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1Academic Journal
المؤلفون: Michael Berlin, Jennifer Cantley, Mark Bookbinder, Elizabeth Bortolon, Fabio Broccatelli, Greg Cadelina, Emily W. Chan, Huifen Chen, Xin Chen, Yunxing Cheng, Tommy K. Cheung, Kim Davenport, Dean DiNicola, Debbie Gordon, Brian D. Hamman, Alicia Harbin, Roy Haskell, Mingtao He, Alison J. Hole, Thomas Januario, Philip S. Kerry, Stefan G. Koenig, Limei Li, Mark Merchant, Inmaculada Pérez-Dorado, Jennifer Pizzano, Connor Quinn, Christopher M. Rose, Emma Rousseau, Leofal Soto, Leanna R. Staben, Hongming Sun, Qingping Tian, Jing Wang, Weifeng Wang, Crystal S. Ye, Xiaofen Ye, Penghong Zhang, Yuhui Zhou, Robert Yauch, Peter S. Dragovich
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, thus highly dependent, pd analysis established, also selectively impair, >) also supported, compounds identified protacs, selectively degraded brm, type calu6 line, h1944 “ brg1, fold degradation selectivity, protacs targeting brm, also known, brm protein, brm (<, vivo <, sw1573 cell, subsequent pk, plau <, mrna associated, molecules exhibit
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2
المؤلفون: Peter W. Fan, Sarah G. Hymowitz, Teresa Dong, Xingyu Lin, Zoe Zhong, Connie Chan, Paul A. McEwan, Wyne P. Lee, Swathi Sujatha-Bhaskar, Baihua Hu, Nicole Blaquiere, Jason Burch, Jianwen Feng, Hans Brightbill, Steven T. Staben, Alison J Hole, James J. Crawford, Guosheng Wu, Suzanne Brown, Moulay Hicham Alaoui Ismaili, Georgette Castanedo, Patrick Lee, Hoa Le, Leonid M. Berezhkovskiy, Po-Chang Chiang, Robert Godemann, Brent S. McKenzie, Emily B. Gogol, Hernani L Silvestre, Ning Liu, Eric Suto, Nico Ghilardi, Yamin Zhang, Lawren C. Wu, Alice Grabbe
المصدر: Journal of Medicinal Chemistry. 61:6801-6813
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell Survival, Protein Conformation, Protein Serine-Threonine Kinases, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, B-cell activating factor, Protein Kinase Inhibitors, B cell, Dose-Response Relationship, Drug, Chemistry, Kinase, Drug discovery, Dendritic cell, In vitro, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Cell culture, 030220 oncology & carcinogenesis, Molecular Medicine
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3
المؤلفون: Sonja Baumli, Hervé Galons, Sétha Douc-Rasy, Jane A. Endicott, Alison J. Hole, Jean Bénard, Nassima Oumata, Laurent Meijer, Dianne Baunbæk, Nadège Loaëc, Claire Delehouzé, Karima Bettayeb
المصدر: Genes & Cancer. 1:369-380
مصطلحات موضوعية: Cancer Research, biology, Kinase, Original Articles, medicine.disease, Cell biology, chemistry.chemical_compound, chemistry, Downregulation and upregulation, Apoptosis, Cyclin-dependent kinase, Cell culture, Neuroblastoma, Genetics, medicine, biology.protein, Seliciclib, Cyclin
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4
المؤلفون: Jane A. Endicott, Chris Pepper, Alison J. Hole, Abdullahi Y. Abbas, Shenhua Shi, Frankie Lam, Shudong Wang, Martin E.M. Noble, Sonja Baumli, Hao Shao, Xiangrui Liu, David W. Foley, Shiliang Huang, Peter Fischer
المساهمون: Shao, Hao, Shi, Shenhua, Huang, Shiliang, Hole, Alison J, Abbas, Abdullahi Y, Baumli, Sonja, Liu, Xiangrui, Lam, Frankiei, Foley, David W, Fischer, Peter M, Noble, Martin, Endicott, Jane A, Pepper, Chris, Wang, Shudong
