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المؤلفون: Mark J. O'Connor, Judith Balmaña, Cristina Cruz, Christopher J. Lord, Elaine Cadogan, Josep V. Forment, J. Carl Barrett, Gordon B. Mills, Carlos Caldas, Brian Dougherty, Susan Critchlow, Alan Lau, Cristina Saura, Javier Cortés, Joaquin Arribas, Judit Grueso, Olga Rodríguez, Marta Guzman, Albert Gris-Oliver, Alejandra Bruna, Ambar Ahmed, Paul W.G. Wijnhoven, Adina Hughes, Zena Wilson, Jenni Nikkilä, Krishna C. Bulusu, Stephen J. Pettitt, Aditi Gulati, Rachel Brough, Alba Llop-Guevara, Filippos Michopoulos, Joshua Armenia, Zhongwu Lai, Gemma N. Jones, Andrea Herencia-Ropero, Marta Palafox, Urszula M. Polanska, Marta Castroviejo-Bermejo, Anderson T. Wang, Violeta Serra
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المؤلفون: Mark J. O'Connor, Judith Balmaña, Cristina Cruz, Christopher J. Lord, Elaine Cadogan, Josep V. Forment, J. Carl Barrett, Gordon B. Mills, Carlos Caldas, Brian Dougherty, Susan Critchlow, Alan Lau, Cristina Saura, Javier Cortés, Joaquin Arribas, Judit Grueso, Olga Rodríguez, Marta Guzman, Albert Gris-Oliver, Alejandra Bruna, Ambar Ahmed, Paul W.G. Wijnhoven, Adina Hughes, Zena Wilson, Jenni Nikkilä, Krishna C. Bulusu, Stephen J. Pettitt, Aditi Gulati, Rachel Brough, Alba Llop-Guevara, Filippos Michopoulos, Joshua Armenia, Zhongwu Lai, Gemma N. Jones, Andrea Herencia-Ropero, Marta Palafox, Urszula M. Polanska, Marta Castroviejo-Bermejo, Anderson T. Wang, Violeta Serra
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المؤلفون: Mark J. O'Connor, Judith Balmaña, Cristina Cruz, Christopher J. Lord, Elaine Cadogan, Josep V. Forment, J. Carl Barrett, Gordon B. Mills, Carlos Caldas, Brian Dougherty, Susan Critchlow, Alan Lau, Cristina Saura, Javier Cortés, Joaquin Arribas, Judit Grueso, Olga Rodríguez, Marta Guzman, Albert Gris-Oliver, Alejandra Bruna, Ambar Ahmed, Paul W.G. Wijnhoven, Adina Hughes, Zena Wilson, Jenni Nikkilä, Krishna C. Bulusu, Stephen J. Pettitt, Aditi Gulati, Rachel Brough, Alba Llop-Guevara, Filippos Michopoulos, Joshua Armenia, Zhongwu Lai, Gemma N. Jones, Andrea Herencia-Ropero, Marta Palafox, Urszula M. Polanska, Marta Castroviejo-Bermejo, Anderson T. Wang, Violeta Serra
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المؤلفون: Matthew J. Sale, Luis Tobalina, Alan Lau, Elizabeth A. Coker, Elisabetta Leo, Andrew J. Pierce, Anderson T. Wang, Violeta Serra, Mark J. O'Connor, Tarrion Baird, Gemma N Jones, Tudor Petreus, Patricia Jaaks, Joshua Armenia, Claudia Winkler, Mathew J. Garnett
المصدر: British Journal of Cancer. 124:951-962
مصطلحات موضوعية: Oncology, 0303 health sciences, Cancer Research, medicine.medical_specialty, Chemotherapy, Standard of care, business.industry, medicine.medical_treatment, medicine.disease, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, chemistry, 030220 oncology & carcinogenesis, Internal medicine, Potential biomarkers, medicine, Upper gastrointestinal, Clinical significance, business, 030304 developmental biology, Predictive biomarker
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المؤلفون: Violeta Serra, Anderson T. Wang, Marta Castroviejo-Bermejo, Urszula M. Polanska, Marta Palafox, Andrea Herencia-Ropero, Gemma N. Jones, Zhongwu Lai, Joshua Armenia, Filippos Michopoulos, Alba Llop-Guevara, Rachel Brough, Aditi Gulati, Stephen J. Pettitt, Krishna C. Bulusu, Jenni Nikkilä, Zena Wilson, Adina Hughes, Paul W.G. Wijnhoven, Ambar Ahmed, Alejandra Bruna, Albert Gris-Oliver, Marta Guzman, Olga Rodríguez, Judit Grueso, Joaquin Arribas, Javier Cortés, Cristina Saura, Alan Lau, Susan Critchlow, Brian Dougherty, Carlos Caldas, Gordon B. Mills, J. Carl Barrett, Josep V. Forment, Elaine Cadogan, Christopher J. Lord, Cristina Cruz, Judith Balmaña, Mark J. O'Connor
