المؤلفون: Barbara Czako (9253750), Yuting Sun (3323220), Timothy McAfoos (9579075), Jason B. Cross (1484188), Paul G. Leonard (8747985), Jason P. Burke (2284534), Christopher L. Carroll (9665652), Ningping Feng (3397070), Angela L. Harris (3637717), Yongying Jiang (2405476), Zhijun Kang (2025967), Jeffrey J. Kovacs (9253762), Pijus Mandal (9253756), Brooke A. Meyers (11558411), Faika Mseeh (2342905), Connor A. Parker (9253771), Simon S. Yu (9253777), Christopher C. Williams (2976312), Qi Wu (263110), Maria Emilia Di Francesco (9579048), Giulio Draetta (1586296), Timothy Heffernan (3485177), Joseph. R. Marszalek (9253753), Nancy E. Kohl (2428660), Philip Jones (14235)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Cancer, Hematology, Plant Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, target activities including, receptor tyrosine kinase, narrow human ether, displayed excellent potency, dichlorophenyl )- 2, containing phosphatase 2, pk across species, activated protein kinase, 6 ‑[( 3, rtk ), neurofibromin, mut , 30 , vivo <, xenograft models, vivo .<, tumor growth, subsequent optimization

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_6_3_i_S_i_4_i_S_i_4-Amino-3-methyl-2-oxa-8-azaspiro_4_5_decan-8-yl_-3-_2_3-dichlorophenyl_-2-methyl-3_4-dihydropyrimidin-4-one_IACS-15414_a_Potent_and_Orally_Bioavailable_SHP2_Inhibitor/16803530

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01132.s001

المؤلفون: Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb5082d82bd02f09e6060ee7ba89279
https://doi.org/10.1158/0008-5472.22425706.v1

المؤلفون: Philip Jones, Nancy E. Kohl, Timothy P. Heffernan, Joseph R. Marszalek, Giulio F. Draetta, Andy M. Zuniga, Simon S. Yu, Christopher C. Williams, Erika Suzuki, Nakia D. Spencer, Sahil Seth, Vandhana Ramamoorthy, Michael Peoples, Robert A. Mullinax, Meredith A. Miller, Timothy McAfoos, Pijus K. Mandal, Xiaoyan Ma, Anastasia M. Lopez, Chiu-Yi Liu, Jeffrey J. Kovacs, Zhijun Kang, Yongying Jiang, Justin K. Huang, Virginia Giuliani, Sonal Gera, Guang Gao, Ningping Feng, Qing Chang, Christopher L. Carroll, Caroline C. Carrillo, Jason P. Burke, Christopher A. Bristow, Benjamin J. Bivona, Maria Emilia Di Francesco, Jason B. Cross, Connor A. Parker, Sarah Johnson, Qi Wu, Angela L. Harris, Faika Mseeh, Paul Leonard, Barbara Czako, Brooke A. Meyers, Yuting Sun

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679aa5c2787960118aa25b0d20d0a771
https://doi.org/10.1158/0008-5472.c.6512119.v1

المؤلفون: Nancy E. Kohl, Zhijun Kang, Connor A. Parker, Yuting Sun, Yongying Jiang, Simon S. Yu, Cross Jason, Ningping Feng, Faika Mseeh, Timothy McAfoos, Maria Emilia Di Francesco, Timothy P. Heffernan, Angela L. Harris, Brooke A. Meyers, Paul G. Leonard, Joseph R. Marszalek, Christopher C. Williams, Qi Wu, Jeffrey J. Kovacs, Pijus K. Mandal, Jason P Burke, Giulio Draetta, Barbara Czako, Philip Jones, Christopher Carroll

المصدر: Journal of Medicinal Chemistry. 64:15141-15169

مصطلحات موضوعية: MAPK/ERK pathway, biology, Chemistry, hERG, Phosphatase, Pharmacology, Receptor tyrosine kinase, In vivo, Drug Discovery, biology.protein, Molecular Medicine, Potency, Protein kinase A, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::52237ec958405671436618b3a028bf48
https://doi.org/10.1021/acs.jmedchem.1c01132

