المؤلفون: Fredrik Pehr Marmsater, Jeffrey M. Schkeryantz, Dana Rae Benesh, Maria-Jesus Blanco, Amy Clemens-Smith, Renee Emkey, Kirk W. Johnson, Michael P. Johnson, Fese Mokube, Groendyke Todd Michael, James Allen Knobelsdorf, Tony Pisal Tang, Mark A. Muhlhauser, Cortez Guillermo S, Thomas Daniel Aicher, Albert Khilevich, Steven Swanson, John T. Catlow

المصدر: Bioorganicmedicinal chemistry letters. 27(2)

مصطلحات موضوعية: 0301 basic medicine, Migraine Disorders, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Pharmacology, Receptors, Metabotropic Glutamate, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Allosteric Regulation, Drug Discovery, Animals, Humans, Molecular Biology, Receptors, Leukotriene, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Metabotropic glutamate receptor 5, Organic Chemistry, Potentiator, Rats, Cysteinyl leukotriene receptor 1, 030104 developmental biology, Metabotropic receptor, Metabotropic glutamate receptor, Molecular Medicine, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 2, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5d8e11f4b6d50d127416a2d5c6aa8c
https://pubmed.ncbi.nlm.nih.gov/27908761

المؤلفون: Charles Chow, John P. Mayer, Eric S Nisenbaum, Liang Zeng Yan, Emily Rothstein, Junqing Li, Renee Vaughn, Renee Lynch, Deborah McCarty, Kevin L. McKnight, Kirk W. Johnson, Patrick J. B. Edwards, Baolin Li, Amy Clemens-Smith, Jirong Lu, David B. Flora

المصدر: Journal of Peptide Science. 17:383-386

مصطلحات موضوعية: Pharmacology, Agonist, chemistry.chemical_classification, medicine.medical_specialty, medicine.drug_class, Chemistry, Organic Chemistry, Antagonist, Peptide, General Medicine, Calcitonin gene-related peptide, medicine.disease, Biochemistry, Endocrinology, Calcitonin gene-related peptide receptor antagonist, Migraine, Structural Biology, Calcitonin, Internal medicine, Drug Discovery, medicine, Molecular Medicine, Receptor, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3cdbb51d05816f3c0c0d8be550174cb5
https://doi.org/10.1002/psc.1358

المؤلفون: Ken H. Ho, Edward L. Mattiuz, Ann Marie L. Ogden, Brian Michael Mathes, Ana I. Mateo, David Bleakman, Kevin John Hudziak, Donna K. Dieckman, Sandra Ann Filla, Mark A. Winter, Thomas J. Bleisch, Ana Maria Escribano, Paul L. Ornstein, Kirk W. Johnson, Douglas Richard Stack, Amy Clemens-Smith, Miriam del Prado, Ana M. Castaño, Mary A. Katofiasc, Robert E. Stratford, E. Dominguez, Michael Gregory Bell, Lee A. Phebus, Jose A. Martinez-Perez

المصدر: Journal of Medicinal Chemistry. 45:4383-4386

مصطلحات موضوعية: Stereochemistry, Migraine Disorders, Carboxylic Acids, Administration, Oral, Biological Availability, Kainate receptor, Pharmacology, Cell Line, Radioligand Assay, Receptors, Kainic Acid, Drug Discovery, medicine, Animals, Humans, Prodrugs, Rats, Wistar, Receptor, Dose-Response Relationship, Drug, Chemistry, Antagonist, Glutamate receptor, Esters, Biological activity, Prodrug, Isoquinolines, Rats, Disease Models, Animal, Mechanism of action, Competitive antagonist, Acute Disease, Molecular Medicine, Calcium, medicine.symptom, Excitatory Amino Acid Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40829499fc5f2801999006c9b4f877df
https://doi.org/10.1021/jm025548q

المؤلفون: Liang Zeng, Yan, Kirk W, Johnson, Emily, Rothstein, David, Flora, Patrick, Edwards, Baolin, Li, Junqing, Li, Renee, Lynch, Renee, Vaughn, Amy, Clemens-Smith, Deborah, McCarty, Charles, Chow, Kevin L, McKnight, Jirong, Lu, Eric S, Nisenbaum, John P, Mayer

المصدر: Journal of peptide science : an official publication of the European Peptide Society. 17(5)

مصطلحات موضوعية: Calcitonin Gene-Related Peptide Receptor Antagonists, Humans, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a9e705758acc1ec821e0d300e5ccaedf
https://pubmed.ncbi.nlm.nih.gov/21412957

