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1Academic JournalPre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47
المؤلفون: Jessica P Wiseman, Joseph M Scarrott, João Alves-Cruzeiro, Afshin Saffari, Cedric Böger, Evangelia Karyka, Emily Dawes, Alexandra K Davies, Paolo M Marchi, Emily Graves, Fiona Fernandes, Zih-Liang Yang, Ian Coldicott, Jennifer Hirst, Christopher P Webster, J Robin Highley, Neil Hackett, Adrienn Angyal, Thushan de Silva, Adrian Higginbottom, Pamela J Shaw, Laura Ferraiuolo, Darius Ebrahimi-Fakhari, Mimoun Azzouz
المصدر: EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2882-2917 (2024)
مصطلحات موضوعية: AAV, AP4B1, Gene Therapy, HSP, SPG47, Medicine (General), R5-920, Genetics, QH426-470
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1757-4684
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2Academic Journal
المؤلفون: Afshin Saffari, Barbara Brechmann, Cedric Böger, Wardiya Afshar Saber, Hellen Jumo, Dosh Whye, Delaney Wood, Lara Wahlster, Julian E. Alecu, Marvin Ziegler, Marlene Scheffold, Kellen Winden, Jed Hubbs, Elizabeth D. Buttermore, Lee Barrett, Georg H. H. Borner, Alexandra K. Davies, Darius Ebrahimi-Fakhari, Mustafa Sahin
المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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3Academic Journal
المؤلفون: Julia P. Schessner, Vincent Albrecht, Alexandra K. Davies, Pavel Sinitcyn, Georg H. H. Borner
المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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4Academic Journal
المؤلفون: Alexandra K. Davies, Julian E. Alecu, Marvin Ziegler, Catherine G. Vasilopoulou, Fabrizio Merciai, Hellen Jumo, Wardiya Afshar-Saber, Mustafa Sahin, Darius Ebrahimi-Fakhari, Georg H. H. Borner
المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
مصطلحات موضوعية: Science
Relation: https://doi.org/10.1038/s41467-022-28609-w; https://doaj.org/toc/2041-1723; https://doaj.org/article/97b080cc62e14bdea601680868183e75
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5
المؤلفون: Pablo Rodríguez-Silvestre, Marco Laub, Alexandra K. Davies, Julia P. Schessner, Patrycja A. Krawczyk, Benjamin J. Tuck, William A. McEwan, Georg H.H. Borner, Patrycja Kozik
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6Academic Journal
المؤلفون: Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, Georg H. H. Borner
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
مصطلحات موضوعية: Science
Relation: https://doi.org/10.1038/s41467-018-06172-7; https://doaj.org/toc/2041-1723; https://doaj.org/article/ff52a2aa9d09459f8fa30ecd00dc3289
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7
المؤلفون: Barbara Brechmann, Sandrine Vuillaumier-Barrot, Kathrin Eberhardt, Mohammad Ali Faghihi, Jennifer Hirst, Jan De Bleecker, Lee Barrett, Stéphane Auvin, Afshin Saffari, Filippo M. Santorelli, Julian E. Alecu, Bernt Popp, Sonja Neuser, Darius Ebrahimi-Fakhari, Alexandra K Davies, Angelica D'Amore, Parham Habibzadeh, Hellen Jumo, Edward Yang, Marvin Ziegler, Mustafa Sahin
المساهمون: Ebrahimi-Fakhari, D [0000-0002-0026-4714], Habibzadeh, P [0000-0002-2086-0425], Auvin, S [0000-0003-3874-9749], Popp, B [0000-0002-3679-1081], Yang, E [0000-0002-9912-4163], Apollo - University of Cambridge Repository
المصدر: Brain Communications
مصطلحات موضوعية: Hereditary spastic paraplegia, Biology, 03 medical and health sciences, 0302 clinical medicine, medicine, high-throughput imaging, Missense mutation, hereditary spastic paraplegia, 030304 developmental biology, 0303 health sciences, AcademicSubjects/SCI01870, General Engineering, Signal transducing adaptor protein, Adaptor Signaling Protein, medicine.disease, Subcellular localization, Molecular biology, Transmembrane protein, Biomarker (cell), Cytoplasm, biomarker, Original Article, AcademicSubjects/MED00310, adaptor protein complex 4, 030217 neurology & neurosurgery, functional assay
وصف الملف: application/pdf; application/zip
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8
مصطلحات موضوعية: Profiling (computer programming), Workflow, Endosome, Computer science, Proteome, Benchmark (computing), Data-independent acquisition, Subcellular localization, Biological system, Proteomics
