المؤلفون: Ferenc, Minya, Buzzetti, Luca, Simone, Zaramella, Alfredo, Paio

المصدر: Chemietage 2024, Graz, 23-25 Aeptember

مصطلحات موضوعية: Organometallic chemistry, Green Chemistry

Relation: https://doi.org/10.5281/zenodo.13927968; https://doi.org/10.5281/zenodo.13927969; oai:zenodo.org:13927969

الاتاحة: https://doi.org/10.5281/zenodo.13927969

المؤلفون: Annunziata D’Ercole (9909666), Lorenzo Pacini (9909669), Giuseppina Sabatino (1383063), Matteo Zini (9909672), Francesca Nuti (694900), Arianna Ribecai (2265907), Alfredo Paio (1738870), Paolo Rovero (1344753), Anna Maria Papini (694904)

مصطلحات موضوعية: Biochemistry, Medicine, Biotechnology, Infectious Diseases, Space Science, successful final result, subsequently successfully scaled, length peptide syntheses, flash column chromatography, eptifibatide linear precursor, api eptifibatide using, phase peptide synthesizer, compliant pilot process, pilot scale plant, pilot cgmp production, optimized safe process, optimized process, produce eptifibatide, scale production, fully cgmp, phase synthesis, phase strategies, phase extraction, process consists, scale microwave, research scale, laboratory scale, direct scale, use microwave, regulatory agencies

Relation: https://figshare.com/articles/journal_contribution/An_Optimized_Safe_Process_from_Bench_to_Pilot_cGMP_Production_of_API_Eptifibatide_Using_a_Multigram-Scale_Microwave-Assisted_Solid-Phase_Peptide_Synthesizer/17076157

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00368.s001

المؤلفون: Giuseppina Sabatino (1383063), Annunziata D’Ercole (9909666), Lorenzo Pacini (9909669), Matteo Zini (9909672), Arianna Ribecai (2265907), Alfredo Paio (1738870), Paolo Rovero (1344753), Anna Maria Papini (694904)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Computational Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Automated Solid-Phase Microwave-Ass., on-resin strategies, kilogram-scale manufacturing, microwave-assisted solid-phase pept., solution, optimized scalable, reactor procedure, disulfide-bridged cyclo-heptapeptid., oxidation byproducts, MPA, antithrombotic agent, CH 3 CN, thiol side-chain, MW-SPPS, latter strategy, Eptifibatide ring, disulfide formation, cysteine side-chain amide bond form., C-terminal Cys residue, disulfide formation procedure, solid-phase microwave-assisted cGMP.

Relation: https://figshare.com/articles/online_resource/An_Optimized_Scalable_Fully_Automated_Solid-Phase_Microwave-Assisted_cGMP-Ready_Process_for_the_Preparation_of_Eptifibatide/13584709

الاتاحة: https://doi.org/10.1021/acs.oprd.0c00490.ls01

المؤلفون: Annunziata D’Ercole, Lorenzo Pacini, Giuseppina Sabatino, Matteo Zini, Lorenzo Milli, Francesca Nuti, Arianna Ribecai, Alfredo Paio, Paolo Rovero, Anna Maria Papini

المصدر: Organic Process Research & Development. 26:2540-2540

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c680b22d62d2758b243be1c6ad337a45
https://doi.org/10.1021/acs.oprd.2c00224

المؤلفون: Paolo Rovero, Alfredo Paio, Annunziata D’Ercole, Matteo Zini, Francesca Nuti, L. Pacini, Anna Maria Papini, Arianna Ribecai, Giuseppina Sabatino

المصدر: Organic process research & development 25 (2021): 2754–2771. doi:10.1021/acs.oprd.1c00368
info:cnr-pdr/source/autori:D'Ercole, Annunziata; Pacini, Lorenzo; Sabatino, Giuseppina; Zini, Matteo; Nuti, Francesca; Ribecai, Arianna; Paio, Alfredo; Rovero, Paolo; Papini, Anna Maria/titolo:An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer/doi:10.1021%2Facs.oprd.1c00368/rivista:Organic process research & development/anno:2021/pagina_da:2754/pagina_a:2771/intervallo_pagine:2754–2771/volume:25

