-
1
المؤلفون: Carolyn Diane Dzierba, Debra J. Post-Munson, Ronald J. Knox, Lorin A. Thompson, Shuya Wang, Matthew G. Soars, Michele Matchett, Linda J. Bristow, James Herrington, Clotilde Bourin, Amy Newton, Rick L. Pieschl, Eric Shields, Amy Easton, Kathy Mosure, Guanglin Luo, Kimberly Newberry, Ling Chen, John D. Graef, Arun K. Senapati, Nicholas A. Meanwell, Digavalli V. Sivarao
المصدر: Journal of Medicinal Chemistry. 62:831-856
مصطلحات موضوعية: Indole test, 0303 health sciences, Indazole, medicine.medical_treatment, Pharmacology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, medicine.anatomical_structure, Allodynia, Dorsal root ganglion, chemistry, Drug Discovery, Neuropathic pain, medicine, Molecular Medicine, Potency, Structure–activity relationship, medicine.symptom, Adjuvant, 030304 developmental biology
-
2
المؤلفون: Kathleen W. Mosure, Michele Matchett, Ronald J. Knox, Richard E. Olson, Joanne J. Bronson, Nicholas A. Meanwell, Matthew G. Soars, Linda J. Bristow, Ramkumar Rajamani, James Herrington, Amy Easton, Digavalli V. Sivarao, Dawn D. Parker, Rick L. Pieschl, Ping Chen, Guanglin Luo, Omar S. Barnaby, Lorin A. Thompson, Yong-Jin Wu, Andrea McClure, Jason M. Guernon, Amy Newton, Alicia Ng, Clotilde Bourin, Carolyn Diane Dzierba
المصدر: Bioorganic & Medicinal Chemistry. 25:5490-5505
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Membrane permeability, Bicyclic molecule, Aryl, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Sulfonamide, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, medicine.anatomical_structure, Nociception, chemistry, Drug Discovery, NAV1, medicine, Molecular Medicine, Moiety, Neuron, Molecular Biology
-
3
المؤلفون: Mahesh Paschapur, Jeffrey M. Brown, Tanmaya Bastia, Lawrence R. Marcin, Jayakumar Sankara Warrier, Srinivasan Thangathirupathy, Joanne J. Bronson, Raja Reddy Kallem, Huiping Zhang, Jyoti Gulia, Alda Fernandes, Digavalli V. Sivarao, Deborah Keavy, Amy Newton, Jianqing Li, Pattipati S. Naidu, Kuchibhotla Vijaya Kumar, James Kempson, Michael R. Weed, Rick L. Pieschl, Mark Bookbinder, Charlie F. Albright, Kimberly Newberry, Yu-Wen Li, Dalton King, Manjunath Ramarao, Jean Simmermacher, Linda J. Bristow, Meenakshee Sinha, Eric Shields, Lorin A. Thompson, John E. Macor, Charulatha Sanmathi, Imadul Islam, B.N. Srikumar, Richard E. Olson, John D. Graef, Arvind Mathur, Narasimharaju Kalidindi, Joseph Polino, Michael Sinz, Thaddeus F. Molski, Jayant Aher, Reeba K. Vikramadithyan
المصدر: Journal of Pharmacology and Experimental Therapeutics. 363:377-393
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Allosteric modulator, Chemistry, digestive, oral, and skin physiology, Allosteric regulation, Glutamate receptor, Long-term potentiation, Prodrug, stomatognathic diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, Molecular Medicine, Receptor, 030217 neurology & neurosurgery, Ex vivo
-
4
المؤلفون: Debra J. Post-Munson, Amy Easton, Carolyn Diane Dzierba, Amy Newton, Yong-Jin Wu, Ronald J. Knox, Kevin J. Robbins, Jason M. Guernon, Clotilde Bourin, Ramkumar Rajamani, Richard E. Olson, James Herrington, Michele Matchett, Kimberly Newberry, John D. Graef, Jianliang Shi, Lorin A. Thompson, Shuya Wang, Jonathan L. Ditta, Nicholas A. Meanwell, Rick L. Pieschl, Matthew G. Soars, Linda J. Bristow, Kathleen W. Mosure
