المؤلفون: Yunsong Tong (1693537), Alan S. Florjancic (1693522), Rick F. Clark (6411851), Chunqiu Lai (2495494), Anthony Mastracchio (2539054), Gui-dong Zhu (11009292), Morey L. Smith (1637704), Peter J. Kovar (1637680), Bailin Shaw (1671436), Daniel H. Albert (221329), Wei Qiu (217045), Kenton L. Longenecker (2523292), Xiaoqin Liu (296429), Amanda M. Olson (1693534), Donald J. Osterling (766107), Stephen K. Tahir (1637689), Darren C. Phillips (1637665), Joel D. Leverson (1738723), Andrew J. Souers (1637668), Thomas D. Penning (1693528)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Virology, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, azaindole-based inhibitors, Lead Optimization Campaign, dosing, pharmacokinetic properties, toxicity challenges, pan-CDK inhibitors, transcription elongation, vivo efficacy, tumor maintenance, Balancing Properties, CDK 9 downregulates, antiapoptotic BCL -2 family member ., CDK 9 Inhibitors Cyclin-dependent k., CDK 9 inhibitors

Relation: https://figshare.com/articles/journal_contribution/Balancing_Properties_with_Carboxylates_A_Lead_Optimization_Campaign_for_Selective_and_Orally_Active_CDK9_Inhibitors/14825148

الاتاحة: https://doi.org/10.1021/acsmedchemlett.1c00161.s001

المؤلفون: David Maag, Julie L. Wilsbacher, Eric F. Johnson, Amanda M. Olson, Yan Shi, Mikkel A. Algire, Vivek C. Abraham, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Paul A. Ellis, William B. Ainsworth, Todd A. Hopkins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e498c80f13b9c6f3eef5213b00c9a4
https://doi.org/10.1158/1541-7786.22514770

المؤلفون: David Maag, Eric F. Johnson, Donald J. Osterling, DeAnne F. Stolarik, Amanda M. Olson, Wenqing Gao, Julie L. Wilsbacher, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Larry R. Solomon, Luis E. Rodriguez, Yan Shi, Todd A. Hopkins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcfa08a35c000c13a490792d1596a75
https://doi.org/10.1158/1541-7786.22514481.v1

المؤلفون: David Maag, Julie L. Wilsbacher, Eric F. Johnson, Amanda M. Olson, Yan Shi, Mikkel A. Algire, Vivek C. Abraham, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Paul A. Ellis, William B. Ainsworth, Todd A. Hopkins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d490333306545aace2682f34c3fb2b1
https://doi.org/10.1158/1541-7786.22514785.v1

المؤلفون: David Maag, Julie L. Wilsbacher, Eric F. Johnson, Amanda M. Olson, Yan Shi, Mikkel A. Algire, Vivek C. Abraham, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Paul A. Ellis, William B. Ainsworth, Todd A. Hopkins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a73200cd0e0b2826cfb29f9594a526
https://doi.org/10.1158/1541-7786.22514782

المؤلفون: David Maag, Julie L. Wilsbacher, Eric F. Johnson, Amanda M. Olson, Yan Shi, Mikkel A. Algire, Vivek C. Abraham, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Paul A. Ellis, William B. Ainsworth, Todd A. Hopkins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a64aa11e2b2967e2f843fb56859904
https://doi.org/10.1158/1541-7786.22514773

المؤلفون: David Maag, Julie L. Wilsbacher, Eric F. Johnson, Amanda M. Olson, Yan Shi, Mikkel A. Algire, Vivek C. Abraham, Sanjay C. Panchal, Enrico L. DiGiammarino, Cherrie K. Donawho, Paul A. Ellis, William B. Ainsworth, Todd A. Hopkins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4316ce74d1ccc2bcb5ea88f60741cf
https://doi.org/10.1158/1541-7786.22514776.v1

المؤلفون: Andrew J. Souers, Wei Qiu, Thomas D. Penning, Darren C. Phillips, Xiaoqin Liu, Rick F. Clark, Joel D. Leverson, Amanda M. Olson, Chunqiu Lai, Daniel H. Albert, Gui-Dong Zhu, Yunsong Tong, Peter Kovar, Kenton L. Longenecker, Anthony Mastracchio, Morey L. Smith, Bailin Shaw, Alan S. Florjancic, Stephen K. Tahir, Donald J. Osterling

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Serine, In vivo, Oral administration, Chemistry, Kinase, Organic Chemistry, Drug Discovery, Toxicity, Cyclin-dependent kinase 9, Dosing, Pharmacology, Pharmacophore, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85e60b25f3e832de4e347a9da8d597e
https://doi.org/10.1021/acsmedchemlett.1c00161

