المؤلفون: Samuel Lessard, Pauline Rimmelé, Hui Ling, Kevin Moran, Benjamin Vieira, Yi-Dong Lin, Gaurav Manohar Rajani, Vu Hong, Andreas Reik, Richard Boismenu, Ben Hsu, Michael Chen, Bettina M. Cockroft, Naoya Uchida, John Tisdale, Asif Alavi, Lakshmanan Krishnamurti, Mehrdad Abedi, Isobelle Galeon, David Reiner, Lin Wang, Anne Ramezi, Pablo Rendo, Mark C. Walters, Dana Levasseur, Robert Peters, Timothy Harris, Alexandra Hicks

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/eeb0c50036ba4eed80ba42d7f6cae1af

المؤلفون: Davide Monteferrario, Marion David, Satish K. Tadi, Yuanyue Zhou, Irène Marchetti, Caroline Jeanneau, Gaëlle Saviane, Coralie F. Dupont, Angélique E. Martelli, Lynn N. Truong, Jason A. Eshleman, Colman C. Ng, Marshall W. Huston, Gregory D. Davis, Jason D. Fontenot, Andreas Reik, Maurus de la Rosa, David Fenard

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101255- (2024)

مصطلحات موضوعية: Zinc finger protein, KRAB, Repressor, epigenetic, lentiviral vector, Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050124000718; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/269b2cd01d1848aea9b701b0a3bea73b

المؤلفون: Friedrich Fauser, Bhakti N. Kadam, Sebastian Arangundy-Franklin, Jessica E. Davis, Vishvesha Vaidya, Nicola J. Schmidt, Garrett Lew, Danny F. Xia, Rakshaa Mureli, Colman Ng, Yuanyue Zhou, Nicholas A. Scarlott, Jason Eshleman, Yuri R. Bendaña, David A. Shivak, Andreas Reik, Patrick Li, Gregory D. Davis, Jeffrey C. Miller

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/e253da149e064566bde5c2f0b036d5c3

المؤلفون: Nikoletta Psatha, Andreas Reik, Susan Phelps, Yuanyue Zhou, Demetri Dalas, Evangelia Yannaki, Dana N. Levasseur, Fyodor D. Urnov, Michael C. Holmes, Thalia Papayannopoulou

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 313-326 (2018)

مصطلحات موضوعية: Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050118300809; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/b6efc929ab464599a50a361672dec62b

المؤلفون: Kai-Hsin Chang, Sarah E. Smith, Timothy Sullivan, Kai Chen, Qianhe Zhou, Jason A. West, Mei Liu, Yingchun Liu, Benjamin F. Vieira, Chao Sun, Vu P. Hong, Mingxuan Zhang, Xiao Yang, Andreas Reik, Fyodor D. Urnov, Edward J. Rebar, Michael C. Holmes, Olivier Danos, Haiyan Jiang, Siyuan Tan

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 137-148 (2017)

مصطلحات موضوعية: genome editing, gene therapy, BCL11A, hemoglobinopathies, fetal hemoglobin, fetal globin reactivation, zinc finger nucleases, Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050117300037; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/78e274bd1cdc4349b7f3df729d3543f4

المؤلفون: Christopher W Peterson, Jianbin Wang, Claire Deleage, Sowmya Reddy, Jasbir Kaur, Patricia Polacino, Andreas Reik, Meei-Li Huang, Keith R Jerome, Shiu-Lok Hu, Michael C Holmes, Jacob D Estes, Hans-Peter Kiem

المصدر: PLoS Pathogens, Vol 14, Iss 4, p e1006956 (2018)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5908070?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/1c2b7e7be53d42f1b7be0b885f75a1b1

المؤلفون: Andreas Reik, Sarah J. Hinkley, Nicholas A. Scarlott, Deepak P. Patil, Yuri R. Bendana, David A. Shivak, Tenzin Wangzor, Stephen Lam, Yuanyue Zhou, David Paschon, Lei Zhang, Patrick Li, Friedrich Fauser, Gary Lee, Jeffrey C. Miller, Charles B Paine, Danny F Xia, Edward J. Rebar, Hunter W. Richards

