المؤلفون: Elshikha, Ahmed S.^1,2 (AUTHOR) morel@uthscsa.edu, Abboud, Georges² (AUTHOR), Avdiaj, Rigena¹ (AUTHOR), Morel, Laurence² (AUTHOR), Song, Sihong¹ (AUTHOR) shsong@ufl.edu

المصدر: Biomolecules (2218-273X). Jan2025, Vol. 15 Issue 1, p43. 14p.

مصطلحات موضوعية: *ALPHA 1-antitrypsin, *T helper cells, *IMMUNOMODULATORS, *SYSTEMIC lupus erythematosus, *CLINICAL medicine, *B cells

المؤلفون: Suri, Anandini¹ (AUTHOR), Zhang, Zidong² (AUTHOR), Neuschwander‐Tetri, Brent³ (AUTHOR), Lomas, David A.⁴ (AUTHOR), Heyer‐Chauhan, Nina⁵ (AUTHOR), Burling, Keith⁶ (AUTHOR), Loomba, Rohit⁷ (AUTHOR), Brenner, David A.⁷ (AUTHOR), Nagy, Rosemary⁸ (AUTHOR), Wilson, Andrew⁹ (AUTHOR), Carpenter, Danielle¹⁰ (AUTHOR), Blomenkamp, Keith¹¹ (AUTHOR), Teckman, Jeffrey¹ (AUTHOR) jeff.teckman@health.slu.edu

المصدر: Liver International. Dec2024, Vol. 44 Issue 12, p3204-3213. 10p.

مصطلحات موضوعية: *ALPHA 1-antitrypsin, *LIVER biopsy, *LIVER proteins, *ASPARTATE aminotransferase, *BODY mass index

المؤلفون: Thomae, Benjamin Louis¹ (AUTHOR), Kaihou, Taisuke¹ (AUTHOR), Pinelli, David F.² (AUTHOR), Friedewald, John J.^2,3 (AUTHOR), Caicedo‐Ramirez, Juan C.³ (AUTHOR), Bharat, Ankit^1,4 (AUTHOR), Nadig, Satish² (AUTHOR), Kurihara, Chitaru¹ (AUTHOR) chitaru.kurihara@northwestern.edu

المصدر: Clinical Transplantation. Dec2024, Vol. 38 Issue 12, p1-4. 4p.

مصطلحات موضوعية: *ALPHA 1-antitrypsin, *FORCED expiratory volume, *HEART transplant recipients, *HLA histocompatibility antigens, *LUNG transplantation

المصدر: A Randomized, Double-Blind, Placebo Controlled Study to Assess the Efficacy and Safety of Two Dose Regimens (60 mg/kg and 120 mg/kg) of Weekly Intravenous Alpha1 Proteinase Inhibitor (Human) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency
Sorrells S, Camprubi S, Griffin R, Chen J, Ayguasanosa J. SPARTA clinical trial design: exploring the efficacy and safety of two dose regimens of alpha1-proteinase inhibitor augmentation therapy in alpha1-antitrypsin deficiency. Respir Med. 2015 Apr;109(4):490-9. doi: 10.1016/j.rmed.2015.01.022. Epub 2015 Feb 13.

المؤلفون: Syneos Health

المصدر: Prospective Phase 3 Multi-center 2-Year Placebo Controlled Double Blind Study to Evaluate the Efficacy and Safety of Kamada-AAT for Inhalation 80 Mg/Day in Alpha-1 Antitrypsin Deficiency with Moderate and Severe Airflow Limitation Followed by a 2-Year Open Label Extension

المصدر: Phase 2, Double-Blind, Randomized, Active-Control, Parallel Group Study to Assess the Pharmacokinetics, Pharmacodynamics, Immunogenicity, and Safety of SAR447537 (INBRX-101) Compared to Plasma-Derived Alpha1-Proteinase Inhibitor (A1PI) Augmentation Therapy in Adults With Alpha-1 Antitrypsin Deficiency (AATD) Emphysema

المصدر: A Phase 2/3, Multicenter, randOmized, Double-blind, Placebo-controlled, stUdy to evaLuate the Safety and Efficacy of Alpha-1 AntiTrypsin for the prEvention of Graft Versus-host Disease in Patients Receiving Hematopoietic Cell Transplant (MODULAATE Study)

المؤلفون: de-Miguel-Diez, Javier¹ (AUTHOR) javier.miguel@salud.madrid.org, Lopez-de-Andres, Ana² (AUTHOR) anailo04@ucm.es, Zamorano-Leon, José J.³ (AUTHOR) josejzam@ucm.es, Hernández-Barrera, Valentín⁴ (AUTHOR) valentin.hernandez@urjc.es, Cuadrado-Corrales, Natividad³ (AUTHOR) mariancu@ucm.es, Jimenez-Sierra, Ana⁵ (AUTHOR) a.jimenez100@usp.ceu.es, Carabantes-Alarcon, David³ (AUTHOR) dcaraban@ucm.es, Jimenez-Garcia, Rodrigo³ (AUTHOR) rodrijim@ucm.es

المصدر: Journal of Clinical Medicine. Nov2024, Vol. 13 Issue 21, p6564. 14p.

