المؤلفون: Alexandra Robciuc, Tuulia Hyötyläinen, Matti Jauhiainen, Juha M. Holopainen

المصدر: Journal of Lipid Research, Vol 53, Iss 11, Pp 2286-2295 (2012)

مصطلحات موضوعية: liquid chromatography-mass spectrometry, cornea, proinflammatory cytokines, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520412465; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/c113d2dc4edb4cb29e6c30ee4766eb10

المؤلفون: Niko L. Setälä, Juha M. Holopainen, Jari Metso, Gebrenegus Yohannes, Jaakko Hiidenhovi, Leif C. Andersson, Ove Eriksson, Alexandra Robciuc, Matti Jauhiainen

المصدر: Journal of Lipid Research, Vol 51, Iss 11, Pp 3126-3134 (2010)

مصطلحات موضوعية: lipid transfer, tear lipid film, lacrimal gland, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520409460; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/5f78059cd14443ad8c079fb2087d4d9f

المؤلفون: Alexandra Robciuc, Hanna Savolainen-Peltonen, Mikko Haanpää, Jukka A. O. Moilanen, Tomi S. Mikkola

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14864

مصطلحات موضوعية: tear fluid, steroid hormones, estrogen, testosterone, mass spectrometry, high performance liquid chromatography

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Biochemistry; https://dx.doi.org/10.3390/ijms232314864

الاتاحة: https://doi.org/10.3390/ijms232314864

المؤلفون: Alexandra Robciuc, Corinna Sanwald, Susanne K. Wiedmer, Suvi-Katriina Ruokonen, Michael Lämmerhofer

المساهمون: Silmäklinikka, Clinicum, Department of Ophthalmology and Otorhinolaryngology, HUS Head and Neck Center, Department of Chemistry, Susanne Wiedmer / Principal Investigator

المصدر: Talanta. 197:472-481

مصطلحات موضوعية: Cell Survival, OF-FLIGHT INSTRUMENT, 116 Chemical sciences, CHROMATOGRAPHY, Ionic Liquids, Toxicometabolomics, 02 engineering and technology, 01 natural sciences, SEQUENTIAL WINDOW ACQUISITION, Analytical Chemistry, Ion, Human corneal epithelial cells, Structure-Activity Relationship, chemistry.chemical_compound, Metabolomics, Data-independent acquisition, Tandem Mass Spectrometry, Partial least squares regression, Humans, AMINO-ACIDS, CYTOTOXICITY, 3125 Otorhinolaryngology, ophthalmology, COMBINATION, Cells, Cultured, chemistry.chemical_classification, Chromatography, Untargeted metabolomics, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Hydrophilic interaction chromatography, 010401 analytical chemistry, Targeted metabolomics, MS, QUANTIFICATION, PERFORMANCE, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Amino acid, Ionic liquid, Mass spectrum, 0210 nano-technology, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb309c8588772f5b06a9db40105f181
https://doi.org/10.1016/j.talanta.2019.01.054

المؤلفون: Alexandra Robciuc, Antti H Rantamäki, Matti Jauhiainen, Juha M Holopainen, Juha M Holopai-Nen

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://iovs.arvojournals.org/data/Journals/IOVS/932988/i1552-5783-55-1-16.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1081.6309; http://iovs.arvojournals.org/data/Journals/IOVS/932988/i1552-5783-55-1-16.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1081.6309
http://iovs.arvojournals.org/data/Journals/IOVS/932988/i1552-5783-55-1-16.pdf

المؤلفون: Riku P. J. Arvola, Juha M. Holopainen, Alexandra Robciuc, Matti Jauhiainen

المصدر: Eye. 32:813-819

مصطلحات موضوعية: Serum, 0301 basic medicine, Polymers, Dry Eye Syndromes, Matrix (biology), Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, In vivo, Laboratory Study, Humans, Medicine, Inducer, Cells, Cultured, Cell Proliferation, Wound Healing, business.industry, Regeneration (biology), Epithelium, Corneal, Epithelial Cells, In vitro, Epithelium, 3. Good health, Ophthalmology, 030104 developmental biology, medicine.anatomical_structure, 030221 ophthalmology & optometry, Cytokines, Heparitin Sulfate, Ophthalmic Solutions, business, Wound healing

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb85fec9d879e764c773631e7a72b9c8
https://doi.org/10.1038/eye.2017.277