المصدر: Nature Biotechnology. 37:945-952

مصطلحات موضوعية: T-Lymphocytes, Protein domain, Biomedical Engineering, Bioengineering, Locus (genetics), Computational biology, Cleavage (embryo), Applied Microbiology and Biotechnology, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, Genome editing, Humans, RNA, Messenger, DNA Cleavage, 030304 developmental biology, Gene Editing, Zinc finger, 0303 health sciences, Base Sequence, biology, Chemistry, RNA, DNA, Flow Cytometry, Hematopoietic Stem Cells, Zinc finger nuclease, FokI, biology.protein, Molecular Medicine, K562 Cells, 030217 neurology & neurosurgery, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cc9ae3ffe9baf7fec7a19c03368407
https://doi.org/10.1038/s41587-019-0186-z

المؤلفون: Evangelia Yannaki, Thalia Papayannopoulou, Yuanyue Zhou, Nikoletta Psatha, Dana N. Levasseur, Demetri Dalas, Andreas Reik, Michael C. Holmes, Susan Phelps, Fyodor D. Urnov

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 10, Iss, Pp 313-326 (2018)
Molecular Therapy. Methods & Clinical Development

مصطلحات موضوعية: 0301 basic medicine, thalassemia, lcsh:QH426-470, CD34, Endogeny, Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, hemic and lymphatic diseases, Fetal hemoglobin, zinc finger nucleases, Genetics, genome editing, Progenitor cell, lcsh:QH573-671, Enhancer, hemoglobinopathies, Molecular Biology, lcsh:Cytology, HbF reactivation, Phenotype, 3. Good health, Cell biology, Haematopoiesis, lcsh:Genetics, 030104 developmental biology, 030220 oncology & carcinogenesis, BCL11a, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9366a8b682eda75efd95b4ea85e916a8
http://www.sciencedirect.com/science/article/pii/S2329050118300809

المؤلفون: Philipp Koch, Christa E. Müller, Julius A. Steinbeck, Ruven Wilkens, Philip D. Gregory, Daniel Poppe, Marion Schneider, Julia Ladewig, Andreas Reik, David Paschon, Allison Tam, Jonas Doerr, Oliver Brüstle

المصدر: Stem Cells Translational Medicine

مصطلحات موضوعية: Gene‐editing, 0301 basic medicine, Adenosine, Neurodegeneration/Neurological Disorders, Human Embryonic Stem Cells, Cellular homeostasis, Adenosine kinase, Polymorphism, Single Nucleotide, Mass Spectrometry, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Translational Research Articles and Reviews, Human neurons, Neural Stem Cells, medicine, Animals, Humans, Enabling Technologies for Cell-Based Clinical Translation, Adenosine Kinase, Chromatography, High Pressure Liquid, Gene Editing, Mice, Knockout, Neurons, Enabling Technologies for Cell‐Based Clinical Translation, Adenosine secretion, biology, Cell Biology, General Medicine, Gene Delivery Systems/Gene Therapy/Gene Editing Technology, Embryonic stem cell, Zinc Finger Nucleases, Neural stem cell, Neural/Progenitor Stem Cells, ADK, Cell biology, Mice, Inbred C57BL, Neuroepithelial cell, 030104 developmental biology, Karyotyping, biology.protein, Neuroepithelial stem cells, Stem cell, 030217 neurology & neurosurgery, Developmental Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9130ac32fa7926737d8d4cf68800fa
https://doi.org/10.1002/sctm.16-0272

المؤلفون: Doi:mol Cell Biol, Claire Francastel, Elliot M. Epner, Daniel M. Cimbora, Dirk Schübeler, Andreas Reik

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mcb.asm.org/content/20/15/5581.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.615.2212; http://mcb.asm.org/content/20/15/5581.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.615.2212
http://mcb.asm.org/content/20/15/5581.full.pdf

المؤلفون: Andreas Reik, Agnes Telling, Galynn Zitnik, Elliot Epner, Mark Groudine, Mol Cell Biol, Daniel Cimbora

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mcb.asm.org/content/18/10/5992.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.7605; http://mcb.asm.org/content/18/10/5992.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.7605
http://mcb.asm.org/content/18/10/5992.full.pdf

