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1Academic Journal
المؤلفون: Bei Wu, Alex J McDonald, Kathleen Markham, Celeste B Rich, Kyle P McHugh, Jörg Tatzelt, David W Colby, Glenn L Millhauser, David A Harris
المصدر: eLife, Vol 6 (2017)
مصطلحات موضوعية: neurotoxicity, prion, protein regulation, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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2
المؤلفون: Bei Wu, Alex J. McDonald, David A. Harris
المصدر: Prion. 11:388-397
مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Magnetic Resonance Spectroscopy, Patch-Clamp Techniques, Dendritic spine, Prions, animal diseases, Mice, Transgenic, Protein aggregation, Biology, Biochemistry, Prion Proteins, Cell Line, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, medicine, Animals, Humans, PrPC Proteins, Gene, Mechanism (biology), Neurodegeneration, Neurotoxicity, Neurodegenerative Diseases, Dendrites, Cell Biology, medicine.disease, Phenotype, nervous system diseases, Extra View - Solicited, 030104 developmental biology, Infectious Diseases
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3
المؤلفون: Alex J, McDonald, Deborah R, Leon, Kathleen A, Markham, Bei, Wu, Christian F, Heckendorf, Kevin, Schilling, Hollis D, Showalter, Philip C, Andrews, Mark E, McComb, M Jake, Pushie, Catherine E, Costello, Glenn L, Millhauser, David A, Harris
المصدر: Structure
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, animal diseases, Molecular Dynamics Simulation, Prion Proteins, Article, nervous system diseases, Cell Line, Mice, Cross-Linking Reagents, Protein Domains, Tandem Mass Spectrometry, Mutation, Animals, Humans, Protein Isoforms, Copper, Protein Binding
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4
المؤلفون: Stephen P. Andrews, Avraham Ashkenazi, Veerle Baekelandt, Jeremy D. Baker, Konrad Beyreuther, Laura J. Blair, Azad Bonni, Erin Bove-Fenderson, Patrik Brundin, Andrea Caricasole, Amarallys F. Cintron, Mark R. Cookson, Utpal Das, Sarah M. de Jager, Maria E. de Sousa Rodrigues, Audrey S. Dickey, Chad A. Dickey, Cheng Fang, Angeleen Fleming, Jens Füllgrabe, Stephen K. Godin, Michel Goedert, Lawrence S. Goldstein, Jorge Gomez-Deza, Ben Gu, David A. Harris, Harm H. Kampinga, Scott Koppel, John Koren, Albert R. La Spada, Simon Laws, Floriana Licitra, Yen Y. Lim, Ana Lopez, Kathryn P. MacPherson, Colin L. Masters, Alex J. McDonald, Robert C.C. Mercer, Mariana Pavel, Wouter Peelaerts, Leonard Petrucelli, Claudia Puri, Maurizio Renna, Thomas Ricketts, Blaine Roberts, David C. Rubinsztein, Jinsoo Seo, Christopher E. Shaw, Lindsey B. Shelton, John Skidmore, Sarah E. Smith, Russell H. Swerdlow, Malú G. Tansey, Tiffany W. Todd, Li-Huei Tsai, Vladimir N. Uversky, Fred W. van Leeuwen, Mariella Vicinanza, Victor L. Villemagne, Alex von Schulze, Xiaowan Wang, Jack M. Webster, Ian Weidling, Heather M. Wilkins, Michael S. Wolfe, Bei Wu
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5
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6
المؤلفون: Robin A. Aglietti, Robert C.C. Mercer, Agnes Lau, Glenn L. Millhauser, Serene Wohlgemuth, Gerold Schmitt-Ulms, David Westaway, Hristina Gapeshina, Charles E. Mays, Chae Kim, Jing Yang, Jennifer Grams, Beipei Shi, Holger Wille, Nathalie Daude, Aru Balachandran, Eric D. Walter, Jiri G. Safar, Alex J. McDonald, Jacques van der Merwe
المصدر: EMBO Molecular Medicine
ResearcherIDمصطلحات موضوعية: Genetically modified mouse, Protein Conformation, Proteolysis, animal diseases, endoproteolysis, DNA Mutational Analysis, Mice, Transgenic, Biology, Cell Line, Prion Diseases, prion, 03 medical and health sciences, 0302 clinical medicine, Protein structure, medicine, Animals, Humans, PrPC Proteins, Allele, C2, 030304 developmental biology, Infectivity, 0303 health sciences, Microscopy, medicine.diagnostic_test, Histocytochemistry, Molecular biology, Cell biology, nervous system diseases, Disease Models, Animal, Cell culture, Infectious disease (medical specialty), copper, Molecular Medicine, Mutant Proteins, octarepeats, Linker, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Research Article
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7
المؤلفون: Glenn L. Millhauser, Jörg Tatzelt, David W. Colby, Kyle P McHugh, David A. Harris, Celeste B. Rich, Kathleen Markham, Bei Wu, Alex J. McDonald
المصدر: eLife
eLife, Vol 6 (2017)مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Magnetic Resonance Spectroscopy, Mouse, QH301-705.5, Protein Conformation, Science, animal diseases, Mutant, Biology, Hippocampus, General Biochemistry, Genetics and Molecular Biology, Epitope, Prion Proteins, prion, 03 medical and health sciences, Mice, Protein structure, neurotoxicity, protein regulation, Animals, Homeostasis, PrPC Proteins, Biology (General), Neurons, General Immunology and Microbiology, Effector, General Neuroscience, C-terminus, General Medicine, Dendrites, Virology, 3. Good health, Cell biology, nervous system diseases, N-terminus, 030104 developmental biology, Docking (molecular), Medicine, Research Article, Neuroscience