المؤلفون: Suvi-Katriina Ruokonen, Juha M. Holopainen, Susanne K. Wiedmer, Joanna Witos, Alexandra Robciuc, Antti H. Rantamäki, Pierre Jean Pisella

المصدر: Cornea. 36:1249-1255

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Cell Survival, Thiazines, Apoptosis, Pharmacology, Cell Line, Membrane Lipids, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Antihypertensive Agents, Intraocular Pressure, Corneal epithelium, Sulfonamides, Liposome, Chemistry, Endoplasmic reticulum, Cell Membrane, Epithelium, Corneal, Pilocarpine, Electrophoresis, Capillary, Glaucoma, 3. Good health, Ophthalmology, 030104 developmental biology, medicine.anatomical_structure, Cell culture, Brimonidine Tartrate, Liposomes, Prostaglandins F, Synthetic, Toxicity, Timolol, 030221 ophthalmology & optometry, Latanoprost, Ocular Hypertension, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153b504978418e2cc94a577829c18514
https://doi.org/10.1097/ico.0000000000001322

المؤلفون: Riku P. J. Arvola, Alexandra Robciuc, Juha M. Holopainen

المصدر: Cornea. 35:451-455

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Visual acuity, genetic structures, Administration, Topical, Fluorophotometry, Cornea, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Prospective Studies, Corneal Ulcer, Prospective cohort study, Aged, Glycosaminoglycans, Aged, 80 and over, Wound Healing, Guided Tissue Regeneration, business.industry, Regeneration (biology), Middle Aged, Corneal perforation, medicine.disease, corneal ulcer, eye diseases, Extracellular Matrix, 3. Good health, Surgery, Ophthalmology, medicine.anatomical_structure, Trigeminal Nerve Diseases, 030220 oncology & carcinogenesis, 030221 ophthalmology & optometry, Female, sense organs, Ophthalmic Solutions, medicine.symptom, Wound healing, business, Tomography, Optical Coherence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925537bb516b2b5ce14be47c9ee42054
https://doi.org/10.1097/ico.0000000000000759

المؤلفون: Antti H. Rantamäki, Sami Hietala, Corinna Sanwald, Suvi-Katriina Ruokonen, Michael Lämmerhofer, Susanne K. Wiedmer, Joanna Witos, Alexandra Robciuc, Alistair W. T. King

المساهمون: Department of Chemistry, University of Helsinki, Silmäklinikka, Clinicum, Susanne Wiedmer / Principal Investigator, Polymers, HUS Head and Neck Center

المصدر: Ruokonen, S K, Sanwald, C, Robciuc, A, Hietala, S, Rantamäki, A H, Witos, J, King, A W T, Lämmerhofer, M & Wiedmer, S K 2018, ' Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions ', Chemistry-A European Journal, vol. 24, no. 11, pp. 2669-2680 . https://doi.org/10.1002/chem.201704924

مصطلحات موضوعية: Erythrocytes, Magnetic Resonance Spectroscopy, IMPACT, 116 Chemical sciences, 02 engineering and technology, MEMBRANES, 01 natural sciences, Micelle, Epithelium, TOXICITY, ionic liquids, chemistry.chemical_compound, Zeta potential, Lipid bilayer, Cytotoxicity, Liposome, Calorimetry, Differential Scanning, BIOLUMINESCENCE, Epithelium, Corneal, Aliivibrio fischeri/drug effects, 021001 nanoscience & nanotechnology, Aliivibrio fischeri, Membrane, SOLUBILIZATION, cytotoxicity, 0210 nano-technology, Liposomes/chemistry, Corneal/cytology, toxicology, Hemolysis/drug effects, liposomes, Differential Scanning, 010402 general chemistry, Hemolysis, Catalysis, Cell Line, Epithelium, Corneal/cytology, Humans, SCATTERING, Organic Chemistry, General Chemistry, Penetration (firestop), IN-VITRO, AGGREGATION, Erythrocytes/cytology, Dynamic Light Scattering, 0104 chemical sciences, analytical methods, CALORIMETRY, chemistry, Ionic liquid, CELLS, Biophysics, Ionic Liquids/chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac36dfafeacf5e3e4c5be0e390e047d
http://hdl.handle.net/10138/307532