المؤلفون: Philip J. Merta, Amanda M. Olson, Fritz G. Buchanan, Nirupama B. Soni, Donald J. Osterling, Alan S. Florjancic, Debra Ferguson, David Maag, Eric F. Johnson, Yunsong Tong, Alexander R. Shoemaker, Maricel Torrent, Kenneth D. Bromberg, Thomas D. Penning, Loren M. Lasko

المصدر: ACS Medicinal Chemistry Letters. 6:58-62

مصطلحات موضوعية: chemistry.chemical_classification, Molecular model, biology, Pyrimidine, Chemistry, Kinase, Organic Chemistry, Pharmacology, Biochemistry, Wee1, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, biology.protein, Pharmacophore, Cytotoxicity, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b451c835e91d1f244b2b91708eb295
https://doi.org/10.1021/ml5002745

المؤلفون: Patrick A. Marcotte, Jun Guo, Michael R. Michaelides, Steven K. Davidsen, David R. Reuter, Junling Li, Yanping Luo, Lori J. Pease, Chris Tse, Terrance J. Magoc, Ru-Qi Wei, Paul Tapang, Eric F. Johnson, Cherrie K. Donawho, Zehan Chen, Amanda M. Olson, Donald J. Osterling, Daniel H. Albert, Michael L. Curtin, Keith B. Glaser, Jennifer J. Bouska, Mai H. Bui, Robin R. Frey

المصدر: Journal of Pharmacology and Experimental Therapeutics. 343:617-627

مصطلحات موضوعية: Male, Time Factors, Aminopyridines, Antineoplastic Agents, Mice, SCID, Protein Serine-Threonine Kinases, Histones, Mice, chemistry.chemical_compound, Growth factor receptor, Aurora Kinases, Cell Line, Tumor, Human Umbilical Vein Endothelial Cells, Animals, Aurora Kinase B, Humans, Receptors, Platelet-Derived Growth Factor, Pharmacology, Mice, Inbred BALB C, Leukemia, Experimental, Dose-Response Relationship, Drug, Molecular Structure, biology, Phenylurea Compounds, Autophosphorylation, Xenograft Model Antitumor Assays, Molecular biology, Vascular endothelial growth factor, Vascular endothelial growth factor A, Receptors, Vascular Endothelial Growth Factor, src-Family Kinases, chemistry, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ff4def0b6e7aabec77986594da503f
https://doi.org/10.1124/jpet.112.197087

المؤلفون: Cherrie K. Donawho, Jennifer J. Bouska, Chang Park, Yan Luo, Yan Shi, Xuesong Liu, Eric F. Johnson, Donald J. Osterling, Thomas D. Penning, Paul Ellis, Vincent L. Giranda, Jianchun Gong, Alexander R. Shoemaker, Viraj B. Gandhi, Gui-Dong Zhu, Amanda M. Olson

المصدر: Bioorganic & Medicinal Chemistry. 20:4635-4645

مصطلحات موضوعية: Models, Molecular, Pyridines, Clinical Biochemistry, Poly (ADP-Ribose) Polymerase-1, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Poly(ADP-ribose) Polymerase Inhibitors, Pharmacology, Crystallography, X-Ray, Biochemistry, Poly (ADP-Ribose) Polymerase Inhibitor, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Temozolomide, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, Cancer, Neoplasms, Experimental, medicine.disease, Xenograft Model Antitumor Assays, Mice, Inbred C57BL, Pyridazines, Enzyme, PARP inhibitor, Molecular Medicine, Female, Poly(ADP-ribose) Polymerases, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6144cafe54a77ad8539097bb36e28bd1
https://doi.org/10.1016/j.bmc.2012.06.021

المؤلفون: Xuesong Liu, Vincent L. Giranda, Luis E. Rodriguez, Paul A. Ellis, Donald J. Osterling, Magdalena Przytulinska, David Frost, Thomas D. Penning, Jason Stavropoulos, Cherrie K. Donawho, Yunsong Tong, Eric F. Johnson, Joel D. Leverson, Jennifer J. Bouska, Yan Shi, Patrick A. Marcotte, Amanda M. Olson, Sheela A. Thomas, Nirupama B. Soni, Yan Luo

المصدر: Journal of Medicinal Chemistry. 52:6803-6813

مصطلحات موضوعية: Male, Benzimidazole, Pyridines, Poly ADP ribose polymerase, Transplantation, Heterologous, Melanoma, Experimental, Poly (ADP-Ribose) Polymerase-1, Administration, Oral, Biological Availability, Antineoplastic Agents, Poly(ADP-ribose) Polymerase Inhibitors, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Temozolomide, Animals, Humans, Cytotoxicity, Antineoplastic Agents, Alkylating, IC50, Oxadiazoles, biology, Drug Synergism, Biological activity, Small molecule, Dacarbazine, Mice, Inbred C57BL, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Female, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adaa42993a9837a478796b4a1a429391
https://doi.org/10.1021/jm900697r

