المؤلفون: Gonçalo Castelo-Branco, Pernilla Stridh, André Ortlieb Guerreiro-Cacais, Milena Z. Adzemovic, Ana Mendanha Falcão, Monica Marta, Rasmus Berglund, Alan Gillett, Kedir Hussen Hamza, Hans Lassmann, Ola Hermanson, Maja Jagodic

المصدر: Neurobiology of Disease, Vol 71, Iss , Pp 220-233 (2014)

مصطلحات موضوعية: Multiple sclerosis, Experimental autoimmune encephalomyelitis, Epigenetics, Histone deacetylases, Thyroid hormone, Neuroinflammation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996114002502; https://doaj.org/toc/1095-953X

URL الوصول: https://doaj.org/article/b58e963bfaa34916963b115082a2be09

المؤلفون: Nada Abdelmagid, Biborka Bereczky-Veress, André Ortlieb Guerreiro-Cacais, Petra Bergman, Katarina M Luhr, Tomas Bergström, Birgit Sköldenberg, Fredrik Piehl, Tomas Olsson, Margarita Diez

المصدر: PLoS Pathogens, Vol 8, Iss 6, p e1002753 (2012)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3386237?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/00349c928f224e4c83d88e5a63ee02a6

المؤلفون: Arnaud Chêne, Daria Donati, André Ortlieb Guerreiro-Cacais, Victor Levitsky, Qijun Chen, Kerstin I Falk, Jackson Orem, Fred Kironde, Mats Wahlgren, Maria Teresa Bejarano

المصدر: PLoS Pathogens, Vol 3, Iss 6, p e80 (2007)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC1891325?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/d7ca1ad98ebf4da6aaa795238496ed30

المؤلفون: Rasmus Berglund, Yufei Cheng, Eliane Piket, Milena Z. Adzemovic, Manuel Zeitelhofer, Tomas Olsson, Andre Ortlieb Guerreiro-Cacais, Maja Jagodic

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

مصطلحات موضوعية: Science

Relation: https://doi.org/10.1038/s41467-023-44556-6; https://doaj.org/toc/2041-1723; https://doaj.org/article/b61d9e7702d14043bf1b0b3ca392caef

الاتاحة: https://doi.org/10.1038/s41467-023-44556-6
https://doaj.org/article/b61d9e7702d14043bf1b0b3ca392caef

المؤلفون: Olivia G. Thomas, Mattias Bronge, Katarina Tengvall, Birce Akpinar, Ola B. Nilsson, Erik Holmgren, Tara Hessa, Guro Gafvelin, Mohsen Khademi, Lars Alfredsson, Roland Martin, André Ortlieb Guerreiro-Cacais, Hans Grönlund, Tomas Olsson, Ingrid Kockum

مصطلحات موضوعية: Multidisciplinary, Neurology, Neurologi

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2c8890e30bc2ca9a99561eb4189c1a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506588

المؤلفون: Keying Zhu, Yang Wang, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin‐Yu Kung, Cindy Bay, Jinming Han, Jin‐Hong Min, Irene Benito‐Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing‐Mei Zhang, Claudia Kutter, André Ortlieb Guerreiro‐Cacais, Björn Högberg, Robert A Harris

المساهمون: Pathology, AII - Inflammatory diseases, Amsterdam Neuroscience - Neuroinfection & -inflammation

المصدر: Zhu, K, Wang, Y, Sarlus, H, Geng, K, Nutma, E, Sun, J, Kung, S-Y, Bay, C, Han, J, Min, J-H, Benito-Cuesta, I, Lund, H, Amor, S, Wang, J, Zhang, X-M, Kutter, C, Guerreiro-Cacais, A O, Högberg, B & Harris, R A 2022, ' Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation ', EMBO Reports, vol. 23, no. 7, e54499, pp. e54499 . https://doi.org/10.15252/embr.202154499
EMBO Reports, 23(7):e54499. Wiley-Blackwell

