المؤلفون: David A. Donkor, Varsha Bhakta, Louise J. Eltringham-Smith, Alan R. Stafford, Jeffrey I. Weitz, William P. Sheffield

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/4219d136fc514ca4a4f9663c24f5819f

المؤلفون: Paul Y. Kim, Calvin H. Yeh, Brian J. Dale, Beverly A. Leslie, Alan R. Stafford, James C. Fredenburgh, Jack Hirsh, Jeffrey I. Weitz

المصدر: TH Open, Vol 02, Iss 02, Pp e190-e201 (2018)

مصطلحات موضوعية: doac, inhibition kinetics, coagulation assays, coagulation inhibitors, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2512-9465

URL الوصول: https://doaj.org/article/4f047f8b39114affb255507bb976a3e4

المؤلفون: Tammy K. Truong, Rida A. Malik, Xintong Yao, James C. Fredenburgh, Alan R. Stafford, Hasam M. Madarati, Colin A. Kretz, Jeffrey I. Weitz

المصدر: Journal of Thrombosis and Haemostasis. 20:821-832

مصطلحات موضوعية: Mice, Polyphosphates, Factor XII, Prekallikrein, Thrombin, Animals, Humans, Proteins, Hematology, Factor XIIa, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c2fe6a475c41bf0b291ab0f7805091
https://doi.org/10.1111/jth.15631

المؤلفون: Jeffrey I. Weitz, Richard P. Whitlock, Iqbal H. Jaffer, James C. Fredenburgh, Alan R. Stafford

المصدر: The Annals of Thoracic Surgery. 110:582-590

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Heart Diseases, 030204 cardiovascular system & hematology, Pharmacology, Thrombin generation, Antithrombins, Dabigatran, Mechanical heart-valve, 03 medical and health sciences, 0302 clinical medicine, Thrombin, Rivaroxaban, medicine, Humans, business.industry, Warfarin, On warfarin, Thrombosis, 3. Good health, 030228 respiratory system, Heart Valve Prosthesis, Surgery, Apixaban, Cardiology and Cardiovascular Medicine, business, Factor Xa Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e09d79e78a2625cde905723daa764bb
https://doi.org/10.1016/j.athoracsur.2019.10.091

المؤلفون: Calvin H Yeh, Alan R Stafford, Beverly A Leslie, James C Fredenburgh, Jeffrey I Weitz

المصدر: PLoS ONE, Vol 11, Iss 6, p e0157471 (2016)

مصطلحات موضوعية: Medicine, Science

Relation: http://europepmc.org/articles/PMC4909201?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/81f882027936471b84dcf2a1f03f2040

الاتاحة: https://doi.org/10.1371/journal.pone.0157471
https://doaj.org/article/81f882027936471b84dcf2a1f03f2040

المؤلفون: Varsha Bhakta, Louise J. Eltringham-Smith, William P. Sheffield, Alan R. Stafford, David A. Donkor, Jeffrey I. Weitz

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Aptamer, Science, 030204 cardiovascular system & hematology, Cleavage (embryo), Article, Factor XIa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Surface plasmon resonance, Factor IX, Serine protease, Multidisciplinary, biology, Antithrombin, SELEX Aptamer Technique, Aptamers, Nucleotide, Molecular biology, Binding constant, 030104 developmental biology, Biochemistry, chemistry, biology.protein, Medicine, DNA, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f3baf6dd350d321a6a015f645fcdb2
https://doaj.org/article/4219d136fc514ca4a4f9663c24f5819f

المؤلفون: Trang T. Vu, Nima Vaezzadeh, James C. Fredenburgh, Ran Ni, Brett P. Monia, Jeffrey I. Weitz, Ji Zhou, Alan R. Stafford, Peter L. Gross, Willi Jahnen-Dechent, Beverly A. Leslie, Shengjun Qiao

المصدر: Blood. 125:2712-2719

مصطلحات موضوعية: Histidine-rich glycoprotein, RNase P, Immunology, Biology, Ferric Compounds, Biochemistry, Thrombosis and Hemostasis, Mice, Thrombin, Chlorides, medicine, Gene Knockdown Techniques, Animals, Blood Coagulation, Hemostasis, Factor XII, Gene knockdown, Proteins, RNA, Thrombosis, Cell Biology, Hematology, Molecular biology, Mice, Inbred C57BL, Coagulation, Female, Gene Deletion, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55de28e0e698a18c4fa1d6a5bb1abb75
https://doi.org/10.1182/blood-2014-11-611319

