المؤلفون: Michon, Maya, Müller-Schiffmann, Andreas, Lingappa, Anuradha, Yu, Shao, Du, Li, Deiter, Fred, Broce, Sean, Mallesh, Suguna, Crabtree, Jackelyn, Lingappa, Usha, Macieik, Amanda, Müller, Lisa, Ostermann, Philipp, Andrée, Marcel, Adams, Ortwin, Schaal, Heiner, Hogan, Robert, Tripp, Ralph, Appaiah, Umesh, Anand, Sanjeev, Campi, Thomas, Ford, Michael, Reed, Jonathan, Lin, Jim, Akintunde, Olayemi, Copeland, Kiel, Nichols, Christine, Petrouski, Emma, Moreira, Ana, Jiang, I-Ting, DeYarman, Nicholas, Brown, Ian, Lau, Sharon, Segal, Ilana, Goldsmith, Danielle, Hong, Shi, Asundi, Vinod, Briggs, Erica, Phyo, Ngwe, Froehlich, Markus, Onisko, Bruce, Matlack, Kent, Dey, Debendranath, Lingappa, Jaisri, Prasad, Dharma, Kitaygorodskyy, Anatoliy, Solas, Dennis, Boushey, Homer, Greenland, John, Pillai, Satish, Lo, Michael, Montgomery, Joel, Spiropoulou, Christina, Korth, Carsten, Selvarajah, Suganya, Paulvannan, Kumar, Lingappa, Vishwanath

المصدر: Open Biology. 14(6)

مصطلحات موضوعية: allosteric modulator, drug discovery, host–viral interface, pan-respiratory antiviral therapeutics, phenotypic screen, viral capsid assembly, Antiviral Agents, Humans, Animals, 14-3-3 Proteins, Multiprotein Complexes, Host-Pathogen Interactions, Cell Line

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4kp6g8gs
https://escholarship.org/content/qt4kp6g8gs/qt4kp6g8gs.pdf

المؤلفون: Anuradha F. Lingappa, Olayemi Akintunde, Erin Samueli, Connie Ewald, Maya Michon, Niloufar Ziari, Ming Lu, Shao Feng Yu, Markus Froehlich, Phuong Uyen Le, Yuniel Fernandez, Suguna Mallesh, Jim Lin, Anatoliy Kitaygorodskyy, Dennis Solas, Jonathan C. Reed, Jaisri R. Lingappa, Andreas Müller-Schiffmann, Carsten Korth, Dharma Prasad, Aysegul Nalca, Emily Aston, Brad Fabbri, Sanjeev K. Anand, Thomas W. Campi, Emma Petrouski, Debendranath Dey, David W. Andrews, James L. Rubenstein, Vishwanath R. Lingappa

المصدر: Open Biology, Vol 14, Iss 12 (2024)

مصطلحات موضوعية: drug discovery, pan-cancer therapeutics, allosteric modulator, restoration of homeostasis, multi-protein complex, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2046-2441

URL الوصول: https://doaj.org/article/c6fa5e29cb2b428cb59f6f90aa2ecaeb

المؤلفون: Elisa Rojas-Prats, Loreto Martinez-Gonzalez, Carmen Gil, David Ramírez, Ana Martinez

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

مصطلحات موضوعية: CDC7, DBF4, allosteric modulator, virtual screening, binding pockets, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/a9474a61b420473c8be3cc0a61492459

المؤلفون: Mundy, Paige C, Werner, Alicia, Singh, Latika, Singh, Vikrant, Mendieta, Rosalia, Patullo, Caitlyn E, Wulff, Heike, Lein, Pamela J

المصدر: Archives of Toxicology. 97(5)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Brain Disorders, Neurosciences, Neurodegenerative, Epilepsy, Animals, Male, Receptors, GABA, Zebrafish, Larva, Triazines, Receptors, GABA-A, gamma-Aminobutyric Acid, GABA(A)R, Positive allosteric modulator, Royal Demolition Explosive, Seizures, GABAAR, Toxicology, Biochemistry and cell biology, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7bf7j9sc

المؤلفون: Weiyi Wang, Wanting Fu, Hongyan Zhu, Jing Ma, Jian Zhang, Jia Qi

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: insomnia, GABAA receptor, benzodiazepines binding site, dimdazenil, partial positive allosteric modulator, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1432726/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/93de1b36b3db4b6489ea8afa34cda86c

المؤلفون: I. R. Svechkareva, A. S. Kolbin

المصدر: Реальная клиническая практика: данные и доказательства, Vol 3, Iss 4, Pp 15-21 (2023)

مصطلحات موضوعية: allosteric modulation, small molecules, allosteric drugs, real-world clinical practice, positive allosteric modulator, negative allosteric modulator, pam, nam, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://www.myrwd.ru/jour/article/view/49; https://doaj.org/toc/2782-3784

URL الوصول: https://doaj.org/article/4a3dd77c29074c54b4bf0a4fdb0f49a7

المؤلفون: Pi-Chuan Fan, Lih-Chu Chiou, Tzu-Hsuan Lai, Dishary Sharmin, James Cook, Ming Tatt Lee