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9
المؤلفون: Georg H. H. Borner, Alexandra K Davies, Darius Ebrahimi-Fakhari, Wardiya Afshar Saber, Marvin Ziegler, Hellen Jumo
مصطلحات موضوعية: chemistry.chemical_classification, Autophagy, Signal transducing adaptor protein, Biology, Endocannabinoid system, Anterograde axonal transport, Cell biology, Vesicular transport protein, medicine.anatomical_structure, Enzyme, nervous system, chemistry, medicine, Axon, Diacylglycerol kinase
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10
المؤلفون: Miriam Wimmer, Mustafa Sahin, Henry Houlden, Elizabeth D. Buttermore, Joseph M. Scarrott, Antje Wiesener, Agathe Roubertie, Teresa Chen, Margaret S. Robinson, Sofia T. Duarte, Thomas Bourinaris, Robert Behne, Lee Barrett, Jonathan O. Lipton, Devorah Segal, James T. Bennett, Darius Ebrahimi-Fakhari, Jennifer Hirst, Julian Teinert, Andrea Martinuzzi, Kathrin Eberhardt, Angelica D'Amore, Filippo M. Santorelli, Barbara Brechmann, Georg H. H. Borner, Sean Dwyer, Ivy Pin-Fang Chen, Alexandra K Davies, Mimoun Azzouz
المصدر: Hum Mol Genet
مصطلحات موضوعية: Autophagosome, Male, Neurite, Adolescent, Protein subunit, Adaptor Protein Complex 4, Iron, Neurogenesis, Induced Pluripotent Stem Cells, Vesicular Transport Proteins, Autophagy-Related Proteins, Biology, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Loss of Function Mutation, Genetics, medicine, Autophagy, Humans, Adaptor Protein Complex beta Subunits, Child, Molecular Biology, Genetics (clinical), 030304 developmental biology, Neurons, 0303 health sciences, Spastic Paraplegia, Hereditary, Neurodegeneration, Autophagosomes, Signal transducing adaptor protein, Adaptor Signaling Protein, Membrane Proteins, General Medicine, Fibroblasts, medicine.disease, Transport protein, Cell biology, Mitochondria, Protein Transport, Child, Preschool, Female, General Article, Microtubule-Associated Proteins, 030217 neurology & neurosurgery, trans-Golgi Network
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11
المصدر: Journal of cell science. 132(20)
مصطلحات موضوعية: Cell, Biology, Endocytosis, Clathrin, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, medicine, Animals, Humans, 030304 developmental biology, 0303 health sciences, Vesicle, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Genetic Diseases, Inborn, Signal transducing adaptor protein, Cell Biology, Golgi apparatus, Cell biology, Adaptor Proteins, Vesicular Transport, medicine.anatomical_structure, Membrane protein, biology.protein, symbols, 030217 neurology & neurosurgery, Function (biology)
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12
المؤلفون: Amy Kendall, Meredith N. Frazier, Markus Voehler, Margaret S. Robinson, Walter J. Chazin, Georg H. H. Borner, Alexandra K Davies, Lauren P. Jackson
المصدر: Traffic. 17:400-415
مصطلحات موضوعية: 0301 basic medicine, Adaptor Protein Complex 4, Protein subunit, Coated vesicle, Plasma protein binding, Biology, Biochemistry, Article, 03 medical and health sciences, Structural Biology, Genetics, Humans, Point Mutation, Binding site, Molecular Biology, Binding Sites, Point mutation, HEK 293 cells, Signal transducing adaptor protein, Cell Biology, Cell biology, HEK293 Cells, 030104 developmental biology, Structural biology, sense organs, HeLa Cells, Protein Binding
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13
المؤلفون: A.I Assis-Pandochi, David J. Seilly, A.P.G Landi, Virgínia Paes Leme Ferriani, Alexandra K Davies, Anne B. Wilson, Peter J. Lachmann
المصدر: Immunology Letters. 90:209-213
مصطلحات موضوعية: Adult, Adolescent, Glycosylphosphatidylinositols, Octoxynol, Immunology, CD59 Antigens, Enzyme-Linked Immunosorbent Assay, CD59, Diluent, Polyethylene Glycols, chemistry.chemical_compound, Glucosides, medicine, Humans, Immunology and Allergy, Octyl glucoside, chemistry.chemical_classification, Chromatography, medicine.diagnostic_test, Infant, Enzyme, chemistry, Biochemistry, Child, Preschool, Immunoassay, CD59 antigen, Complement membrane attack complex, Lipoprotein
