المؤلفون: Valerie Cavett, Alix I Chan, Christian N. Cunningham, Brian M. Paegel

المصدر: ACS Central Science, Vol 9, Iss 8, Pp 1603-1610 (2023)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2374-7951

URL الوصول: https://doaj.org/article/3c8ccd3584724c61af88e6c23b412553

المؤلفون: Alix I Chan (14340186), Manali S. Sawant (14340189), Daniel J. Burdick (1346385), Jeffrey Tom (1626802), Aimin Song (1626814), Christian N. Cunningham (2307340)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, genetic code reprogramming, drug discovery campaigns, tolerate amino acids, measuring translation within, developing druglike peptide, ligand discovery efforts, noncanonical amino acids, template translation data, shorter peptide libraries, scale translation yield, relative translation yield, evaluating translational efficiency, combinatorial library consisting, chemical space via, noncanonical amino acid, amino acid, translation yield, translational yield, chemical space, translation machinery

Relation: https://figshare.com/articles/journal_contribution/Evaluating_Translational_Efficiency_of_Noncanonical_Amino_Acids_to_Inform_the_Design_of_Druglike_Peptide_Libraries/21830373

الاتاحة: https://doi.org/10.1021/acschembio.2c00712.s001

المؤلفون: Juan Hu, Alix I Chan, Emel Adaligil, Ivy Kekessie, Mifune Takahashi, Aimin Song, Christian N. Cunningham, Brian M. Paegel

المصدر: Journal of Medicinal Chemistry. 66:6288-6296

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::25660f2143f10e27703c822d080f42a3
https://doi.org/10.1021/acs.jmedchem.3c00138

المؤلفون: Alexander A. Peterson, Aziz M. Rangwala, Manish K. Thakur, Patrick S. Ward, Christie Hung, Ian R. Outhwaite, Alix I. Chan, Dmitry L. Usanov, Vamsi K. Mootha, Markus A. Seeliger, David R. Liu

المصدر: Nature Chemical Biology. 18:1184-1195

مصطلحات موضوعية: Cell Biology, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d93a6ef4e32465c480b6a8815a376b46
https://doi.org/10.1038/s41589-022-01116-1

المؤلفون: Alix I Chan, Manali S. Sawant, Daniel J. Burdick, Jeffrey Tom, Aimin Song, Christian N. Cunningham

المصدر: ACS chemical biology.

مصطلحات موضوعية: Molecular Medicine, General Medicine, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cf6e4c3b29b6e1dc433975d6e06a79
https://pubmed.ncbi.nlm.nih.gov/36607609

المؤلفون: Sonia M Vallabh, Arthur J. Campbell, Jayme L. Dahlin, Michael F. Mesleh, Kong T. Nguyen, Dominick Casalena, S. Kirk Wright, Dmitry L. Usanov, Christopher T. Lemke, Jamie A. Moroco, Joshua R. Sacher, Andrew G. Reidenbach, Murugappan Sathappa, Om K. Shrestha, Eric Vallabh Minikel, Jenna B. Yehl, Douglas S. Auld, Stuart L. Schreiber, V.L. Rangel, Alix I. Chan, Rishi N. Shah, Maria Cristina Nonato, David R. Liu, Florence F. Wagner, Alison Leed, Virendar K. Kaushik

المصدر: J Biol Chem

مصطلحات موضوعية: 0301 basic medicine, Benzimidazole, Magnetic Resonance Spectroscopy, animal diseases, In silico, Drug Evaluation, Preclinical, Biochemistry, Prion Proteins, Prion Diseases, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Screening method, Humans, Native protein, Prion protein, Molecular Biology, 030102 biochemistry & molecular biology, Drug discovery, Cell Biology, Progressive neurodegenerative disorder, Small molecule, nervous system diseases, 030104 developmental biology, chemistry, Saturation transfer, Benzimidazoles, Molecular Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8fc34d169f5f23f5d3171c3a119372
https://doi.org/10.1074/jbc.ra120.014905

المؤلفون: Xiaohong Zhang, David R. Liu, Thibault J. Harmand, Djenet Bousbaine, Alix I. Chan, James P. Tam, Hidde L. Ploegh

