المؤلفون: Anne-Sophie Rebstock, Mareike Wiedmann, Beatrix Stelte-Ludwig, Harvey Wong, Amy J. Johnson, Raquel Izumi, Ahmed Hamdy, Hans-Georg Lerchen

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: αvβ3 integrin, tumor microenvironment, neutrophil elastase (NE), small molecule drug conjugate, camptothecin, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1358393/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/48196de27ca84870b273d09b3f4c3f6d

المؤلفون: Anne-Sophie Rebstock, Mareike Wiedmann, Beatrix Stelte-Ludwig, Harvey Wong, Amy J. Johnson, Raquel Izumi, Ahmed Hamdy, Hans-Georg Lerchen

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, αvβ3 integrin, tumor microenvironment, neutrophil elastase (NE), small molecule drug conjugate, camptothecin

Relation: https://figshare.com/articles/dataset/DataSheet1_Neutrophil_elastase_as_a_versatile_cleavage_enzyme_for_activation_of_v_3_integrin-targeted_small_molecule_drug_conjugates_with_different_payload_classes_in_the_tumor_microenvironment_pdf/25322086

الاتاحة: https://doi.org/10.3389/fphar.2024.1358393.s001
https://figshare.com/articles/dataset/DataSheet1_Neutrophil_elastase_as_a_versatile_cleavage_enzyme_for_activation_of_v_3_integrin-targeted_small_molecule_drug_conjugates_with_different_payload_classes_in_the_tumor_microenvironment_pdf/25322086

المؤلفون: Hannah JÖRIßEN, Beatrix Stelte-Ludwig, Lisa Dietz, Simone Greven, Anette Sommer, Sarah Johannes, Anne-Sophie Rebstock, Hans-Georg Lerchen, Christoph Mahlert, Sandra Berndt

المصدر: Bioconjugate Chemistry. 31:1893-1898

مصطلحات موضوعية: Urologic Neoplasms, Immunoconjugates, medicine.medical_treatment, Biomedical Engineering, Kinesins, Pharmaceutical Science, Bioengineering, Healthy tissue, 02 engineering and technology, Legumain, 01 natural sciences, Mice, Structure-Activity Relationship, Drug Delivery Systems, medicine, Animals, Humans, Prodrugs, In patient, Asparagine, Pharmacology, Therapeutic window, Protease, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Neoplasms, Experimental, 021001 nanoscience & nanotechnology, 0104 chemical sciences, body regions, Cysteine Endopeptidases, Biophysics, biology.protein, Urothelium, 0210 nano-technology, Linker, Biotechnology, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252e84c3e966a667b671fd1d96b8ef77
https://doi.org/10.1021/acs.bioconjchem.0c00357

المؤلفون: Hans-Georg Lerchen, Anne-Sophie Rebstock, Marieke Wiedmann, Beatrix Stelte-Ludwig, Harvey Wong, Dmitry Zubov, Raquel Izumi, Ahmed Hamdy

المصدر: Cancer Research. 83:2722-2722

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::90c368bbe82b4e59e6d3866b1c24cfc2
https://doi.org/10.1158/1538-7445.am2023-2722

المؤلفون: Christoph Mahlert, Beatrix Stelte-Ludwig, Sarah Johannes, Lisa Dietz, Hannah JÖRIßEN, Hans-Georg Lerchen, Anette Sommer, Anne-Sophie Rebstock, Simone Greven, Leo Marx, Sandra Berndt

المصدر: Chemistry – A European Journal. 25:8208-8213

مصطلحات موضوعية: B7 Antigens, Immunoconjugates, Metabolite, Kinesins, Antineoplastic Agents, 010402 general chemistry, Cleavage (embryo), Legumain, 01 natural sciences, Antibodies, Catalysis, Mice, chemistry.chemical_compound, Cell Line, Tumor, Animals, Humans, Prodrugs, Peptide sequence, Active metabolite, Cathepsin, biology, 010405 organic chemistry, Organic Chemistry, General Chemistry, Prodrug, Endopeptidase, 0104 chemical sciences, Cysteine Endopeptidases, chemistry, Biochemistry, biology.protein, Heterografts, Oligopeptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca64068636167b875be009f30e537947
https://doi.org/10.1002/chem.201900441