المؤلفون: Viraj B. Gandhi, Kennan C. Marsh, Vered Klinghofer, Elizabeth H. Fry, Eric F. Johnson, David Frost, Amanda M. Olson, Vincent L. Giranda, Jianchun Gong, Chang H. Park, Yan Luo, Jennifer J. Bouska, Wolfgang Wernet, Roland Grandel, Gui-Dong Zhu, W. Lubisch, Saul H. Rosenberg, Sheela A. Thomas, Yan Shi, Cherrie K. Donawho, Xuesong Liu, Thomas D. Penning, Velitchka Bontcheva-Diaz

المصدر: Bioorganic & Medicinal Chemistry. 16:6965-6975

مصطلحات موضوعية: Benzimidazole, medicine.drug_class, Poly ADP ribose polymerase, Transplantation, Heterologous, Clinical Biochemistry, Melanoma, Experimental, Pharmaceutical Science, Breast Neoplasms, Carboxamide, Poly(ADP-ribose) Polymerase Inhibitors, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Antineoplastic Combined Chemotherapy Protocols, Drug Discovery, Temozolomide, medicine, Animals, Humans, Potency, Enzyme Inhibitors, Molecular Biology, Polymerase, biology, Organic Chemistry, Xenograft Model Antitumor Assays, Dacarbazine, chemistry, Enzyme inhibitor, PARP inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Cisplatin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f9dfff4a264cde0e806e9b06f79cf0
https://doi.org/10.1016/j.bmc.2008.05.044

المؤلفون: David R. Reuter, Patrick A. Marcotte, Niru B. Soni, Amanda M. Olson, Jennifer J. Bouska, Yujia Dai, Lori J. Pease, Donald J. Osterling, Kresna Hartandi, Daniel H. Albert, Keith B. Glaser, Stella Z. Doktor, Kent D. Stewart, Steven K. Davidsen, Michael R. Michaelides

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:386-390

مصطلحات موضوعية: Models, Molecular, Platelet-derived growth factor, Clinical Biochemistry, Administration, Oral, Aminopyridines, Biological Availability, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Growth factor receptor, In vivo, Drug Discovery, Pyrazolopyridine, Animals, Edema, Urea, Receptors, Platelet-Derived Growth Factor, Protein Kinase Inhibitors, neoplasms, Molecular Biology, Uterine Diseases, biology, Kinase, Organic Chemistry, In vitro, Receptors, Vascular Endothelial Growth Factor, chemistry, embryonic structures, cardiovascular system, biology.protein, Cancer research, Pyrazoles, Molecular Medicine, Female, Signal transduction, Platelet-derived growth factor receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1fe6f2e83f5001005ed414b7c94447
https://doi.org/10.1016/j.bmcl.2007.10.018

المؤلفون: James G. Murphy, Jennifer J. Duchnick, Rudy E. Vuchinich, John W. Davison, Rhonda S. Karg, Amanda M. Olson, Anna F. Smith, Timothy T. Coffey

المصدر: Psychology of Addictive Behaviors. 15:373-379

مصطلحات موضوعية: Psychiatry and Mental health, Clinical Psychology, Medicine (miscellaneous)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3131a940fd4a1e67bb049d6669f6ebfc
https://doi.org/10.1037/0893-164x.15.4.373

المؤلفون: Michael R. Michaelides, Terrance J. Magoc, Keith B. Glaser, Debra Montgomery, David R. Reuter, Amanda M. Olson, Patrick A. Marcotte, H. Robin Heyman, Robin R. Frey, Jennifer J. Bouska, Kent D. Stewart, Cherrie K. Donawho, James R. Jankowski, Daniel H. Albert, Chris Tse, Michael L. Curtin, Joann P. Palma

المصدر: Bioorganicmedicinal chemistry letters. 22(14)

مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Aurora B kinase, Pharmaceutical Science, Antineoplastic Agents, Pyrazole, Pharmacology, Protein Serine-Threonine Kinases, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Aurora Kinases, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Aurora Kinase B, Humans, Molecular Biology, Protein Kinase Inhibitors, Amination, Cell Proliferation, Antitumor activity, Molecular Structure, Kinase, Chemistry, Organic Chemistry, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Pyrimidines, Cell culture, Microsome, Microsomes, Liver, Molecular Medicine, Pyrazoles

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52dc5f202c23f026711490221f77123
https://pubmed.ncbi.nlm.nih.gov/22695126

المؤلفون: Niru B. Soni, Steven K. Davidsen, Lori J. Pease, Zhiwen Guan, H. Robin Heyman, Patrick A. Marcotte, Amanda M. Olson, James S. Polakowski, Jennifer J. Bouska, Kent D. Stewart, Robin R. Frey, Michael R. Michaelides, Daniel H. Albert, Chris Tse, Michael L. Curtin, Lee C. Preusser, Donald J. Osterling, Terrance J. Magoc, Keith B. Glaser, Paul Tapang