مصطلحات موضوعية: Mice, Macrophages, Neuroinflammatory Diseases, Genetics, Animals, DNA, Topoisomerase I Inhibitors, Topotecan, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae29cc9ca4c1f6c3062b5c4799732bc
http://www.scopus.com/inward/record.url?scp=85130275635&partnerID=8YFLogxK

المؤلفون: Xing-Mei Zhang, André Ortlieb Guerreiro Cacais, Harald Lund, Keying Zhu, Heela Sarlus, Robert A. Harris, Erik Nutma, Jinming Han, Jingxian Sun, Cindy Bay, Shin-Yu Kung, Sandra Amor, Yang Wang, Keyi Geng, Björn Högberg, Claudia Kutter, Jun Wang

مصطلحات موضوعية: Microglia, biology, business.industry, Multiple sclerosis, Topoisomerase, medicine.disease, Transcriptome, medicine.anatomical_structure, Drug development, Cancer research, biology.protein, Medicine, Topotecan, business, Camptothecin, Neuroinflammation, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3f78caee2c41605c8e79ea32cddc0328
https://doi.org/10.1101/2021.10.04.462880

المؤلفون: Hannes Lindahl, M Lindén, Karolina Tandre, Sahl Khalid Bedri, Mohsen Khademi, Lars Alfredsson, Colin P. Glover, André Ortlieb Guerreiro-Cacais, Maja Jagodic, Mathias Linnerbauer, Ingrid Kockum, Lars Rönnblom, Tomas Olsson, Lorraine Irving, Clare A. Jones, Nada Abdelmagid, Claire Hollins

المصدر: The Journal of Immunology. 203:888-898

مصطلحات موضوعية: Candidate gene, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Genotype, T-Lymphocytes, medicine.medical_treatment, Immunology, Biology, Lymphocyte Activation, Polymorphism, Single Nucleotide, Interleukin 22, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Receptor, Multiple sclerosis, Binding protein, Receptors, Interleukin, medicine.disease, In vitro, Rats, Cytokine, Cancer research, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b57ed0a1b95786d58a161fe602a2ef6
https://doi.org/10.4049/jimmunol.1900400

المؤلفون: Sandra Amor, Erik Nutma, Manuel Zeitelhofer, Tomas Olsson, Harald Lund, Rasmus Berglund, Melanie Thessen-Hedreul, Robert A. Harris, Maja Jagodic, André Ortlieb Guerreiro-Cacais, Ewoud Ewing, Roham Parsa, Sabrina Ruhrmann, Milena Z. Adzemovic

المساهمون: Pathology, Amsterdam Neuroscience - Neuroinfection & -inflammation, AII - Inflammatory diseases

المصدر: Science immunology, 5(52):eabb5077. American Association for the Advancement of Science
Berglund, R, Guerreiro-Cacais, A O, Adzemovic, M Z, Zeitelhofer, M, Lund, H, Ewing, E, Ruhrmann, S, Nutma, E, Parsa, R, Thessen-Hedreul, M, Amor, S, Harris, R A, Olsson, T & Jagodic, M 2020, ' Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation ', Science immunology, vol. 5, no. 52, eabb5077 . https://doi.org/10.1126/sciimmunol.abb5077
Science Immunology

مصطلحات موضوعية: 0301 basic medicine, Male, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Immunology, Central nervous system, Primary Cell Culture, Inflammation, Biology, Autophagy-Related Protein 7, 03 medical and health sciences, Myelin, Mice, 0302 clinical medicine, Phagocytosis, medicine, Autophagy, Animals, Autophagy-Related Protein-1 Homolog, Humans, Neuroinflammation, Cells, Cultured, Myelin Sheath, Mice, Knockout, Microglia, Multiple sclerosis, Neurodegeneration, Brain, General Medicine, medicine.disease, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Spinal Cord, Female, medicine.symptom, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fc8dc9dac85a325d15eed7fcf96dae
https://research.vumc.nl/en/publications/ec650131-e4ad-4559-a0f8-867ce80e096e

المؤلفون: Victor Levitsky, Andre Ortlieb Guerreiro-cacais, Mehmet Uzunel

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jvi.asm.org/content/81/3/1390.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.503; http://jvi.asm.org/content/81/3/1390.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.585.503
http://jvi.asm.org/content/81/3/1390.full.pdf