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Models, Molecular, Programmed cell death, Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Pyrimidine, Stereochemistry, antiapoptotic proteins, Antineoplastic Agents, Crystallography, X-Ray, Article, chemistry.chemical_compound, Medicinal and Biomolecular Chemistry, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Moiety, Structure–activity relationship, Humans, Protein Kinase Inhibitors, CDK9 inhibition, chemistry.chemical_classification, Molecular Structure, Cyclin-Dependent Kinase 9, Enzyme, Pyrimidines, chemistry, Cell culture, Apoptosis, Cancer cell, cancer cells, Molecular Medicine, Drug Screening Assays, Antitumor
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5
المؤلفون: Lan-Zhen Wang, Sonja Baumli, Jane A. Endicott, Martin E.M. Noble, Alison J. Hole
المصدر: Structure(London, England:1993)
مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, RNA polymerase II, Biology, Crystallography, X-Ray, Article, 03 medical and health sciences, 0302 clinical medicine, Structural Biology, Catalytic Domain, Humans, Positive Transcriptional Elongation Factor B, Amino Acid Sequence, Binding site, P-TEFb, Molecular Biology, Protein Kinase Inhibitors, 030304 developmental biology, Cyclin, 0303 health sciences, Cyclin T, Cyclin-Dependent Kinase 9, Peptide Fragments, 3. Good health, Cell biology, Elongation factor, Kinetics, Biochemistry, Amino Acid Substitution, 030220 oncology & carcinogenesis, biology.protein, Mutagenesis, Site-Directed, Phosphorylation, Cyclin-dependent kinase 9, Transcription factor II B, Dichlororibofuranosylbenzimidazole, Protein Binding
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6
المؤلفون: Alison J. Hole, Sonja Baumli, Jane A. Endicott, Martin E.M. Noble
المصدر: ACS Chemical Biology
مصطلحات موضوعية: Models, Molecular, Cyclin A, RNA polymerase II, Biology, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Humans, Letters, P-TEFb, 030304 developmental biology, Cyclin, 0303 health sciences, Binding Sites, Cyclin T, Cyclin-dependent kinase 2, General Medicine, Cyclin-Dependent Kinase 9, 3. Good health, 030220 oncology & carcinogenesis, Cyclin-dependent kinase complex, biology.protein, Biophysics, Molecular Medicine, Pyrazoles, Cyclin-dependent kinase 9, Azo Compounds
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7
المؤلفون: Chris Pepper, Alison J. Hole, Hao Shao, Jane A. Endicott, Shiliang Huang, Peter Fischer, Shudong Wang, Martin E.M. Noble, Sonja Baumli, Shenhua Shi
المساهمون: Hole, Alison J, Baumli, Sonja, Shao, Hao, Shi, Shenhua, Huang, Shiliang, Pepper, Chris, Fischer, Peter M, Wang, Shudong, Endicott, Jane A, Noble, Martin
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Cyclin A, Article, 03 medical and health sciences, Structure-Activity Relationship, Medicinal and Biomolecular Chemistry, 0302 clinical medicine, Cyclin-dependent kinase, Drug Discovery, Humans, cancer, P-TEFb, Protein Kinase Inhibitors, 030304 developmental biology, Cyclin, 0303 health sciences, biology, Chemistry, Kinase, Cyclin-dependent kinase 2, Molecular biology, Cyclin-Dependent Kinase 9, 3. Good health, Pyrimidines, 030220 oncology & carcinogenesis, Cyclin-dependent kinase complex, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9
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8
المؤلفون: Shenhua Shi, Shudong Wang, David W. Foley, Martin E.M. Noble, Shiliang Huang, Tracey D. Bradshaw, Abdullahi Y. Abbas, Sonja Baumli, Jane A. Endicott, Alison J. Hole, Peter Fischer, Hao Shao, Chris Pepper
المصدر: Cancer Research. 73:697-697
مصطلحات موضوعية: Cancer Research, Cyclin-dependent kinase 1, Kinase, Cyclin-dependent kinase 2, Cancer, Biology, medicine.disease, Oncology, Biochemistry, Cyclin-dependent kinase, Cancer cell, biology.protein, medicine, Cyclin-dependent kinase 9, Cyclin-dependent kinase 7