المؤلفون: Sven Wittrock, Carsten Terjung, Anne-Sophie Rebstock, Nils Griebenow, Anette Sommer, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Yolanda Cancho-Grande, Christoph Mahlert, Sarah Johannes, Sandra Berndt, Simone Greven

المصدر: Angewandte Chemie International Edition. 57:15243-15247

مصطلحات موضوعية: 0301 basic medicine, Drug, Immunoconjugates, media_common.quotation_subject, Kinesins, Antineoplastic Agents, Computational biology, Catalysis, 03 medical and health sciences, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Humans, Pyrroles, Mode of action, media_common, Bioconjugation, Drug discovery, Payload, Chemistry, technology, industry, and agriculture, General Chemistry, body regions, 030104 developmental biology, Kinesin, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1540c754f2b5da57e05a920741a4d1
https://doi.org/10.1002/anie.201807619

المؤلفون: Dennis Kirchhoff, Sandra Johanssen, Pascale Lejeune, Hannah JÖRIßEN, Stephan Märsch, Christoph Mahlert, Sarah Johannes, Sandra Berndt, Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Leo Marx, Anette Sommer, Lisa Dietz, Ruprecht Zierz, Anne-Sophie Rebstock, Sven Wittrock, Simone Greven

المصدر: ADC Review / Journal of Antibody-drug Conjugates.

مصطلحات موضوعية: Drug, biology, Chemistry, Proteinase inhibitor, Mechanical Engineering, media_common.quotation_subject, Energy Engineering and Power Technology, Management Science and Operations Research, body regions, Biochemistry, Hardware_INTEGRATEDCIRCUITS, biology.protein, Kinesin, Hardware_ARITHMETICANDLOGICSTRUCTURES, Antibody, Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION, Linker, media_common, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e82f03c28658701b2284dce2d292d811
https://doi.org/10.14229/jadc.2019.11.12.002

المؤلفون: Hans-Georg Lerchen, Hilmar Weinmann, Anne-Sophie Rebstock, Hannah Joerissen, Sandra Berndt, Lisa Dietz, Leo Marx, Anette Sommer, Beatrix Stelte-Ludwig, Sarah Johannes, Christoph Mahlert, Simone Greven

المصدر: Cancer Research. 79:228-228

مصطلحات موضوعية: Cancer Research, Proteases, Protease, biology, Chemistry, medicine.medical_treatment, Elastase, Cleavage (embryo), Legumain, body regions, Oncology, Biochemistry, medicine, biology.protein, Kinesin, Mode of action, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::72e82e9722c24889b6b3601ff4657063
https://doi.org/10.1158/1538-7445.am2019-228

المؤلفون: Beatrix Stelte-Ludwig, Oliver von Ahsen, Pascale Buchmann, Dominik Mumberg, Antje Margret Wengner, Anette Sommer, Dennis Kirchhoff, Bertolt Kreft, Anne-Sophie Rebstock, Sandra Johanssen, Hans-Georg Lerchen, Lisa Dietz

المصدر: Cancer Research. 79:4828-4828

مصطلحات موضوعية: Cancer Research, biology, medicine.diagnostic_test, business.industry, Cell cycle, Flow cytometry, Haematopoiesis, Oncology, Cell culture, biology.protein, Cancer research, Medicine, Interleukin-3 receptor, Stem cell, Antibody, business, Interleukin 3

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7d15e2e1fea6eb87fbe52f688b59e353
https://doi.org/10.1158/1538-7445.am2019-4828

