المؤلفون: Peiqi Yin, Nicholas A. May, Laura Sandra Lello, Atef Fayed, M. Guston Parks, Adam M. Drobish, Sainan Wang, Meghan Andrews, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Andres Merits, Margaret Kielian, Thomas E. Morrison

المصدر: mBio, Vol 15, Iss 6 (2024)

مصطلحات موضوعية: alphavirus, chikungunya virus, mayaro virus, antiviral, RNA replication, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2150-7511

URL الوصول: https://doaj.org/article/dfff5e12899b43dd9c8db8e7247e88db

المؤلفون: Robert M. Cox, Josef D. Wolf, Nicole A. Lieberman, Carolin M. Lieber, Hae-Ji Kang, Zachary M. Sticher, Jeong-Joong Yoon, Meghan K. Andrews, Mugunthan Govindarajan, Rebecca E. Krueger, Elizabeth B. Sobolik, Michael G. Natchus, Andrew T. Gewirtz, Rik L. deSwart, Alexander A. Kolykhalov, Khan Hekmatyar, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/c318e8440b28489e92886789df7a2812

المؤلفون: Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Amirhossein Karimi, Nicole A. P. Lieberman, Zachary M. Sticher, Pavitra Roychoudhury, Meghan K. Andrews, Rebecca E. Krueger, Michael G. Natchus, George R. Painter, Alexander A. Kolykhalov, Alexander L. Greninger, Richard K. Plemper

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/61d1e30d9f164794bdecb43d97a77a87

المؤلفون: Carolin M Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K Johnson, Cheryl A Jones, Zachary M Sticher, Alexander A Kolykhalov, Manohar T Saindane, Stephen M Tompkins, Oliver Planz, George R Painter, Michael G Natchus, Kaori Sakamoto, Richard K Plemper

المصدر: PLoS Pathogens, Vol 19, Iss 4, p e1011342 (2023)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/6936c60659ba4a96b921b668517dfbee

المؤلفون: Julien Sourimant, Carolin M. Lieber, Megha Aggarwal, Robert M. Cox, Josef D. Wolf, Jeong-Joong Yoon, Mart Toots, Chengin Ye, Zachary Sticher, Alexander A. Kolykhalov, Luis Martinez-Sobrido, Gregory R. Bluemling, Michael G. Natchus, George R. Painter, Richard K. Plemper

المصدر: bioRxiv
Science

مصطلحات موضوعية: Transcription, Genetic, Uracil Nucleotides, viruses, Administration, Oral, Microbial Sensitivity Tests, Respiratory Mucosa, Respiratory Syncytial Virus Infections, Virus Replication, Antiviral Agents, Article, Cell Line, Mice, Animals, Humans, Mice, Inbred BALB C, Multidisciplinary, Coronavirus RNA-Dependent RNA Polymerase, SARS-CoV-2, fungi, Ferrets, virus diseases, COVID-19, respiratory system, RNA-Dependent RNA Polymerase, respiratory tract diseases, COVID-19 Drug Treatment, Disease Models, Animal, Respiratory Syncytial Virus, Human, Female, Mononegavirales

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9a490333684dc23dc48664090d7f06
https://pubmed.ncbi.nlm.nih.gov/34031658

المؤلفون: Robert M Cox, Carolin M Lieber, Josef D Wolf, Amirhossein Karimi, Nicole A P Lieberman, Zachary M Sticher, Pavitra Roychoudhury, Meghan K Andrews, Rebecca E Krueger, Michael G Natchus, George R Painter, Alexander A Kolykhalov, Alexander L Greninger, Richard K Plemper

المصدر: bioRxiv

مصطلحات موضوعية: Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d826bcf5816628c7ba9b71dc6797bf6
https://pubmed.ncbi.nlm.nih.gov/36451893

المؤلفون: Carolin M. Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M. Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K. Johnson, Cheryl A. Jones, Zachary M. Sticher, Alexander A. Kolykhalov, Manohar T. Saindane, Stephen M. Tompkins, Oliver Planz, George R. Painter, Michael G. Natchus, Kaori Sakamoto, Richard K. Plemper