المؤلفون: Ilkka Kilpeläinen, Alistair W. T. King, Susanne K. Wiedmer, Juha M. Holopainen, Alexandra Robciuc, Jana Lokajová, Suvi-Katriina Mikkola, Michael Lämmerhofer, Ashley J. Holding

المصدر: Mikkola, S K, Robciuc, A, Lokajová, J, Holding, A J, Lämmerhofer, M, Kilpeläinen, I, Holopainen, J M, King, A W T & Wiedmer, S K 2015, ' Impact of amphiphilic biomass-dissolving ionic liquids on biological cells and liposomes ', Environmental Science and Technology, vol. 49, no. 3, pp. 1870-1878 . https://doi.org/10.1021/es505725g

مصطلحات موضوعية: Cell Survival, Ionic Liquids, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Cell Line, chemistry.chemical_compound, Capillary electrophoresis, Dynamic light scattering, Amphiphile, Escherichia coli, Humans, Environmental Chemistry, Organic chemistry, Biomass, Surface charge, Phosphonium, Liposome, Electrophoresis, Capillary, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Solubility, chemistry, Chemical engineering, Critical micelle concentration, Liposomes, Ionic liquid, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b337c9064438b8bee85912c7b644da
https://doi.org/10.1021/es505725g

المؤلفون: Juha M. Holopainen, Katri Koli, Sirpa Loukovaara, Kaisa Lehti, Timo Pessi, Ilkka Immonen, Alexandra Robciuc, Jorma Keski-Oja

المصدر: Graefe's Archive for Clinical and Experimental Ophthalmology. 252:881-888

مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, Proliferative vitreoretinopathy, medicine.medical_specialty, genetic structures, Enzyme-Linked Immunosorbent Assay, Angiopoietin-2, Transforming Growth Factor beta1, Pathogenesis, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Ophthalmology, Angiopoietin-1, Humans, Medicine, Prospective Studies, Erythropoietin, Macular hole, Aged, business.industry, Retinal Detachment, Retinal detachment, Middle Aged, medicine.disease, Matrix Metalloproteinases, eye diseases, Sensory Systems, Vitreous Body, Vascular endothelial growth factor, Endothelial stem cell, chemistry, Female, sense organs, business, Biomarkers, medicine.drug, Transforming growth factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5eefca704aa2d6f59d46dbc7298046
https://doi.org/10.1007/s00417-013-2508-z

المؤلفون: Katri Koli, Sirpa Loukovaara, Johanna Liinamaa, Kaisa Lehti, Timo Pessi, Kirsi-Tiina Kukkonen, Alexandra Robciuc, Juha M. Holopainen, Matti Jauhiainen, Jorma Keski-Oja, Ilkka Immonen

المصدر: Acta Ophthalmologica. 91:531-539

مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Angiogenesis, medicine.medical_treatment, Vesicular Transport Proteins, Enzyme-Linked Immunosorbent Assay, Vitrectomy, Retinal Neovascularization, Proinflammatory cytokine, Transforming Growth Factor beta1, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Angiopoietin-1, medicine, Humans, Prospective Studies, Erythropoietin, Aged, 030304 developmental biology, 0303 health sciences, Diabetic Retinopathy, business.industry, General Medicine, Diabetic retinopathy, Middle Aged, Retinal Perforations, medicine.disease, Up-Regulation, Vitreous Body, Vascular endothelial growth factor, Ophthalmology, Diabetes Mellitus, Type 1, Endocrinology, Diabetes Mellitus, Type 2, Matrix Metalloproteinase 9, chemistry, 030221 ophthalmology & optometry, Matrix Metalloproteinase 2, Female, business, Tomography, Optical Coherence, medicine.drug, Retinopathy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0f514a8078796bd1a7775a37117c51
https://doi.org/10.1111/j.1755-3768.2012.02473.x

المؤلفون: Alexandra Robciuc, Juha M. Holopainen, Susanne K. Wiedmer, Juhani Kronholm, Tuulia Hyötyläinen

المصدر: Journal of Separation Science. 35:1845-1853

مصطلحات موضوعية: 0303 health sciences, Programmed cell death, Ceramide, Chromatography, medicine.diagnostic_test, Chemistry, 010401 analytical chemistry, Filtration and Separation, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Membrane, Biochemistry, Lipidomics, medicine, lipids (amino acids, peptides, and proteins), Gas chromatography–mass spectrometry, Sphingomyelin, Lipid profile, 030304 developmental biology, Lipoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7bb930035b7941da680b661db3b79dc2
https://doi.org/10.1002/jssc.201200252