المصدر: Journal of Medicinal Chemistry. 60:2513-2525
مصطلحات موضوعية: 0301 basic medicine, Formalin Test, Membrane permeability, 010405 organic chemistry, Drug discovery, Stereochemistry, Cyclohexylamine, Pharmacology, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, medicine.anatomical_structure, chemistry, Dorsal root ganglion, Drug Discovery, NAV1, medicine, Molecular Medicine, Piperidine
-
5
المؤلفون: Amy Newton, Joanna Hu, Thorsten Rosner, George O. Tora, Yu-Wen Li, Joseph Raybon, Yi Hsiao, Xiaoping Hou, Joanne J. Bronson, Nicholas J. Lodge, John E. Macor, David A. Conlon, Carl D. Davis, Jung-Hui Sun, Michael K. Wong, Kevin W. Gillman, Sarah J. Taylor, Umesh Hanumegowda, Rudolph G. Krause, Huiping Zhang, Hong Huang, Matthew T. Taber, Andrew P. Degnan, Rick L. Pieschl
المصدر: ACS Chemical Neuroscience. 7:1635-1640
مصطلحات موضوعية: 0301 basic medicine, Indazoles, Physiology, Cognitive Neuroscience, hERG, Drug Evaluation, Preclinical, Administration, Oral, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Neurokinin-1 Receptor Antagonists, Transcriptional Regulator ERG, In vivo, Drug Discovery, Animals, Humans, Serotonin Uptake Inhibitors, Receptor, Serotonin transporter, Serotonin Plasma Membrane Transport Proteins, Depressive Disorder, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Chemistry, Cell Biology, General Medicine, Receptors, Neurokinin-1, Antidepressive Agents, Rats, Disease Models, Animal, 030104 developmental biology, biology.protein, Gerbillinae, Reuptake inhibitor, Selective Serotonin Reuptake Inhibitors, 030217 neurology & neurosurgery
-
6
المؤلفون: Guanglin, Luo, Ling, Chen, Amy, Easton, Amy, Newton, Clotilde, Bourin, Eric, Shields, Kathy, Mosure, Matthew G, Soars, Ronald J, Knox, Michele, Matchett, Rick L, Pieschl, Debra J, Post-Munson, Shuya, Wang, James, Herrington, John, Graef, Kimberly, Newberry, Digavalli V, Sivarao, Arun, Senapati, Linda J, Bristow, Nicholas A, Meanwell, Lorin A, Thompson, Carolyn, Dzierba
المصدر: Journal of medicinal chemistry. 62(4)
-
7
المؤلفون: Linda J. Bristow, Yu-Wen Li, Amy Newton, Trevor Wojcik, Praveena Baireddy, Yang Hong, Alda Fernandes, Yuan Tian, Rick L. Pieschl
المصدر: European Journal of Pharmacology. 766:1-8
مصطلحات موضوعية: Male, Pharmacology, Chemistry, Traxoprodil, Brain, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Dizocilpine, Mice, Radioligand Assay, In vivo, Lanicemine, Excitatory Amino Acid Antagonists, medicine, Animals, NMDA receptor, Channel blocker, Dizocilpine Maleate, Receptor, medicine.drug
-
8
المؤلفون: Yong-Jin, Wu, Jason, Guernon, Andrea, McClure, Guanglin, Luo, Ramkumar, Rajamani, Alicia, Ng, Amy, Easton, Amy, Newton, Clotilde, Bourin, Dawn, Parker, Kathleen, Mosure, Omar, Barnaby, Matthew G, Soars, Ronald J, Knox, Michele, Matchett, Rick, Pieschl, James, Herrington, Ping, Chen, D V, Sivarao, Linda J, Bristow, Nicholas A, Meanwell, Joanne, Bronson, Richard, Olson, Lorin A, Thompson, Carolyn, Dzierba
المصدر: Bioorganicmedicinal chemistry. 25(20)
مصطلحات موضوعية: Inflammation, Male, Neurons, Nociception, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Freund's Adjuvant, NAV1.7 Voltage-Gated Sodium Channel, Administration, Oral, Models, Biological, Disease Models, Animal, Mice, Structure-Activity Relationship, HEK293 Cells, Drug Discovery, Animals, Humans, Chronic Pain
