المؤلفون: Markéta Pimková Polidarová (8052770), Petra Břehová (2259607), Martin Maxmilian Kaiser (10843630), Miroslav Smola (7135004), Martin Dračínský (1398268), Joshua Smith (734814), Aleš Marek (1860241), Milan Dejmek (1600816), Michal Šála (1398271), Ondrej Gutten (1455745), Lubomír Rulíšek (1263147), Barbora Novotná (8052761), Andrea Brázdová (8052773), Zlatko Janeba (1585501), Radim Nencka (808341), Evzen Boura (302259), Ondřej Páv (1546600), Gabriel Birkuš (2325874)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Physiology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, Q STING, WT, proinflammatory cytokines, Biological Evaluation, peak intracellular concentration, 2 h, STING allelic forms, Phosphorothioate Prodrugs, phosphorothioate analogues, REF, CDNs results, parent CDN, parent CDNs, reporter-cell-based assays, intracellular cleavage, pivaloyloxymethyl prodrugs, type, X-ray crystallography, isopropyloxycarbonyl phosphoester p., interferon genes

Relation: https://figshare.com/articles/journal_contribution/Synthesis_and_Biological_Evaluation_of_Phosphoester_and_Phosphorothioate_Prodrugs_of_STING_Agonist_3_3_-c-Di_2_F_2_dAMP_/14639956

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00301.s003

المؤلفون: Markéta Pimková Polidarová (8052770), Petra Břehová (2259607), Martin Maxmilian Kaiser (10843630), Miroslav Smola (7135004), Martin Dračínský (1398268), Joshua Smith (734814), Aleš Marek (1860241), Milan Dejmek (1600816), Michal Šála (1398271), Ondrej Gutten (1455745), Lubomír Rulíšek (1263147), Barbora Novotná (8052761), Andrea Brázdová (8052773), Zlatko Janeba (1585501), Radim Nencka (808341), Evzen Boura (302259), Ondřej Páv (1546600), Gabriel Birkuš (2325874)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Physiology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, Q STING, WT, proinflammatory cytokines, Biological Evaluation, peak intracellular concentration, 2 h, STING allelic forms, Phosphorothioate Prodrugs, phosphorothioate analogues, REF, CDNs results, parent CDN, parent CDNs, reporter-cell-based assays, intracellular cleavage, pivaloyloxymethyl prodrugs, type, X-ray crystallography, isopropyloxycarbonyl phosphoester p., interferon genes

Relation: https://figshare.com/articles/dataset/Synthesis_and_Biological_Evaluation_of_Phosphoester_and_Phosphorothioate_Prodrugs_of_STING_Agonist_3_3_-c-Di_2_F_2_dAMP_/14639950

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00301.s001