المؤلفون: Alan R. Stafford, Jeffrey I. Weitz, Paul Y. Kim, Calvin H. Yeh, James C. Fredenburgh, Brian Dale, Jack Hirsh, Beverly A. Leslie

المصدر: TH Open: Companion Journal to Thrombosis and Haemostasis
TH Open, Vol 02, Iss 02, Pp e190-e201 (2018)

مصطلحات موضوعية: Prothrombin time, lcsh:Diseases of the circulatory (Cardiovascular) system, 0303 health sciences, Rivaroxaban, medicine.diagnostic_test, Chemistry, DOAC, coagulation assays, coagulation inhibitors, Inhibition kinetics, 030204 cardiovascular system & hematology, Pharmacology, Differential effects, 03 medical and health sciences, 0302 clinical medicine, Coagulation, lcsh:RC666-701, inhibition kinetics, medicine, Apixaban, Original Article, 030304 developmental biology, medicine.drug, Partial thromboplastin time

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a294114d0be7a41c33c32c43be27ee8
https://pubmed.ncbi.nlm.nih.gov/31249942

المؤلفون: Chengliang Wu, Paul Y. Kim, Alan R. Stafford, Kai Chen, James C. Fredenburgh, Jeffrey I. Weitz, Calvin H. Yeh

المصدر: Biochemistry. 56(24)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Aptamer, Thrombomodulin, Allosteric regulation, Peptide, Ligands, Biochemistry, Fibrin, 03 medical and health sciences, Enzyme activator, Thrombin, medicine, Human Umbilical Vein Endothelial Cells, Humans, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, Surface Plasmon Resonance, 3. Good health, Enzyme Activation, 030104 developmental biology, chemistry, biology.protein, Biophysics, Protein C, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6f26bccf9cdcc297c9731444be3500
https://pubmed.ncbi.nlm.nih.gov/28549218

المؤلفون: Paul Declerck, James C. Fredenburgh, Paul Y. Kim, Jeffrey I. Weitz, Ann Gils, Chengliang Wu, Alan R. Stafford

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 37

مصطلحات موضوعية: Thrombin, Antifibrinolytic, Plasmin, medicine.drug_class, Chemistry, medicine, Pharmacology, Cardiology and Cardiovascular Medicine, Thrombomodulin, Fibrinolysis inhibitor, Fibrinolytic agent, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3abb76050e3f5f960b52af2dbba5b6a8
https://doi.org/10.1161/atvb.37.suppl_1.348

المؤلفون: Paul Y. Kim, Jeffrey I. Weitz, Trang T. Vu, Alan R. Stafford, Beverly A. Leslie, James C. Fredenburgh

المصدر: Journal of Biological Chemistry. 289:27494-27503

مصطلحات موضوعية: Lysis, Plasmin, medicine.medical_treatment, Biochemistry, Tissue plasminogen activator, Fibrin, Thrombin, Fibrinolysis, medicine, Humans, Fibrinopeptide, Fibrinolysin, Blood Coagulation, Molecular Biology, Fibrinopeptide B, biology, Chemistry, Fibrinogen, Plasminogen, Cell Biology, Molecular biology, Kinetics, Enzymology, biology.protein, Factor XIIIa, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065fc35901e8624a474636ae1c13ebec
https://doi.org/10.1074/jbc.m114.588640

المؤلفون: Brett P. Monia, Jonathan W. Yau, Alexey S. Revenko, Jeffrey I. Weitz, James C. Fredenburgh, Peng Liao, Alan R. Stafford

المصدر: Blood. 123:2102-2107

مصطلحات موضوعية: Catheter Obstruction, Male, Catheters, Immunology, Pharmacology, Biochemistry, Substrate Specificity, hemic and lymphatic diseases, medicine, Animals, cardiovascular diseases, Factor XI, Prothrombin time, Factor XII, medicine.diagnostic_test, business.industry, Thrombosis, Genetic Therapy, Cell Biology, Hematology, Oligonucleotides, Antisense, medicine.disease, Venous Obstruction, Disease Models, Animal, Catheter, Gene Expression Regulation, Coagulation, Anesthesia, RNA Interference, Rabbits, business, Partial thromboplastin time