-
9
المؤلفون: Linda J, Bristow, Jyoti, Gulia, Michael R, Weed, Bettadapura N, Srikumar, Yu-Wen, Li, John D, Graef, Pattipati S, Naidu, Charulatha, Sanmathi, Jayant, Aher, Tanmaya, Bastia, Mahesh, Paschapur, Narasimharaju, Kalidindi, Kuchibhotla Vijaya, Kumar, Thaddeus, Molski, Rick, Pieschl, Alda, Fernandes, Jeffrey M, Brown, Digavalli V, Sivarao, Kimberly, Newberry, Mark, Bookbinder, Joseph, Polino, Deborah, Keavy, Amy, Newton, Eric, Shields, Jean, Simmermacher, James, Kempson, Jianqing, Li, Huiping, Zhang, Arvind, Mathur, Raja Reddy, Kallem, Meenakshee, Sinha, Manjunath, Ramarao, Reeba K, Vikramadithyan, Srinivasan, Thangathirupathy, Jayakumar, Warrier, Imadul, Islam, Joanne J, Bronson, Richard E, Olson, John E, Macor, Charlie F, Albright, Dalton, King, Lorin A, Thompson, Lawrence R, Marcin, Michael, Sinz
المصدر: The Journal of pharmacology and experimental therapeutics. 363(3)
مصطلحات موضوعية: Male, Depressive Disorder, Major, Xenopus, Brain, Dissociative Disorders, Motor Activity, Brain Waves, Receptors, N-Methyl-D-Aspartate, Antidepressive Agents, Organophosphates, Pyrrolidinones, Rats, Sprague-Dawley, Macaca fascicularis, Mice, Radioligand Assay, Memory, Short-Term, Allosteric Regulation, Piperidines, Animals, Administration, Intravenous, Prodrugs
-
10
المؤلفون: Emmanuelle Pare, Amy Newton, Samuel Parry, Dominick Pucci, Thomas F. McElrath, Kee-Hak Lim
المصدر: Obstetrics & Gynecology. 124:763-770
مصطلحات موضوعية: Adult, medicine.medical_specialty, Comorbidity, Severity of Illness Index, Preeclampsia, Cohort Studies, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Risk Factors, Severity of illness, Diabetes Mellitus, Ethnicity, medicine, Humans, Obesity, Prospective Studies, Prospective cohort study, Gynecology, Obstetrics, business.industry, Incidence, Incidence (epidemiology), Pregnancy Outcome, Reproducibility of Results, Obstetrics and Gynecology, medicine.disease, Logistic Models, Hypertension, Multivariate Analysis, Gestation, Female, business, Maternal Age, Cohort study
-
11
المؤلفون: Kimberly Newberry, Kevin W. Gillman, Matthew T. Taber, Snjezana Lelas, Tanya L. Wallace-Boone, Yu-Wen Li, Carl D. Davis, Rick L. Pieschl, Nicholas J. Lodge, John E. Macor, Thaddeus F. Molski, Michael F. Parker, Joanne J. Bronson, Amy Newton
المصدر: Neuropharmacology. 73:232-240
مصطلحات موضوعية: Male, Serotonin, medicine.medical_specialty, Morpholines, Serotonin reuptake inhibitor, Prefrontal Cortex, Citalopram, Pharmacology, Gerbil, Radioligand Assay, Cellular and Molecular Neuroscience, Neurokinin-1 Receptor Antagonists, Piperidines, Fluoxetine, Internal medicine, medicine, Animals, Humans, Aprepitant, Serotonin transporter, Serotonin Plasma Membrane Transport Proteins, Dose-Response Relationship, Drug, biology, Chemistry, Antagonist, Drug Synergism, Immobility Response, Tonic, Receptors, Neurokinin-1, Antidepressive Agents, HEK293 Cells, Endocrinology, biology.protein, Gerbillinae, Selective Serotonin Reuptake Inhibitors, medicine.drug
-
12
المؤلفون: Yong-Jin, Wu, Jason, Guernon, Jianliang, Shi, Jonathan, Ditta, Kevin J, Robbins, Ramkumar, Rajamani, Amy, Easton, Amy, Newton, Clotilde, Bourin, Kathleen, Mosure, Matthew G, Soars, Ronald J, Knox, Michele, Matchett, Rick L, Pieschl, Debra J, Post-Munson, Shuya, Wang, James, Herrington, John, Graef, Kimberly, Newberry, Linda J, Bristow, Nicholas A, Meanwell, Richard, Olson, Lorin A, Thompson, Carolyn, Dzierba