المؤلفون: Norma Rogers, Stephan Krapp, Faika Mseeh, Richard T. Lewis, Keith Mikule, Michelle Han, Jay Theroff, Yongying Jiang, Keith M. Wilcoxen, Cross Jason, Dana Pfaffinger, Michael J. Soth, Paul G. Leonard, Philip Jones, Pijus K. Mandal, Angela L. Harris, Martin R. Tremblay, Simon S. Yu, Jason P Burke, Connor A. Parker, Barbara Czako, Alessia Petrocchi, Naphtali J. Reyna, Joseph R. Marszalek, Matthew M. Hamilton, Timothy McAfoos, Brett W. Virgin-Downey, Graham Trevitt, Alfred Lammens, Alan Xu

المصدر: Journal of Medicinal Chemistry. 64:11302-11329

مصطلحات موضوعية: chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Context (language use), Metabolism, Pharmacology, Structure-Activity Relationship, chemistry.chemical_compound, Enzyme, chemistry, Pharmacodynamics, Drug Discovery, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Molecular Medicine, Potency, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Kynurenine, Whole blood

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec33cf6551a670d4d40eaab2894a6f60
https://doi.org/10.1021/acs.jmedchem.1c00679

المؤلفون: Timothy P. Heffernan, Angela L. Harris, Martin R. Tremblay, Connor A. Parker, Yongying Jiang, Robert A. Mullinax, Cross Jason, Jihai Pang, Qi Wu, Edward Q. Chang, Sonal Gera, Keith M. Wilcoxen, Paul G. Leonard, Zhen Liu, Jeffrey J. Kovacs, Erika Suzuki, Barbara Czako, Ningping Feng, Joseph R. Marszalek, Nakia D. Spencer, Pijus K. Mandal, Jason P Burke, Simon S. Yu, Keith Mikule, Faika Mseeh, Philip Jones, Giulio Draetta

المصدر: Journal of Medicinal Chemistry. 63:9888-9911

مصطلحات موضوعية: Molecular Structure, THP-1 Cells, Chemistry, Macrophage polarization, Antineoplastic Agents, Phenotype, Structure-Activity Relationship, Pyrimidines, Drug Stability, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Neoplasms, Tumor-Associated Macrophages, Drug Discovery, Microsomes, Liver, Cancer research, Humans, Molecular Medicine, Structure–activity relationship, THP1 cell line, Benzothiazoles, Kinase activity, Signal transduction, Receptor, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477eb096ec2e1d0be3af1800c7acd0a9
https://doi.org/10.1021/acs.jmedchem.0c00936

المؤلفون: Christine N. Spencer, Jennifer L. McQuade, Vancheswaran Gopalakrishnan, John A. McCulloch, Marie Vetizou, Alexandria P. Cogdill, Md A. Wadud Khan, Xiaotao Zhang, Michael G. White, Christine B. Peterson, Matthew C. Wong, Golnaz Morad, Theresa Rodgers, Jonathan H. Badger, Beth A. Helmink, Miles C. Andrews, Richard R. Rodrigues, Andrey Morgun, Young S. Kim, Jason Roszik, Kristi L. Hoffman, Jiali Zheng, Yifan Zhou, Yusra B. Medik, Laura M. Kahn, Sarah Johnson, Courtney W. Hudgens, Khalida Wani, Pierre-Olivier Gaudreau, Angela L. Harris, Mohamed A. Jamal, Erez N. Baruch, Eva Perez-Guijarro, Chi-Ping Day, Glenn Merlino, Barbara Pazdrak, Brooke S. Lochmann, Robert A. Szczepaniak-Sloane, Reetakshi Arora, Jaime Anderson, Chrystia M. Zobniw, Eliza Posada, Elizabeth Sirmans, Julie Simon, Lauren E. Haydu, Elizabeth M. Burton, Linghua Wang, Minghao Dang, Karen Clise-Dwyer, Sarah Schneider, Thomas Chapman, Nana-Ama A. S. Anang, Sheila Duncan, Joseph Toker, Jared C. Malke, Isabella C. Glitza, Rodabe N. Amaria, Hussein A. Tawbi, Adi Diab, Michael K. Wong, Sapna P. Patel, Scott E. Woodman, Michael A. Davies, Merrick I. Ross, Jeffrey E. Gershenwald, Jeffrey E. Lee, Patrick Hwu, Vanessa Jensen, Yardena Samuels, Ravid Straussman, Nadim J. Ajami, Kelly C. Nelson, Luigi Nezi, Joseph F. Petrosino, P. Andrew Futreal, Alexander J. Lazar, Jianhua Hu, Robert R. Jenq, Michael T. Tetzlaff, Yan Yan, Wendy S. Garrett, Curtis Huttenhower, Padmanee Sharma, Stephanie S. Watowich, James P. Allison, Lorenzo Cohen, Giorgio Trinchieri, Carrie R. Daniel, Jennifer A. Wargo