مصطلحات موضوعية: Virology, Immunology, Genetics, Parasitology, Molecular Biology, Microbiology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b4a0e6406c62c40e4bba51689586e8
https://doi.org/10.1101/2022.11.05.515296

المؤلفون: Gregory R. Bluemling, Shuli Mao, Michael G. Natchus, Wendy Painter, Sabue Mulangu, Mark Lockwood, Abel De La Rosa, Trevor Brasel, Jason E. Comer, Alexander N. Freiberg, Alexander A. Kolykhalov, George R. Painter

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::54dc3248a92fa332815e96410974c759
https://doi.org/10.1101/2022.10.18.512767

المؤلفون: Gregory R, Bluemling, Shuli, Mao, Michael G, Natchus, Wendy, Painter, Sabue, Mulangu, Mark, Lockwood, Abel, De La Rosa, Trevor, Brasel, Jason E, Comer, Alexander N, Freiberg, Alexander A, Kolykhalov, George R, Painter

المصدر: Antiviral research. 209

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::54c76b10578980536022477c62606374
https://pubmed.ncbi.nlm.nih.gov/36379378

المؤلفون: Benhur Lee, Robert M. Cox, Jose R. Marengo, Negar Makhsous, Mart Toots, Jeong-Joong Yoon, Richard K. Plemper, Mugunthan Govindarajan, Satoshi Ikegame, Alexander L. Greninger, Michael G. Natchus, Ruth E. Watkinson, Michelle J. Lin, Julien Sourimant, Zachary M. Sticher, Alexander A. Kolykhalov, Patricia A. Thibault

المصدر: Nature microbiology

مصطلحات موضوعية: Microbiology (medical), viruses, Viral pathogenesis, Immunology, Allosteric regulation, Molecular Conformation, Administration, Oral, Respiratory Mucosa, Adaptive Immunity, Molecular Dynamics Simulation, Antiviral Agents, Applied Microbiology and Biotechnology, Microbiology, Article, Respirovirus, Cell Line, Measles virus, Mice, Structure-Activity Relationship, 03 medical and health sciences, Allosteric Regulation, Genetics, Animals, Humans, Enzyme Inhibitors, Polymerase, 030304 developmental biology, 0303 health sciences, Molecular Structure, biology, 030306 microbiology, Respiratory infection, DNA-Directed RNA Polymerases, Cell Biology, biology.organism_classification, Immunohistochemistry, Virology, Sendai virus, Molecular Docking Simulation, Human Parainfluenza Virus, Cell culture, biology.protein, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52729f7232a684354bf11b7c3674a89
https://doi.org/10.1038/s41564-020-0752-7

المؤلفون: Gregory R. Bluemling, Shuli Mao, Michael G. Natchus, Wendy Painter, Sabue Mulangu, Mark Lockwood, Abel De La Rosa, Trevor Brasel, Jason E. Comer, Alexander N. Freiberg, Alexander A. Kolykhalov, George R. Painter

المصدر: Antiviral Research. 209:105453

مصطلحات موضوعية: Pharmacology, Virology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c23f03f1420e913d1fd5890771076dbf
https://doi.org/10.1016/j.antiviral.2022.105453

المؤلفون: Julien Sourimant, Mart Toots, Carolin M. Lieber, Zachary M. Sticher, Richard K. Plemper, Michael G. Natchus, Alexander A. Kolykhalov, Megha Aggarwal, Robert M. Cox, Luis Martinez-Sobrido, Jeong-Joong Yoon, George R. Painter, Chengjin Ye, Gregory R. Bluemling, Josef D. Wolf

مصطلحات موضوعية: biology, business.industry, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus diseases, RNA, respiratory system, Ribonucleoside, Virology, In vitro, Virus, In vivo, biology.protein, Medicine, Respiratory system, business, Polymerase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7e6df8af719de894a0c1101eb8de1a4b
https://doi.org/10.1101/2021.05.19.444875

المؤلفون: Eric J. Miller, Carrie Q. Sun, Petra Gregorova, Edgars Jecs, Yesim Altas Tahirovic, Robert J. Wilson, Huy H. Nguyen, Savita K. Sharma, Perry Bartsch, Zachary Sticher, Levi Moellering, Priscilla Davidson, Ryan Jajosky, Michael D'Erasmo, Manohar Saindane, Zafer Sahin, Nicholas S. Akins, Alexander A. Kolykhalov, Lawrence Wilson, Rebecca S. Arnold, John A. Petros, Haydn Kissick, Lingjie Xu, Yi Jiang, Dennis C. Liotta

