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1
المؤلفون: Felix Orben, Svenja Lier, Bo Kong, Lukas Krauß, Carolin Schneider, Matthias Wirth, Christoph Schlag, Anna Kuisl, Dieter Saur, Stephanie Heinzlmeir, Arlette Schäfer, Herwig Pongratz, Bernhard Kuster, Stefan Dove, Maximilian Reichert, Rupert Öllinger, Siavosh Mahboobi, Christian Schneeweis, Günter Schneider, Roland Rad, Zonera Hassan, Florian Bassermann, Andreas Sellmer, Thomas Engleitner
المصدر: Bioorganic chemistry. 119
مصطلحات موضوعية: Ubiquitin-Protein Ligases, Antineoplastic Agents, Protein degradation, Biochemistry, PLK1, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, medicine, Tumor Cells, Cultured, Humans, Molecular Biology, 030304 developmental biology, Cell Proliferation, Gastrointestinal Neoplasms, 0303 health sciences, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Kinase, Cereblon, Organic Chemistry, Proteolysis targeting chimera, Cancer, medicine.disease, 3. Good health, Ubiquitin ligase, Thalidomide, Thiazoles, Proteasome, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Drug Screening Assays, Antitumor
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2
المؤلفون: Brenda A. Schulman, Ulrich Keller, Katharina Götze, Mareike Verbeek, Jacob Stroh, Arne Skerra, Bernhard Kuster, Anna Kuisl, Simone Lemeer, Volker Morath, Michael Heider, Kheewoong Baek, Jana Zecha, Florian Bassermann, Martina Rudelius, Anne-Kathrin Garz, Vanesa Fernández-Sáiz, Johannes Buchner, Ruth Eichner, Wolfgang A. Weber, Jannis Lawatscheck, Friedrich-Christian Deuschle
المساهمون: Sub Education Institute Chemistry, Biomolecular Mass Spectrometry and Proteomics
المصدر: Molecular Cell, 81(6), 1170. Cell Press
Molecular Cellمصطلحات موضوعية: Cancer Research, CD98hc, Fusion Regulatory Protein 1, Heavy Chain, Ubiquitin-Protein Ligases, Cellular homeostasis, Mice, SCID, Biology, Proteomics, Article, Large Neutral Amino Acid-Transporter 1, 03 medical and health sciences, Mice, 0302 clinical medicine, Ubiquitin, Mice, Inbred NOD, ubiquitin, Tumor Cells, Cultured, Animals, Humans, Immunologic Factors, chaperones, HSP90, Amino acid transporter, HSP90 Heat-Shock Proteins, protein quality control, IMiDs, Molecular Biology, 030304 developmental biology, Adaptor Proteins, Signal Transducing, Mice, Knockout, 0303 health sciences, Cereblon, Cell Biology, Hsp90, Transmembrane protein, LAT1, ddc, 3. Good health, Cell biology, Neoplasm Proteins, multiple myeloma, HEK293 Cells, CRBN, biology.protein, radio-theranostics, 030217 neurology & neurosurgery, Anticalin, Molecular Chaperones
وصف الملف: application/pdf; application/zip
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3The IMiD-Target Cereblon Determines Transmembrane Protein Quality Control Promoting Tumor Metabolism
المؤلفون: Vanesa Fernández-Sáiz, Ruth Eichner, Martina Rudelius, Florian Bassermann, Bernhard Kuster, Jannis Lawatscheck, Christian Peschel, Jacob Stroh, Michael Heider, Jana Zecha, Anne-Kathrin Garz, Anna Kuisl, Katharina Götze, Simone Lemeer, Johannes Buchner, Ulrich Keller
المصدر: Blood. 134:314-314
مصطلحات موضوعية: biology, Chemistry, Cereblon, Immunology, HSP90 Heat-Shock Proteins, Cell Biology, Hematology, Metabolism, Biochemistry, Transmembrane protein, Cell biology, Ubiquitin, Proteome, biology.protein, Amino acid transporter, Integral membrane protein