المؤلفون: Ryan G. Lim, Chris Quan, Andrea M. Reyes-Ortiz, Sarah E. Lutz, Amanda J. Kedaigle, Theresa A. Gipson, Jie Wu, Gad D. Vatine, Jennifer Stocksdale, Malcolm S. Casale, Clive N. Svendsen, Ernest Fraenkel, David E. Housman, Dritan Agalliu, Leslie M. Thompson

المصدر: Cell Reports, Vol 19, Iss 7, Pp 1365-1377 (2017)

مصطلحات موضوعية: Huntington’s disease, neurodegeneration, induced pluripotent stem cell, transcriptome, RNA sequencing, brain microvascular endothelial cell, BMEC, angiogenesis, blood-brain barrier, WNT signaling, epigenetics, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717304965; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/a4c8006ac0ea461986232304206450ef

المؤلفون: Bruna Paulsen, Silvia Velasco, Amanda J. Kedaigle, Martina Pigoni, Giorgia Quadrato, Anthony J. Deo, Xian Adiconis, Ana Uzquiano, Rafaela Sartore, Sung Min Yang, Sean K. Simmons, Panagiotis Symvoulidis, Kwanho Kim, Kalliopi Tsafou, Archana Podury, Catherine Abbate, Ashley Tucewicz, Samantha N. Smith, Alexandre Albanese, Lindy Barrett, Neville E. Sanjana, Xi Shi, Kwanghun Chung, Kasper Lage, Edward S. Boyden, Aviv Regev, Joshua Z. Levin, Paola Arlotta

المصدر: Nature. 602:268-273

مصطلحات موضوعية: Cerebral Cortex, Neurons, Proteomics, Multidisciplinary, Autism Spectrum Disorder, Histone-Lysine N-Methyltransferase, DNA-Binding Proteins, Organoids, Humans, Genetic Predisposition to Disease, RNA-Seq, GABAergic Neurons, Single-Cell Analysis, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd53e57f536ce5e648278370de37b1d
https://doi.org/10.1038/s41586-021-04358-6

المؤلفون: Chelsy R Eddings, Ernest Fraenkel, Mali Jiang, C. Conover Talbot, Paul T. Ranum, Lauren R. DeVine, Robert N. Cole, Emma Whelan, Anthony Tang, Amanda J. Kedaigle, Leonard O Marque, Beverly L. Davidson, Ronald Wang, Nicolas Arbez, Tamara Ratovitski, Christopher A. Ross, Sergey S Akimov

المساهمون: Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biological Engineering

المصدر: Prof. Fraenkel
Hum Mol Genet

مصطلحات موضوعية: Neurons, Telomerase, Induced Pluripotent Stem Cells, Cell, Cell Differentiation, General Medicine, Biology, medicine.disease, Medium spiny neuron, Phenotype, Cell Line, Cell biology, Huntington Disease, medicine.anatomical_structure, Huntington's disease, Cell culture, Genetics, medicine, Humans, Telomerase reverse transcriptase, General Article, Induced pluripotent stem cell, Molecular Biology, Genetics (clinical)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1865400d87031d19ad0d1a4727da4586
https://doi.org/10.1093/hmg/ddab200

المؤلفون: Tyler Burks, Jiarui Ding, Shaina Carroll, Lan T. Nguyen, Shuqiang Li, Travis K. Hughes, Boaz Barak, Joshua Z. Levin, Alex K. Shalek, William Ge, Xian Adiconis, Nir Hacohen, John Y. Kwon, Sean Simmons, Aviv Regev, Nemanja D. Marjanovic, Cynthia C. Hession, Alexandra-Chloé Villani, Monika S. Kowalczyk, Orit Rozenblatt-Rosen, Marc H. Wadsworth, Amanda J. Kedaigle

المصدر: Nature Biotechnology. 38:737-746

مصطلحات موضوعية: Computer science, Extramural, business.industry, Biomedical Engineering, Cell mapping, Bioengineering, Computational biology, Brain tissue, Applied Microbiology and Biotechnology, Pipeline (software), Software, Molecular Medicine, business, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6f433fb14838c93f171dd3dfb3379b39
https://doi.org/10.1038/s41587-020-0465-8