المصدر: Cancer Research. 82:2649-2649

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1d27eabc5a921f9e628cb90e2d983ea4
https://doi.org/10.1158/1538-7445.am2022-2649

المؤلفون: Frederic B. Askin, Claire Johnson, J. Victor Garcia, Kendra Gully, Corbin D. Jones, Tanzila Zaman, Gregory R. Bluemling, Wenbo Yao, Sarah R. Leist, Michael G. Natchus, Angela Wahl, Paul O. Grant, Alexander A. Kolykhalov, Edward P. Browne, Halina M. Krzystek, Kenneth H. Dinnon, Martina Kovarova, Kristen K. White, Raymond J. Pickles, Chandrav De, Hongwei Liu, Ralph S. Baric, Lisa E. Gralinski, Alexandra Schäfer, George R. Painter, Victoria J. Madden

المصدر: Research Square
article-version (status) pre
article-version (number) 1
Nature

مصطلحات موضوعية: 0301 basic medicine, Male, Viral pathogenesis, viruses, Administration, Oral, Cytidine, medicine.disease_cause, Virus Replication, Mice, 0302 clinical medicine, Interferon, Chiroptera, Lung, Multidisciplinary, virus diseases, respiratory system, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Interferon Type I, Cytokines, Heterografts, Female, Post-Exposure Prophylaxis, medicine.drug, Lung Transplantation, Middle East respiratory syndrome coronavirus, Hydroxylamines, Chemoprevention, Virus, Article, 03 medical and health sciences, Clinical Trials, Phase II as Topic, In vivo, medicine, Animals, Humans, business.industry, SARS-CoV-2, COVID-19, Epithelial Cells, Virology, Immunity, Innate, respiratory tract diseases, COVID-19 Drug Treatment, 030104 developmental biology, Viral replication, Clinical Trials, Phase III as Topic, Alveolar Epithelial Cells, Pre-Exposure Prophylaxis, business, Interferon type I

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fef697236f62f3b6848c8fd1cbd8ae
https://pubmed.ncbi.nlm.nih.gov/32995766

المؤلفون: Manohar Saindane, Debbie G. Mitchell, Prabhakar Reddy, Abel De La Rosa, Gregory R. Bluemling, Alexander A. Kolykhalov, Vindhya Edpuganti, Douglas L. Mayers, Katherine E. Squires, Zachary M. Sticher, David B. Guthrie

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: 0301 basic medicine, Hepatitis B virus, phosphoramidate, 030106 microbiology, Viremia, Pharmacology, medicine.disease_cause, liver, Antiviral Agents, 03 medical and health sciences, 0302 clinical medicine, Hepatitis B, Chronic, clevudine, medicine, Adefovir, Humans, Pharmacology (medical), nucleoside analogs, Nucleoside analogue, business.industry, Nucleotides, Lamivudine, virus diseases, Entecavir, medicine.disease, Hepatitis B, Infectious Diseases, Clevudine, HBV DNA, Toxicity, 030211 gastroenterology & hepatology, prodrug, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1b3d002d80deb59b3cf88491e49ca3
https://pubmed.ncbi.nlm.nih.gov/32540975

المؤلفون: Maria L. Agostini, Ronald Swanstrom, Natalie J. Thornburg, Sarah R. Leist, Kenneth H. Dinnon, Gregory R. Bluemling, Andrea J. Pruijssers, Alexandra Schaefer, Azaibi Tamin, Stephanie A. Montgomery, Ariane J. Brown, James D. Chappell, Amy C. Sims, Rachel L. Graham, George R. Painter, Manohar Saindane, Shuntai Zhou, Jennifer L Harcourt, Timothy P. Sheahan, Ralph S. Baric, Michael G. Natchus, Alexander A. Kolykhalov, Mark R. Denison, Collin S. Hill