المصدر: Science (New York, N.Y.). 374(6575)

مصطلحات موضوعية: Dietary Fiber, Male, Multidisciplinary, Probiotics, T-Lymphocytes, Melanoma, Experimental, Fecal Microbiota Transplantation, Fatty Acids, Volatile, Progression-Free Survival, Gastrointestinal Microbiome, Cohort Studies, Mice, Inbred C57BL, Feces, Mice, Animals, Humans, Female, Immunotherapy, Immune Checkpoint Inhibitors, Melanoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333675406957cdc475454320562634b6
https://pubmed.ncbi.nlm.nih.gov/35235771

المؤلفون: Barbara, Czako, Yuting, Sun, Timothy, McAfoos, Jason B, Cross, Paul G, Leonard, Jason P, Burke, Christopher L, Carroll, Ningping, Feng, Angela L, Harris, Yongying, Jiang, Zhijun, Kang, Jeffrey J, Kovacs, Pijus, Mandal, Brooke A, Meyers, Faika, Mseeh, Connor A, Parker, Simon S, Yu, Christopher C, Williams, Qi, Wu, Maria Emilia, Di Francesco, Giulio, Draetta, Timothy, Heffernan, Joseph R, Marszalek, Nancy E, Kohl, Philip, Jones

المصدر: Journal of medicinal chemistry. 64(20)

مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, Administration, Oral, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Neoplasms, Experimental, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Animals, Humans, Drug Screening Assays, Antitumor, Enzyme Inhibitors, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ef1c5b3d344a33f3d6564080b26ff7f2
https://pubmed.ncbi.nlm.nih.gov/34643390

المؤلفون: Akira Inoue, Takashi Shingu, Johnathon L. Rose, Xiaoyan Ma, Christopher A. Bristow, Takahiro Kodama, Alessandro Carugo, Andy M. Zuniga, Angela K. Deem, Giannicola Genovese, Timothy P. Heffernan, Bahar Salimian Rizi, Frederick S. Robinson, Joseph R. Daniele, Ningping Feng, Scott Kopetz, Rosalba Minelli, Mary Sobieski, Kadir C. Akdemir, Jason Roszik, Robert A. Mullinax, Sahil Seth, Michael Peoples, Hideo Tomihara, David G. Menter, Clifford Stephan, Sanjana Srinivasan, Giulio Draetta, Sara Loponte, Yonathan Lissanu Deribe, David Brunell, Virginia Giuliani, Tin Oo Khor, Angela L. Harris, Andrea Viale

المصدر: Gastroenterology. 161(1)

مصطلحات موضوعية: 0301 basic medicine, Indoles, Combination therapy, Colorectal cancer, Pyridines, Morpholines, Receptors, Cytoplasmic and Nuclear, Ataxia Telangiectasia Mutated Proteins, Karyopherins, Piperazines, Transcriptome, 03 medical and health sciences, Mice, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Databases, Genetic, Biomarkers, Tumor, Medicine, Animals, Humans, Epidermal growth factor receptor, neoplasms, Protein Kinase Inhibitors, Sulfonamides, Hepatology, biology, business.industry, Gastroenterology, Cancer, G2-M DNA damage checkpoint, medicine.disease, HCT116 Cells, Xenograft Model Antitumor Assays, 030104 developmental biology, Pyrimidines, Mutation, Cancer research, biology.protein, 030211 gastroenterology & hepatology, Tumor Suppressor Protein p53, business, Colorectal Neoplasms, Functional genomics, Ataxia telangiectasia and Rad3 related, HT29 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f698b264050723f59e7b5f4cf101237
https://pubmed.ncbi.nlm.nih.gov/33798528