مصطلحات موضوعية: chemistry.chemical_classification, Materials science, Chromatography, technology transfer, Organic Chemistry, multigram-scale microwave-assisted peptide synthesis, Peptide, generic peptide drug, Microwave assisted, peptide production scale-up, peptide production pilot plant, chemistry, Phase (matter), generic peptide drug, peptide production scale-up, multigram-scale microwave-assisted peptide synthesis, technology transfer, peptide production pilot plant, Eptifibatide, medicine, Physical and Theoretical Chemistry, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29c2a766b49246c4ffd343dfd85a016
https://publications.cnr.it/doc/464122

المؤلفون: L. Pacini, Annunziata D’Ercole, Matteo Zini, Alfredo Paio, Paolo Rovero, Anna Maria Papini, Giuseppina Sabatino, Arianna Ribecai

المصدر: Organic process research & development (2021). doi:10.1021/acs.oprd.0c00490
info:cnr-pdr/source/autori:Papini, Anna Maria; Sabatino, Giuseppina; D'Ercole, Annunziata; Pacini, Lorenzo; Zini, Matteo; Ribecai, Arianna; Paio, Alfredo; Rovero, Paolo/titolo:An optimized scalable fully automated solid-phase microwave-assisted cGMP-ready process for the preparation of eptifibatide/doi:10.1021%2Facs.oprd.0c00490/rivista:Organic process research & development/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

مصطلحات موضوعية: Materials science, Scale-up, Nanotechnology, active pharmaceutical ingredient, peptide, scale-up, oxidation, automated on-resin disulfide bond formation, off-resin disulfide bond formation, single reactor solid-phase synthesis, 010402 general chemistry, 01 natural sciences, Microwave assisted, chemistry.chemical_compound, Phase (matter), Oxidation, medicine, Peptide synthesis, Physical and Theoretical Chemistry, Active ingredient, 010405 organic chemistry, Organic Chemistry, Off-resin disulfide bond formation, 0104 chemical sciences, Fully automated, chemistry, Scientific method, Peptide, Single reactor solid-phase synthesis, Scalability, Eptifibatide, Active pharmaceutical ingredient, Automated on-resin disulfide bond formation, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c4b0fe2aba17e3983bfb82d507cdb0
http://hdl.handle.net/2158/1219739

المؤلفون: Daniele Donati, Stefano Biondi, Alfredo Paio, Stjepan Mutak, Sergio Lociuro, Elisa Piga, Francesca Cardullo, Dražen Pavlović, Daniele Andreotti

المصدر: ACS Medicinal Chemistry Letters. 5:1133-1137

مصطلحات موضوعية: chemistry.chemical_classification, medicine.drug_class, Stereochemistry, Organic Chemistry, Telithromycin, Erythromycin, Biology, Biochemistry, In vitro, Macrolide Antibiotics, Microbiology, chemistry, Clarithromycin, Drug Discovery, medicine, Antibacterial activity, Ketolide, Lactone, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8c82745e0260869ef5d53f6e44524e
https://doi.org/10.1021/ml500279k

المؤلفون: MANFREDINI, Stefano, NAPOLITANO, Carmela, Alfredo Paio

المساهمون: Manfredini, Stefano, Alfredo, Paio, Napolitano, Carmela

وصف الملف: STAMPA

Relation: ispartofbook:DOC-CAREERS II Workshop 5; DOC-CAREERS II Workshop 5; firstpage:1; lastpage:1; http://hdl.handle.net/11392/1526936

الاتاحة: http://hdl.handle.net/11392/1526936

المؤلفون: Daniele Donati, Francesca Cardullo, Carmela Napolitano, Stefano Manfredini, Alfredo Paio, Manuela Borriello