المؤلفون: Anca V. Sima, Claudia Musina, Gabriela Botez, Camelia S. Stancu, Maya Simionescu, Alexandra Robciuc, Constantina Heltianu

المصدر: Cell Biochemistry and Biophysics. 61:209-216

مصطلحات موضوعية: Glycation End Products, Advanced, Agonist, medicine.medical_specialty, Hydrocarbons, Fluorinated, medicine.drug_class, Myocytes, Smooth Muscle, Biophysics, Peroxisome proliferator-activated receptor, Biochemistry, Gene Expression Regulation, Enzymologic, Internal medicine, medicine, Humans, Liver X receptor, Fatty acid homeostasis, Liver X Receptors, chemistry.chemical_classification, Sulfonamides, Endothelial Cells, Cell Biology, General Medicine, Sterol Esterase, Orphan Nuclear Receptors, Lipoproteins, LDL, PPAR gamma, Endothelial stem cell, Enzyme, Endocrinology, chemistry, lipids (amino acids, peptides, and proteins), Signal transduction, Rosiglitazone, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6541171ec04f5644a5dfebf6f9636511
https://doi.org/10.1007/s12013-011-9190-8

المؤلفون: Matti Jauhiainen, Juha M. Holopainen, Alexandra Robciuc, Leif C. Andersson, Gebrenegus Yohannes, Niko L. Setälä, Jaakko Hiidenhovi, Jari Metso, Ove Eriksson

المساهمون: Silmäklinikka, Department of Chemistry, Department of Pathology, Research Programme for Molecular Neurology, Medicum, Research Programs Unit, Institute for Molecular Medicine Finland

المصدر: Journal of Lipid Research, Vol 51, Iss 11, Pp 3126-3134 (2010)

مصطلحات موضوعية: Meibomian gland, Plasma protein binding, Biochemistry, Substrate Specificity, 0302 clinical medicine, Endocrinology, Phospholipid transfer protein, 311 Basic medicine, Phospholipid Transfer Proteins, Research Articles, 0303 health sciences, medicine.diagnostic_test, Chemistry, LIPOCALINS, Lacrimal Apparatus, 3. Good health, Blot, CORNEAL SURFACE, medicine.anatomical_structure, MEIBOMIAN GLAND, Dry Eye Syndromes, LIPIDS, Protein Binding, EXPRESSION, tear lipid film, GENES, education, QD415-436, Lacrimal apparatus, 03 medical and health sciences, Western blot, Affinity chromatography, medicine, Animals, Humans, lipid transfer, 030304 developmental biology, Heparin, Mucin, Mucins, OCULAR SURFACE, Cell Biology, eye diseases, lacrimal gland, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tears, PLTP, 030221 ophthalmology & optometry, OVOMUCIN, Cattle, sense organs

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff5ec7496be953962b8df91abb9c0c0
http://www.sciencedirect.com/science/article/pii/S0022227520409460

المؤلفون: Simona-Adriana Manea, Cristian Guja, Constantin Ionescu-Tirgoviste, Alexandra Robciuc, Constantina Heltianu

المصدر: Open Life Sciences, Vol 4, Iss 4, Pp 521-527 (2009)

مصطلحات موضوعية: medicine.medical_specialty, Diabetic neuropathy, type 1 diabetes, QH301-705.5, Biology, low molecular weight-ages, General Biochemistry, Genetics and Molecular Biology, Nitric oxide, chemistry.chemical_compound, Enos, nitric oxide, Internal medicine, Diabetes mellitus, Genotype, medicine, Endothelial dysfunction, Biology (General), Type 1 diabetes, General Immunology and Microbiology, medicine.diagnostic_test, General Neuroscience, medicine.disease, biology.organism_classification, Endocrinology, enos polymorphisms, chemistry, neuropathy, General Agricultural and Biological Sciences, Lipid profile

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab4d3e66720da41faa1aec287bb4f16
https://doaj.org/article/54244dca8fe34257b925285c4d9392e7

المؤلفون: Matti Jauhiainen, Juha M. Holopainen, Alexandra Robciuc, Antti H. Rantamäki