المؤلفون: Andre Ortlieb Guerreiro-cacais, Liqi Li, Daria Donati, Maria Teresa Bejarano, Andrew Morgan, Maria G. Masucci, Lindsey Hutt-fletcher, Victor Levitsky

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://vir.sgmjournals.org/content/85/10/2767.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.7769; http://vir.sgmjournals.org/content/85/10/2767.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.7769
http://vir.sgmjournals.org/content/85/10/2767.full.pdf

المؤلفون: Sudeepta Kumar, Panda, Gustaf, Wigerblad, Long, Jiang, Yanek, Jiménez-Andrade, Vaishnavi Srinivasan, Iyer, Yunbing, Shen, Sanjaykumar V, Boddul, André Ortlieb, Guerreiro-Cacais, Bruno, Raposo, Zsolt, Kasza, Fredrik, Wermeling

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Mice, Knockout, Mice, Inbred BALB C, Neutrophils, Arthritis, Receptors, IgG, IL-4, Biological Sciences, Mice, Inbred C57BL, Disease Models, Animal, Mice, Immunology and Inflammation, Neutrophil Infiltration, inflammation, Animals, FcγR2b, Interleukin-4

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::bfa3ba21d70ca33a4ac2b3fcc59f0753
https://pubmed.ncbi.nlm.nih.gov/31980518

المؤلفون: André Ortlieb Guerreiro-Cacais, Andrew L. Croxford, Maja Jagodic, Andreas Warnecke, Robert A. Harris, Roham Parsa, Mikael C. I. Karlsson, Xing-Mei Zhang, David Grommisch, Anna-Maria Georgoudaki, Burkhard Becher, Harald Lund

المساهمون: University of Zurich, Harris, Robert A

المصدر: The Journal of Experimental Medicine
The Journal of experimental medicine

مصطلحات موضوعية: 0301 basic medicine, Neutropenia, Neutrophils, Plasma Cells, Immunology, 610 Medicine & health, Granulocyte, Plasma cell, 10263 Institute of Experimental Immunology, Granulopoiesis, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, hemic and lymphatic diseases, B-Cell Activating Factor, Animals, Immunology and Allergy, Medicine, B-cell activating factor, Research Articles, B cell, Mice, Knockout, Myelopoiesis, 2403 Immunology, business.industry, Interleukin-17, Dendritic cell, medicine.disease, Immunity, Humoral, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Antibody Formation, 2723 Immunology and Allergy, 570 Life sciences, biology, business, 030215 immunology

وصف الملف: ZORA129053.pdf - application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a005afafd6c59b991f6ad15151b8497
https://doi.org/10.1084/jem.20150577

المؤلفون: Tomas Olsson, Pernilla Nikamo, André Ortlieb Guerreiro-Cacais, Liv Eidsmo, Elisa Martini, Mona Ståhle, Hannes Lindahl, Irène Gallais Sérézal, Maja Jagodic, Susanna Brauner

المصدر: Experimental Dermatology. 26:444-446

مصطلحات موضوعية: Male, 0301 basic medicine, Inflammation, Imiquimod, Dermatology, Dermatitis, Contact, Biochemistry, Interleukin 22, Oxazolone, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Psoriasis, medicine, Animals, Humans, Aminoquinolines, Molecular Biology, business.industry, Binding protein, Receptors, Interleukin, medicine.disease, 030104 developmental biology, chemistry, Case-Control Studies, Immunology, Female, medicine.symptom, business, Contact dermatitis, 030215 immunology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5888d796e8be62aa6456f0c3ada7c701
https://doi.org/10.1111/exd.13225

المؤلفون: Anna Williams, Ana Mendanha Falcão, Darya P. Vanichkina, Mandy Meijer, Gonçalo Castelo-Branco, Sarah Jäkel, Samudyata, Eneritz Agirre, Sueli Marques, David van Bruggen, Charles ffrench-Constant, Elisa M. Floriddia, André Ortlieb Guerreiro-Cacais