المصدر: Synthetic Communications. 41:2031-2035

مصطلحات موضوعية: Piperazine, chemistry.chemical_compound, chemistry, Organic Chemistry, Rapid access, Organic chemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9d03e38c7789a8fa1ea9c58b8881b3e2
https://doi.org/10.1080/00397911.2010.491171

المؤلفون: Daniele Andreotti, Roberto Profeta, Alfredo Paio, Simone Spada, Francesco Ferroni, Jens Klein

المصدر: Tetrahedron Letters. 51:5521-5524

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Stereochemistry, Aryl, Organic Chemistry, Drug Discovery, Organic chemistry, Biochemistry, Octane

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9a9af09b68927810407ff57c9b2f1aa6
https://doi.org/10.1016/j.tetlet.2010.07.145

المؤلفون: Daniele Donati, Manuela Borriello, Carmela Napolitano, Francesca Cardullo, Alfredo Paio, Stefano Manfredini

المصدر: Tetrahedron. 66:5492-5497

مصطلحات موضوعية: chemistry.chemical_classification, Heptane, Bicyclic molecule, Intramolecular reaction, Stereochemistry, Carboxylic acid, Organic Chemistry, Biochemistry, Chemical synthesis, chemistry.chemical_compound, chemistry, Drug Discovery, Lactam, Chemoselectivity, Imide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7a1ac1b673e036f9e01973adaa531100
https://doi.org/10.1016/j.tet.2010.05.006

المؤلفون: Bruna DalPizol Novello, Marcela Maria Zanatta, Felipe Pompolim Mendes, Alfredo Paiola Albrecht, Arthur Arrobas Martins Barroso

المصدر: Acta Scientiarum: Biological Sciences, Vol 45, Iss 1 (2023)

مصطلحات موضوعية: genetic improvement, transgenic, sustainability, genetically modified organisms., Biology (General), QH301-705.5, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/64163; https://doaj.org/toc/1679-9283; https://doaj.org/toc/1807-863X

URL الوصول: https://doaj.org/article/c8d7396ceebb4e9ea02b251293641c68

المؤلفون: Giovanna Zinzalla, Carla Marchioro, Laura Casiraghi, Stefano Maiorana, Clara Baldoli, Elisabetta de Magistris, Pierfausto Seneci, and Alfredo Paio, Emanuela Licandro

المصدر: Journal of Combinatorial Chemistry. 5:809-813

مصطلحات موضوعية: Polymers, Ligand, chemistry.chemical_element, General Chemistry, Dichlorobenzene, Chromium, chemistry.chemical_compound, chemistry, Nucleophile, Chromium Compounds, Polymer chemistry, Technology, Pharmaceutical, Organic chemistry, Reactivity (chemistry), Polystyrene, Polymer supported

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefdddcaaabc2d9c1f6606b85b493db9
https://doi.org/10.1021/cc0340123

المؤلفون: Gianna Reginato, Pierfausto Seneci, Sylvie Gehanne, Elena Grandini, Alfredo Paio

المصدر: Tetrahedron letters 44 (2003): 1867–1870. doi:10.1016/S0040-4039(03)00090-X
info:cnr-pdr/source/autori:Paio, Alfredo; Gehanne, Sylvie; Grandini, Elena; Reginato, Gianna; Seneci, Pierfausto/titolo:A new analytical method for anchoring quantification of amines on resin support/doi:10.1016%2FS0040-4039(03)00090-X/rivista:Tetrahedron letters/anno:2003/pagina_da:1867/pagina_a:1870/intervallo_pagine:1867–1870/volume:44

مصطلحات موضوعية: Carbamate, medicine.medical_treatment, amines, Organic Chemistry, Anchoring, Chromophore, Biochemistry, loading, chemistry.chemical_compound, chemistry, Yield (chemistry), Drug Discovery, solid phase, medicine, Organic chemistry, Polystyrene, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6972436ee7da4dd8270dcee08d6d78
https://doi.org/10.1016/s0040-4039(03)00090-x

