المؤلفون: Abellanas Pérez, Pedro, Andrades, Diandra de, Alcántara León, Andrés Rafael, Polizeli, Maria de Lourdes Teixeira de Moraes, Rocha Martín, Javier, Fernández Lafuente, Roberto

مصطلحات موضوعية: 577.1, 577.15, 577.2, 539.199, Multipoint covalent enzyme immobilization, Optimization of the activation conditions, Divinyl sulfone, Bioquímica (Biología), Biología molecular (Biología), 2403 Bioquímica, 2415 Biología Molecular, 2302.09 Enzimología, 2302.91 Química de Macromoléculas Biológicas

وصف الملف: application/pdf

Relation: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136535OB-I00; info:eu-repo/grantAgreement/MICIU/info:eu-repo/grantAgreement/MICIU//CNS2022-135135/ES/DESARROLLANDO LA PROXIMA GENERACION DE BIOCATALIZADORES: FABRICACION DE SISTEMAS BIOSINTETICOS HETEROGENEOS ORDENADOS PARA SU USO EN REACCIONES EN CASCADA; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-139209OB-C22; Abellanas-Perez, P., de Andrades, D., Alcántara, A. R., Polizeli, M. d. L. T. d. M., Rocha-Martin, J., & Fernandez-Lafuente, R. (2024). Optimizing the activation of agarose beads with divinyl sulfone for enzyme immobilization and stabilization. International Journal of Biological Macromolecules, 282. https://doi.org/10.1016/J.IJBIOMAC.2024.136812; https://hdl.handle.net/20.500.14352/111280

الاتاحة: https://hdl.handle.net/20.500.14352/111280
https://doi.org/10.1016/j.ijbiomac.2024.136812

المؤلفون: Khiari, Oussama, Bouzemi, Nassima, Sánchez Montero, José, Alcántara León, Andrés Rafael

المساهمون: Sánchez Montero, José, Alcántara León, Andrés Rafael

مصطلحات موضوعية: 612.015, kinetic resolution, ibuprofen, eutomer, lipase, irreversible esterification, orthoformates, water trapping, cosolvents, Ciencias, Ciencias Biomédicas, 23 Química, 24 Ciencias de la Vida

Time: 6

وصف الملف: application/pdf

Relation: info:eu-repo/grantAgreement/PID2019-105337RB-C22; https://hdl.handle.net/20.500.14352/92528; Khiari, O.; Bouzemi, N.; Sánchez-Montero, J.M.; Alcántara, A.R. On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen. Catalysts 2023, 13, 251. https://doi.org/10.3390/catal13020251; https://doi.org/10.3390/catal13020251; https://www.mdpi.com/2073-4344/13/2/251

الاتاحة: https://hdl.handle.net/20.500.14352/92528
https://doi.org/10.3390/catal13020251
https://www.mdpi.com/2073-4344/13/2/251

المؤلفون: Khiari, Oussama, Bouzemi, Nassima, Sánchez Montero, José, Alcántara León, Andrés Rafael

المساهمون: Sánchez Montero, José, Alcántara León, Andrés Rafael

مصطلحات موضوعية: 615.03, CLEA-like copolymers, one-pot immobilization, cross-linkers, pH Jump, amine activation, ibuprofen resolution, enzymatic hydrolysis, Ciencias, Ciencias Biomédicas, 23 Química, 24 Ciencias de la Vida

Time: 6

وصف الملف: application/pdf

Relation: info:eu-repo/grantAgreement/PID2019-105337RB-C22; https://hdl.handle.net/20.500.14352/92476; Khiari, O.; Bouzemi, N.; Sánchez-Montero, J.M.; Alcántara, A.R. Easy and Versatile Technique for the Preparation of Stable and Active Lipase-Based CLEA-like Copolymers by Using Two Homofunctional Cross-Linking Agents: Application to the Preparation of Enantiopure Ibuprofen. Int. J. Mol. Sci. 2023, 24, 13664. https://doi.org/10.3390/ijms241713664; https://www.mdpi.com/1422-0067/24/17/13664; www.mdpi.com/journal/ijms

