المؤلفون: Marwa E. Abdelaziz, Mostafa M. M. El-Miligy, Salwa M. Fahmy, Marwa M. Abu-Serie, Aly A. Hazzaa, Mona A. Mahran

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

مصطلحات موضوعية: Pyridine, anticancer, apoptosis induction, caspase 3/7 activation, PIM-1 kinase inhibitors, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/e162c88d829d4fc1b977203714ab0d09

المؤلفون: Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Rasha A. Nassra, Saad R. El-Zemity, Aly A. Hazzaa

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

مصطلحات موضوعية: thiazole, anti-inflammatory, dual COX-2/5-LOX inhibitors, induced fit docking, molecular dynamic simulation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/fec79da2057e482d91a08ba9a8c001f5

المؤلفون: Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Mohamed G. Bekhit, Saad R. El-Zemity, Rasha A. Nassra, Aly A. Hazzaa

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 294-308 (2023)

مصطلحات موضوعية: Thymol, pyrazole, anti-inflammatory, COX-2, 5-LOX, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/485b30dba1ca464192537cae444e109e

المؤلفون: Mostafa M. M. El-Miligy, Marwa E. Abdelaziz, Salwa M. Fahmy, Tamer M. Ibrahim, Marwa M. Abu-Serie, Mona A. Mahran, Aly A. Hazzaa

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

مصطلحات موضوعية: Pyridine, quinoline, apoptosis induction, caspase 3/7 activation, PIM-1 kinase inhibitors, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/9e34b94d9a5b4637adf59e548997a9d7

المؤلفون: Mostafa M. M. El-Miligy (12881511), Marwa E. Abdelaziz (14379129), Salwa M. Fahmy (14379132), Tamer M. Ibrahim (1943959), Marwa M. Abu-Serie (11835422), Mona A. Mahran (14379135), Aly A. Hazzaa (14146633)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Pyridine, quinoline, apoptosis induction, caspase 3/7 activation, PIM-1 kinase inhibitors

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_new_pyridine-quinoline_hybrids_as_competitive_and_non-competitive_PIM-1_kinase_inhibitors_with_apoptosis_induction_and_caspase_3_7_activation_capabilities/21864690

الاتاحة: https://doi.org/10.6084/m9.figshare.21864690.v1

المؤلفون: Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Mohamed G. Bekhit, Saad R. El-Zemity, Rasha A. Nassra, Aly A. Hazzaa

مصطلحات موضوعية: Pharmacology, Cyclooxygenase 2 Inhibitors, Anti-Inflammatory Agents, General Medicine, Thymol, Rats, Molecular Docking Simulation, Cyclooxygenase 2, Celecoxib, Drug Discovery, Animals, Pyrazoles, Quercetin, Lipoxygenase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8501bd817ebdaaf26eadbff92cae524

المؤلفون: Marwa M. Abu-Serie, Ahmed K. Al-Kubeisi, Mostafa M.M. El-Miligy, Saad R. El-Zemity, Aly A. Hazzaa, Rasha A. Nassra

المصدر: Bioorganic chemistry. 115

مصطلحات موضوعية: Anti-Inflammatory Agents, Caspase 3, Antineoplastic Agents, Apoptosis, Pharmacology, Biochemistry, Small Molecule Libraries, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, In vivo, Catalytic Domain, Cell Line, Tumor, Drug Discovery, medicine, Staurosporine, Animals, Edema, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Arachidonate 5-Lipoxygenase, Binding Sites, Chemistry, Kinase, Cell growth, Organic Chemistry, In vitro, Rats, Molecular Docking Simulation, Enzyme, Cell culture, Cyclooxygenase 2, Drug Design, Thiazolidines, Colorectal Neoplasms, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7089d3caa86517d6127c3e15cd8c52
https://pubmed.ncbi.nlm.nih.gov/34303896

المؤلفون: Ahmed K. Al-Kubeisi, Saad R. El-Zemity, Aly A. Hazzaa, Mostafa Mohamed Mahmod El-Miligy

المصدر: Current Bioactive Compounds. 15:125-137

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Traditional medicine, chemistry, General Pharmacology, Toxicology and Pharmaceutics, Antimicrobial, 01 natural sciences, Thymol, 010606 plant biology & botany

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::15bdaed4055149c17df1a9f761c1c449
https://doi.org/10.2174/1573407213666171115161626

المؤلفون: Aly A. Hazzaa, Salwa M. Fahmy, Mona A. Mahran, Marwa Abdelaziz, Mostafa M.M. El-Miligy