المؤلفون: Ana Uzquiano, Amanda J. Kedaigle, Martina Pigoni, Bruna Paulsen, Xian Adiconis, Kwanho Kim, Tyler Faits, Surya Nagaraja, Noelia Antón-Bolaños, Chiara Gerhardinger, Ashley Tucewicz, Evan Murray, Xin Jin, Jason Buenrostro, Fei Chen, Silvia Velasco, Aviv Regev, Joshua Z. Levin, Paola Arlotta

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b05221f5be4c8356051a37014a0f136d
https://doi.org/10.1101/2022.03.17.484798

المؤلفون: Marina Rocha, Amanda J. Kedaigle, Paola Arlotta, Xian Adiconis, Giorgia Quadrato, Aviv Regev, Sean Simmons, Bruna Paulsen, Joshua Z. Levin, Lan Nguyen, Allison Nash, Silvia Velasco

المصدر: Nature

مصطلحات موضوعية: Male, 0301 basic medicine, Cell type, Time Factors, Induced Pluripotent Stem Cells, Context (language use), Biology, Article, Cell Line, Tissue Culture Techniques, 03 medical and health sciences, Fetus, Prosencephalon, 0302 clinical medicine, Single-cell analysis, medicine, Organoid, Humans, RNA-Seq, Cerebral Cortex, Multidisciplinary, Reproducibility of Results, Human brain, Organoids, 030104 developmental biology, medicine.anatomical_structure, Cerebral cortex, Forebrain, Female, Single-Cell Analysis, Stem cell, Transcriptome, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01794fa5421f3bccb44bd4284d659266
https://doi.org/10.1038/s41586-019-1289-x

المؤلفون: Ana Uzquiano, Amanda J. Kedaigle, Martina Pigoni, Bruna Paulsen, Xian Adiconis, Kwanho Kim, Tyler Faits, Surya Nagaraja, Noelia Antón-Bolaños, Chiara Gerhardinger, Ashley Tucewicz, Evan Murray, Xin Jin, Jason Buenrostro, Fei Chen, Silvia Velasco, Aviv Regev, Joshua Z. Levin, Paola Arlotta

المصدر: Cell. 185:3770-3788.e27

مصطلحات موضوعية: Cerebral Cortex, Neurons, Organoids, Neurogenesis, Humans, Cell Differentiation, General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab72a5eb25f151edae483321cce01486
https://doi.org/10.1016/j.cell.2022.09.010

المؤلفون: Roberto R. Ricardo-Gonzalez, Leif S. Ludwig, Georg Gasteiger, Holly R. Steach, Lina Kroehling, Maria Carolina Amezcua Vesely, Monika S. Kowalczyk, Autumn G. York, Mathias H. Skadow, Richard M. Locksley, Ruaidhri Jackson, Piotr Bielecki, Caroline B. M. Porter, Heather M. McGee, Aviv Regev, Hao Xu, Michal Slyper, Samantha J. Riesenfeld, Danielle Dionne, Will Bailis, Amanda J. Kedaigle, Elena Christian, Abigail Jarret, Richard A. Flavell, Elena Torlai Triglia, Paula Licona-Limón, Liming Tao, Mi Lian, Nicola Gagliani, Christoph Muus, Parastou Yaghoubi, Jan-Christian Hütter

المصدر: Nature, vol 592, iss 7852
Nature

مصطلحات موضوعية: 0301 basic medicine, Male, Time Factors, Cellular differentiation, Interleukin-23, Mice, 0302 clinical medicine, Small Cytoplasmic, RNA, Small Cytoplasmic, 2.1 Biological and endogenous factors, Innate, Lymphocytes, Aetiology, skin and connective tissue diseases, Skin, Multidisciplinary, Effector, Innate lymphoid cell, Cell Differentiation, Chromatin, Cell biology, Latent Class Analysis, Female, medicine.symptom, General Science & Technology, 1.1 Normal biological development and functioning, Inflammation, Biology, Autoimmune Disease, Article, 03 medical and health sciences, Immune system, Underpinning research, Psoriasis, Genetics, medicine, Animals, Cell Lineage, Transcription factor, Innate immune system, Animal, Inflammatory and immune system, Immunity, Reproducibility of Results, medicine.disease, Immunity, Innate, body regions, Disease Models, Animal, Emerging Infectious Diseases, 030104 developmental biology, Disease Models, RNA, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84e4925bc69bf051396bee0fdabe30e
https://escholarship.org/uc/item/4cc9s2xz