الاتاحة: https://hdl.handle.net/20.500.14352/92476
https://doi.org/10.3390/ijms241713664
https://www.mdpi.com/1422-0067/24/17/13664

المؤلفون: da Rocha, T.N., Morellon-Sterling, R., Gonçalves, L.R.B, Bolívar Bolívar, Juan Manuel, Alcántara León, Andrés Rafael, Rocha Martín, Javier, Fernández-Lafuente, R

مصطلحات موضوعية: 66.0, Ion exchangerheterofunctional supports, Vinyl sulfone-activated support, Heterofunctional supports, Synergy in enzyme immobilization, Covalent enzyme immobilization, Penicillin G acylase, Química, Bioquímica (Química), Ingeniería química, 2302 Bioquímica, 3302 Tecnología Bioquímica, 3303 Ingeniería y Tecnología Químicas

وصف الملف: application/pdf

Relation: MCIN PID2019-105337RB-C22; MCIN/AEI/10.13039/501100011033; https://hdl.handle.net/20.500.14352/101579; da Rocha, T. N., Morellon-Sterling, R., Gonçalves, L. R. B., Bolivar, J. M., Alcántara, A. R., Rocha-Martin, J., & Fernández-Lafuente, R. (2023). Synergy of Ion Exchange and Covalent Reaction: Immobilization of Penicillin G Acylase on Heterofunctional Amino-Vinyl Sulfone Agarose. Catalysts, 13(1). https://doi.org/10.3390/CATAL13010151; https://www.mdpi.com/2073-4344/13/1/151

الاتاحة: https://hdl.handle.net/20.500.14352/101579
https://doi.org/10.3390/catal13010151
https://www.mdpi.com/2073-4344/13/1/151

المؤلفون: Guimarães, José R., Carballares, Diego, Rocha Martín, Javier, Alcántara León, Andrés Rafael, Tardioli, Paulo W., Fernandez-Lafuente, Roberto

مصطلحات موضوعية: heterofunctional supports, lipase stabilization, lipase specificity tuning, interfacial activation of lipases, Biología, Farmacia, 3209 Farmacología, 2302 Bioquímica

Time: 577, 615

وصف الملف: application/pdf

Relation: (CAPES, Finance Code 001; CAPES‑PRINT, number 88887.571985/2020‑00); MCIN/ AEI/10.1 3039/501100011033 (PID2021‑122398OB‑I00); PID2019‑105337RB‑C22. D.C.; https://hdl.handle.net/20.500.14352/104847; Guimarães, J.R.; Carballares, D.; Rocha-Martin, J.; Alcántara, A.R.; Tardioli, P.W.; Fernandez-Lafuente, R. Heterofunctional Methacrylate Beads Bearing Octadecyl and Vinyl Sulfone Groups: Tricks to Obtain an Interfacially Activated Lipase from Thermomyces lanuginosus and Covalently Attached to the Support. Catalysts 2023, 13, 108. https://doi.org/10.3390/catal13010108; https://www.mdpi.com/2073-4344/13/1/108

الاتاحة: https://hdl.handle.net/20.500.14352/104847
https://doi.org/10.3390/catal13010108
https://www.mdpi.com/2073-4344/13/1/108

المؤلفون: Aranaz Corral, Inmaculada, Acosta Contreras, Florentina Niuris, Revuelta, Julia, Bastida, Agatha, Gómez-Casado, Víctor, Civera Tejuca, María Concepción, Garrido, Leoncio, García-Junceda, Eduardo, Heras Caballero, Ángeles María, Alcántara León, Andrés Rafael, Fernández-Mayoralas, Alfonso, Doncel-Pérez, Ernesto

مصطلحات موضوعية: Brain-derived neurotrophic factor, Chitosan, Microspheres, Dynamic light scattering, PC12 cells, Zeta potential, Farmacia, 32 Ciencias Médicas