المصدر: Journal of medicinal chemistry. 60(6)
مصطلحات موضوعية: Male, Voltage-Gated Sodium Channel Blockers, Analgesics, Mice, Sulfonamides, HEK293 Cells, Piperidines, Ganglia, Spinal, Drug Discovery, NAV1.7 Voltage-Gated Sodium Channel, Animals, Humans, Pain
-
13
المؤلفون: Yu-Wen Li, George O. Tora, Snjezana Lelas, Kim A. Johnson, Matthew T. Taber, Joanne J. Bronson, Michael F. Parker, Rudolf G. Krause, Amy Newton, Robert L. Bertekap, Kelly D. Lengyel, Kevin W. Gillman, Nicholas J. Lodge, Rick L. Pieschl, John E. Macor, Andrew P. Degnan, Silva Mark, Sarah J. Taylor
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:407-411
مصطلحات موضوعية: Phenylpiperidine, Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Pharmacology, Gerbil, Biochemistry, Inhibitory Concentration 50, chemistry.chemical_compound, Neurokinin-1 Receptor Antagonists, In vivo, Drug Discovery, Pyridine, Animals, Receptor, Molecular Biology, Molecular Structure, Depression, Chemistry, Organic Chemistry, Disease Models, Animal, Drug Design, Molecular Medicine, Serotonin Antagonists, Gerbillinae, Antagonism, Behavioural despair test
-
14
المؤلفون: Debra J. Post-Munson, Clotilde Bourin, Carolyn Diane Dzierba, Ling Chen, Michele Matchett, John D. Graef, Ronald J. Knox, Kimberly Newberry, Guanglin Luo, James B Herrington, Amy Newton, Matthew G. Soars, Arun K. Senapati, Kathy Mosure, Nicholas A. Meanwell, Digavalli V. Sivarao, Shuya Wang, Rick L. Pieschl, Linda J. Bristow, Eric Shields, Lorin A. Thompson, Amy Easton
المصدر: Journal of Medicinal Chemistry. 62:2213-2213
مصطلحات موضوعية: Indole test, Indazole, chemistry.chemical_compound, Chemistry, Drug Discovery, Molecular Medicine, Pharmacology
-
15
المصدر: Neuropsychopharmacology. 33:1919-1928
مصطلحات موضوعية: Male, Antidepressive Agents, Tricyclic, Motor Activity, Pharmacology, Gerbil, Buspirone, Neurokinin-1 Receptor Antagonists, Desipramine, medicine, Haloperidol, Animals, Amphetamine, Swimming, Depressive Disorder, Sex Characteristics, Fluoxetine, Adrenergic Uptake Inhibitors, Body Weight, Reproducibility of Results, Antidepressive Agents, Psychiatry and Mental health, Data Interpretation, Statistical, Anesthesia, Antidepressive Agents, Second-Generation, Antidepressant, Central Nervous System Stimulants, Female, Gerbillinae, Psychology, human activities, Selective Serotonin Reuptake Inhibitors, Antipsychotic Agents, medicine.drug, Behavioural despair test
-
16
المؤلفون: Zoeckler Mary Edson, Digavalli V. Sivarao, Thomas Philip, David Weaver, Li-Qiang Sun, Carl D. Davis, Steven I. Dworetzky, Amy Newton, Huan He, David G. Harden, Craig Polson, Ronald J. Knox, Yong-Jin Wu, Michael Sinz, Suresh Yeola, William Fitzpatrick, Svetlana Tertyshnikova
المصدر: Journal of Medicinal Chemistry. 46:3778-3781
مصطلحات موضوعية: Male, Patch-Clamp Techniques, Potassium Channels, medicine.drug_class, Stereochemistry, Migraine Disorders, Morpholines, Reactive intermediate, Administration, Oral, Biological Availability, Stereoisomerism, Carboxamide, Chemical synthesis, Cell Line, Membrane Potentials, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Oral administration, Parietal Lobe, Drug Discovery, medicine, Animals, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, KCNQ2 Potassium Channel, Structure–activity relationship, Chemistry, Biological activity, Fluorine, Rats, Disease Models, Animal, Cinnamates, Potassium Channels, Voltage-Gated, Acrylamide, Injections, Intravenous, Molecular Medicine, Ion Channel Gating