المؤلفون: Qing Chang, Simon S. Yu, Christopher A. Bristow, Meredith A. Miller, Pijus K. Mandal, Yongying Jiang, Maria Emilia Di Francesco, Angela L. Harris, Christopher Carroll, Jason P Burke, Brooke A. Meyers, Zhijun Kang, Erika Suzuki, Cross Jason, Qi Wu, Connor A. Parker, Timothy McAfoos, Guang Gao, Sarah B. Johnson, Nancy E. Kohl, Ningping Feng, Yuting Sun, Chiu Yi Liu, Caroline C. Carrillo, Andy M. Zuniga, Paul G. Leonard, Sahil Seth, Virginia Giuliani, Faika Mseeh, Timothy P. Heffernan, Jeffrey J. Kovacs, Joseph R. Marszalek, Barbara Czako, Justin K. Huang, Giulio Draetta, Christopher C. Williams, Xiaoyan Ma, Anastasia M. Lopez, Nakia D. Spencer, Robert A. Mullinax, Vandhana Ramamoorthy, Philip Jones, Sonal Gera, Benjamin J. Bivona, Michael Peoples

المصدر: Cancer research. 80(21)

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Lung Neoplasms, Allosteric regulation, Antineoplastic Agents, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Biology, Receptor tyrosine kinase, 03 medical and health sciences, Mice, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Animals, Humans, Osimertinib, EGFR inhibitors, Cell Proliferation, Acrylamides, Aniline Compounds, Neoplasms, Experimental, Xenograft Model Antitumor Assays, ErbB Receptors, 030104 developmental biology, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, biology.protein, Cancer research, Tyrosine kinase, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614d2e4bc8f9b4ddee8a36ce57a0dcd4
https://pubmed.ncbi.nlm.nih.gov/32928921

المؤلفون: Matthew M. Hamilton (2209738), Faika Mseeh (2342905), Timothy J. McAfoos (2007100), Paul G. Leonard (8747985), Naphtali J. Reyna (11172075), Angela L. Harris (3637717), Alan Xu (69533), Michelle Han (1618693), Michael J. Soth (3045525), Barbara Czako (9253750), Jay P. Theroff (11172078), Pijus K. Mandal (831065), Jason P. Burke (2284534), Brett Virgin-Downey (11172081), Alessia Petrocchi (1586272), Dana Pfaffinger (11172084), Norma E. Rogers (11172087), Connor A. Parker (9253771), Simon S. Yu (9253777), Yongying Jiang (2405476), Stephan Krapp (2030503), Alfred Lammens (411252), Graham Trevitt (2357203), Martin R. Tremblay (2030578), Keith Mikule (1705576), Keith Wilcoxen (3238704), Jason B. Cross (1484188), Philip Jones (14235), Joseph R. Marszalek (9045521), Richard T. Lewis (2060488)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Pharmacology, Biotechnology, Cancer, Mental Health, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, IACS -70465, IDO 1, BMS, IACS -9779, SKOV 3 tumor model

Relation: https://figshare.com/articles/dataset/Discovery_of_IACS-9779_and_IACS-70465_as_Potent_Inhibitors_Targeting_Indoleamine_2_3-Dioxygenase_1_IDO1_Apoenzyme/15036375

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00679.s003

المؤلفون: Angela L. Harris, Timothy P. Heffernan, Prabhjot Mundi, Shirong Cai, Sabrina Jeter-Jones, Joseph R. Marszalek, Gloria V. Echeverria, Alessandro Carugo, Sahil Seth, Xiaoyan Ma, Xinhui Zhou, Huan Qiu, Yun Wu, Andrea Califano, Jeffrey T. Chang, Michael Peoples, Yizheng Tu, Yuting Sun, Mariano J. Alvarez, Stacy L. Moulder, Zhongqi Ge, Xiaomei Zhang, Jiansu Shao, Vandhana Ramamoorthy, Helen Piwnica-Worms, Aaron McCoy, Qing Chang, Christopher A. Bristow, Rosanna Lau, William Fraser Symmans

مصطلحات موضوعية: Cyclophosphamide, medicine.medical_treatment, Triple Negative Breast Neoplasms, Drug resistance, Mice, SCID, Article, Transcriptome, Breast cancer, Cell Line, Tumor, medicine, Animals, Humans, Doxorubicin, Neoadjuvant therapy, Triple-negative breast cancer, Chemotherapy, business.industry, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, Neoadjuvant Therapy, Drug Resistance, Neoplasm, Cancer research, Female, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1b6fdb5fb8c374ed6a03be6865f479
https://europepmc.org/articles/PMC6541393/

