المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/journal_contribution/Summary_of_fatty_acid_content_of_cell_culture_media_used_in_this_study_/18797739

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.s005

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Cellular_ARA_and_ARA_DGLA_ratio_by_genotype_at_rs174537_and_LA_dietary_exposure_/18797733

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.s004

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Immunohistochemistry_of_3D_hepatic_constructs_revealed_positive_staining_of_Connexin-32_and_actin_filaments_/18797724

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.s002

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Hepatocyte_viability_is_maintained_over_study_period_/18797754

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.g004

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Live-dead_imaging_of_primary_human_hepatocytes_cultured_in_2D_vs_3D_constructs_/18797718

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.s001

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Cholesterol_efflux_from_3D_cultured_hepatic_constructs_/18797748

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.g003

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Genotype_at_i_rs174537_i_is_strongly_associated_with_cellular_ARA_levels_and_ARA_DGLA_ratio_in_3D_cultured_hepatocytes_/18797766

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.g006

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Viability_of_3D_human_hepatic_cultures_/18797742

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.g001

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Lipid_metabolic_functionality_in_3D_human_hepatic_constructs_/18797745

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.g002

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Saturated_fatty_acid_levels_increased_over_time_in_LA_and_control_hepatic_constructs_/18797730

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.s003

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Cellular_fatty_acid_content_after_incubation_with_LA_/18797760

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.g005

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/figure/Expression_of_i_FADS1_i_and_i_FADS2_i_is_associated_with_genotype_at_i_rs174537_i_/18797772

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.g007

المؤلفون: L. Madison Kirk (11978844), Charlotte Mae K. Waits (11978847), Alexander C. Bashore (11978850), Beverly Dosso (11978853), Allison K. Meyers (11821457), Antonio C. Renaldo (11978856), Thomas J. DePalma (11978859), Kelli N. Simms (11978862), Nathaniel Hauser (11978865), Chia-Chi Chuang Key (11978868), Charles E. McCall (7486847), John S. Parks (11807758), Susan Sergeant (134416), Carl D. Langefeld (9321905), Aleksander Skardal (6472949), Elaheh Rahbar (4476481)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Ecology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, specifically linoleic acid, genetic variants near, fatty acid desaturase, div >< p, dimensional hepatic construct, dimensional culture models, de novo lipogenesis, fatty acid metabolism, significantly reduced fads1, reproducibly displayed allele, modern western diet, including lipid esterification, driving human disease, specific metabolic activity, slowest metabolic conversion, human pufa metabolism, lipid metabolism, subsequent metabolism, minor allele, including obesity

Relation: https://figshare.com/articles/dataset/Overview_of_primary_human_hepatocytes_PHHs_used_in_the_experiments_/18797778

الاتاحة: https://doi.org/10.1371/journal.pone.0262173.t001

المؤلفون: Qingxia Zhao (789655), Zhan Wang (283758), Allison K. Meyers (11821457), Jennifer Madenspacher (11821460), Manal Zabalawi (11821463), Qianyi Zhang (663737), Elena Boudyguina (11821466), Fang-Chi Hsu (73595), Charles E. McCall (7486847), Cristina M. Furdui (736776), John S. Parks (11807758), Michael B. Fessler (11821469), Xuewei Zhu (1765681)

مصطلحات موضوعية: Cardiology, Cardiology (incl. Cardiovascular Diseases), Cardiorespiratory Medicine and Haematology not elsewhere classified, glucose 6-phosphate transporter, macrophage inflammation, IL-10, efferocytosis, atherosclerosis

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_Hematopoietic_Cell-Specific_SLC37A2_Deficiency_Accelerates_Atherosclerosis_in_LDL_Receptor-Deficient_Mice_pdf/17156711

الاتاحة: https://doi.org/10.3389/fcvm.2021.777098.s001