وصف الملف: application/pdf

Relation: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105337RB-C21/ES/MATERIALES BASADOS EN QUITOSANOS HEPARA(I)NIZADOS: MODIFICACIONES SELECTIVAS PARA NUEVAS APLICACIONES BIOMEDICAS/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105337RB-C22/ES/QUITOSANOS ESPECIFICOS: DESDE LA SINTESIS SOSTENIBLE DE LOS POLIMEROS HASTA EL DISEÑO DE MATERIALES INTELIGENTES PARA APLICACIONES BIOMEDICAS/; https://hdl.handle.net/20.500.14352/103585; Aranaz, I., Acosta, N., Revuelta, J., Bastida, A., Gómez-Casado, V., Civera, C., Garrido, L., García-Junceda, E., Heras, Á., Alcántara, A. R., Fernández-Mayoralas, A., & Doncel-Pérez, E. (2023). Fast and Sustained Axonal Growth by BDNF Released from Chitosan Microspheres. Marine drugs, 21(2), 91. https://doi.org/10.3390/md21020091; https://doi.org/10.3390/md21020091

الاتاحة: https://hdl.handle.net/20.500.14352/103585
https://doi.org/10.3390/md21020091

المؤلفون: Sánchez Montero, José, Alcántara León, Andrés Rafael, Khiari, Oussama, Bouzemi, Nassima

مصطلحات الفهرس: 6, 612.015, kinetic resolution, ibuprofen, eutomer, lipase, irreversible esterification, orthoformates, water trapping, cosolvents, Ciencias, Ciencias Biomédicas, 23 Química, 24 Ciencias de la Vida, journal article, VoR

URL: https://hdl.handle.net/20.500.14352/92528
https://doi.org/10.3390/catal13020251
https://www.mdpi.com/2073-4344/13/2/251
info:eu-repo/grantAgreement/PID2019-105337RB-C22

المؤلفون: Sánchez Montero, José, González Matilla, Juan Francisco, Alcántara León, Andrés Rafael, Doadrio Villarejo, Antonio Luis

مصطلحات الفهرس: 6, 616.894-053.9, Alzheimer’s disease, current hypotheses, multi-target direct ligand, privileged building blocks, Ciencias Biomédicas, Ciencias, 24 Ciencias de la Vida, 23 Química, journal article, AM

URL: https://hdl.handle.net/20.500.14352/92533
https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1623201?scroll=top&needAccess=true
info:eu-repo/grantAgreement/TQ2017-86170
info:eu-repo/grantAgreement/PR26/16-16B h

المؤلفون: Ramos-Martín, Jesús, Khiari, Oussama, Alcántara León, Andrés Rafael, Sánchez Montero, José

مصطلحات الفهرس: 6, 001.891.5, Geobacillus thermocatenolatus, lipases, ethanolysis, ionic liquids, kinetic resolution, mandelic acid, Ciencias, Ciencias Biomédicas, 23 Química, 24 Ciencias de la Vida, journal article, AM

URL: https://hdl.handle.net/20.500.14352/92557
https://www.mdpi.com/2073-4344/10/9/1055
info:eu-repo/grantAgreement/MINECO/CTQ2017-86170-R
info:eu-repo/grantAgreement/PR87/19-22676

المؤلفون: Sánchez Montero, José, Alcántara León, Andrés Rafael, Khiari, Oussama, Bouzemi, Nassima

مصطلحات الفهرس: 6, 615.03, CLEA-like copolymers, one-pot immobilization, cross-linkers, pH Jump, amine activation, ibuprofen resolution, enzymatic hydrolysis, Ciencias, Ciencias Biomédicas, 23 Química, 24 Ciencias de la Vida, journal article, VoR

URL: https://hdl.handle.net/20.500.14352/92476
https://www.mdpi.com/1422-0067/24/17/13664
info:eu-repo/grantAgreement/PID2019-105337RB-C22

المؤلفون: Sánchez Montero, José, Gonzalo, Gonzalo de, Alcántara León, Andrés Rafael, Domínguez de María, Pablo

