المؤلفون: W. Cameron Black, Abbas Abdoli, Xiuli An, Anick Auger, Patrick Beaulieu, Michel Bernatchez, Cathy Caron, Amandine Chefson, Sheldon Crane, Mohamed Diallo, Stéphane Dorich, Lee D. Fader, Gino B. Ferraro, Sara Fournier, Qi Gao, Yelena Ginzburg, Martine Hamel, Yongshuai Han, Paul Jones, Stéphanie Lanoix, Cyrus M. Lacbay, Marie-Eve Leclaire, Maayan Levy, Yael Mamane, Amina Mulani, Robert Papp, Charles Pellerin, Audrey Picard, Alexander Skeldon, Kathryn Skorey, Rino Stocco, Miguel St.-Onge, Jean-François Truchon, Vouy Linh Truong, Michal Zimmermann, Michael Zinda, Anne Roulston

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Science Policy, Virology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, preclinical evaluation focused, intermittent dosing schedules, excellent adme properties, related kinase mtor, key hydrogen bond, key kinase, synthetic lethal, single agent, pharmacophore model, nct04855656 ), mitigate anemia, erythroid compartment, damage response, attractive target, allow recovery

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_the_Potent_and_Selective_ATR_Inhibitor_Camonsertib_RP-3500_/25126367

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01917.s001
https://figshare.com/articles/journal_contribution/Discovery_of_the_Potent_and_Selective_ATR_Inhibitor_Camonsertib_RP-3500_/25126367

المؤلفون: Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant

المصدر: Journal of Medicinal Chemistry. 65:13198-13215

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998

المؤلفون: W. Cameron Black, Michael Zinda, Jordan T.F. Young, Zuomei Li, Yael Mamane, Rino Stocco, Martine Hamel, Artur Veloso, Victoria Rimkunas, Amina Mulani, Kathryn Skorey, Sabrina Vignini-Hammond, Chloe Fugère-Desjardins, William Yang, Hunain Alam, Amandine Chefson, Shou Yun Yin, Marie-Eve Leclaire, Li Li, Sara Fournier, Lee D. Fader, Stéphane Dorich, Valerie Dumais, Émilie Dumas-Bérube, Charles Pellerin, Alexander Skeldon, Robert Papp, Michal Zimmermann, Anne Roulston

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062cfaf9177f49a3206feb599326f494
https://doi.org/10.1158/1535-7163.22896018

المؤلفون: W. Cameron Black, Michael Zinda, Jordan T.F. Young, Zuomei Li, Yael Mamane, Rino Stocco, Martine Hamel, Artur Veloso, Victoria Rimkunas, Amina Mulani, Kathryn Skorey, Sabrina Vignini-Hammond, Chloe Fugère-Desjardins, William Yang, Hunain Alam, Amandine Chefson, Shou Yun Yin, Marie-Eve Leclaire, Li Li, Sara Fournier, Lee D. Fader, Stéphane Dorich, Valerie Dumais, Émilie Dumas-Bérube, Charles Pellerin, Alexander Skeldon, Robert Papp, Michal Zimmermann, Anne Roulston

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a51beae2425d617ba7d0ef61e96c7e6
https://doi.org/10.1158/1535-7163.c.6651330.v1

المؤلفون: Anne Roulston, Michal Zimmermann, Robert Papp, Alexander Skeldon, Charles Pellerin, Émilie Dumas-Bérube, Valerie Dumais, Stéphane Dorich, Lee D. Fader, Sara Fournier, Li Li, Marie-Eve Leclaire, Shou Yun Yin, Amandine Chefson, Hunain Alam, William Yang, Chloe Fugère-Desjardins, Sabrina Vignini-Hammond, Kathryn Skorey, Amina Mulani, Victoria Rimkunas, Artur Veloso, Martine Hamel, Rino Stocco, Yael Mamane, Zuomei Li, Jordan T.F. Young, Michael Zinda, W. Cameron Black

المصدر: Molecular Cancer Therapeutics. 21:245-256

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c5c2c693c809fd51b04d00ce59692a4
https://doi.org/10.1158/1535-7163.mct-21-0615

المؤلفون: Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant

المصدر: Journal of medicinal chemistry. 65(19)

مصطلحات موضوعية: DNA Replication, Ovarian Neoplasms, Mice, Drug Design, Drug Discovery, Animals, Humans, Female, DNA-Directed DNA Polymerase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059

المؤلفون: Anne Roulston, Michal Zimmerman, Robert Papp, Alex Skeldon, Charles Pellerin, Émilie Dumas-Bérube, Valerie Dumais, Stephane Dorich, Sara Fournier, Li Li, Marie-Ève Leclaire, Shou Yun Yin, Amandine Chefson, Hunain Alam, William Yang, Chloe Fugère-Desjardins, Sabrina Hammond, Kathryn Skorey, Amina Mulani, Victoria Rimkunas, Artur Veloso, Martine Hamel, Rino Stocco, Yael Mamane, Zuomei Li, Jordan Young, Mike Zinda, Cameron Black