المؤلفون: Jason A. West, Olivier Danos, Edward J. Rebar, Kai-Hsin Chang, Kai Chen, Fyodor D. Urnov, Andreas Reik, Mingxuan Zhang, Michael C. Holmes, Chao Sun, Benjamin Vieira, Mei Liu, Timothy J. Sullivan, Vu P. Hong, Qianhe Zhou, Siyuan Tan, Sarah Smith, Yingchun Liu, Xiao Yang, Haiyan Jiang

المصدر: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 137-148 (2017)

مصطلحات موضوعية: 0301 basic medicine, fetal hemoglobin, lcsh:QH426-470, Genetic enhancement, medicine.medical_treatment, CD34, Biology, Cell therapy, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, BCL11A, zinc finger nucleases, Genetics, medicine, genome editing, Globin, Progenitor cell, lcsh:QH573-671, hemoglobinopathies, Molecular Biology, lcsh:Cytology, Stem-cell therapy, fetal globin reactivation, gene therapy, Haematopoiesis, lcsh:Genetics, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Original Article, Bone marrow

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ec1b8cf042a1a80e31f4a3ab93f859
http://europepmc.org/articles/PMC5363298

المؤلفون: Joal D. Beane, David Paschon, Richard A. Morgan, Mary A. Black, Martin A. Giedlin, Andreas Reik, Philip D. Gregory, Zhili Zheng, Jeffrey C. Miller, Gary Lee, Daniel Abate-Daga, Michael C. Holmes, Matthew C. Mendel, Edward J. Rebar, Dmitry Guschin, Zhiya Yu, Smita S. Chandran, Mini Bharathan, Steven A. Feldman, Nicholas P. Restifo, Nimisha Gandhi, Dale Ando, Steven A. Rosenberg

المصدر: Molecular Therapy. 23:1380-1390

مصطلحات موضوعية: Adoptive cell transfer, medicine.medical_treatment, Green Fluorescent Proteins, Programmed Cell Death 1 Receptor, Population, Cell Separation, Biology, Lymphocyte Activation, Immunotherapy, Adoptive, Interferon-gamma, Mice, Lymphocytes, Tumor-Infiltrating, Endoribonucleases, Drug Discovery, Genetics, medicine, Animals, Humans, Interferon gamma, Neoplasm Metastasis, education, Melanoma, Molecular Biology, Alleles, Pharmacology, Zinc finger, education.field_of_study, Tumor Necrosis Factor-alpha, Tumor-infiltrating lymphocytes, Granulocyte-Macrophage Colony-Stimulating Factor, Zinc Fingers, Immunotherapy, Flow Cytometry, medicine.disease, Zinc finger nuclease, Gene Expression Regulation, Neoplastic, Phenotype, Immunology, Cancer research, Cytokines, Molecular Medicine, Original Article, Female, Immunologic Memory, Neoplasm Transplantation, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693fa05bd8b9498036b2d7a660d38336
https://doi.org/10.1038/mt.2015.71

المؤلفون: Zulema Romero, Edward J. Rebar, Andrew Wilber, Roger P. Hollis, Matthew C. Mendel, Lei Zhang, Fabrizia Urbinati, David Gray, Alok V. Joglekar, Michael L. Kaufman, Allen Zhu, Shantha Senadheera, Michael C. Holmes, Aaron R. Cooper, Philip D. Gregory, David Paschon, Michelle Ho, Megan D. Hoban, Dianne Lumaquin, Donald B. Kohn, Gregory J. Cost, Andreas Reik, Georgia R. Lill, Xiaoyan Wang, Pei-Qi Liu

المصدر: Blood. 125:2597-2604

مصطلحات موضوعية: medicine.medical_treatment, Molecular Sequence Data, Immunology, CD34, Antigens, CD34, Bone Marrow Cells, Anemia, Sickle Cell, Mice, SCID, beta-Globins, Hematopoietic stem cell transplantation, Biology, Biochemistry, Mice, Mice, Inbred NOD, medicine, Animals, Humans, Progenitor cell, Cells, Cultured, Severe combined immunodeficiency, Endodeoxyribonucleases, Base Sequence, Point mutation, Hematopoietic Stem Cell Transplantation, Zinc Fingers, Genetic Therapy, Cell Biology, Hematology, Fetal Blood, Hematopoietic Stem Cells, medicine.disease, Molecular biology, Haematopoiesis, medicine.anatomical_structure, Genetic Loci, Mutation, Bone marrow, Stem cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7456de13001543a5d1c22eb7deeb9f43
https://doi.org/10.1182/blood-2014-12-615948