المساهمون: Institut Català de la Salut, [Serra V] Experimental Therapeutics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. CIBERONC, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Wang AT, Polanska UM] AstraZeneca Oncology R&D, Cambridge, United Kingdom. [Castroviejo-Bermejo M, Palafox M, Llop-Guevara A, Guzman M, Rodríguez O, Grueso J] Experimental Therapeutics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Herencia-Ropero A] Experimental Therapeutics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Arribas J] CIBERONC, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Growth Factors Laboratory, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Cortés J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Saura C] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Breast Cancer and Melanoma Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Cruz C] Experimental Therapeutics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. High Risk and Familial Cancer, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Balmaña J] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. High Risk and Familial Cancer, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر: Scientia
مصطلحات موضوعية: Cancer Research, Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], Antineoplastic Agents, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas [ENFERMEDADES], Carcinoma, Ovarian Epithelial, Poly(ADP-ribose) Polymerase Inhibitors, Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors [CHEMICALS AND DRUGS], Humans, Other subheadings::/therapeutic use [Other subheadings], Protein Kinase Inhibitors, Ovarian Neoplasms, neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::inhibidores enzimáticos::inhibidores de proteínas cinasas [COMPUESTOS QUÍMICOS Y DROGAS], Otros calificadores::/uso terapéutico [Otros calificadores], BRCA1 Protein, Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms [DISEASES], Nucleosides, Ovaris - Càncer - Tractament, Protein-Tyrosine Kinases, Oncology, Mama - Càncer - Tractament, Phthalazines, Female, Biomarkers, Proteïnes quinases - Inhibidors - Ús terapèutic
وصف الملف: application/pdf
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المؤلفون: Belinda K. Cornes, Agata Smogorzewska, Stephen C. Kowalczykowski, Carrie Sougnez, Taeho Kim, Henrik Molina, Brooke A. Conti, Avinash Abhyankar, Francis P. Lach, Erica Sanborn, Athena L. Huang, Arleen D. Auerbach, Anderson T. Wang, Heather Zierhut, John E. Wagner, Stacey Gabriel
المصدر: Molecular cell, vol 59, iss 3
مصطلحات موضوعية: Heterozygote, Werner Syndrome Helicase, DNA Repair, Cell Survival, DNA repair, genetic processes, RAD51, Biology, Medical and Health Sciences, Genetic recombination, Article, Genomic Instability, Homology directed repair, Replication Protein A, Genetics, Humans, Molecular Biology, Replication protein A, RecQ Helicases, DNA Helicases, Infant, DNA, Hematology, Cell Biology, Biological Sciences, DNA repair protein XRCC4, Molecular biology, Non-homologous end joining, enzymes and coenzymes (carbohydrates), Fanconi Anemia, Exodeoxyribonucleases, Cross-Linking Reagents, HEK293 Cells, Mutation, health occupations, Female, Rad51 Recombinase, Generic health relevance, Homologous recombination, Developmental Biology
وصف الملف: application/pdf
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المؤلفون: Maureen Hattersley, Gordon B. Mills, Stephen Fawell, Brandon Willis, Alan Lau, Huawei Chen, Jingwen Zhang, Corinne Reimer, Austin Dulak, Michael Zinda, Anderson T. Wang, Jenni Nikkilä
المصدر: Oncogene. 37(28)
مصطلحات موضوعية: 0301 basic medicine, DNA Replication, Cancer Research, Indoles, DNA damage, Morpholines, Cell Cycle Proteins, Mice, SCID, Biology, Heterocyclic Compounds, 2-Ring, Piperazines, Article, 03 medical and health sciences, Mice, Cell Line, Tumor, Genetics, Animals, Humans, Phosphorylation, Molecular Biology, Gene, Transcription factor, Regulation of gene expression, Sulfonamides, DNA replication, Nuclear Proteins, Xenograft Model Antitumor Assays, Cell biology, DNA replication checkpoint, Gene Expression Regulation, Neoplastic, Pyridazines, 030104 developmental biology, Cell killing, Pyrimidines, Sulfoxides, Cancer cell, Pyrazoles, Female, DNA Damage, Signal Transduction, Transcription Factors