المؤلفون: Sophie Huss, Araceli Mallo, Alfredo Paio, Jose M. Bueno, Paola Zarantonello, Silvestre Garcı́a-Ochoa, Fabrizio Micheli, Elisa Piga, Esther Fernández

المصدر: Tetrahedron Letters. 43:4741-4745

مصطلحات موضوعية: Pyrazine, Chemistry, Organic Chemistry, Chlorine atom, Solution chemistry, Solution synthesis, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, Nucleophile, Phase (matter), Drug Discovery, Organic chemistry, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fb427161a868d885141adabef20b935f
https://doi.org/10.1016/s0040-4039(02)00913-9

المؤلفون: Mariella Mella, Annalisa Mortoni, Alfredo Paio, Pierfausto Seneci, Giuseppe Faita, Paolo Quadrelli

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Pericyclic reaction, chemistry.chemical_compound, Wang resin, Solid-phase synthesis, Nitrile, chemistry, Phase (matter), Organic Chemistry, Reactive intermediate, Organic chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5a9b29656a36cef1bbcbae04d113c1
https://doi.org/10.1002/1099-0690(200204)2002:7<1175::aid-ejoc1175>3.0.co;2-z

المؤلفون: Fabio Rancati, Paolo Quadrelli, Giuseppe Faita, Pierfausto Seneci, Alfredo Paio

المصدر: Tetrahedron. 57:8313-8322

مصطلحات موضوعية: chemistry.chemical_classification, Chiral auxiliary, Nitrile, Organic Chemistry, Enantioselective synthesis, Biochemistry, Medicinal chemistry, Asymmetric induction, Nitrone, Lewis acid catalysis, Catalysis, chemistry.chemical_compound, chemistry, Drug Discovery, 1,3-Dipolar cycloaddition, Organic chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4636f42689295c2bc5c7e8b5453ef2fd
https://doi.org/10.1016/s0040-4020(01)00769-4

المؤلفون: Sylvie Gehanne, Michele Dal Cin, and Pierfausto Seneci, Nadia Conti, Alfredo Paio, Alessio Zaramella

المصدر: Journal of Combinatorial Chemistry. 3:410-420

مصطلحات موضوعية: Dansyl Compounds, Chromatography, Accurate estimation, Calibration curve, Chromogenic, General Chemistry, Chromophore, Mass spectrometry, Mass Spectrometry, p-Dimethylaminoazobenzene, chemistry.chemical_compound, Solid-phase synthesis, chemistry, Calibration, polycyclic compounds, Molecule, Indicators and Reagents, Spectrophotometry, Ultraviolet, Chromatography, High Pressure Liquid, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0035b6e96812ccd292af027b1138b089
https://doi.org/10.1021/cc0001147

المؤلفون: Paola Zarantonello, Fabrizio Micheli, Aldo Feriani, Alfredo Paio, Alfonso Pozzan, Fabio Degiorgis, Pierfausto Seneci

المصدر: Journal of Combinatorial Chemistry. 3:224-228

مصطلحات موضوعية: Scaffold, Magnetic Resonance Spectroscopy, Bacteria, Thiazepines, Chemistry, General Chemistry, Computational biology, Mass Spectrometry, Anti-Bacterial Agents, Solutions, Combinatorial Chemistry Techniques, Indicators and Reagents, Spectrophotometry, Ultraviolet, Chromatography, High Pressure Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96de4f951479e0f9b976123395799173
https://doi.org/10.1021/cc0000949

المؤلفون: Maria Pia Catalani, Alfredo Paio, Lorenzo Perugini

المصدر: Tetrahedron Letters. 51:6783-6785

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Organic Chemistry, Drug Discovery, Chlorine atom, Pyridine, Organic chemistry, Moiety, Biochemistry, Medicinal chemistry, Coupling reaction, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5242627eb812c437c33489072cf65114
https://doi.org/10.1016/j.tetlet.2010.10.119