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8Author response: The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
المؤلفون: David A. Harris, Alex J. McDonald, Celeste B. Rich, David W. Colby, Jörg Tatzelt, Kyle P McHugh, Glenn L. Millhauser, Bei Wu, Kathleen Markham
مصطلحات موضوعية: 0301 basic medicine, N-terminus, 03 medical and health sciences, 030104 developmental biology, Chemistry, Effector, C-terminus, Prion protein, Cell biology
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9
المؤلفون: Alex J. McDonald, Kevin M. Schilling, Deborah R. Leon, M. Jake Pushie, Bei Wu, Mark E. McComb, H. D. Hollis Showalter, Catherine E. Costello, Christian F. Heckendorf, Philip C. Andrews, David A. Harris, Glenn L. Millhauser, Kathleen Markham
المصدر: Structure (London, England : 1993), vol 27, iss 6
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, animal diseases, Neurodegenerative, medicine.disease_cause, Mice, Molecular dynamics, Tandem Mass Spectrometry, Structural Biology, Protein Isoforms, 2.1 Biological and endogenous factors, Aetiology, Receptor, mass spectrometry, 0303 health sciences, Mutation, Chemistry, 030302 biochemistry & molecular biology, protein domain, Biological Sciences, Cross-Linking Reagents, Infectious Diseases, Protein Binding, Gene isoform, Protein domain, Biophysics, Molecular Dynamics Simulation, patch clamp, Prion Proteins, Cell Line, Domain (software engineering), prion, 03 medical and health sciences, Rare Diseases, Protein Domains, Information and Computing Sciences, medicine, Animals, Humans, Prion protein, Molecular Biology, Ion channel, 030304 developmental biology, Neurosciences, Transmissible Spongiform Encephalopathy (TSE), NMR, molecular dynamics, nervous system diseases, Emerging Infectious Diseases, Good Health and Well Being, copper, ion channel, Chemical Sciences, cross-linking
وصف الملف: application/pdf
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10
المصدر: Journal of Biological Chemistry. 289:803-813
مصطلحات موضوعية: Models, Molecular, animal diseases, ADAM10, Proteolysis, Peptide, ADAM17 Protein, Cleavage (embryo), Biochemistry, Mass Spectrometry, ADAM10 Protein, Mice, Disintegrin, medicine, Animals, Humans, PrPC Proteins, Molecular Biology, chemistry.chemical_classification, biology, medicine.diagnostic_test, C-terminus, Membrane Proteins, Cell Biology, ADAM Proteins, Peptide Fragments, Recombinant Proteins, nervous system diseases, Protein Structure, Tertiary, Amino acid, Zinc, chemistry, Protein Structure and Folding, biology.protein, Biophysics, Amyloid Precursor Protein Secretases, Reactive Oxygen Species, Oxidation-Reduction, Copper, Chromatography, Liquid
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11
المصدر: The Journal of Physical Chemistry B. 117:13822-13841
مصطلحات موضوعية: Prions, chemistry.chemical_element, Crystal structure, Plasma protein binding, Article, Metal, Tandem repeat, Materials Chemistry, Amino Acid Sequence, Physical and Theoretical Chemistry, Peptide sequence, X-ray absorption spectroscopy, Extended X-ray absorption fine structure, Electron Spin Resonance Spectroscopy, Hydrogen-Ion Concentration, Copper, Protein Structure, Tertiary, Surfaces, Coatings and Films, Crystallography, X-Ray Absorption Spectroscopy, chemistry, visual_art, visual_art.visual_art_medium, Thermodynamics, Peptides, Protein Binding
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12
المؤلفون: Bei Wu, Alex J. McDonald, Graham Roseman, Glenn L. Millhauser, David A. Harris
المصدر: Biophysical Journal. 114:568a
مصطلحات موضوعية: Metal, Chemistry, visual_art, Toxicity, Biophysics, visual_art.visual_art_medium, Construct (python library), Prion protein, Cell biology
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13
المؤلفون: Alex J. McDonald, Glenn L. Millhauser, Boaz Vilozny, David Beeler, Paolo Actis, Nader Pourmand
مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, General Chemical Engineering, Metal ions in aqueous solution, fungi, chemistry.chemical_element, food and beverages, Peptide, General Chemistry, Prion protein, Combinatorial chemistry, Copper, Article
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14
المؤلفون: Lin Liu, Alex J. McDonald, Dianlu Jiang, Yuanqiang Hao, Glenn L. Millhauser, Feimeng Zhou
مصطلحات موضوعية: Models, Molecular, Time Factors, Prions, chemistry.chemical_element, Electrochemistry, Biochemistry, Neuroprotection, Catalysis, Article, chemistry.chemical_compound, Colloid and Surface Chemistry, Amide, Molecule, Binding site, chemistry.chemical_classification, Reactive oxygen species, Binding Sites, Molecular Structure, General Chemistry, Hydrogen Peroxide, Copper, chemistry, Biophysics, Redox cycling, Oxidation-Reduction
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