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المؤلفون: Violeta Serra, Josep V. Forment, Brian Dougherty, Christopher J. Lord, J. Carl Barrett, Cristina Saura, Rachel Brough, Krishna C. Bulusu, Judith Balmaña, Elaine Cadogan, Stephen Fawell, Zhongwu Lai, Cristina Cruz, Mark J. O'Connor, Carlos Caldas, Susan E. Critchlow, Alejandra Bruna, Marta Castroviejo-Bermejo, Anderson T. Wang, Urszula M. Polanska, Gemma N Jones, Alba Llop-Guevara
المصدر: Cancer Research. 79:932-932
مصطلحات موضوعية: Cancer Research, DNA damage, RAD51, Cancer, Biology, medicine.disease, Olaparib, Wee1, chemistry.chemical_compound, PARP1, Oncology, chemistry, PARP inhibitor, medicine, biology.protein, Cancer research, Homologous recombination
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المؤلفون: Peter J. McHugh, Blanka Sengerová, Anderson T. Wang
مصطلحات موضوعية: DNA Replication, DNA Repair, DNA repair, Replication Origin, Eukaryotic DNA replication, Biology, Recombinases, Structure-Activity Relationship, Control of chromosome duplication, Minichromosome maintenance, Animals, Humans, Molecular Biology, Replication protein A, Genetics, Endodeoxyribonucleases, Extra View, DNA replication, DNA, Cell Biology, Endonucleases, Multifunctional Enzymes, Protein Structure, Tertiary, DNA-Binding Proteins, Enzyme Activation, Exodeoxyribonucleases, Fanconi Anemia, Origin recognition complex, Developmental Biology, Nucleotide excision repair
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المؤلفون: Anderson T. Wang, Jacqueline H. Enzlin, Lonnie P. Swift, N.A. Burgess-Brown, Opher Gileadi, Peter J. McHugh, Blanka Sengerová, Janet M. Hartley, John A. Hartley, Konstantinos Kiakos, Christopher J. Schofield, Emma Cattell, Takabumi Inagawa
المصدر: Genes & Development. 25:1859-1870
مصطلحات موضوعية: DNA Interstrand Cross-Link Repair, Exonuclease, DNA Repair, DNA repair, Biology, DNA-binding protein, chemistry.chemical_compound, Cell Line, Tumor, Genetics, Humans, DNA Breaks, Double-Stranded, DNA Breaks, Single-Stranded, Nuclear Proteins, DNA, Endonucleases, Molecular biology, MUS81, DNA-Binding Proteins, DNA Repair Enzymes, Exodeoxyribonucleases, chemistry, biology.protein, ERCC1, Research Paper, HeLa Cells, Developmental Biology, Nucleotide excision repair
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المؤلفون: Anderson T. Wang, Patricia Stuckert, Anna L. Olsen, Peter J. McHugh, Alan D. D'Andrea, Katsuhiro Hanada, Laura J. Niedernhofer, Roland Kanaar, Nikhil R. Bhagwat
المساهمون: Molecular Genetics
المصدر: Molecular and Cellular Biology, 29(24), 6427-6437. American Society for Microbiology
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, DNA Repair, DNA repair, DNA damage, Biology, Cell Line, Mice, Cricetulus, Fanconi anemia, Cricetinae, hemic and lymphatic diseases, FANCD2, medicine, Animals, Humans, Monoubiquitination, DNA Breaks, Double-Stranded, RNA, Small Interfering, Molecular Biology, Ubiquitin, Fanconi Anemia Complementation Group D2 Protein, nutritional and metabolic diseases, Articles, Cell Biology, Endonucleases, medicine.disease, Molecular biology, MUS81, Chromatin, Fanconi Anemia Complementation Group Proteins, DNA-Binding Proteins, Fanconi Anemia, Homologous recombination, Gene Deletion, DNA Damage
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المؤلفون: Christopher P. Guise, William R. Wilson, Anke Theil, Anderson T. Wang, Adam V. Patterson, David J. A. Bridewell
المصدر: Biochemical Pharmacology. 74:810-820
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Cell Death, biology, Cytochrome P450, Antineoplastic Agents, Transfection, Reductase, Biochemistry, Cytoprotection, Cell Hypoxia, chemistry, Oxidoreductase, Cell Line, Tumor, Mustard Prodrug, Nitrogen Mustard Compounds, NAD(P)H Dehydrogenase (Quinone), biology.protein, Humans, Prodrugs, NAD+ kinase, Oxidoreductases, Cytotoxicity, NADPH-Ferrihemoprotein Reductase
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المؤلفون: Agata Smogorzewska, Anderson T. Wang
المصدر: Cell. 160(1-2)
