المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/figure/Mechanism_of_action_of_PrP_sup_C_sup_regulators_/16890409

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s003

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/dataset/MAGMA_and_VEGAS_scores_for_the_comparison_of_PrP_sup_C_sup_hits_and_sCJD_GWAS_dataset_/16890430

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s009

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/figure/Establishment_experimental_setup_and_results_of_CRISPRi_in_dCas9KRAB-U251MG_cells_/16890406

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s002

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/figure/Establishment_experimental_setup_and_results_of_CRISPRa_in_dCas9VPR-U251MG_cells_/16890412

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s004

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/dataset/Whole_genome-RNAi_screen_results_/16890415

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s005

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/dataset/Summary_of_the_final_nine_hits_/16890433

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s010

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/dataset/RNA-Seq_normalized_counts_for_U251-MG_/16890421

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s006

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/dataset/Sequences_of_primers_used_in_the_study_/16890427

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s008

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/figure/Secondary_screening_and_validation_of_hits_in_smNPC-derived_neurons_/16890439

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.g002

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/figure/Workflow_of_the_siRNA_screen_and_primary_screening_round_in_U251-MG_glioblastoma_cell_line_/16890436

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.g001

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/dataset/RNA-Seq_normalized_counts_for_U251-MG_/16890424

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.s007

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/figure/Hit_validation_in_U251-MG_cells_by_CRISPR_interference_/16890442

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.g003

المؤلفون: Daniel Heinzer (6029003), Merve Avar (6029000), Daniel Patrick Pease (11614483), Ashutosh Dhingra (3424031), Jiang-An Yin (11614486), Elke Schaper (838689), Berre Doğançay (11614489), Marc Emmenegger (11614492), Anna Spinelli (1511230), Kevin Maggi (11614495), Andra Chincisan (6028994), Simon Mead (237364), Simone Hornemann (269068), Peter Heutink (39587), Adriano Aguzzi (49294)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Science Policy, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, transcriptional repressor pumilio, recursive candidate attrition, perturbation screen delivers, div >< p, cultured human u251, human prion diseases, genes regulating prp, 180 enhanced prp, mg glioblastoma cells, wide rna interference, c , prnp <, crispr interference, prion replication, prion infection, measured prp, unbiased landscape, robust regulators

Relation: https://figshare.com/articles/figure/PUM1_regulates_i_PRNP_i_mRNA_via_its_3_UTR_/16890445

الاتاحة: https://doi.org/10.1371/journal.ppat.1010013.g004