مصطلحات موضوعية: 0303 health sciences, 030306 microbiology, viruses, RNA, virus diseases, Biology, respiratory system, biochemical phenomena, metabolism, and nutrition, Ribonucleoside, medicine.disease_cause, Virology, In vitro, 3. Good health, respiratory tract diseases, 03 medical and health sciences, Titer, In vivo, medicine, Potency, Nucleoside, 030304 developmental biology, Coronavirus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97916e086b88bd18f3c8d1a0a88d1cb3

المؤلفون: James D. Chappell, Amy C. Sims, Gregory R. Bluemling, Jennifer Gribble, Maria L. Agostini, Timothy P. Sheahan, Mark A. Lockwood, Ralph S. Baric, Erica L. Andres, Michael G. Natchus, George R. Painter, Xiaotao Lu, Manohar Saindane, Andrea J. Pruijssers, Mark R. Denison, Alexander A. Kolykhalov

المصدر: Journal of Virology

مصطلحات موضوعية: Nucleoside analogue, viruses, Immunology, virus diseases, RNA-dependent RNA polymerase, Biology, medicine.disease, medicine.disease_cause, Microbiology, Virology, Virus, Viral replication, Insect Science, medicine, Middle East respiratory syndrome, Proofreading, Nucleoside, Coronavirus, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ebdd71ba2959b277f4b3ed92a7c09c
https://doi.org/10.1128/jvi.01348-19

المؤلفون: Deborah G. Mitchell, Zachary M. Sticher, Joshua Marlow, Michael G. Natchus, Gregory R. Bluemling, Gaofei Lu, Levi Moellering, Alexander A. Kolykhalov, David B. Guthrie, George R. Painter

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Pharmacology, 0303 health sciences, Mitochondrial DNA, POLRMT, biology, 030306 microbiology, Chemistry, RNA, medicine.disease, Molecular biology, 03 medical and health sciences, Mitochondrial toxicity, chemistry.chemical_compound, Infectious Diseases, Cell culture, RNA polymerase, medicine, biology.protein, Pharmacology (medical), Cytotoxicity, Polymerase, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6368af32de667f36851dbfe5dcb128b6

المؤلفون: Jeong-Joong Yoon, Gregory R. Bluemling, Mart Toots, Alexander L. Greninger, Ryan C. Shean, Richard K. Plemper, Prabhakar Reddy, Alec H. Barrena, Robert M. Cox, Michael G Hart, Deborah G. Mitchell, Roland Plesker, George R. Painter, Alexander A. Kolykhalov, Zachary M. Sticher, Michael G. Natchus, Negar Makhsous

المصدر: Sci Transl Med

مصطلحات موضوعية: 0301 basic medicine, Drug, media_common.quotation_subject, 030106 microbiology, Inflammation, Antiviral Agents, Article, Virus, Madin Darby Canine Kidney Cells, Mice, 03 medical and health sciences, Dogs, Influenza A Virus, H1N1 Subtype, Orthomyxoviridae Infections, Pharmacokinetics, Drug Resistance, Viral, Influenza, Human, Pandemic, medicine, Animals, Humans, Dosing, media_common, Microscopy, Confocal, business.industry, Ferrets, High-Throughput Nucleotide Sequencing, General Medicine, Prodrug, 030104 developmental biology, Immunology, RNA, Viral, Respiratory epithelium, Female, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940f3acf5cb7bbdf642c7255f3ece1f7
https://doi.org/10.1126/scitranslmed.aax5866

المؤلفون: Zachary M, Sticher, Gaofei, Lu, Deborah G, Mitchell, Joshua, Marlow, Levi, Moellering, Gregory R, Bluemling, David B, Guthrie, Michael G, Natchus, George R, Painter, Alexander A, Kolykhalov

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Cell Survival, NHC, Gene Dosage, N4-hydroxycytidine, Mitochondria, Liver, Cytidine, DNA-Directed RNA Polymerases, Hep G2 Cells, DNA, Mitochondrial, Antiviral Agents, POLRMT, Culture Media, Phosphates, ribonucleoside analog, Humans, mitochondrial toxicity, Lactic Acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a8286945f21d6c7561ea8c71855b315a
https://pubmed.ncbi.nlm.nih.gov/31767721