المصدر: Mendanha Falcão, A, van Bruggen, D, Marques, S, Meijer, M, Jaekel, S, Agirre, E, Samudyata, Floriddia, E M, Vanichkina, D P, ffrench-Constant, C, Williams, A, Ortlieb Guerreiro-Cacais, A & Castelo-Branco, G 2018, ' Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis ', Nature Medicine, vol. 24, no. 12, pp. 1837–1844 . https://doi.org/10.1038/s41591-018-0236-y
Nature Medicine

مصطلحات موضوعية: 0301 basic medicine, Lineage (genetic), Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Biology, Major histocompatibility complex, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Myelin, Mice, Immune system, medicine, Animals, Humans, Cell Lineage, Myelin Sheath, Oligodendrocyte Precursor Cells, Antigen Presentation, Antigen processing, Multiple sclerosis, Experimental autoimmune encephalomyelitis, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, General Medicine, medicine.disease, Oligodendrocyte, 3. Good health, Cell biology, Alternative Splicing, Oligodendroglia, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, Immune System, biology.protein, Single-Cell Analysis, Transcriptome

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93de6ec6146168779a3274b56d78789f
https://www.pure.ed.ac.uk/ws/files/76565091/accepted_smaller.pdf

المؤلفون: Ewoud Ewing, Maja Jagodic, Roham Parsa, Maria J. Forteza, Melanie Pieber, Lara Kular, Jik Nijssen, Oleg Butovsky, Jinming Han, David Grommisch, Maria Needhamsen, Rasmus Berglund, Robert A. Harris, Sabrina Ruhrmann, Eva Hedlund, Daniel F. J. Ketelhuth, Xing-Mei Zhang, Harald Lund, Keying Zhu, André Ortlieb Guerreiro-Cacais

المصدر: Nat Immunol

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Immunology, Antigen presentation, Inflammation, Biology, Article, 03 medical and health sciences, Mice, Transforming Growth Factor beta, CX3CR1, Demyelinating disease, medicine, Immunology and Allergy, Macrophage, Animals, Microglia, Macrophages, Brain, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Spinal Cord, medicine.symptom, Transforming growth factor, Demyelinating Diseases, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5004e578fc541bba3b33d02bac9605
https://pubmed.ncbi.nlm.nih.gov/29662171

المؤلفون: Alexandra Gyllenberg, Amennai Daniel Beyeen, Maja Jagodic, Rasmus Berglund, Abdelhadi Saoudi, Ulrika Norin, Elisabeth Petit-Teixeira, François Cornelis, Lars Alfredsson, Lars Klareskog, André Ortlieb Guerreiro-Cacais, Leonid Padyukov, Tomas Olsson, Gilbert J. Fournié, Ingrid Kockum, Rikard Holmdahl

المساهمون: Laboratoire de recherche européen pour la polyarthrite rhumatoïde (GenHotel), Université d'Évry-Val-d'Essonne (UEVE), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institut National de Veille Sanitaire, Institut national de veille sanitaire, Faculty of Civil and Geodetic Engineering, University of Ljubljana, Department of Public Health and Clinical Medicine, Umeå University

المصدر: Genes and Immunity
Genes and Immunity, Nature Publishing Group: Open Access Hybrid Model Option B, 2017, 18 (1), pp.48--56. ⟨10.1038/gene.2016.49⟩
Genes and Immunity, 2017, 18 (1), pp.48--56. ⟨10.1038/gene.2016.49⟩

مصطلحات موضوعية: Male, 0301 basic medicine, Immunology, Congenic, Arthritis, Single-nucleotide polymorphism, Immunogenetics, Biology, Peptides, Cyclic, Autoimmune Diseases, Arthritis, Rheumatoid, Cohort Studies, 03 medical and health sciences, Rats, Inbred BN, Genetics, medicine, Animals, Humans, Genetic Predisposition to Disease, Proto-Oncogene Proteins c-vav, Genetics (clinical), Autoantibodies, Genetic association, Polymorphism, Genetic, Haplotype, Autoantibody, Prognosis, medicine.disease, Arthritis, Experimental, Rats, 3. Good health, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Case-Control Studies, Rheumatoid arthritis, Female, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd4bff5cc24c35aa462d1f82f6dfdd7
https://pubmed.ncbi.nlm.nih.gov/28053322

