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1
المؤلفون: Robert C. Bruckner, Andrew M. Stern, Anne Higley, Graciani Nilsa R, Sandya Mandlekar, Maria Rafalski, Melody Diamond, Ross L. Stein, Eddy W. Yue, Xiang Jiang, Pearl S. Huang, Randine Dowling, Dimeo Susan, Lisa C. Grimminger, Mingzhu Zhang, Zhihong Lai, Amy L. Musselman, Swamy Yeleswaram, Davette L. Behrens, Robert A. Copeland, Andrew P. Combs, Oliff Allen I, Wei Han, Shu-Yun Zhang, Rebecca Taub, Bruce Car, George L. Trainor, Charles F. Albright, Steve P. Seitz, Daniel Hu
المصدر: Molecular Cancer Therapeutics. 4:751-760
مصطلحات موضوعية: Cancer Research, Reticulocytes, Drug-Related Side Effects and Adverse Reactions, Matrix Metalloproteinases, Membrane-Associated, Fibrosarcoma, Transplantation, Heterologous, Pharmacology, Mice, Therapeutic index, Tumor Cells, Cultured, medicine, Animals, Humans, Prodrugs, Doxorubicin, Neprilysin, Chemistry, Metalloendopeptidases, Prodrug, medicine.disease, Peptide Fragments, In vitro, Transplantation, Matrix Metalloproteinase 9, Oncology, Matrix Metalloproteinase 2, HT1080, Drug Screening Assays, Antitumor, medicine.drug
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2
المؤلفون: Angela Smallwood, Jodi K. Muckelbauer, Sarah Cox, C. Anne Higley, Steven P. Seitz, Eddy W. Yue, George L. Trainor, Dimeo Susan, Haiying Chen, Robert H. Grafstrom, Pamela A. Benfield, Jay A. Markwalder, Catherine R. Burton, Chong Hwan Chang
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:343-346
مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Heterocyclic Compounds, Cyclin-dependent kinase, Cell Line, Tumor, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Protein kinase A, Fibroblast, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Fibroblasts, Blood proteins, Cyclin-Dependent Kinases, In vitro, medicine.anatomical_structure, Enzyme, Enzyme inhibitor, Cell culture, biology.protein, Pyrazoles, Molecular Medicine
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3
المؤلفون: Angela Smallwood, Dimeo Susan, Carrie Benware, Eddy W. Yue, David J. Carini, C. Anne Higley, Lisa M. Sisk, David A. Nugiel, Chong-Hwan Chang, Catherine R. Burton, Diane M. Sharp, Pamela A. Benfield, Jodi K. Muckelbauer, Sarah Cox, Steven P. Seitz, Haiying Chen, John F. Boylan, Robert H. Grafstrom, George L. Trainor
المصدر: Journal of Medicinal Chemistry. 45:5233-5248
مصطلحات موضوعية: chemistry.chemical_classification, biology, Molecular model, Kinase, medicine.drug_class, Stereochemistry, Carboxamide, Chemical synthesis, chemistry, Enzyme inhibitor, Cyclin-dependent kinase, Drug Discovery, biology.protein, medicine, Molecular Medicine, Transferase, Alkyl
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4
المؤلفون: Santella Joseph B, John Wityak, Ruth R. Wexler, Robert A. Copeland, Pitts William J, Deborah A. Stradley, Frank W. Hobbs, Peggy Scherle, Elizabeth J. Manos, A. Christine Tabaka, Jung-Hui Sun, Kurumi Y. Horiuchi, James M. Trzaskos, William Eric Frietze, Ronald L. Magolda, Duncia John, Andrea J. Daulerio, Richard E. Olson, C. Anne Higley, Christopher A. Teleha, Richard A. Earl, F.Wayne Rankin, Margaret F. Favata, Karl F. Blom, George L. Trainor
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:2839-2844
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Protein Serine-Threonine Kinases, Biochemistry, Non-competitive inhibition, In vivo, Nitriles, Drug Discovery, Butadienes, medicine, Animals, Enzyme Inhibitors, Molecular Biology, IC50, Biotransformation, Transcriptional activity, Chemistry, Organic Chemistry, NF-kappa B, Dual-specificity kinase, Biological activity, Rats, Transcription Factor AP-1, Mechanism of action, Cyclization, Molecular Medicine, medicine.symptom, Isomerization
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5