المؤلفون: Sara Mastaglio, Pietro Genovese, Zulma Magnani, Elisa Landoni, Barbara Camisa, Giulia Schiroli, Elena Provasi, Angelo Lombardo, Andreas Reik, Nicoletta Cieri, Ponzoni Maurilio, Fabio Ciceri, Claudio Bordignon, Michael C. Holmes, Philip D. Gregory, Luigi Naldini, Chiara Bonini.

المساهمون: Mastaglio, S, Genovese, P, Magnani, Z, Landoni, E, Camisa, B, Schiroli, G, Provasi, E, Lombardo, A, Reich, A, Cieri, N, Ponzoni, M, Ciceri, F, Bordignon, C, Holmes MC, Gregory, PD, Naldini, L, Bonini C, Sara, Mastaglio, Pietro, Genovese, Zulma, Magnani, Elisa, Landoni, Barbara, Camisa, Giulia, Schiroli, Elena, Provasi, Lombardo, ANGELO LEONE, Andreas, Reik, Nicoletta, Cieri, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Holmes, Michael C., Gregory, Philip D., Naldini, Luigi, Bonini, MARIA CHIARA

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000349242707032; ispartofbook:NY-ESO-1 single edited T cells to treat multiple myeloma without inducing GVHD; ASH; volume:124; issue:21; journal:BLOOD; http://hdl.handle.net/20.500.11768/82359

الاتاحة: https://hdl.handle.net/20.500.11768/82359

المؤلفون: Ann Dean, Gerd A. Blobel, Andreas Reik, Laura Breda, Wulan Deng, Ivan Krivega, Stefano Rivella, Jeremy Rupon, Kristen S. Jahn, Irene Motta, Philip D. Gregory

المصدر: Cell. 158:849-860

مصطلحات موضوعية: Transcriptional Activation, Erythroblasts, Primary Cell Culture, Antigens, CD34, beta-Globins, Editorials: Cell Cycle Features, Biology, General Biochemistry, Genetics and Molecular Biology, Mice, Transcription (biology), hemic and lymphatic diseases, Gene expression, Animals, Humans, Enhancer, Fetal Hemoglobin, Locus control region, Zinc finger, Biochemistry, Genetics and Molecular Biology(all), Promoter, Embryo, Mammalian, Locus Control Region, Molecular biology, Embryonic stem cell, Chromatin, Hemoglobinopathies, Genetic Techniques

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ad857a1ad6466c0cc04d47bcdbd95d
https://doi.org/10.1016/j.cell.2014.05.050

المؤلفون: Edward J. Rebar, Michael C. Holmes, Fyodor Urnov, Trevor N. Collingwood, Philip D. Gregory, Jeffrey C. Miller, Andreas Reik, Laurence J. N. Cooper

المساهمون: Board of Regents, The University of Texas System, Sangamo Therapeutics, Inc.

مصطلحات موضوعية: A61K35/17, C07K14/70539, C07K2319/81, C12N15/907, C12N2800/80

وصف الملف: application/pdf

Relation: University of Texas Patents; https://hdl.handle.net/2152/76511; http://dx.doi.org/10.26153/tsw/3600

الاتاحة: https://hdl.handle.net/2152/76511
https://doi.org/10.26153/tsw/3600

المؤلفون: Philip D. Gregory, Ann Dean, Hongxin Wang, Gerd A. Blobel, Jongjoo Lee, Wulan Deng, Andreas Reik, Jeffrey C. Miller

المصدر: Cell. 149:1233-1244

مصطلحات موضوعية: Male, Erythroblasts, Transcription, Genetic, RNA polymerase II, Cell Separation, beta-Globins, Biology, DNA-binding protein, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Transcription (biology), Animals, GATA1 Transcription Factor, Promoter Regions, Genetic, Enhancer, Locus control region, 030304 developmental biology, Genetics, 0303 health sciences, Biochemistry, Genetics and Molecular Biology(all), Zinc Fingers, Promoter, LIM Domain Proteins, Embryo, Mammalian, Chromatin, Protein Structure, Tertiary, DNA-Binding Proteins, Gene Expression Regulation, biology.protein, Female, Chromatin Loop, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fd4f017628c37868ecd44b0cb88bda
https://doi.org/10.1016/j.cell.2012.03.051