المؤلفون: Milena Z. Adzemovic, Ana Mendanha Falcão, Rasmus Berglund, Kedir Hussen Hamza, Pernilla Stridh, Alan Gillett, Gonçalo Castelo-Branco, Hans Lassmann, Maja Jagodic, Monica Marta, André Ortlieb Guerreiro-Cacais, Ola Hermanson

المصدر: Neurobiology of Disease, Vol 71, Iss, Pp 220-233 (2014)

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Myelin, 0302 clinical medicine, Histone deacetylases, Neuroinflammation, Medicine, Enzyme Inhibitors, 0303 health sciences, CD11b Antigen, Experimental autoimmune encephalomyelitis, biology, Interleukin-17, Brain, Flow Cytometry, 3. Good health, medicine.anatomical_structure, Neurology, Epigenetics, Interleukin 17, Encephalomyelitis, Autoimmune, Experimental, T cells, lcsh:RC321-571, Multiple sclerosis, 03 medical and health sciences, Immune system, Animals, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030304 developmental biology, Analysis of Variance, Dose-Response Relationship, Drug, business.industry, Valproic Acid, Oligodendrocyte precursor, Myelin Basic Protein, medicine.disease, Peptide Fragments, Oligodendrocyte, Rats, Myelin basic protein, Thyroid hormone, Disease Models, Animal, Thyroxine, Ki-67 Antigen, Immunology, biology.protein, business, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af8db025ea3f924eb3d52d064ae760d
http://www.sciencedirect.com/science/article/pii/S0969996114002502

المؤلفون: Petra Bergman, Sonja Hochmeister, André Ortlieb Guerreiro-Cacais, Milena Z. Adzemovic, David Gomez-Cabrero, Jesper Tegnér, Sabrina Ruhrmann, Marie N’diaye, Atul Paulson, Malin Almgren, Maja Jagodic, Manuel Zeitelhofer, Tomas J. Ekström

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 114(9)

مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Down-Regulation, Biology, Lymphocyte Activation, Epigenesis, Genetic, Transcriptome, 03 medical and health sciences, microRNA, medicine, Vitamin D and neurology, Animals, Epigenetics, Vitamin D, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Multidisciplinary, Experimental autoimmune encephalomyelitis, Cell Differentiation, Genomics, Th1 Cells, medicine.disease, Molecular biology, Cell biology, Rats, Up-Regulation, 030104 developmental biology, PNAS Plus, DNA methylation, Th17 Cells, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7e6fd9383c24d57b45ca99e992ac21
https://pubmed.ncbi.nlm.nih.gov/28196884

المؤلفون: Fredrik Piehl, Roham Parsa, Mikael Ström, Tiit Mathiesen, André Ortlieb Guerreiro-Cacais, Rickard P. F. Lindblom, Faiez Al Nimer, Olle Lidman, Shahin Aeinehband

المصدر: Brain, Behavior, and Immunity. 27:109-122

مصطلحات موضوعية: Neutrophils, Traumatic brain injury, Immunology, Cell, Complement Membrane Attack Complex, Biology, Monocytes, Behavioral Neuroscience, Immune system, Cell Movement, Leukocytes, medicine, Animals, RNA, Messenger, Complement Activation, Complement C1q, Oligonucleotide Array Sequence Analysis, Microglia, Endocrine and Autonomic Systems, Gene Expression Profiling, Rats, Inbred Strains, Complement C3, Complement System Proteins, medicine.disease, Rats, Complement system, Killer Cells, Natural, CXCL1, medicine.anatomical_structure, Brain Injuries, Cytokines, Complement membrane attack complex, Neuroscience, NK Cell Lectin-Like Receptor Subfamily B

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e10b97353c793170ca1ca4660bde44a
https://doi.org/10.1016/j.bbi.2012.10.002