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: trigeminovascular system, GABA, α6GABAAR, positive allosteric modulator, trigeminal ganglia, pyrazoloquinolinone, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1451634/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/9ce24f26600c4d24bc37ede64fe6fd4a

المؤلفون: Hong-Wei Dong, Kelly Weiss, Kathryn Baugh, Mac J. Meadows, Colleen M. Niswender, Jeffrey L. Neul

المصدر: Neurotherapeutics, Vol 21, Iss 4, Pp e00384- (2024)

مصطلحات موضوعية: Rett syndrome, Neurophysiological biomarkers, Auditory event related potential, M1 acetylcholine receptor, Positive allosteric modulator, Mouse models, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1878747924000709; https://doaj.org/toc/1878-7479

URL الوصول: https://doaj.org/article/662280363bb541b78198ddb9e19cb5b5

المؤلفون: Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa

المصدر: Open Biology, Vol 14, Iss 6 (2024)

مصطلحات موضوعية: drug discovery, host–viral interface, phenotypic screen, pan-respiratory antiviral therapeutics, allosteric modulator, viral capsid assembly, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2046-2441

URL الوصول: https://doaj.org/article/ab895c6ab92c405ab16479c74bcf64ea

المؤلفون: Casey I. Gallagher, David P. Bishop, Thomas E. Lockwood, Tristan Rawling, Robert J. Vandenberg

المصدر: Frontiers in Molecular Neuroscience, Vol 17 (2024)

مصطلحات موضوعية: zinc, glycine receptor, chelator, tricine, positive allosteric modulator, bioactive lipid, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2024.1392715/full; https://doaj.org/toc/1662-5099

URL الوصول: https://doaj.org/article/4d425daf67854576a2c4286ff073812a

المؤلفون: Fadime Canbolat, Nigar Kantarci-Carsibasi, Sevim Isik, Suhair Rami Mohammed Shamshir, Münteha Girgin

المصدر: Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 788-807 (2024)

مصطلحات موضوعية: metabotropic glutamate receptor, cell viability, SH-SY5Y, positive allosteric modulator, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1467-3045/46/1/51; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

URL الوصول: https://doaj.org/article/cf8c27840af140168fb82c319d01bc8f

المؤلفون: Colson, Thomas, Valembois, S., Leroy, Charline, Bay, Y., Pickering, D.S., Kristensen, A.S., Pirotte, Bernard, Kastrup, J.S., Francotte, Pierre

المساهمون: CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège, BE

المصدر: 10th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS), Zagreb, Croatia [HR], September 7 and 8, 2023

مصطلحات موضوعية: kainate, receptor, PAM, Allosteric Modulator, Positive Allosteric Modulator, Glutamate, benzothiadiazines dioxydes, BPAM344, BPAM121, BPAM521, IDRA21, AMPA, GluK1, Ligand, GluK2, GluK3, Drug, Alzheimer, Human health sciences, Pharmacy, pharmacology & toxicology, Sciences de la santé humaine, Pharmacie, pharmacologie & toxicologie

URL الوصول: https://orbi.uliege.be/handle/2268/307922

المؤلفون: Odoemelam, Chiemela S., Hunter, Elena, Simms, John, Ahmad, Zeeshan, Chang, Ming-Wei, Percival, Benita, Williams, Ian H., Molinari, Marco, Kamerlin, Shina C. Lynn, 1981, Wilson, Philippe B.

المصدر: Applied Biosciences. 1(2):143-162

مصطلحات موضوعية: ADME/Tox, GLP-1R, ligand binding, allosteric binding site, allosteric modulator, GPCR

وصف الملف: electronic

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-505594
https://doi.org/10.3390/applbiosci1020010
https://uu.diva-portal.org/smash/get/diva2:1771354/FULLTEXT01.pdf

المؤلفون: Dhir, Ashish, Bruun, Donald A, Guignet, Michelle, Tsai, Yi‐Hua, González, Eduardo, Calsbeek, Jonas, Vu, Joan, Saito, Naomi, Tancredi, Daniel J, Harvey, Danielle J, Lein, Pamela J, Rogawski, Michael A

المصدر: Annals of the New York Academy of Sciences. 1480(1)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Agricultural, Veterinary and Food Sciences, Biomedical and Clinical Sciences, Brain Disorders, Neurosciences, Epilepsy, Neurodegenerative, Animals, Behavior, Animal, Drug Therapy, Combination, Electroencephalography, Isoflurophate, Male, Midazolam, Nitriles, Pregnanolone, Pyridones, Rats, Rats, Sprague-Dawley, Status Epilepticus, organophosphate nerve agent, status epilepticus, AMPA receptor antagonist, GABA(A)receptor positive allosteric modulator, neuroactive steroid, benzodiazepine, GABAA receptor positive allosteric modulator, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8bf600d3