المؤلفون: Ashley Tucewicz, Anthony Deo, Sean Simmons, Kwanho Kim, Kasper Lage, Giorgia Quadrato, Paola Arlotta, Xian Adiconis, Samantha Smith, Martina Pigoni, Bruna Paulsen, Kwanghun Chung, Aviv Regev, Kalliopi Tsafou, Joshua Z. Levin, Catherine Abbate, Alex Albanese, Silvia Velasco, Rafaela C. Sartore, Amanda J. Kedaigle, Ana Uzquiano

مصطلحات موضوعية: biology, Human brain, medicine.disease, Phenotype, medicine.anatomical_structure, Autism spectrum disorder, Cerebral cortex, medicine, biology.protein, Autism, PTEN, Haploinsufficiency, Gene, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8e491090536d8832a3365b8e531ba8b4
https://doi.org/10.1101/2020.11.10.376509

المؤلفون: Aviv Regev, Orit Rozenblatt-Rosen, Cynthia C. Hession, Travis K. Hughes, Jiarui Ding, Nir Hacohen, Amanda J. Kedaigle, Marc H. Wadsworth, Alex K. Shalek, Sean Simmons, William Ge, Joshua Z. Levin, Lan T. Nguyen, Nemanja D. Marjanovic, Boaz Barak, Tyler Burks, Shaina Carroll, Monika S. Kowalczyk, Shuqiang Li, John Y. Kwon, Alexandra-Chloé Villani, Xian Adiconis

المصدر: Nat Biotechnol

مصطلحات موضوعية: Published Erratum, Cell, Biomedical Engineering, RNA, Bioengineering, Computational biology, Biology, Applied Microbiology and Biotechnology, Article, medicine.anatomical_structure, medicine, Molecular Medicine, Nucleus, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513c3ecab186aee029bed31db4de61f3
https://pubmed.ncbi.nlm.nih.gov/32341560

المؤلفون: Olesya Chayka, Paloma Tejera Nevado, Valentina Nieddu, Gabriele Corda, Göran Stenman, Lilam Rai, Mattias K Andersson, Giovanna Mangiapane, Therese Carlsson, Alexia Tsakaneli, Michael J Wick, Carla Abrahamian, Amanda J. Kedaigle, Arturo Sala

المصدر: Oncogenesis
Oncogenesis, Vol 9, Iss 1, Pp 1-10 (2020)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, animal structures, Oncogene, Cell growth, Kinase, DNA repair, Biology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Article, stomatognathic diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Checkpoint signalling, Downregulation and upregulation, 030220 oncology & carcinogenesis, Cancer research, Transcriptional regulation, MYB, Head and neck cancer, Enhancer, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c55e230b49da29550201c9b956d190
https://doi.org/10.1038/s41389-020-0194-3

المؤلفون: Malcolm Casale, Ernest Fraenkel, Jennifer Stocksdale, Miriam Adam, Amanda J. Kedaigle, Ryan G. Lim, Jie Wu, Brook T. Wassie, Leslie M. Thompson, Jack C. Reidling

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering

المصدر: Prof. Fraenkel via Howard Silver
Hum Mol Genet
Human molecular genetics, vol 29, iss 2

مصطلحات موضوعية: Huntington's Disease, Male, Huntingtin, Striatum, Behavioral Symptoms, Neurodegenerative, Pharmacology, Medical and Health Sciences, Transgenic, Epigenesis, Genetic, Pathogenesis, Histones, Mice, 0302 clinical medicine, 2.1 Biological and endogenous factors, RNA-Seq, Aetiology, Genetics (clinical), Epigenomics, Genetics & Heredity, Cerebral Cortex, 0303 health sciences, Huntingtin Protein, Acetylation, General Medicine, Azepines, Biological Sciences, Huntington Disease, Neurological, Chromatin Immunoprecipitation Sequencing, General Article, Signal Transduction, Mice, Transgenic, Biology, Motor Activity, 03 medical and health sciences, Rare Diseases, Genetic, Huntington's disease, Genetics, medicine, Animals, Epigenetics, Molecular Biology, 030304 developmental biology, Animal, Human Genome, Neurosciences, Triazoles, medicine.disease, Corpus Striatum, Brain Disorders, Bromodomain, Disease Models, Animal, Gene Ontology, Gene Expression Regulation, Protein Biosynthesis, Disease Models, Behavior Rating Scale, H3K4me3, Energy Metabolism, 030217 neurology & neurosurgery, Epigenesis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fd7b8a05980c4f83508ddc48b7f814
https://hdl.handle.net/1721.1/125919