مصطلحات الفهرس: 6, 615.015.3, Biocatalysis, asymmetric synthesis, active pharmaceutical ingredients, sustainable chemistry, Ciencias, Ciencias Biomédicas, 23 Química, 24 Ciencias de la Vida, journal article, AM

URL: https://hdl.handle.net/20.500.14352/92538
https://doi.org/10.1080/17460441.2022.2114453

المؤلفون: Sánchez Montero, José, Sánchez Cebrián, Juan Domingo, Alcántara León, Andrés Rafael, González Matilla, Juan Francisco

مصطلحات الفهرس: 6, 616.894-053.9, Alzheimer’s disease, benzopyrane scaffold, benzothiazole, heterocyclic building blocks, multi-target direct ligand, pyridine scaffold, small drug, Ciencias Biomédicas, Ciencias, 24 Ciencias de la Vida, 23 Química, journal article, VoR

URL: https://hdl.handle.net/20.500.14352/92498
https://www.tandfonline.com/doi/abs/10.1080/17460441.2023.2264766

المؤلفون: Molinari, Francesco, Elsevier, Rabuffetti, Marco, Cannazza, Pietro, Martina Letizia Contente, Andrea Pinto, Diego Romano, Hoyos Vidal, María Pilar, Alcántara León, Andrés Rafael, Ivano Eberini, Tommaso Laurenzi, Louise Gourlay, Flavio Di Pisa, Francesco Molinari

مصطلحات الفهرس: Biocatalysis, Ketoreductase, Pichia glucozyma, Enzymatic reduction, Crystal structure, In silico analysis, Ciencias Biomédicas, 23 Química, journal article, VoR

URL: https://hdl.handle.net/20.500.14352/96618

المؤلفون: Gonzalo, Gonzalo de, Alcántara León, Andrés Rafael

مصطلحات موضوعية: Biocatalysis, Whole cells, Cascade reactions, Redox enzymes, Monooxygenases, Baeyer–Villiger alcohol dehydrogenases, Ene-reductases, Química orgánica (Farmacia)

Time: 547

وصف الملف: application/pdf

Relation: PID2019-105337RB-C22; PR87/19-22676; https://www.mdpi.com/journal/catalysts; https://hdl.handle.net/20.500.14352/7435

الاتاحة: https://hdl.handle.net/20.500.14352/7435
https://doi.org/10.3390/catal11050605
https://www.mdpi.com/journal/catalysts

المؤلفون: Aranaz Corral, Inmaculada, Alcántara León, Andrés Rafael, Civera Tejuca, María Concepción, Arias García, Concepción, Elorza Barroeta, Begoña, Heras Caballero, Ángeles María, Acosta Contreras, Florentina Niuris

مصطلحات موضوعية: Chitosan, chitin, biological activity, drug delivery, antioxidant, antimicrobial, metallic nanoparticles, biocatalysis, Ciencias Biomédicas, Ciencias, 23 Química, 24 Ciencias de la Vida

وصف الملف: application/pdf

Relation: info:eu-repo/grantAgreement/PID2019-105337RB-C22; info:eu-repo/grantAgreement/PR87/19-2267; https://hdl.handle.net/20.500.14352/96565; Aranaz I, Alcántara AR, Civera MC, Arias C, Elorza B, Heras Caballero A, et al. Chitosan: An Overview of Its Properties and Applications. Polymers 2021;13:3256. https://doi.org/10.3390/polym13193256.; https://doi.org/10.3390/polym13193256

الاتاحة: https://hdl.handle.net/20.500.14352/96565
https://doi.org/10.3390/polym13193256

المؤلفون: Arana-Peña, Sara, Carballares, Diego, Berenguer-Murcia, Ángel, Alcántara León, Andrés Rafael, Rodrigues, Rafael, Fernandez-Lafuente, Roberto

مصطلحات موضوعية: lipases, combilipases, enzyme specificity, full modification, coimmobilization, cascade reaction, Química farmaceútica, 2390 Química Farmacéutica

وصف الملف: application/pdf

Relation: CTQ2017-86170-R; PROMETEO/2018/076; https://hdl.handle.net/20.500.14352/8314