-
17
المؤلفون: Shing Hong Kang, Svetlana Tertyshnikova, Michael Sinz, Sanna Lehtinen-Oboma, John E. Starrett, Yong-Jin Wu, Steven I. Dworetzky, Alexandre L'Heureux, Digavalli V. Sivarao, Mark W. Thompson, Gene G. Kinney, Christopher G. Boissard, Amy Newton, David Weaver, Henry S. Wong, Ronald J. Knox, Valentin K. Gribkoff, Li-Qiang Sun, Lei Zhang, JoAnne E Natale, Corinne R. Greco, Huan He, David G. Harden
المصدر: Journal of Medicinal Chemistry. 46:3197-3200
مصطلحات موضوعية: Patch-Clamp Techniques, Potassium Channels, Stereochemistry, Migraine Disorders, Morpholines, Potassium, Administration, Oral, Biological Availability, chemistry.chemical_element, Pharmacology, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, Xenopus laevis, Dogs, Pharmacokinetics, Oral administration, KCNQ2 Potassium Channel, Drug Discovery, medicine, Animals, Humans, Cerebral Cortex, Acrylamides, Chemistry, Stereoisomerism, Biological activity, medicine.disease, Rats, Bioavailability, Disease Models, Animal, Migraine, Potassium Channels, Voltage-Gated, Cortical spreading depression, Oocytes, Molecular Medicine, Ion Channel Gating
-
18
المؤلفون: Lori Otis, Lorna Potaka-Osborne, Amy Newton, Austin Lovenstein, Marlene Walden, Deborah Hutts, Kimberly Gibson, Kimberly Bynum
المصدر: Journal of PeriAnesthesia Nursing. 32:e34
مصطلحات موضوعية: Medical–Surgical Nursing, medicine.medical_specialty, Cross-training, business.industry, Pediatric hospital, Emergency medicine, medicine, business, Patient flow
-
19
المؤلفون: Kimberly Newberry, Amy Newton, Laszlo Kiss, John D. Graef, Eric Shields, Linda J. Bristow, Jean Simmermacher, Rick L. Pieschl, Fu-ni Luan, Eric Schaeffer, David Luchetti, Yu-Wen Li
المصدر: Brain research. 1609
مصطلحات موضوعية: Male, Time Factors, Long-Term Potentiation, Hippocampus, Pharmacology, Hippocampal formation, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Tissue Culture Techniques, Piperidines, medicine, Animals, Ketamine, Molecular Biology, Chemistry, General Neuroscience, Antagonist, Long-term potentiation, Antidepressive Agents, Electric Stimulation, nervous system, Synaptic plasticity, NMDA receptor, Antidepressant, Neurology (clinical), Neuroscience, Excitatory Amino Acid Antagonists, Developmental Biology, medicine.drug
-
20
المؤلفون: Huan He, Amy Newton, Dedong Wu, Carl D. Davis, Ryan Westphal, Snjezana Lelas, Joanne J. Bronson, Matthew T. Taber, John E. Macor, Qi Gao, Tanya L. Wallace, Yong-Jin Wu, Robert L. Bertekap
المصدر: Bioorganicmedicinal chemistry letters. 24(6)
مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Administration, Oral, Cyclopentanes, Pharmacology, Motor Activity, Gerbil, Crystallography, X-Ray, Biochemistry, Neurokinin-1 Receptor Antagonists, Drug Discovery, Animals, Humans, Molecular Biology, Serotonin Plasma Membrane Transport Proteins, Chemistry, Organic Chemistry, Transporter, Serotonin reuptake, Receptors, Neurokinin-1, Orally active, Molecular Medicine, NK1 receptor antagonist, Reuptake inhibitor, Gerbillinae, Selective Serotonin Reuptake Inhibitors, Behavioural despair test, Protein Binding