المصدر: Bioorganic Chemistry. 80:674-692

مصطلحات موضوعية: Thienopyridines, Stereochemistry, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Neoplasms, Drug Discovery, Pyridine, Humans, Protein Kinase Inhibitors, Molecular Biology, biology, 010405 organic chemistry, Kinase, Pim-1 Kinase, Organic Chemistry, Active site, In vitro, 0104 chemical sciences, Molecular Docking Simulation, chemistry, Design synthesis, Cell culture, Docking (molecular), Drug Design, biology.protein, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec1c037c884e084112af501f5660728
https://doi.org/10.1016/j.bioorg.2018.07.024

المؤلفون: Soad Am El Hawash, Ashraf M Omar, Maha A El Demellawy, Abeer E. Abdel Wahab, Maryam A.Z. El-Attar, Heba A. Abd El Razik, Aly A. Hazzaa

المصدر: Future medicinal chemistry. 11(13)

مصطلحات موضوعية: Antioxidant, medicine.medical_treatment, Radical, Antineoplastic Agents, Pharmacology, 01 natural sciences, Antioxidants, 03 medical and health sciences, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Humans, Cyclooxygenase Inhibitors, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Inhibitory potential, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Triazoles, 0104 chemical sciences, Cancer treatment, Molecular Docking Simulation, Pyrimidines, Cyclooxygenase 2, biology.protein, Cyclooxygenase 1, Molecular Medicine, Cyclooxygenase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d527733bb770fd18d68db0efbe34f660
https://pubmed.ncbi.nlm.nih.gov/31469327

المؤلفون: Aly A. Hazzaa, Ibrahim A. Abdelwahab, El-Sayeda M. El-Khawass, Mohamed G. Bekhit, Ola H. Rizk

المصدر: Archiv der Pharmazie. 352(10)

مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, Pharmaceutical Science, Microbial Sensitivity Tests, medicine.disease_cause, 01 natural sciences, DNA gyrase, chemistry.chemical_compound, Inhibitory Concentration 50, Drug Discovery, medicine, Humans, Topoisomerase II Inhibitors, IC50, Novobiocin, Binding Sites, biology, Molecular Structure, 010405 organic chemistry, Quinoline, biology.organism_classification, In vitro, 0104 chemical sciences, Anti-Bacterial Agents, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Biochemistry, chemistry, Staphylococcus aureus, Drug Design, Pseudomonas aeruginosa, Quinolines, Antibacterial activity, Bacteria, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aacc5be1eed2b8db57adf9a8a31cdc3
https://pubmed.ncbi.nlm.nih.gov/31389630

المؤلفون: Ahmed S.F. Belal, Rasha A. Nassra, Yasser S. Abdel-Ghany, Rana Alaaeddine, Lynn M. Alaeddine, Ahmed F. El-Yazbi, Ghandoura Moussa, Aly A. Hazzaa, Azza Ismail

المصدر: European journal of medicinal chemistry. 144

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Diclofenac, Drug Discovery, medicine, Tumor Cells, Cultured, Animals, Arachidonate 15-Lipoxygenase, Humans, Cyclooxygenase Inhibitors, Lipoxygenase Inhibitors, Sulfhydryl Compounds, Rats, Wistar, IC50, Quinazolinones, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Macrophages, Organic Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Cell Differentiation, General Medicine, Zileuton, Diclofenac Sodium, 0104 chemical sciences, Rats, Molecular Docking Simulation, 030104 developmental biology, Docking (molecular), Cyclooxygenase 2, Drug Design, Meclofenamate Sodium, Click chemistry, biology.protein, Cyclooxygenase 1, Click Chemistry, Female, Cyclooxygenase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a9eda19bc540bb0042d8816e7a3ef7
https://pubmed.ncbi.nlm.nih.gov/29289887

المؤلفون: Soad A.M. El-Hawash, Rasha A. Nassra, Mostafa M.M. El-Miligy, Hanan El-Messmary, Aly A. Hazzaa

المصدر: Future medicinal chemistry. 9(5)

مصطلحات موضوعية: 0301 basic medicine, Thiophenes, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Formaldehyde, Drug Discovery, medicine, Animals, Edema, Humans, Cyclooxygenase Inhibitors, Lipoxygenase Inhibitors, Stomach Ulcer, Benzofuran, Arachidonate 5-Lipoxygenase, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Benzothiophene, Rats, Molecular Docking Simulation, 030104 developmental biology, Docking (molecular), Cyclooxygenase 2, Celecoxib, Meclofenamate Sodium, Cyclooxygenase 1, Molecular Medicine, Bioisostere, Pharmacophore, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b8ca2fe6c141ee1090abf78cd4601c
https://pubmed.ncbi.nlm.nih.gov/28362117