الاتاحة: https://hdl.handle.net/20.500.14352/8314
https://doi.org/10.3390/catal10060605

المؤلفون: da Rocha, Thays N., Morellon-Sterling, Roberto, Gonçalves, Luciana R. B., Bolívar Bolívar, Juan Manuel, Alcántara León, Andrés Rafael, Rocha Martín, Javier, Fernández-Lafuente, Roberto

مصطلحات الفهرس: 577.1, Ion exchanger, Vinyl sulfone-activated support, Heterofunctional supports, Synergy in enzyme immobilization, Covalent enzyme immobilization, Penicillin G acylase, Ciencias, Bioquímica (Química), 2302 Bioquímica, journal article, VoR

URL: https://hdl.handle.net/20.500.14352/105719
da Rocha, T.N.; Morellon-Sterling, R.; Gonçalves, L.R.B.; Bolivar, J.M.; Alcántara, A.R.; Rocha-Martin, J.; Fernández-Lafuente, R. Synergy of Ion Exchange and Covalent Reaction: Immobilization of Penicillin G Acylase on Heterofunctional Amino-Vinyl Sulfone Agarose. Catalysts 2023, 13, 151. https://doi.org/10.3390/catal13010151

المؤلفون: da Rocha, Thays, Morellon-Sterling, Roberto, Gonçalves, Luciana, Bolívar Bolívar, Juan Manuel, Alcántara León, Andrés Rafael, Rocha Martín, Javier, Fernández-Lafuente, Roberto

مصطلحات الفهرس: 66.0, Ion exchangerheterofunctional supports, Vinyl sulfone-activated support, Heterofunctional supports, Synergy in enzyme immobilization, Covalent enzyme immobilization, Penicillin G acylase, Química, Bioquímica (Química), Ingeniería química, 2302 Bioquímica, 3302 Tecnología Bioquímica, 3303 Ingeniería y Tecnología Químicas, journal article, VoR

URL: https://hdl.handle.net/20.500.14352/101579
MCIN PID2019-105337RB-C22
MCIN/AEI/10.13039/501100011033
da Rocha, T. N., Morellon-Sterling, R., Gonçalves, L. R. B., Bolivar, J. M., Alcántara, A. R., Rocha-Martin, J., & Fernández-Lafuente, R. (2023). Synergy of Ion Exchange and Covalent Reaction: Immobilization of Penicillin G Acylase on Heterofunctional Amino-Vinyl Sulfone Agarose. Catalysts, 13(1). https://doi.org/10.3390/CATAL13010151

المؤلفون: Tacias-Pascacio, Veymar G., Ortiz, Claudia, Rueda, Nazzoly, Berenguer-Murcia, Ángel, Acosta Contreras, Niuris, Aranaz Corral, Inmaculada, Civera Tejuca, María Concepción, Fernandez-Lafuente, Roberto, Alcántara León, Andrés Rafael

مصطلحات موضوعية: dextran, dextran-aldehyde, enzyme immobilization, enzyme modification, Química farmaceútica, 2390 Química Farmacéutica

وصف الملف: application/pdf

Relation: MAT2015-65184-C2-1-R y CTQ2017-86170-R; FP 44842-076-2016; https://doi.org/10.3390/catal9070622; https://www.mdpi.com/2073-4344/9/7/622; https://hdl.handle.net/20.500.14352/12660

الاتاحة: https://hdl.handle.net/20.500.14352/12660
https://doi.org/10.3390/catal9070622
https://www.mdpi.com/2073-4344/9/7/622

المؤلفون: Alcántara León, Andrés Rafael

مصطلحات موضوعية: Química farmaceútica, 2390 Química Farmacéutica

وصف الملف: application/pdf

Relation: https://doi.org/10.3390/catal9100792; https://www.mdpi.com/2073-4344/9/10/792; https://hdl.handle.net/20.500.14352/12661

الاتاحة: https://hdl.handle.net/20.500.14352/12661
https://doi.org/10.3390/catal9100792
https://www.mdpi.com/2073-4344/9/10/792