المؤلفون: Xu, Lizhen, Zhang, Heng, Wang, Yunfei, Lu, Xiancui, Zhao, Zhenye, Ma, Cheng, Yang, Shilong, Yarov‐Yarovoy, Vladimir, Tian, Yuhua, Zheng, Jie, Yang, Fan

المصدر: Advanced Science. 8(17)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Pain Research, Biotechnology, Chronic Pain, 5.1 Pharmaceuticals, Allosteric Regulation, Analgesics, Animals, Disease Models, Animal, Male, Nociceptors, Pain, Peptides, Rats, TRPV Cation Channels, ion channel, pain, positive allosteric modulator, protein design, TRPV1

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0c62k2pm
https://escholarship.org/content/qt0c62k2pm/qt0c62k2pm.pdf

المؤلفون: Bay, Yasmin, Cabello, Federico Javier Miguez, Koens, Chloe C., Frantsen, Stine M., Pickering, Darryl S., Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Kristensen, Anders S., Bowie, Derek, Kastrup, Jette Sandholm

المصدر: Bay , Y , Cabello , F J M , Koens , C C , Frantsen , S M , Pickering , D S , Frydenvang , K , Francotte , P , Pirotte , B , Kristensen , A S , Bowie , D & Kastrup , J S 2024 , ' Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538 ' , Journal of Structural Biology , vol. 216 , no. 3 , 108113 . https://doi.org/10.1016/j.jsb.2024.108113

مصطلحات موضوعية: Binding mode, Kainate, Ligand-binding domain of GluK1, Positive allosteric modulator, X-ray crystallography

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/crystal-structure-of-the-gluk1-ligandbinding-domain-with-kainate-and-the-fullspanning-positive-allosteric-modulator-bpam538(df268a28-8a1e-4e7e-9d39-cc934d06f3b1).html
https://doi.org/10.1016/j.jsb.2024.108113
https://curis.ku.dk/ws/files/403255036/1_s2.0_S1047847724000534_main.pdf

المؤلفون: Brunetti Leonardo, Francavilla Fabio, Leopoldo Marcello, Enza Lacivita

المساهمون: Brunetti, Leonardo, Francavilla, Fabio, Leopoldo, Marcello, Lacivita, Enza

مصطلحات موضوعية: allosteric modulator, cannabinoid, GPCR, natural compound, serotonin

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001256070100001; volume:17; issue:6; journal:PHARMACEUTICALS; https://hdl.handle.net/11586/506680

الاتاحة: https://hdl.handle.net/11586/506680
https://doi.org/10.3390/ph17060695

المؤلفون: D’Andrea, Tiziano, Benedetti, Maria Cristina, Monaco, Lucia, Rosa, Alessandro, Fucile, Sergio

المساهمون: D’Andrea, Tiziano, Benedetti, Maria Cristina, Monaco, Lucia, Rosa, Alessandro, Fucile, Sergio

مصطلحات موضوعية: Ca2+ permeability, Excitotoxicity, Human iPSC, Negative allosteric modulator, Neurodegeneration, Neuroprotection

Relation: info:eu-repo/semantics/altIdentifier/pmid/38240993; info:eu-repo/semantics/altIdentifier/wos/WOS:001145754400001; numberofpages:10; journal:MOLECULAR NEUROBIOLOGY; https://hdl.handle.net/11573/1700969; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85182700650

الاتاحة: https://hdl.handle.net/11573/1700969
https://doi.org/10.1007/s12035-024-03944-9

المؤلفون: Minere, Marielle, Mortensen, Martin, Dorovykh, Valentina, Warnes, Gary, Nizetic, Dean, Smart, Trevor G, Hannan, Saad B

المصدر: Brain , Article awae232. (2024) (In press).

مصطلحات موضوعية: GABA, GABAB receptor, epilepsy, inhibition, neurodevelopmental disorder, positive allosteric modulator

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10195096/1/Smart_Saad%20GABABR%20epilepsy%20paper%20ver23%20Brain_Format.pdf; https://discovery.ucl.ac.uk/id/eprint/10195096/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10195096/1/Smart_Saad%20GABABR%20epilepsy%20paper%20ver23%20Brain_Format.pdf
https://discovery.ucl.ac.uk/id/eprint/10195096/

المؤلفون: Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa

مصطلحات موضوعية: Biochemistry and cell biology not elsewhere classified, Medical biotechnology not elsewhere classified, drug discovery, host–viral interface, phenotypic screen, pan-respiratory antiviral therapeutics, allosteric modulator, viral capsid assembly

Relation: https://figshare.com/articles/journal_contribution/Electronic_supplementary_material_for_Open_Biology_article_230363_from_A_pan-respiratory_antiviral_chemotype_targeting_a_transient_host_multi-protein_complex/25934182

الاتاحة: https://doi.org/10.6084/m9.figshare.25934182.v1
https://figshare.com/articles/journal_contribution/Electronic_supplementary_material_for_Open_Biology_article_230363_from_A_pan-respiratory_antiviral_chemotype_targeting_a_transient_host_multi-protein_complex/25934182