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5ab447b4612d9c470da35882fce90e
https://doi.org/10.1182/blood-2013-12-540872

المؤلفون: Beverly A. Leslie, Teresa Lim, Howard H.W. Chan, James C. Fredenburgh, Alan R. Stafford, Jeffrey I. Weitz

المصدر: Journal of Biological Chemistry. 288:29394-29402

مصطلحات موضوعية: Plasmin, Molecular Sequence Data, Fibrinogen, Binding, Competitive, Biochemistry, Antithrombins, Fibrin, Thrombin, medicine, Humans, Platelet, Amino Acid Sequence, Molecular Biology, Binding Sites, Peptide analog, biology, Heparin, Chemistry, Antithrombin, Cell Biology, Surface Plasmon Resonance, Kinetics, Zinc, Spectrometry, Fluorescence, Protein Structure and Folding, Factor Xa, biology.protein, Peptides, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9e5a29aca2073da1364ba5e6e160e2
https://doi.org/10.1074/jbc.m113.469916

المؤلفون: Paul Y. Kim, Paul Declerck, Ann Gils, Jeffrey I. Weitz, James C. Fredenburgh, Chengliang Wu, Alan R. Stafford

المصدر: Thrombosis and haemostasis. 117(8)

مصطلحات موضوعية: 0301 basic medicine, Carboxypeptidase B2, Antifibrinolytic, Genotype, medicine.drug_class, medicine.medical_treatment, Thrombomodulin, 030204 cardiovascular system & hematology, medicine.disease_cause, Arginine, 03 medical and health sciences, 0302 clinical medicine, Thrombin, Cricetinae, Fibrinolysis, medicine, Human Umbilical Vein Endothelial Cells, Animals, Humans, Alanine, Mutation, Chemistry, Activator (genetics), Lysine, Hematology, Enzyme Activation, Kinetics, 030104 developmental biology, Phenotype, Biochemistry, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65427f6e32e4a35ab2515a55683d2032
https://pubmed.ncbi.nlm.nih.gov/28640323

المؤلفون: Alan R. Stafford, Jeffrey I. Weitz, Beverly A. Leslie, James C. Fredenburgh, Calvin H. Yeh

المصدر: PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157471 (2016)

مصطلحات موضوعية: 0301 basic medicine, Glycobiology, lcsh:Medicine, Amperometry, Plasma protein binding, Biochemistry, Argatroban, Substrate Specificity, Binding Analysis, Mathematical and Statistical Techniques, Catalytic Domain, lcsh:Science, Enzyme Chemistry, Antithrombins, Sulfonamides, Multidisciplinary, biology, Chemistry, Organic Compounds, Thrombin, Dabigatran, Bioassays and Physiological Analysis, Pipecolic Acids, Physical Sciences, Regression Analysis, Statistics (Mathematics), medicine.drug, circulatory and respiratory physiology, Research Article, Biotechnology, Protein Binding, Allosteric regulation, Research and Analysis Methods, Arginine, Fibrin, Enzyme Regulation, 03 medical and health sciences, Allosteric Regulation, medicine, Humans, Binding site, Statistical Methods, Blood Coagulation, Bioelectrochemical Analysis, Chemical Characterization, Glycoproteins, Binding Sites, 030102 biochemistry & molecular biology, lcsh:R, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Proteins, Fibrinogen, Surface Plasmon Resonance, 030104 developmental biology, Small Molecules, biology.protein, Biophysics, Enzymology, Biocatalysis, lcsh:Q, Biochemical Analysis, Mathematics, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9340109ea5a33d902111691d52088eb
http://europepmc.org/articles/PMC4909201

المؤلفون: Alan R. Stafford, Robin S. Roberts, John L. Brash, Peng Liao, Jeffrey I. Weitz, Jonathan W. Yau, James C. Fredenburgh