المؤلفون: John Y. Kwon, Sean Simmons, Tyler Burks, Joshua Z. Levin, Shaina Carroll, Aviv Regev, Jiarui Ding, Monika S. Kowalczyk, Lan T. Nguyen, Alexandra-Chloé Villani, Orit Rozenblatt-Rosen, Boaz Barak, Cynthia C. Hession, Shuqiang Li, Amanda J. Kedaigle, Travis K. Hughes, Xian Adiconis, Marc H. Wadsworth, Alex K. Shalek, William Ge, Nir Hacohen, Nemanja D. Marjanovic

مصطلحات موضوعية: medicine.anatomical_structure, Computer science, Cell, medicine, RNA, Computational biology, Brain tissue

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34a09c1cf4ed435014e1154d27078bd

المؤلفون: Jiarui, Ding, Xian, Adiconis, Sean K, Simmons, Monika S, Kowalczyk, Cynthia C, Hession, Nemanja D, Marjanovic, Travis K, Hughes, Marc H, Wadsworth, Tyler, Burks, Lan T, Nguyen, John Y H, Kwon, Boaz, Barak, William, Ge, Amanda J, Kedaigle, Shaina, Carroll, Shuqiang, Li, Nir, Hacohen, Orit, Rozenblatt-Rosen, Alex K, Shalek, Alexandra-Chloé, Villani, Aviv, Regev, Joshua Z, Levin

المصدر: Nature biotechnology. 38(6)

مصطلحات موضوعية: Mice, Sequence Analysis, RNA, Leukocytes, Mononuclear, Animals, Brain, Humans, Single-Cell Analysis, Cells, Cultured, Software

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::2b9be9d951142f253e0256a7a87a726b
https://pubmed.ncbi.nlm.nih.gov/32341567

المؤلفون: Ernest Fraenkel, Amanda J. Kedaigle

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering, Fraenkel, Ernest, Kedaigle, Amanda Joy

المصدر: Prof. Fraenkel via Howard Silver

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Proteomics methods, Computer science, MEDLINE, Computational biology, Article, Omics data, 03 medical and health sciences, Drug Discovery, Animals, Humans, Metabolomics, Disease, Precision Medicine, Pharmacology, business.industry, Drug Repositioning, Genomics, Subtyping, Multiple data, Drug repositioning, 030104 developmental biology, Personalized medicine, business, Omics technologies

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97abe699de91a3f7f39f91eb67065811
https://europepmc.org/articles/PMC6204089/

المؤلفون: Julia A. Kaye, Malcolm Casale, Ping H Wang, Steven Finkbeiner, Yumay Chen, Ryan G. Lim, Ernest Fraenkel, Min Wu, Alvin R. King, Leslie M. Thompson, Jennifer Stocksdale, Marcy E. MacDonald, Virginia B. Mattis, Nicolas Arbez, Tamara Ratovitski, Clive N. Svendsen, Christopher A. Ross, Amanda J. Kedaigle, James F. Gusella, Colton M Tom, Ranjit Singh Atwal, Sergey S Akimov

المصدر: Human Molecular Genetics

مصطلحات موضوعية: 0301 basic medicine, AcademicSubjects/SCI01140, Bioenergetics, Induced Pluripotent Stem Cells, Oxidative phosphorylation, Biology, Mitochondrion, Proteomics, Oxidative Phosphorylation, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Adenosine Triphosphate, Huntington's disease, Genetics, medicine, Humans, Glycolysis, Molecular Biology, Genetics (clinical), chemistry.chemical_classification, Neurons, Cell Differentiation, General Medicine, Metabolism, medicine.disease, Corpus Striatum, Cell biology, Mitochondria, 030104 developmental biology, Enzyme, Huntington Disease, chemistry, Metabolome, General Article, Energy Metabolism, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ba2a92baf49dc7f08b70392e7573cf
https://pubmed.ncbi.nlm.nih.gov/30768179