المصدر: Investigative ophthalmologyvisual science. 55(1)

مصطلحات موضوعية: Adult, Male, Chemistry, Blotting, Western, Epithelium, Corneal, Inflammation, Sphingolipid, Epithelium, Proinflammatory cytokine, Cell biology, medicine.anatomical_structure, Sphingomyelin Phosphodiesterase, Stress, Physiological, Tears, medicine, Extracellular, Ceramidases, Humans, Secretion, Female, sense organs, medicine.symptom, Homeostasis, Cells, Cultured, Corneal epithelium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d5aa38bda9ddde22712409d4a59547
https://pubmed.ncbi.nlm.nih.gov/24302584

المؤلفون: Matti Jauhiainen, Alexandra Robciuc, Tuulia Hyötyläinen, Juha M. Holopainen

المصدر: Robciuc, A, Hyötyläinen, T, Jauhiainen, M & Holopainen, J M 2013, ' Ceramides in the pathophysiology of the anterior segment of the eye ', Current Eye Research, vol. 38, no. 10, pp. 1006-1016 . https://doi.org/10.3109/02713683.2013.810273

مصطلحات موضوعية: Ceramide, Eye Diseases, Biology, anterior segment, Ceramides, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Anterior Eye Segment, Lipidomics, Animals, Humans, ceramide, 030304 developmental biology, 0303 health sciences, sphingolipids, Lipid metabolism, Lipid Metabolism, Sphingolipid, eye, Sensory Systems, Pathophysiology, 3. Good health, Ophthalmology, Biochemistry, chemistry, Biological significance, 030221 ophthalmology & optometry, lipidomics, Neuroscience, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a45be704fed13ecf048df1416e77fe2
https://pubmed.ncbi.nlm.nih.gov/23885886

المؤلفون: Maria Fernanda Suarez, Julio A Urrets-Zavalia, Juha M. Holopainen, Khalid F. Tabbara, Thamara A. Cafaro, Timo Sorsa, Taina Tervahartiala, Horacio M. Serra, Alexandra Robciuc, Yrjö T. Konttinen, Hind M. Alkatan

المصدر: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

مصطلحات موضوعية: Male, Gelatinases, CIENCIAS MÉDICAS Y DE LA SALUD, medicine.medical_treatment, CDK, Blotting, Western, Inmunología, Enzyme-Linked Immunosorbent Assay, Matrix metalloproteinase, GELATINASES, Proinflammatory cytokine, Corneal Diseases, 03 medical and health sciences, 0302 clinical medicine, Cyclin-dependent kinase, medicine, Gelatinase, Humans, Cells, Cultured, 030304 developmental biology, Corneal epithelium, Aged, Inflammation, 0303 health sciences, biology, CYTOKINES, CORNEA, Epithelium, Corneal, purl.org/becyt/ford/3.1 [https], Middle Aged, Molecular biology, Immunohistochemistry, Medicina Básica, medicine.anatomical_structure, Cytokine, Matrix Metalloproteinase 9, Tears, Immunology, 030221 ophthalmology & optometry, biology.protein, Cytokines, Matrix Metalloproteinase 2, Cytokine secretion, Female, purl.org/becyt/ford/3 [https], sense organs, Follow-Up Studies

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ad4743f5684d320057533b9700070c
https://www.ncbi.nlm.nih.gov/pubmed/22570354

المؤلفون: Simona-Adriana Manea, Alexandra Robciuc, Cristian Guja, Constantina Heltianu

المصدر: Biochemical and biophysical research communications. 407(3)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Nitric Oxide Synthase Type III, Biophysics, Type 2 diabetes, Biochemistry, Receptor, Angiotensin, Type 1, Nephropathy, Diabetic nephropathy, Internal medicine, medicine, Humans, cardiovascular diseases, Obesity, Allele, Molecular Biology, Aged, Aged, 80 and over, Polymorphism, Genetic, Endothelin-1, business.industry, Incidence (epidemiology), Microangiopathy, Cell Biology, Middle Aged, medicine.disease, body regions, Endocrinology, Diabetes Mellitus, Type 2, cardiovascular system, ras Proteins, Female, Gene polymorphism, business, Diabetic Angiopathies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ded3f2e788a8c873c5d0482f1a8f6c
https://pubmed.ncbi.nlm.nih.gov/21406182