المؤلفون: Giulia Casorati, Pietro Genovese, Luigi Naldini, Philip D. Gregory, Angelo Lombardo, Maurilio Ponzoni, Chiara Bonini, Claudio Bordignon, Jürgen Kuball, Philip D. Greenberg, David Paschon, Victoria Chu, Andreas Reik, Michael C. Holmes, Elena Provasi, Zulma Magnani, Attilio Bondanza, Pei-Qi Liu, Lei Zhang, Fabio Ciceri, Barbara Camisa

المساهمون: Provasi, E, Genovese, P, Lombardo, ANGELO LEONE, Magnani, Z, Liu Pei, Q, Reik, A, Chu, V, Paschon, D. E., Zhang, L, Kuball, J, Camisa, B, Bondanza, Attilio, Casorati, G, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Greenberg, P. D., Holmes, Mc, Gregory, Pd, Naldini, Luigi, Bonini, MARIA CHIARA

المصدر: Nature Medicine

مصطلحات موضوعية: T-Lymphocytes, medicine.medical_treatment, CD3, Molecular Sequence Data, Receptors, Antigen, T-Cell, T-Cell Antigen Receptor Specificity, chemical and pharmacologic phenomena, Endogeny, Gene transfer, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Jurkat Cells, 03 medical and health sciences, 0302 clinical medicine, Cancer immunotherapy, medicine, Humans, Deoxyribonucleases, Type II Site-Specific, WT1 Proteins, 030304 developmental biology, 0303 health sciences, Leukemia, Base Sequence, Lentivirus, T-cell receptor, Gene Transfer Techniques, food and beverages, Zinc Fingers, hemic and immune systems, General Medicine, medicine.disease, Zinc finger nuclease, Molecular biology, Tumor antigen, 3. Good health, 030220 oncology & carcinogenesis, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e47493964fa34a30844986e8098780
https://doi.org/10.1038/nm.2700

المؤلفون: Dean A. Lee, Helen Huls, Michael C. Holmes, Pei-Qi Liu, Chiara Bonini, Laurence J.N. Cooper, Partow Kebriaei, Yuanyue Zhou, Sourindra Maiti, Richard E. Champlin, Edward J. Rebar, Luigi Naldini, Brian Rabinovitch, Hiroki Torikai, Philip D. Gregory, Ling Zhang, Andreas Reik, Jeffrey C. Miller

المساهمون: Torikai, H1, Reik, A, Liu, Pq, Zhou, Y, Zhang, L, Maiti, S, Huls, H, Miller, Jc, Kebriaei, P, Rabinovitch, B, Lee, Da, Champlin, Re, Bonini, MARIA CHIARA, Naldini, Luigi, Rebar, Ej, Gregory, Pd, Holmes, Mc, Cooper, Lj

المصدر: Blood
Blood; Vol 119

مصطلحات موضوعية: Adult, CD3 Complex, T-Lymphocytes, T cell, Antigens, CD19, Immunology, Receptors, Antigen, T-Cell, Antigen-Presenting Cells, Streptamer, Biology, Lymphocyte Activation, Biochemistry, Epitopes, Gene Knockout Techniques, 03 medical and health sciences, 0302 clinical medicine, CD28 Antigens, Antigens, Neoplasm, medicine, Humans, Cytotoxic T cell, IL-2 receptor, Antigen-presenting cell, Cells, Cultured, 030304 developmental biology, 0303 health sciences, T-cell receptor, Zinc Fingers, Gene Therapy, Cell Biology, Hematology, Endonucleases, Molecular biology, Recombinant Proteins, Chimeric antigen receptor, 3. Good health, Cell biology, medicine.anatomical_structure, Immunotherapy, Genetic Engineering, K562 Cells, CD8, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ada2876bd543b5915b436e8a3c47f79