المؤلفون: Lisa Dietz, Anne-Sophie Rebstock, Anette Sommer, Leo Marx, Simone Greven, Sandra Berndt, Christoph Mahlert, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Sarah Johannes, Hannah JÖRIßEN

المصدر: Chemistry – A European Journal. 25:8171-8171

مصطلحات موضوعية: biology, Stereochemistry, Metabolite, Organic Chemistry, General Chemistry, Prodrug, Legumain, Catalysis, chemistry.chemical_compound, Front cover, chemistry, biology.protein, Antibody, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a36f0c24bfff5dcbf28e082d7dfb4606
https://doi.org/10.1002/chem.201901769

المؤلفون: Gareth H. Williams, Cristina Visintin, Henry Dube, Dimitris Lagos, Kai Stoeber, Roberta J. Worthington, Slavica Tudzarova, Heike Laman, Sarah R. Kingsbury, Chris Boshoff, Michela I. Simone, Matt Gooding, Anne-Sophie Rebstock, Juan-Manuel Funes Quesada, David L. Selwood

المصدر: Chemical Biology & Drug Design. 79:9-21

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Molecular model, Biomolecule, Aryl, Organic Chemistry, Chemical biology, RNA, Isothermal titration calorimetry, Biochemistry, Small molecule, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Helix, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e55b3a95cf4f5500bd2307bd2cb077d6
https://doi.org/10.1111/j.1747-0285.2011.01249.x

المؤلفون: Anette Sommer, Carsten Terjung, Yolanda Cancho-Grande, Beatrix Stelte-Ludwig, Anne-Sophie Rebstock, Sven Wittrock, Christoph Mahlert, Hans-Georg Lerchen, Sarah Johannes, Simone Greven, Nils Griebenow, Sandra Berndt

المصدر: Angewandte Chemie International Edition. 57:14950-14950

مصطلحات موضوعية: Drug, chemistry.chemical_compound, Bioconjugation, Chemistry, media_common.quotation_subject, Payload (computing), INT, General Chemistry, Combinatorial chemistry, Catalysis, media_common, Pyrrole, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea796ec937c2947f8cb17c22bb66e2c8
https://doi.org/10.1002/anie.201810987

المؤلفون: Nils Griebenow, Sarah Johannes, Anne-Sophie Rebstock, Carsten Terjung, Anette Sommer, Beatrix Stelte-Ludwig, Simone Greven, Christoph Mahlert, Yolanda Cancho-Grande, Hans-Georg Lerchen, Sven Wittrock, Sandra Berndt

المصدر: Angewandte Chemie. 130:15166-15166

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6da34b412945ffb7343d23f431d8000e
https://doi.org/10.1002/ange.201810987

المؤلفون: Anne-Sophie Rebstock, François Trécourt, Guy Quéguiner, Florence Mongin

المصدر: Tetrahedron. 60:2181-2186

مصطلحات موضوعية: Quenching (fluorescence), Alkaloid, Organic Chemistry, Biochemistry, Medicinal chemistry, chemistry.chemical_compound, Deprotonation, chemistry, Amide, Drug Discovery, Electrophile, Organic chemistry, Benzamide, Benzoic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bc0e2cf152af0d66bdf766c367fde58a
https://doi.org/10.1016/j.tet.2004.01.050

المؤلفون: François Trécourt, Guy Quéguiner, Florence Mongin, Anne-Sophie Rebstock

المصدر: Org. Biomol. Chem.. 2:291-295

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Stereochemistry, Group (periodic table), Organic Chemistry, Sequence (biology), Biological activity, General Medicine, Carboxylate, Physical and Theoretical Chemistry, Biochemistry, Benzoic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1baed078d30628f8a41fe65107ea90
https://doi.org/10.1039/b312723k

المؤلفون: Anne-Sophie Rebstock, Guy Quéguiner, François Trécourt, Florence Mongin

المصدر: Tetrahedron. 59:4973-4977

مصطلحات موضوعية: Deprotonation, chemistry, Organic Chemistry, Drug Discovery, chemistry.chemical_element, Lithium, Ring (chemistry), Biochemistry, Medicinal chemistry, Benzoates

