicine.diagnostic_test, Health, Toxicology and Mutagenesis, Frequency data, Cell Count, Computational biology, Biology, Flow Cytometry, Toxicology, Flow cytometry, Mammalian cell, Micronucleus test, medicine, Animals, Humans, Micronucleus, Cells, Cultured, Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efd7275f820fe75ac97ea3a9d3c7de9
https://doi.org/10.1093/mutage/geq058