المصدر: Bioorganicmedicinal chemistry letters. 22(9)

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, Thienopyridine, Pyridines, VEGF receptors, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Aurora kinase, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Urea, Dosing, Kinase activity, Molecular Biology, Protein Kinase Inhibitors, biology, Kinase, Chemistry, Organic Chemistry, Cancer, medicine.disease, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c99d66a1972bb151f3489fd31cd6e73
https://pubmed.ncbi.nlm.nih.gov/22465635

المؤلفون: Xuesong Liu, Gail Bukofzer, Chang H. Park, Yan Luo, Sheela A. Thomas, Kennan C. Marsh, David Frost, Vered Klinghofer, Amanda M. Olson, Thomas D. Penning, Viraj B. Gandhi, Cherrie K. Donawho, Elizabeth H. Fry, Eric F. Johnson, Jennifer J. Bouska, Fritz G. Buchanan, Luis E. Rodriguez, Vincent L. Giranda, Velitchka Bontcheva-Diaz, Donald J. Osterling, Yan Shi, Jianchun Gong, Gui-Dong Zhu

المصدر: Journal of medicinal chemistry. 53(8)

مصطلحات موضوعية: Models, Molecular, Benzimidazole, medicine.drug_class, Stereochemistry, Poly ADP ribose polymerase, Transplantation, Heterologous, Melanoma, Experimental, Biological Availability, Carboxamide, Antineoplastic Agents, Mice, SCID, Poly(ADP-ribose) Polymerase Inhibitors, Crystallography, X-Ray, Poly (ADP-Ribose) Polymerase Inhibitor, Carboplatin, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Antineoplastic Combined Chemotherapy Protocols, medicine, Temozolomide, Potency, Structure–activity relationship, Animals, Polymerase, biology, BRCA1 Protein, Stereoisomerism, Transplantation, Dacarbazine, Mice, Inbred C57BL, chemistry, Blood-Brain Barrier, biology.protein, Molecular Medicine, Benzimidazoles, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c570bdd2710139f17e2d617b98240cb
https://pubmed.ncbi.nlm.nih.gov/20337371

المؤلفون: Yan Luo, Amanda M. Olson, Xuesong Liu, Yan Shi, Thomas D. Penning, Jennifer J. Bouska, Keith W. Woods, Julie M. Miyashiro, Vincent L. Giranda, Elizabeth H. Fry, Eric F. Johnson, Chang H. Park

المصدر: Bioorganicmedicinal chemistry letters. 19(15)

مصطلحات موضوعية: Models, Molecular, Niacinamide, DNA Repair, Stereochemistry, Poly ADP ribose polymerase, Chemistry, Pharmaceutical, Clinical Biochemistry, Substituent, Molecular Conformation, Pharmaceutical Science, Antineoplastic Agents, Apoptosis, Poly(ADP-ribose) Polymerase Inhibitors, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Quinoxalines, Drug Discovery, Humans, Molecular Biology, chemistry.chemical_classification, Cell Nucleus, Organic Chemistry, Kinetics, Enzyme, chemistry, Drug Design, Molecular Medicine, Amine gas treating, Drug Screening Assays, Antitumor, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347e44e9858b4e87e81a2598c5565f45
https://pubmed.ncbi.nlm.nih.gov/19553114

المؤلفون: Viraj B. Gandhi, Jianchun Gong, Yan Shi, Yan Luo, Donald J. Osterling, Jennifer J. Bouska, Amanda M. Olson, Kennan C. Marsh, Vered Klinghofer, David Frost, Velitchka Bontcheva-Diaz, Cherrie K. Donawho, Vincent L. Giranda, Gui-Dong Zhu, Xuesong Liu, Eric F. Johnson, Thomas D. Penning

المصدر: Journal of medicinal chemistry. 52(2)

مصطلحات موضوعية: Benzimidazole, Magnetic Resonance Spectroscopy, Veliparib, medicine.drug_class, Poly ADP ribose polymerase, Melanoma, Experimental, Biological Availability, Carboxamide, Antineoplastic Agents, Mice, SCID, Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase Inhibitor, Carboplatin, chemistry.chemical_compound, Mice, Dogs, In vivo, Drug Discovery, medicine, Temozolomide, Potency, Animals, Humans, Enzyme Inhibitors, Cyclophosphamide, Haplorhini, Molecular biology, Rats, Dacarbazine, chemistry, Area Under Curve, PARP inhibitor, Molecular Medicine, Benzimidazoles, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904c2806eccea1986b854bd543bbf65c
https://pubmed.ncbi.nlm.nih.gov/19143569