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14
المصدر: Infection and Immunity. 70:4908-4916
مصطلحات موضوعية: Streptococcus pyogenes, Immunology, Proteinase Inhibitory Proteins, Secretory, In Vitro Techniques, medicine.disease_cause, Microbiology, chemistry.chemical_compound, Complement Inactivator Proteins, Bacterial Proteins, stomatognathic system, medicine, Animals, Humans, Secretory Leukocyte Peptidase Inhibitor, Enzyme Inhibitors, Immunity, Mucosal, chemistry.chemical_classification, Cellular Microbiology: Pathogen-Host Cell Molecular Interactions, biology, Lactoferrin, Proteins, Biological activity, Immunity, Innate, Recombinant Proteins, In vitro, Infectious Diseases, Enzyme, chemistry, Biochemistry, biology.protein, Thermodynamics, Muramidase, Parasitology, Lysozyme, Chickens, Protein Binding, SLPI
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15
المؤلفون: Daniel L. Gustafson, Alexandra K Davies, B.A. Fernie, A.B. Wilson, Diane Vannais, C. Willers, Charles A. Waldren
المصدر: Experimental and Clinical Immunogenetics. 18:71-79
مصطلحات موضوعية: Molecular Sequence Data, Immunology, Population, CD59 Antigens, chemical and pharmacologic phenomena, CHO Cells, Arginine, medicine.disease_cause, Epitope, HeLa, Methionine, Cricetinae, Complementary DNA, Genetics, medicine, Animals, Humans, Amino Acid Sequence, education, Genetics (clinical), Mutation, education.field_of_study, Polymorphism, Genetic, biology, cDNA library, Chinese hamster ovary cell, Complement System Proteins, Sequence Analysis, DNA, biology.organism_classification, Molecular biology, Rats, Amino Acid Substitution, Cell culture, Epitopes, B-Lymphocyte, Rabbits, HeLa Cells
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16
المؤلفون: Anne B. Wilson, David J. Seilly, Diane Vannais, Alexandra K Davies, Tom K. Hei, Charles A. Waldren, Megan McGraw, Christine Willers
المصدر: Somatic Cell and Molecular Genetics. 25:147-157
مصطلحات موضوعية: biology, CD46, C4A, chemical and pharmacologic phenomena, Cell Biology, CD59, FOSL1, Molecular biology, Epitope, Antigen, Genetics, biology.protein, Antibody, Gene
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17
المؤلفون: Alexandra K Davies, Peter J. Lachmann
المصدر: Immunological Reviews. 159:69-77
مصطلحات موضوعية: viruses, Immunology, Proteins, chemical and pharmacologic phenomena, Complement System Proteins, Complement receptor, biochemical phenomena, metabolism, and nutrition, Biology, Virology, Receptors, Complement, Complement (complexity), Complement system, Viral Proteins, Classical complement pathway, Immune system, Virus Diseases, Immunity, Viruses, Humoral immunity, Alternative complement pathway, Animals, Humans, Receptors, Virus, Immunology and Allergy
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18
المؤلفون: Joanne M Elloway, Alexandra K Davies, Julie Hayes, Ann T. Doherty
المصدر: Toxicological Sciences. :kfx014
مصطلحات موضوعية: 0301 basic medicine, Genetics, Chromosome, Aneuploidy, Biology, Toxicology, medicine.disease, 03 medical and health sciences, Spindle poison, 030104 developmental biology, Nondisjunction, Micronucleus test, Centromere, medicine, Aneugen, Anaphase, medicine.drug
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19
المؤلفون: Alexandra K Davies, Peter J. Lachmann
المصدر: Immunologic Research. 12
مصطلحات موضوعية: Complement Inactivator Proteins, Membrane Glycoproteins, biology, Complement component 2, CD46, T-Lymphocytes, Complement receptor 1, Immunology, CD59 Antigens, Complement Membrane Attack Complex, Complement receptor, Complement system, Cell biology, Complement inhibitor, Immune System Diseases, Biochemistry, Antigens, CD, biology.protein, Animals, Humans, Tissue Distribution, biology.gene, Complement membrane attack complex, Complement Activation, Complement control protein
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20
المؤلفون: G.A. Butcher, R.E. Sinden, Alexandra K Davies, Peter J. Lachmann, G. Margos
المصدر: Immunopharmacology. 49:73
مصطلحات موضوعية: Pharmacology, Vector (epidemiology), medicine, Parasite hosting, Biology, medicine.disease, Virology, Malaria, Complement (complexity)