المؤلفون: Timothy P. Heffernan, Michael J. Soth, Mikhila Mahendra, Nakia D. Spencer, Timothy A. Yap, Sonal Gera, Jennifer R. Molina, Erika Suzuki, Angela L. Harris, Jeffrey J. Kovacs, Giulio Draetta, Ningping Feng, Kang Le, Christopher A. Bristow, Philip Jones

المصدر: Cancer Research. 81:2338-2338

مصطلحات موضوعية: Glutamine, Cancer Research, Tumor microenvironment, Stromal cell, Immune system, Oncology, Cancer research, Context (language use), Pembrolizumab, Biology, CD8, Blockade

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5b9a5fe12ba1c0846d4f527998dd251b
https://doi.org/10.1158/1538-7445.am2021-2338

المؤلفون: Elisa de Stanchina, Charles M. Rudin, Virginia Giluiani, Timothy P. Heffernan, Alessandro Carugo, Philip Jones, Meredith A. Miller, Giulio Draetta, Nakia D. Spencer, Kang Le, Christopher A. Bristow, Jeffrey J. Kovacs, Ningping Feng, Michael L. Soth, Angela L. Harris, Timothy A. Yap

المصدر: Cancer Research. 81:1102-1102

مصطلحات موضوعية: Cancer Research, Glutaminase, Cancer, Drug resistance, Biology, medicine.disease, Oncology, Drug development, In vivo, medicine, Cancer research, Functional genomics, Protein kinase B, PI3K/AKT/mTOR pathway

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f5d10dcaf6692e72ebed72af28565ac8
https://doi.org/10.1158/1538-7445.am2021-1102

المؤلفون: Qing Chang, John N. Weinstein, Nakia D. Spencer, Philip Jones, Jinsong Liu, Rosalba Minelli, Wei-Lien Wang, Christopher A. Bristow, Alessandro Carugo, Angela L. Harris, Ningpeng Feng, Timothy A. Yap, Michael J. Soth, Philip L. Lorenzi, Virginia Giulani, Meredith A. Miller, Timothy P. Heffernan, Kang Le, Jeffrey J. Kovacs, Giulio Draetta

المصدر: Cancer Research. 81:87-87

مصطلحات موضوعية: Cancer Research, Tissue microarray, DNA damage, Asparagine synthetase, Cancer, Biology, medicine.disease, Glutamine, Oncology, In vivo, Cell culture, medicine, Cancer research, Ovarian cancer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea5b3bdbfb3f41ed4dd0fc431facabce
https://doi.org/10.1158/1538-7445.am2021-87

المؤلفون: Suma Gopinathan, Kenneth G. Carson, Alan G. E. Wilson, Zhi-Ming Ding, Bryce Alden Harrison, Damaris S. Diaz, Angela L. Harris, Debra Bruce, Nicole Cathleen Goodwin, Emily O’Neill, David R. Powell, Melinda Smith, Eric Strobel, David B. Rawlins, Wendy Xiong, Ling Li, Andrea Y. Thompson, Mary Thiel, Faika Mseeh

المصدر: Journal of Medicinal Chemistry. 60:710-721

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, 030209 endocrinology & metabolism, Glucose absorption, Structure-Activity Relationship, 03 medical and health sciences, Sodium-Glucose Transporter 1, 0302 clinical medicine, In vivo, Diabetes mellitus, Internal medicine, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Benzhydryl Compounds, Glycemic, Mice, Knockout, Chemistry, Glucose Tolerance Test, medicine.disease, Phenylbutyrates, In vitro, Glucose, 030104 developmental biology, Endocrinology, Intestinal Absorption, Thioglycosides, Molecular Medicine, Cotransporter, Sodium dependent

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8541b1a58e42776d5a5b4773e40351f7
https://doi.org/10.1021/acs.jmedchem.6b01541