المصدر: Molecular Cancer Therapeutics. 20:P054-P054

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::64546a898e05e3470c5622263c464f40
https://doi.org/10.1158/1535-7163.targ-21-p054

المؤلفون: Mihaela Friciu, Amandine Chefson, Grégoire Leclair

المصدر: The Canadian Journal of Hospital Pharmacy. 69

مصطلحات موضوعية: Nifedipine, business.industry, Compounded preparations, Research Letters / Communiqués de Recherche, Medicine, Pharmacology (medical), Pharmacy, Pharmacology, business, medicine.drug, Hydrocortisone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c50f64494ead5b9cbe179298f958197
https://doi.org/10.4212/cjhp.v69i4.1578

المؤلفون: Sébastien Gagné, Amandine Chefson, Sylvie Toulmond, Patrick Lacombe, Mélissa Arbour, Austin Chen, Dan McKay, Elizabeth Cauchon, Erich L. Grimm, Yeeman K. Ramtohul, M. David Percival, Jean-François Lévesque, Yves Ducharme, Dwight Macdonald, Yongxin Han, René St-Jacques, Robert Houle, Bruce Mackay, Jean-Pierre Falgueyret, Pierre-André Fournier

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2670-2674

مصطلحات موضوعية: Dependent manner, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Renin inhibitor, Structure-Activity Relationship, Enzyme activator, chemistry.chemical_compound, Catalytic Domain, Renin, Drug Discovery, Renin–angiotensin system, medicine, Animals, Humans, Structure–activity relationship, Isoxazole, Molecular Biology, Antihypertensive Agents, Molecular Structure, CYP3A4, Chemistry, Organic Chemistry, Isoxazoles, Rats, Enzyme Activation, Drug Design, Molecular Medicine, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb21bf0f8aa1b021cd6fbd529e12bdc
https://doi.org/10.1016/j.bmcl.2012.03.014

المؤلفون: Kelly Bleasby, Dwight Macdonald, Bruce Mackay, Richard Tschirret-Guth, Robert Houle, Sebastien Laliberte, Patrick Lacombe, Robert Papp, Erich L. Grimm, Amandine Chefson, Jean-François Lévesque, Michael J. Hafey, Pierre-André Fournier, Sébastien Gagné, Yongxin Han, Yves Ducharme, Michel Gallant, Austin Chen, Daniel Dube

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5547-5551

مصطلحات موضوعية: ATP Binding Cassette Transporter, Subfamily B, Cell Membrane Permeability, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, ATP-binding cassette transporter, Absorption (skin), Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Piperidines, Renin, Drug Discovery, Renin–angiotensin system, Animals, Structure–activity relationship, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Biological Transport, Stereoisomerism, Transporter, Rats, Bioavailability, Permeability (electromagnetism), Molecular Medicine, Efflux

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b390428a9f09b127996a8190fb39ae
https://doi.org/10.1016/j.bmcl.2011.06.095

المؤلفون: Karine Auclair, Amandine Chefson, Jin Zhao

المصدر: Journal of Biotechnology. 130:436-440

مصطلحات موضوعية: Sucrose, Carbohydrates, Bioengineering, Applied Microbiology and Biotechnology, Catalysis, chemistry.chemical_compound, Freeze-drying, Cytochrome P-450 Enzyme System, medicine, Cytochrome P-450 CYP3A, Humans, Sugar, chemistry.chemical_classification, Chromatography, Chemistry, General Medicine, Trehalose, Enzyme Activation, Enzyme, Cytochrome P-450 CYP2D6, Biochemistry, Biocatalysis, Sorbitol, Mannitol, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b26e57ca4f4f8ba3a42a8f4a662a26
https://doi.org/10.1016/j.jbiotec.2007.05.009

المؤلفون: Karine Auclair, Amandine Chefson, Jin Zhao

المصدر: ChemBioChem. 7:916-919

مصطلحات موضوعية: NADP metabolism, Hydroxylation, Biochemistry, Catalysis, Cofactor, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Cytochrome P-450 CYP3A, Humans, Organic chemistry, Hydrogen peroxide, Molecular Biology, Chromatography, High Pressure Liquid, Hydrogen peroxide metabolism, biology, CYP3A4, Chemistry, Organic Chemistry, Hydrogen Peroxide, Peroxides, Up-Regulation, Enzyme Activation, Kinetics, Cytochrome P-450 CYP2D6, biology.protein, Molecular Medicine, NADP, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd108d1976569cf4318416c759b639aa
https://doi.org/10.1002/cbic.200600006

