المؤلفون: Lee A. Harrison (2160145), Stephen J. Atkinson (1297362), Anna Bassil (10233082), Chun-wa Chung (1343454), Paola Grandi (1343472), James R. J. Gray (9105255), Etienne Levernier (11090201), Antonia Lewis (1899874), David Lugo (2803279), Cassie Messenger (8189169), Anne-Marie Michon (1343457), Darren J. Mitchell (1343451), Alex Preston (9105252), Rab K. Prinjha (449759), Inmaculada Rioja (8539), Jonathan T. Seal (2119816), Simon Taylor (441637), Ian D. Wall (2525425), Robert J. Watson (1343463), James M. Woolven (2119828), Emmanuel H. Demont (1399288)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, BD 2 phenotype, GSK, compound, Proteins Domain-specific BET bromod., BD 2, BD 1, Extra Terminal Domain, Brd 4 data

Relation: https://figshare.com/articles/journal_contribution/Identification_of_a_Series_of_i_N_i_Methylpyridine-2-carboxamides_as_Potent_and_Selective_Inhibitors_of_the_Second_Bromodomain_BD2_of_the_Bromo_and_Extra_Terminal_Domain_BET_Proteins/14924558

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02155.s001

المؤلفون: Helen E. Aylott (5896082), Stephen J. Atkinson (1297362), Paul Bamborough (1343466), Anna Bassil (10233082), Chun-wa Chung (1343454), Laurie Gordon (1357524), Paola Grandi (1343472), James R. J. Gray (9105255), Lee A. Harrison (2160145), Thomas G. Hayhow (3624884), Cassie Messenger (8189169), Darren Mitchell (3834424), Alexander Phillipou (8806631), Alex Preston (9105252), Rab K. Prinjha (449759), Francesco Rianjongdee (9260972), Inmaculada Rioja (8539), Jonathan T. Seal (2119816), Ian D. Wall (2525425), Robert J. Watson (1343463), James M. Woolven (2119828), Emmanuel H. Demont (1399288)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Pharmacology, Evolutionary Biology, Cancer, Infectious Diseases, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, GSK 046, BET, bioavailable compounds 28, ZA, structure-based drug design, BD 2-selective series

Relation: https://figshare.com/articles/journal_contribution/Template-Hopping_Approach_Leads_to_Potent_Selective_and_Highly_Soluble_Bromo_and_Extraterminal_Domain_BET_Second_Bromodomain_BD2_Inhibitors/14167144

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02156.s001

المؤلفون: Lee A. Harrison (2160145), Stephen J. Atkinson (1297362), Anna Bassil (10233082), Chun-wa Chung (1343454), Paola Grandi (1343472), James R. J. Gray (9105255), Etienne Levernier (11090201), Antonia Lewis (1899874), David Lugo (2803279), Cassie Messenger (8189169), Anne-Marie Michon (1343457), Darren J. Mitchell (1343451), Alex Preston (9105252), Rab K. Prinjha (449759), Inmaculada Rioja (8539), Jonathan T. Seal (2119816), Simon Taylor (441637), Ian D. Wall (2525425), Robert J. Watson (1343463), James M. Woolven (2119828), Emmanuel H. Demont (1399288)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, BD 2 phenotype, GSK, compound, Proteins Domain-specific BET bromod., BD 2, BD 1, Extra Terminal Domain, Brd 4 data

Relation: https://figshare.com/articles/dataset/Identification_of_a_Series_of_i_N_i_Methylpyridine-2-carboxamides_as_Potent_and_Selective_Inhibitors_of_the_Second_Bromodomain_BD2_of_the_Bromo_and_Extra_Terminal_Domain_BET_Proteins/14924561

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02155.s002

المؤلفون: Jonathan T. Seal (2119816), Stephen J. Atkinson (1297362), Paul Bamborough (1343466), Anna Bassil (10233082), Chun-wa Chung (1343454), James Foley (1694122), Laurie Gordon (1357524), Paola Grandi (1343472), James R. J. Gray (9105255), Lee A. Harrison (2160145), Ryan G. Kruger (2013604), Jeanne J. Matteo (2335558), Michael T. McCabe (449753), Cassie Messenger (8189169), Darren Mitchell (3834424), Alex Phillipou (8551068), Alex Preston (9105252), Rab K. Prinjha (449759), Francesco Rianjongdee (9260972), Inmaculada Rioja (8539), Simon Taylor (441637), Ian D. Wall (2525425), Robert J. Watson (1343463), James M. Woolven (2119828), Anastasia Wyce (449747), Xi-Ping Zhang (11128371), Emmanuel H. Demont (1399288)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, drug-like pan-BD 2 inhibitors, furan 24, pharmacology-driven toxicity, pyrrole fragment 6, GSK 620 2, representative example, pyridone series, chemistry efforts, safety profile, Second Bromodomain, Soluble Bromo, pyrazole 23, Extra Terminal Domain, novel class, pan-BET inhibitors, BET family, Fragment-based Scaffold Hopping

Relation: https://figshare.com/articles/dataset/Fragment-based_Scaffold_Hopping_Identification_of_Potent_Selective_and_Highly_Soluble_Bromo_and_Extra_Terminal_Domain_BET_Second_Bromodomain_BD2_Inhibitors/14977137

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00365.s001