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::591a479a09495298d1cff35d47e91a82
https://doi.org/10.1016/s0040-4020(03)00761-0

المؤلفون: François Trécourt, Florence Mongin, Guy Quéguiner, Anne-Sophie Rebstock

المصدر: Org. Biomol. Chem.. 1:3064-3068

مصطلحات موضوعية: Quenching (fluorescence), Organic Chemistry, chemistry.chemical_element, Ether, General Medicine, Biochemistry, Medicinal chemistry, chemistry.chemical_compound, Deprotonation, chemistry, Reagent, Organic chemistry, Lithium, Phenols, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7451d194b1bb306b7ed7675ab1c34b28
https://doi.org/10.1039/b305043b

المؤلفون: Heiner Apeler, Nils Griebenow, Anette Sommer, Christoph Mahlert, Simone Greven, Anne-Sophie Rebstock, Sandra Berndt, Sven Wittrock, Carsten Terjung, Mario Lobell, Bertolt Kreft, Beatrix Stelte-Ludwig, Hans-Georg Lerchen, Yolanda Cancho-Grande, Rolf Jautelat

المصدر: Cancer Research. 77:3234-3234

مصطلحات موضوعية: Cancer Research, Biodistribution, Oncology, Chemistry, In vivo, Cancer research, Potency, Topoisomerase-I Inhibitor, Mode of action, Small molecule, Linker, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::440db8b0666f78f42dddfa8c3be1fcfa
https://doi.org/10.1158/1538-7445.am2017-3234

المؤلفون: Anette Sommer, Sven Wittrock, Heiner Apeler, Hans-Georg Lerchen, Rolf Jautelat, Bertolt Kreft, Simone Greven, Yolanda Cancho-Grande, Sandra Berndt, Anne-Sophie Rebstock, Nils Griebenow, Lisa Dietz, Beatrix Stelte-Ludwig, Christoph Mahlert

المصدر: Cancer Research. 77:46-46

مصطلحات موضوعية: Cancer Research, Chemistry, Cancer, medicine.disease, Molecular biology, In vitro, Oncology, Antigen, In vivo, Cancer cell, Cancer research, medicine, Cytotoxic T cell, Cytotoxicity, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::90fee3ad3c02387199c06ec2426e9393
https://doi.org/10.1158/1538-7445.am2017-46

المؤلفون: Amrita Ahluwalia, Reshma S. Baliga, Adrian J. Hobbs, Concepción Peiró, Roberta J. Worthington, Fernando Rivilla, Amie J Moyes, Paul J. Gane, Inmaculada C Villar, Filipa Mota, Natalie G. Lumsden, Snezana Djordjevic, Raymond J. MacAllister, Mark J. Caulfield, Susana Vallejo, Anne Sophie Rebstock, Fang Xiao, David L. Selwood, Carlos F. Sánchez Ferrer, Kristen J. Bubb, Michela I. Simone, Rayomand S. Khambata

المصدر: The Journal of clinical investigation. 124(9)

مصطلحات موضوعية: Blood Platelets, Male, medicine.medical_specialty, Endothelium, medicine.drug_class, Vasodilation, Blood Pressure, Muscle, Smooth, Vascular, Mice, Internal medicine, medicine, Natriuretic peptide, Leukocytes, Animals, Homeostasis, Endothelial dysfunction, Receptor, Mice, Knockout, business.industry, Natriuretic Peptide, C-Type, General Medicine, medicine.disease, Atherosclerosis, Vasoprotective, Aortic Aneurysm, Rats, Mice, Inbred C57BL, Blood pressure, medicine.anatomical_structure, Endocrinology, Calcium, Female, Endothelium, Vascular, business, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb059e71868067b469021249ee8c502c
https://pubmed.ncbi.nlm.nih.gov/25105365