المؤلفون: Nguyen Natalie, Ernest Asante-Appiah, Manuel Chan, Nathalie Coulombe, Yves Ducharme, Mark Wrona, C. Bayly, Paul Tawa, Serge Plamondon, Kristina Dupont-Gaudet, Amandine Chefson, Jean-François Truchon, Sébastien Guiral, Louis-Charles Campeau, Joe Vacca, Sébastien Gagné, Rob Papp, Elizabeth Cauchon, Leanne Bedard, Eric Langlois, Robert Forget, Stéphane G. Ouellet, Stephanie Roy, Mélina Girardin, Jason Burch, Jean-Pierre Falgueyret, Bernard Cote, Danny Gauvreau, St-Onge Miguel, Marc Blouin, Ria Seliniotakis, Wanda Cromlish, Chun Sing Li, Amélie Roy, Smita Debnath, Youwei Yan, Denis Deschenes

المصدر: Bioorganicmedicinal chemistry letters. 24(3)

مصطلحات موضوعية: Anti-HIV Agents, Pyridones, viruses, Clinical Biochemistry, Mutant, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Nucleoside Reverse Transcriptase Inhibitor, Rats, Sprague-Dawley, chemistry.chemical_compound, Inhibitory Concentration 50, Dogs, Pharmacokinetics, immune system diseases, Doravirine, Drug Discovery, Drug Resistance, Viral, Potency, Animals, Humans, Molecular Biology, Cells, Cultured, Molecular Structure, Chemistry, Organic Chemistry, Wild type, virus diseases, Triazoles, Virology, Reverse transcriptase, Rats, Regimen, Mutation, HIV-1, Molecular Medicine, Reverse Transcriptase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62223ea91d052361c00f8debcf009fe0
https://pubmed.ncbi.nlm.nih.gov/24412110

المؤلفون: Christopher P. Regan, Elizabeth Cauchon, Bruce Mackay, Yves Ducharme, Sylvie Toulmond, Sebastien Laliberte, Patrick Lacombe, Sébastien Gagné, M. David Percival, Daniel Dube, Jean-Pierre Falgueyret, JingQi Huang, Jean-François Lévesque, Dan McKay, Yongxin Han, René St-Jacques, Louis-Charles Campeau, Austin Chen, Hillary K. Regan, Pierre-André Fournier, Amandine Chefson, Erich L. Grimm, Robert Houle, Dwight Macdonald, Susana Liu

المصدر: Bioorganicmedicinal chemistry letters. 21(13)

مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Renin inhibitor, Chemical synthesis, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Piperidines, In vivo, Drug Discovery, Renin–angiotensin system, Renin, medicine, Structure–activity relationship, Animals, Enzyme Inhibitors, Molecular Biology, biology, Molecular Structure, Organic Chemistry, Rats, chemistry, Enzyme inhibitor, Drug Design, Lipophilicity, Hypertension, Lactam, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6984bb7f944791450d3c0856db18d4c4
https://pubmed.ncbi.nlm.nih.gov/21621998

المؤلفون: Amandine Chefson, Karine Auclair

المصدر: Chembiochem : a European journal of chemical biology. 8(10)

مصطلحات موضوعية: Time Factors, Chemistry, Organic, Ionic Liquids, Buffers, Biochemistry, Catalysis, Enzyme catalysis, Hydroxylation, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Organic chemistry, Cytochrome P-450 CYP3A, Humans, Testosterone, Molecular Biology, Alkane, chemistry.chemical_classification, Ions, Aqueous solution, Hydrogen bond, Chemistry, Organic Chemistry, Water, Hydrogen Bonding, Carbon, Models, Chemical, Ionic liquid, Solvents, Molecular Medicine, Solvent effects, Hydrogen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee34961b18a27ae05f39a0619f451a25
https://pubmed.ncbi.nlm.nih.gov/17526062

المؤلفون: Karine Auclair, Amandine Chefson

المصدر: Molecular BioSystems. 2:462

مصطلحات موضوعية: Hemeprotein, Camphor 5-Monooxygenase, Mutagenesis (molecular biology technique), Protein Engineering, Models, Biological, Catalysis, Cofactor, Mixed Function Oxygenases, Substrate Specificity, chemistry.chemical_compound, Bacterial Proteins, Cytochrome P-450 Enzyme System, Biosynthesis, Enzyme Stability, Molecule, Molecular Biology, NADPH-Ferrihemoprotein Reductase, chemistry.chemical_classification, Molecular Structure, biology, Cytochrome P450, Enzyme, chemistry, Biochemistry, Mutagenesis, Solvents, biology.protein, Substrate specificity, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec8c82cd4313f489c4ed08eb091472b
https://doi.org/10.1039/b607001a

المؤلفون: Amandine Chefson, Jin Zhao, Karine Auclair

المصدر: ChemBioChem; Jun2006, Vol. 7 Issue 6, p916-919, 4p