المساهمون: School of Biological Sciences

المصدر: Bioconjugate Chemistry. 29:3245-3249

مصطلحات موضوعية: Recombinant Fusion Proteins, Immunology, Biomedical Engineering, Pharmaceutical Science, Bioengineering, Peptide, Protein Engineering, 010402 general chemistry, 01 natural sciences, Article, Ligases, Bacterial Proteins, Polyacrylamide gel electrophoresis, Pharmacology, chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, Chemical modification, Protein engineering, Aminoacyltransferases, Fusion protein, Carbon, 0104 chemical sciences, Peptides and Proteins, Cysteine Endopeptidases, Enzyme, chemistry, Biochemistry, Immunoglobulin G, Biological sciences::Biochemistry [Science], Sortase A, Electrophoresis, Polyacrylamide Gel, Function (biology), Chromatography, Liquid, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98ec8df0861ac4cdfc373cd215e6389
https://doi.org/10.1021/acs.bioconjchem.8b00563

المؤلفون: Juan Pablo Maianti, Alix I. Chan, Dmitry L. Usanov, David R. Liu

المصدر: Nature chemistry

مصطلحات موضوعية: Macrocyclic Compounds, General Chemical Engineering, Structural diversity, Computational biology, 010402 general chemistry, 01 natural sciences, Article, Small Molecule Libraries, chemistry.chemical_compound, DNA-templated synthesis, Purification methods, Codon, 010405 organic chemistry, Extramural, Chemistry, DNA-encoded libraries, Stereoisomerism, in vitro selections, General Chemistry, Experimental validation, DNA, Templates, Genetic, Template library, Small molecule, insulin-degrading enzyme, 0104 chemical sciences, 3. Good health, Template, macrocycles

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a163a8541f3e4d0a98b2e355f0a1d3
http://europepmc.org/articles/PMC6014893

المؤلفون: Alix I. Chan, David R. Liu, Lynn M. McGregor

المصدر: Current Opinion in Chemical Biology. 26:55-61

مصطلحات موضوعية: Combinatorial Chemistry Techniques, Exploit, business.industry, Drug discovery, Gene Expression, Small Molecule Libraries, Computational biology, Nucleic acid amplification technique, Biology, Biochemistry, Article, High-Throughput Screening Assays, Analytical Chemistry, Biotechnology, Drug Discovery, Humans, Genomic library, business, Nucleic Acid Amplification Techniques, Selection (genetic algorithm), Gene Library

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d081217c012813726356cf8501f533
https://doi.org/10.1016/j.cbpa.2015.02.010

المؤلفون: Lynn M. McGregor, David R. Liu, Tara Jain, Alix I. Chan

المصدر: Journal of the American Chemical Society. 139(30)

مصطلحات موضوعية: Plasma protein binding, MAP Kinase Kinase 6, 010402 general chemistry, Ligands, 01 natural sciences, Biochemistry, Catalysis, MAP2K6, Article, Protein–protein interaction, Small Molecule Libraries, Structure-Activity Relationship, Colloid and Surface Chemistry, Peptide Library, Drug Discovery, Humans, Peptide library, Protein Kinase Inhibitors, Molecular Structure, 010405 organic chemistry, Ligand, Chemistry, Drug discovery, General Chemistry, DNA, Small molecule, 0104 chemical sciences, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe23c8dc0c7791a3cd2213a6a00bdd64
https://pubmed.ncbi.nlm.nih.gov/28689404

المؤلفون: Ralph E. Kleiner, Agatha Lyczek, Barbara P. Craddock, Miguel Garcia-Diaz, Markus A. Seeliger, W. Todd Miller, David R. Liu, George Georghiou, Alix I. Chan, Saadat Aleem, Kip E. Guja

المصدر: Cell chemical biology. 23(9)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Macrocyclic Compounds, Clinical Biochemistry, Biochemistry, Article, MAP2K7, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, TANK-binding kinase 1, Cell Movement, Cell Line, Tumor, Drug Discovery, Humans, c-Raf, Molecular Biology, Protein Kinase Inhibitors, Pharmacology, biology, Dose-Response Relationship, Drug, Molecular Structure, Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, 030104 developmental biology, src-Family Kinases, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9, Janus kinase, Oligopeptides, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88611271a5ad48f8b6d42fc506168a0
https://pubmed.ncbi.nlm.nih.gov/27593110