المؤلفون: Amanda J. Kedaigle, Ernest Fraenkel

المصدر: Methods in Molecular Biology ISBN: 9781493974924

مصطلحات موضوعية: Epigenomics, Proteomics, 0301 basic medicine, Biological data, Computer science, Genomics, Computational biology, computer.software_genre, Omics, Article, Gene Expression Regulation, Neoplastic, Transcriptome, 03 medical and health sciences, 030104 developmental biology, Neoplasms, Humans, Gene Regulatory Networks, computer, Software, Biological network, Data integration

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddbf2fa7fd52ef093291c70d9c38689
https://doi.org/10.1007/978-1-4939-7493-1_2

المؤلفون: Amanda J. Kedaigle

المصدر: BCB

مصطلحات موضوعية: business.industry, Throughput, Biology, computer.software_genre, Omics, Data type, Variety (cybernetics), Software, Integrator, Data mining, State (computer science), business, computer, Biological network

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cc1be44b94010229c2ce4c5df7f72670
https://doi.org/10.1145/3107411.3107461

المؤلفون: Jeff W. Lichtman, Marzieh Zonouzi, Amanda J. Kedaigle, Daniel R. Berger, Paola Arlotta, Vahbiz Jokhi

المصدر: Cell Reports, Vol 27, Iss 10, Pp 2799-2808.e3 (2019)
Cell Rep

مصطلحات موضوعية: Male, 0301 basic medicine, Interneuron, Mice, Transgenic, Neocortex, Biology, Inhibitory postsynaptic potential, Article, General Biochemistry, Genetics and Molecular Biology, Neuron types, Mice, 03 medical and health sciences, Myelin, 0302 clinical medicine, Interneurons, medicine, Animals, lcsh:QH301-705.5, Myelin Sheath, Pyramidal Cells, fungi, Neural Inhibition, Axons, Oligodendrocyte, Mice, Inbred C57BL, Oligodendroglia, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), nervous system, Excitatory postsynaptic potential, Female, Neuroscience, Software, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86ea4252e0bfc9d2710b61e6bc0cdfe
https://doi.org/10.1016/j.celrep.2019.05.018

المؤلفون: Murodzhon Akhmedov, Francesco Bertoni, Renan Escalante Chong, Amanda J. Kedaigle, Roberto Montemanni, Ivo Kwee, Ernest Fraenkel

المساهمون: Massachusetts Institute of Technology. Department of Biological Engineering, Akhmedov, Murodzhon, Kedaigle, Amanda Joy, Escalante, Renan A., Fraenkel, Ernest

المصدر: PLoS Computational Biology
PLoS Computational Biology, Vol 13, Iss 7, p e1005694 (2017)
PLoS

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Databases, Factual, Computer science, Forests, computer.software_genre, Biochemistry, Lung and Intrathoracic Tumors, Database and Informatics Methods, 0302 clinical medicine, Software, Medicine and Health Sciences, Subnetwork, lcsh:QH301-705.5, Ecology, Proteomic Databases, Applied Mathematics, Simulation and Modeling, Terrestrial Environments, 3. Good health, Computational Theory and Mathematics, Oncology, Modeling and Simulation, Physical Sciences, Protein Interaction Networks, Data mining, Network Analysis, Algorithms, Network analysis, Research Article, Computer and Information Sciences, Bioinformatics, Throughput, Research and Analysis Methods, Ecosystems, 03 medical and health sciences, Cellular and Molecular Neuroscience, Genetics, Protein Interactions, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Interpretation (logic), business.industry, Mechanism (biology), Ecology and Environmental Sciences, Computational Biology, Biology and Life Sciences, Proteins, Cancers and Neoplasms, High-Throughput Screening Assays, R package, 030104 developmental biology, Biological Databases, lcsh:Biology (General), Protein-Protein Interactions, business, computer, 030217 neurology & neurosurgery, Biological network, Mathematics

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ac21fa1387d377a5596e4c6e48eb96
https://hdl.handle.net/11380/1176640