مصطلحات موضوعية: Genetics, Genome instability, congenital, hereditary, and neonatal diseases and abnormalities, Fanconi anemia, complementation group C, DNA Repair, Biochemistry, Genetics and Molecular Biology(all), DNA repair, Genetic disorder, Bone marrow failure, nutritional and metabolic diseases, Biology, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Fanconi Anemia Complementation Group Proteins, chemistry.chemical_compound, Fanconi Anemia, chemistry, Fanconi anemia, hemic and lymphatic diseases, medicine, Animals, Humans, Gene, DNA
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المؤلفون: David Jones, Mark J. O'Connor, Lenka Oplustil O'Connor, Claire Sadler, Peter Cotton, Anderson T. Wang, Jaimini Reens, Jen Barnes, Michael J. Spreadborough, Joanne Wilson, Aaron Smith, Andres Tellez, Rajesh Odedra, Victoria Sheridan, Scott Eliasof, Alan Lau
المصدر: Molecular Cancer Research. 15:B32-B32
مصطلحات موضوعية: Cancer Research, Cell cycle checkpoint, business.industry, DNA repair, Pharmacology, Topoisomerase-I Inhibitor, Olaparib, chemistry.chemical_compound, Therapeutic index, Oncology, chemistry, CRLX101, PARP inhibitor, Cancer research, Medicine, business, Molecular Biology, Camptothecin, medicine.drug
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المؤلفون: J. English, S. Powell, Zhongwu Lai, P. Kirschmeier, Andrew J. Pierce, Anderson T. Wang, B. Dougherty, Rajesh Odedra, S. Zhou, Ursula A. Matulonis, A. Hughes, Q. Zeng, J.C. Barrett, E. Ivanova, S. Dharma, Joyce F. Liu, James W.T. Yates, Mark J. O'Connor, S. Palakurthi, P. Jewsbury
المصدر: European Journal of Cancer. 69:S142
مصطلحات موضوعية: 0301 basic medicine, WEE1 Inhibitor AZD1775, Antitumor activity, Cancer Research, business.industry, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Oncology, chemistry, 030220 oncology & carcinogenesis, PARP inhibitor, Cancer research, Medicine, In patient, business, Explant culture
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المؤلفون: Claire Sadler, Rajesh Odedra, Michael J. Spreadborough, Joanne Wilson, Aaron Smith, Alan Lau, Andres Tellez, Anderson T. Wang, Jaimini Reens, Mark J. O'Connor, Scott Eliasof, Lenka Oplustil O'Connor, Victoria Sheridan, Peter Cotton, Jen Barnes, David R. Jones
المصدر: Cancer Research. 76:3721-3721
مصطلحات موضوعية: WEE1 Inhibitor AZD1775, Cancer Research, Chemotherapy, business.industry, medicine.medical_treatment, Topoisomerase-I Inhibitor, Olaparib, chemistry.chemical_compound, Therapeutic index, Oncology, chemistry, CRLX101, PARP inhibitor, Cancer research, Medicine, business, Camptothecin, medicine.drug
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المؤلفون: John A. Hartley, Peter J. McHugh, Anderson T. Wang
المصدر: Advances in DNA Repair in Cancer Therapy ISBN: 9781461447405
مصطلحات موضوعية: Melphalan, Cisplatin, medicine.disease, Carboplatin, Nitrogen mustard, chemistry.chemical_compound, chemistry, Biochemistry, Fanconi anemia, medicine, Bifunctional, DNA, medicine.drug, Nucleotide excision repair
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المؤلفون: Timothy A. Sato, Anna P. Ponnampalam, Jeffrey Keelan, Michelle Glass, Murray D. Mitchell, Anderson T. Wang
المصدر: American journal of physiology. Endocrinology and metabolism. 294(2)
مصطلحات موضوعية: Adult, medicine.medical_specialty, Cannabinoid receptor, Cannabinoid Receptor Modulators, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Placenta, Blotting, Western, Prostaglandin, Biology, In Vitro Techniques, Dinoprostone, chemistry.chemical_compound, Rimonabant, Piperidines, Receptor, Cannabinoid, CB1, Fetal membrane, Pregnancy, Physiology (medical), Internal medicine, medicine, Decidua, Humans, Cyclooxygenase Inhibitors, Amnion, Receptors, Cannabinoid, Nitrobenzenes, Sulfonamides, Cyclooxygenase 2 Inhibitors, Chorion, Cyclohexanols, Endocannabinoid system, medicine.anatomical_structure, Endocrinology, chemistry, Prostaglandin-Endoperoxide Synthases, Prostaglandins, Pyrazoles, lipids (amino acids, peptides, and proteins), Female, Cannabinoid, medicine.drug