مصطلحات موضوعية: *ALPHA 1-antitrypsin deficiency, *HOSPITAL admission & discharge, *HOSPITAL mortality, *DATABASES, *NONINVASIVE ventilation

المؤلفون: de Avila, Ana Carolina¹ (AUTHOR), Matos Fernandes, Lucas¹ (AUTHOR) lucas.fernandes@hc.fm.usp.br, Pola dos Reis, Flávio¹ (AUTHOR), Lucas dos Santos, Samuel¹ (AUTHOR), Abdalla, Luis Gustavo¹ (AUTHOR), Campos, Silvia Vidal¹ (AUTHOR), de Camargo, Priscila Cilene León Bueno¹ (AUTHOR), Pêgo-Fernandes, Paulo Manuel¹ (AUTHOR)

المصدر: Transplantation Proceedings. Nov2024, Vol. 56 Issue 9, p2096-2099. 4p.

مصطلحات موضوعية: *BEHCET'S disease, *ALPHA 1-antitrypsin deficiency, *VENOUS thrombosis, *LUNG transplantation, *ORAL diseases

المؤلفون: Kamal, Tahir¹ skinlifeclinic8833@gmail.com, Mufti, Shaiqa¹

المصدر: Journal of Pakistan Association of Dermatologists. 2024 Supplement, Vol. 34, pS52-S56. 5p.

مصطلحات موضوعية: *ALPHA 1-antitrypsin, *PEMPHIGUS vulgaris, *PULMONARY function tests, *VITAL capacity (Respiration), *AUTOIMMUNE diseases

المؤلفون: Zhu, Ye^1,2 (AUTHOR), Yuan, Haitao¹ (AUTHOR), Qu, Huiting^3,4 (AUTHOR) quht@email.sdu.edu.cn

المصدر: Heart & Vessels. Sep2024, Vol. 39 Issue 9, p803-809. 7p.

مصطلحات موضوعية: *BRAIN natriuretic factor, *ALPHA 1-antitrypsin, *RECEIVER operating characteristic curves, *HDL cholesterol, *CARDIAC amyloidosis, *HEART failure

المؤلفون: Balderacchi, Alice M.¹ (AUTHOR), Bignotti, Mattia² (AUTHOR), Ottaviani, Stefania¹ (AUTHOR), Denardo, Andrea² (AUTHOR), Barzon, Valentina³ (AUTHOR), Ben Khlifa, Emna² (AUTHOR), Vailati, Guido⁴ (AUTHOR), Piloni, Davide¹ (AUTHOR), Benini, Federica⁴ (AUTHOR), Corda, Luciano⁴ (AUTHOR), Corsico, Angelo G.^1,3 (AUTHOR), Ferrarotti, Ilaria^1,3 (AUTHOR), Fra, Annamaria² (AUTHOR) annamaria.fra@unibs.it

المصدر: Clinical Chemistry & Laboratory Medicine. Sep2024, Vol. 62 Issue 10, p1980-1990. 11p.

مصطلحات موضوعية: *ALPHA 1-antitrypsin deficiency, *LEUCOCYTE elastase, *BLOOD plasma, *GENETIC disorders, *C-reactive protein, *ELASTASES

المصدر: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Fazirsiran in the Treatment of Alpha-1 Antitrypsin Deficiency-Associated Liver Disease With METAVIR Stage F1 Fibrosis

Other URLs: https://vivli.org/ourmember/takeda/

المصدر: Phase 1/2 Multicenter, Open-label Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-3001 in Participants with Alpha-1 Antitrypsin Deficiency (AATD)-Associated Lung Disease

المصدر: A Phase 1/2a, Single- and Multiple-dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KRRO 110 in Healthy Adult Volunteers and in Adult Participants with Alpha-1 Antitrypsin Deficiency (AATD) (REWRITE)

المصدر: A Phase 1/2 Dose-exploration and Dose-expansion Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)-Associated Lung Disease and/or Liver Disease

المصدر: A Placebo-Controlled, Multi-dose, Phase 2 Study to Determine the Safety, Tolerability and Pharmacodynamic Effect of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency (AATD) [SEQUOIA]
Remih K, Amzou S, Strnad P. Alpha1-antitrypsin deficiency: New therapies on the horizon. Curr Opin Pharmacol. 2021 Aug;59:149-156. doi: 10.1016/j.coph.2021.06.001. Epub 2021 Jul 10.

المؤلفون: Miravitlles, Marc¹ (AUTHOR) marcm@separ.es, Turner, Alice M.^2,3 (AUTHOR), Sucena, Maria⁴ (AUTHOR), Mornex, Jean-François⁵ (AUTHOR), Greulich, Timm⁶ (AUTHOR), Wencker, Marion⁷ (AUTHOR), McElvaney, N. Gerard⁸ (AUTHOR)

المصدر: Respiratory Research. 8/19/2024, Vol. 25 Issue 1, p1-13. 13p.

مصطلحات موضوعية: *ALPHA 1-antitrypsin, *DELPHI method, *COMPUTED tomography, *DISEASE management, *PHYSICIANS, *ALPHA 1-antitrypsin deficiency

المؤلفون: Takeda Development Center Americas, Inc.

المصدر: A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Fazirsiran in the Treatment of Alpha-1 Antitrypsin Deficiency-Associated Liver Disease With METAVIR Stage F2 to F4 Fibrosis

Other URLs: https://vivli.org/ourmember/takeda/

المصدر: A Randomized, Double-Blind, Placebo-Controlled, Single Oral Dose Study Evaluating the Safety and Pharmacokinetics of BMN 349 in Homozygous for the Z Mutation of Alpha 1 Antitrypsin Gene (PiZZ) and Heterozygous for the Z Mutation (PiMZ/MASH)