المؤلفون: Patricia C. Weber, Richard S. Alexander, Charles A. Kettner, Mimi L. Quan, Duncia John, Robert M. Knabb, Mary K. VanAtten, C. Anne Higley, Ruth R. Wexler, Santella Joseph B, Anne Y. Liauw, James Russell Pruitt
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:775-780
مصطلحات موضوعية: Models, Molecular, inorganic chemicals, Steric effects, Molecular model, Clinical Biochemistry, Tetrazoles, Pharmaceutical Science, Peptide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, Drug Discovery, medicine, Organic chemistry, Molecular Biology, chemistry.chemical_classification, Binding Sites, Dipeptide, Molecular Structure, biology, Organic Chemistry, Stereoisomerism, Triazoles, Amides, Boronic Acids, Combinatorial chemistry, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine, Indicators and Reagents, Discovery and development of direct thrombin inhibitors, medicine.drug
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6
المؤلفون: Chu-Biao Xue, John Wityak, Thais M. Sielecki, Donald J. Pinto, Douglas G. Batt, Gary A. Cain, Michael Sworin, Arlene L. Rockwell, John J. Roderick, Shuaige Wang, Michael J. Orwat, William E. Frietze, Lori L. Bostrom, Jie Liu, C. Anne Higley, F. Wayne Rankin, A. Ewa Tobin, George Emmett, George K. Lalka, Jean Y. Sze, Susan V. Di Meo, Shaker A. Mousa, Martin J. Thoolen, Adrienne L. Racanelli, Elizabeth A. Hausner, Thomas M. Reilly, William F. DeGrado, Ruth R. Wexler, Richard E. Olson
المصدر: Journal of Medicinal Chemistry. 40:2064-2084
مصطلحات موضوعية: Blood Platelets, Male, Stereochemistry, medicine.drug_class, Administration, Oral, Carboxamide, Platelet Glycoprotein GPIIb-IIIa Complex, Chemical synthesis, Stereocenter, Amidine, chemistry.chemical_compound, Dogs, In vivo, Drug Discovery, medicine, Animals, Moiety, Potency, Isoxazoles, Macaca mulatta, Models, Chemical, chemistry, Drug Design, Molecular Medicine, Female, Glycoprotein IIb/IIIa, Platelet Aggregation Inhibitors, Papio
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7
المؤلفون: Thomas P. Maduskuie, Richard G. Wilde, Jeffrey T. Billheimer, Debra A. Cromley, Sandra Germain, Peter J. Gillies, C. Anne Higley, Alex L. Johnson, Penio Pennev, Edward J. Shimshick, Ruth R. Wexler
المصدر: Journal of Medicinal Chemistry. 38:1067-1083
مصطلحات موضوعية: Sterol O-acyltransferase, Chemical synthesis, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Foam cell, chemistry.chemical_classification, biology, Cholesterol, Macrophages, Imidazoles, In vitro, Rats, Isoenzymes, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Sterol O-Acyltransferase
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8
المؤلفون: Ruth R. Wexler, Hollis Smith Kezar, Edward S. Shimshick, Jeffrey T. Billheimer, C. Anne Higley, Richard G. Wilde, Peter J. Gillies, Sandra J. Germain, Thomas P. Maduskuie
المصدر: Bioorganic & Medicinal Chemistry Letters. 5:167-172
مصطلحات موضوعية: chemistry.chemical_classification, Quantitative structure–activity relationship, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Sterol O-acyltransferase, Pharmaceutical Science, Biochemistry, In vitro, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, Molecular Medicine, Imidazole, Potency, Molecular Biology
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9
المؤلفون: Peter J. Gillies, C. Anne Higley, Pennio Pennev, Alexander L. Johnson, Candy S. Robinson, Richard G. Wilde, Thomas P. Maduskuie, Jeffrey T. Billheimer, Ruth R. Wexler
المصدر: Journal of Medicinal Chemistry. 37:3511-3522
مصطلحات موضوعية: Male, Stereochemistry, Sterol O-acyltransferase, Thio, Structure-Activity Relationship, In vivo, Cricetinae, Drug Discovery, Animals, Urea, Structure–activity relationship, IC50, chemistry.chemical_classification, Mesocricetus, Molecular Structure, biology, Anticholesteremic Agents, Imidazoles, In vitro, Rats, Cholesterol, Enzyme, Biochemistry, chemistry, Enzyme inhibitor, Microsomes, Liver, biology.protein, Molecular Medicine, Sterol O-Acyltransferase