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1
المؤلفون: Sylvie Gomez, Karine Malagu, Thomas Presnot, Sally Ewen, Mihiro Sunose, Xiao-Ling Fan Cockcroft, Niall M. B. Martin, Alexandra Fundo, Armelle Le Gall, Keith Allan Menear, Hermann Gesine Johanna, Luisa Sebastian, Kristel Blackburn, Ian Hickson, Christine Bailey, Graeme C. M. Smith, Eleanor Torode, Kurt Gordon Pike
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:5898-5901
مصطلحات موضوعية: Morpholines, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Non-specific serine/threonine protein kinase, Biochemistry, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Humans, Protein Kinase Inhibitors, Molecular Biology, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, biology, Triazines, Kinase, Chemistry, TOR Serine-Threonine Kinases, Organic Chemistry, Pyrimidines, Enzyme, Enzyme inhibitor, Benzene derivatives, biology.protein, Molecular Medicine, Signal transduction, Pharmacophore, Protein Kinases
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2
المؤلفون: Claire Adcock, Francisco Cuenca Alonso, Niall M. B. Martin, Chris Mydlowski, Kristel Blackburn, Keith Allan Menear, Louise Copsey, Armelle Le Gall, Sylvie Gomez, Graeme C. M. Smith, Carlos Fenandez Lence, Hashim Javaid, Jan Drzewiecki, Alexandra Fundo
المصدر: Bioorganicmedicinal chemistry letters. 18(14)
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Poly ADP ribose polymerase, Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Poly (ADP-Ribose) Polymerase-1, Pharmaceutical Science, Carboxamide, Poly(ADP-ribose) Polymerase Inhibitors, Biochemistry, Chemical synthesis, Substrate Specificity, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Molecular Structure, Hydrogen bond, Organic Chemistry, NAD+ ADP-Ribosyltransferase, Hydrogen Bonding, Enzyme, chemistry, Models, Chemical, Enzyme inhibitor, Intramolecular force, Drug Design, biology.protein, Molecular Medicine, Poly(ADP-ribose) Polymerases, HeLa Cells