المؤلفون: Alan Wilson, Angela L. Harris, Brian Zambrowicz, Wendy Xiong, Christopher M. DaCosta, David R. Powell, Bryce Alden Harrison, Nicole Cathleen Goodwin, Melinda Smith, Sabrina Jeter-Jones, Andrea Y. Thompson, Eric Strobel, Faika Mseeh, David B. Rawlins, Jennifer Greer, Deon Doree, Suma Gopinathan, Kenneth G. Carson, Zhi-Ming Ding

المصدر: The Journal of pharmacology and experimental therapeutics. 362(1)

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, 030209 endocrinology & metabolism, Carbohydrate metabolism, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Random Allocation, 0302 clinical medicine, Oral administration, Glucagon-Like Peptide 1, Diabetes mellitus, Internal medicine, medicine, Animals, Hypoglycemic Agents, Benzhydryl Compounds, Glycemic, Pharmacology, Dose-Response Relationship, Drug, business.industry, medicine.disease, Glucagon-like peptide-1, Rats, Mice, Inbred C57BL, 030104 developmental biology, Postprandial, Glycemic index, Endocrinology, Glycemic Index, Thioglycosides, Sitagliptin, Molecular Medicine, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38140540d80f7939267c966c2d73c1da
https://pubmed.ncbi.nlm.nih.gov/28442582

المؤلفون: Barbara Czako, Angela L. Harris, Sonal Sonal, Sarah B. Johnson, Mikhila Mahendra, Faika Mseeh, Erika Suzuki, Nakia D. Spencer, Ningping Feng, Andy M. Zuniga, Jason P Burke, Martin Tremblay, Zhen Liu, Tin Oo Khor, Joseph R. Marszalek, Jeffrey J. Kovacs, Timothy P. Heffernan, Robert A. Mullinax, Philip Jones, Keith Mikule

المصدر: Cancer Research. 78:LB-124

مصطلحات موضوعية: Antitumor activity, Cancer Research, Tumor microenvironment, Kinase signaling, Immune system, Oncology, Tumor progression, media_common.quotation_subject, Cancer research, Art, Highly selective, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::60c359b7fff872a86a15857010577854
https://doi.org/10.1158/1538-7445.am2018-lb-124

المؤلفون: Alessia Petrocchi, Naphtali J. Reyna, Faika Mseeh, Connor A. Parker, Simon Yu, Quanyun Xu, Ningping Feng, Paul Leonard, Norma Rogers, Jason B. Cross, Angela L. Harris, Yongying Jiang, Tin Oo Khor, Mikhila G. Mahendra, Jihai Pang, Qi Wu, Andy M. Zuniga, Timothy McAfoos, Matthew M. Hamilton, Joe R. Marszalek, Keith Mikule, Paul Vancutsem, Keith Wilcoxen, Martin Tremblay, Philip Jones, Richard T. Lewis

المصدر: Cancer Research. 78:LB-071

مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, Tumor microenvironment, Imidazopyridine, biology, Protein Data Bank (RCSB PDB), biology.organism_classification, HeLa, chemistry.chemical_compound, Enzyme, Oncology, chemistry, Cell culture, Cancer research, IC50, Kynurenine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3c0efdf3558a82bc49107b3bec62cbd8
https://doi.org/10.1158/1538-7445.am2018-lb-071

المؤلفون: Alan Wilson, Melinda Smith, Wendy Xiong, Damaris Diaz, David R. Powell, Suma Gopinathan, Faika Mseeh, Eric Strobel, Nicole Cathleen Goodwin, Brian Zambrowicz, Kenneth G. Carson, Zhi-Ming Ding, David B. Rawlins, Deon Doree, Bryce Alden Harrison, Angela L. Harris

المصدر: Pharmacology Research & Perspectives

مصطلحات موضوعية: medicine.medical_specialty, business.industry, digestive, oral, and skin physiology, Diabetes, Glucose transporter, small molecule, Original Articles, medicine.disease, SGLT2, SGLT1, Renal glucose reabsorption, Excretion, Endocrinology, Neurology, Pharmacokinetics, Internal medicine, Diabetes mellitus, Knockout mouse, medicine, urinary glucose excretion, General Pharmacology, Toxicology and Pharmaceutics, SGLT2 Inhibitor, business, IC50, knockout mice

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6d149223edb9772922ab5a05df83eb
https://pubmed.ncbi.nlm.nih.gov/26038705