المؤلفون: Kirk W. Johnson, David Bleakman, Donna K. Dieckman, Paul L. Ornstein, Sandra Ann Filla, Kevin John Hudziak, Edward R. Siuda, Amy Clemens-Smith, Dell Colin Peter, Michael P. Johnson, Veronique Dehlinger, Eric S. Nisenbaum, Nabih M. Ramadan

المصدر: Innovative drug development for headache disorders

مصطلحات موضوعية: Drug development, business.industry, Anesthesia, Glutamate receptor, Medicine, Headache Disorders, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::598d62a15eb1129e4f4cdc2ba1ab18a9
https://doi.org/10.1093/med/9780199552764.003.0022

المؤلفون: David O. Calligaro, Amy Clemens-Smith, Ken H. Ho, Darryle D. Schoepp, Marlene L. Cohen, Mary Gates, Robert E. Stratford, Paul L. Ornstein, K.R Jarvie, Ann Marie L. Ogden, Sandra Ann Filla, Rebecca A. Wright, Mary A. Katofiasc, Brianne Weiss, Bryan G. Johnson, Geihan Rizkalla, Andrew Alt, Craig R. Salhoff, Kathryn W. Schenck, David Bleakman, Donna K. Dieckman, Kirk W. Johnson, Edward L. Mattiuz, Lee A. Phebus

المصدر: The Journal of pharmacology and experimental therapeutics. 318(2)

مصطلحات موضوعية: Male, medicine.drug_class, Migraine Disorders, Phencyclidine, Kainate receptor, AMPA receptor, Pharmacology, In Vitro Techniques, Motor Activity, Ligands, Transfection, Binding, Competitive, Muscle, Smooth, Vascular, Trigeminal ganglion, Benzodiazepines, Dorsal root ganglion, Receptors, Kainic Acid, medicine, Animals, Humans, Saphenous Vein, Receptors, AMPA, Receptor, Neurons, Chemistry, Glutamate receptor, Antagonist, Blood Proteins, Receptor antagonist, Isoquinolines, Rats, Electrophysiology, medicine.anatomical_structure, Molecular Medicine, Calcium, Rabbits, Excitatory Amino Acid Antagonists, Proto-Oncogene Proteins c-fos, Muscle Contraction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5211cdf990741fc3ac26cc363aeecbe0
https://pubmed.ncbi.nlm.nih.gov/16690725

المؤلفون: Amy Clemens-Smith, Jason Katner, Beth J. Hoffman, Hong Yu, Patrick L. Love, K.W. Perry, Richard J. Davis, George G. Nomikos, Lee A. Phebus, Kirk W. Johnson, Harlan E. Shannon, Frank P. Bymaster

المصدر: Annals of the New York Academy of Sciences. 1003

مصطلحات موضوعية: Brain Chemistry, Dose-Response Relationship, Drug, Chemistry, General Neuroscience, Glycine, Prefrontal Cortex, Sarcosine, medicine.disease, Hippocampus, General Biochemistry, Genetics and Molecular Biology, Rats, Amino Acid Transport Systems, Neutral, History and Philosophy of Science, Biochemistry, In vivo, Schizophrenia, Glycine Plasma Membrane Transport Proteins, medicine, Animals, Chromatography, High Pressure Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97c52b8693af7ce440ee2b955a26019
https://pubmed.ncbi.nlm.nih.gov/14684475

المؤلفون: Gerald F. Smith, Matthew J. Fisher, John E. Toth, Nickolay Y. Chirgadze, Deborah D. Giera, Dianna L. Bailey, John A. Buben, Amy Clemens-Smith, Michael L. Denney, Michael Enrico Richett, Richard Waltz Harper, Jolie Anne Bastian, Alan David Palkowitz, Minsheng Zhang, Valentine J. Klimkowski, Todd J. Kohn, Jefferson Ray Mccowan, Kumiko Takeuchi, Ho-Shen Lin, Daniel Jon Sall, Donetta S. Gifford-Moore, Lea M. Johnson, David W. Snyder

المصدر: Journal of medicinal chemistry. 43(4)

مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Serine Proteinase Inhibitors, Stereochemistry, Drug Evaluation, Preclinical, Thiophenes, In Vitro Techniques, Crystallography, X-Ray, Chemical synthesis, Structure-Activity Relationship, Thrombin, In vivo, Drug Discovery, medicine, Potency, Animals, Humans, Binding Sites, biology, Bicyclic molecule, Chemistry, Active site, Anticoagulants, Thrombosis, Rats, Enzyme inhibitor, biology.protein, Molecular Medicine, medicine.drug, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b65bb93c4bac89d1ca25c10915de94
https://pubmed.ncbi.nlm.nih.gov/10691691