المؤلفون: Mostafa M.M. El-Miligy, Soad A.M. El-Hawash, Aly A. Hazzaa, Hanan El-Messmary, Rasha A. Nassra

المصدر: Bioorganic chemistry. 72

مصطلحات موضوعية: 0301 basic medicine, Male, Rhodanine, Stereochemistry, Thiophenes, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Catalytic Domain, Formaldehyde, Drug Discovery, Animals, Edema, Cyclooxygenase Inhibitors, Lipoxygenase Inhibitors, Benzofuran, Rats, Wistar, Molecular Biology, Benzofurans, Arachidonate 5-Lipoxygenase, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Benzothiophene, 0104 chemical sciences, Rats, Molecular Docking Simulation, 030104 developmental biology, chemistry, Docking (molecular), Cyclooxygenase 2, Meclofenamate Sodium, Cyclooxygenase 1, Bioisostere, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fde0a8d8a86e20a52d7f7e7c0c123ea
https://pubmed.ncbi.nlm.nih.gov/28390993

المؤلفون: Ibrahim M. Labouta, Magdy M. Abdel Khalek, Amal M. Youssef, Aly A. Hazzaa, Georgina N. Masoud, Abeer E. Abdel Wahab

المصدر: Medicinal Chemistry Research. 22:707-725

مصطلحات موضوعية: Drug, Benzimidazole, Chemistry, media_common.quotation_subject, Hepatitis C virus, Organic Chemistry, Pharmacology, Ring (chemistry), medicine.disease, medicine.disease_cause, chemistry.chemical_compound, Design synthesis, Hepatocellular carcinoma, medicine, Cytotoxic T cell, Doxorubicin, General Pharmacology, Toxicology and Pharmaceutics, media_common, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e5069277f79f8cb658ebcfb074360c32
https://doi.org/10.1007/s00044-012-0057-3

المؤلفون: Aly A. Hazzaa, Yasser S. Abdel-Ghany, Zahra A. Kassem, Mohamad M. Abdul Ghani

المصدر: Letters in Organic Chemistry. 5:316-318

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Organic Chemistry, Pyridine, One-Step, Biochemistry, Medicinal chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::15d17a2e0610df427031d4883ed8bf7f
https://doi.org/10.2174/157017808784049416

المؤلفون: Yasser S. Abdel-Ghany, Zahra A. Kassem, Mohamad M. Abdul Ghani, Aly A. Hazzaa

المصدر: ChemInform. 39

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Pyridine, Organic chemistry, One-Step, General Medicine, Medicinal chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2ac5f80892e454305edb778b6575cc58
https://doi.org/10.1002/chin.200840150

المؤلفون: Mostafa M. M. El-Meligy, Hesham Fahmy, S. M. Rida, Soad A.M. El-Hawash, Aly A. Hazzaa

المصدر: Archives of pharmacal research. 29(10)

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Benzimidazole, Staphylococcus aureus, Stereochemistry, Cell Survival, Substituent, Molecular Conformation, Microbial Sensitivity Tests, medicine.disease_cause, Cell Line, chemistry.chemical_compound, Heterocyclic Compounds, Cell Line, Tumor, Drug Discovery, Candida albicans, medicine, Humans, Benzofuran, Benzofurans, Cell Proliferation, biology, Organic Chemistry, Biological activity, biology.organism_classification, Antimicrobial, Combinatorial chemistry, In vitro, chemistry, Drug Design, HIV-1, Molecular Medicine, Benzimidazoles, Female, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a231ae0a1c36e79ed37d78fc9a4330d
https://pubmed.ncbi.nlm.nih.gov/17121175

المؤلفون: A. M. Ismail, Aly A. Hazzaa, M. A. El-Dawy, A.-M. M. E. Omar

المصدر: Chemischer Informationsdienst. 14

مصطلحات موضوعية: Broad spectrum, Design synthesis, Chemistry, Antiparasitic, medicine.drug_class, medicine, General Medicine, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e3327d4f18636110d50dc1357ed73fae
https://doi.org/10.1002/chin.198327253

المؤلفون: O. M. Aboulwafa, E. M. El-Khawass, Ibrahim Chaaban, Aly A. Hazzaa

المصدر: ChemInform. 20

مصطلحات موضوعية: Thiadiazoles, Chemistry, General Medicine, Antimicrobial, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6406e9e6462119d5af98f5ddab3a8fac
https://doi.org/10.1002/chin.198943160