المصدر: Acta Biomaterialia. 8:4092-4100

مصطلحات موضوعية: Catheters, Surface Properties, Biomedical Engineering, Pharmacology, Fibrinogen, Fondaparinux, Biochemistry, Biomaterials, Percutaneous Coronary Intervention, Thrombin, Coated Materials, Biocompatible, Polysaccharides, Animals, Humans, Medicine, Blood Coagulation, Molecular Biology, Plant Proteins, Factor XII, business.industry, Photoelectron Spectroscopy, Water, Thrombosis, General Medicine, Heparin, medicine.disease, Catheter, Coagulation, Anesthesia, Adsorption, Rabbits, business, Protein Binding, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a18a363b68fbfbb48ec4fd24abf60f
https://doi.org/10.1016/j.actbio.2012.07.019

المؤلفون: Robin S. Roberts, Howard H.W. Chan, Beverly A. Leslie, Alan R. Stafford, James C. Fredenburgh, Jeffrey I. Weitz, Nadine N Al-Aswad

المصدر: Biochemistry. 51:7964-7973

مصطلحات موضوعية: Models, Molecular, Time Factors, Protein Conformation, Plasma protein binding, Biochemistry, Antithrombins, Fibrin, Plasma, Thrombin, Protein structure, medicine, Humans, Thrombus, Blood Coagulation, biology, Heparin, Protein Stability, Chemistry, Antithrombin, medicine.disease, Zinc, biology.protein, Biophysics, Ternary operation, Protein Binding, circulatory and respiratory physiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5819677aec4caa02ebedfb90ace1180f
https://doi.org/10.1021/bi301046b

المؤلفون: James C. Fredenburgh, Jeffrey I. Weitz, Paul Y. Kim, Long D. Tieu, Alan R. Stafford

المصدر: Journal of Biological Chemistry. 287:4652-4661

مصطلحات موضوعية: medicine.medical_treatment, Plasma protein binding, Biochemistry, Tissue plasminogen activator, Cofactor, Fibrin, Enzyme activator, Kringles, Enzyme Stability, Fibrinolysis, medicine, Humans, Surface plasmon resonance, Molecular Biology, biology, Chemistry, Plasminogen, Cell Biology, Surface Plasmon Resonance, Molecular biology, Enzyme Activation, Tissue Plasminogen Activator, Enzymology, biology.protein, Plasminogen activator, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4af5eed5c8ddbf8216cbb90eea8847
https://doi.org/10.1074/jbc.m111.317719

المؤلفون: Robin S. Roberts, James C. Fredenburgh, Jeffrey I. Weitz, Alan R. Stafford, Peng Liao, Jonathan W. Yau

المصدر: Blood. 118:6667-6674

مصطلحات موضوعية: Blood Platelets, Male, Catheters, medicine.medical_treatment, Immunology, Fondaparinux, Biochemistry, Polysaccharides, Antithrombotic, medicine, Animals, Humans, Bivalirudin, Enoxaparin, Blood Coagulation, Blood coagulation test, Heparin, business.industry, Anticoagulants, Percutaneous coronary intervention, Drug Synergism, Thrombosis, Cell Biology, Hematology, Disease Models, Animal, Catheter, Anesthesia, Factor XII, Blood Coagulation Tests, Rabbits, business, Fibrinolytic agent, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cc0391a4f9b73aa40f03374e7cfeb0
https://doi.org/10.1182/blood-2011-07-364141

المؤلفون: Richard C. Austin, Alan R. Stafford, Salvatore V. Pizzo, Jennifer Caldwell, Mario Gonzalez-Gronow, Donald W. Jacobsen, Ali Al-Hashimi, Hiam Al-Bayati, Lindsay M. Pozza, Howard H.W. Chan, Danya Aboumrad, Jeffrey I. Weitz, Jeffrey G. Dickhout, Anil Kapoor

المصدر: Journal of Biological Chemistry. 285:28912-28923

مصطلحات موضوعية: Male, Thapsigargin, Antibodies, Neoplasm, Cell, chemistry.chemical_element, Phosphatidylserines, Calcium, Biology, Endoplasmic Reticulum, Biochemistry, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Thromboplastin, Epitopes, chemistry.chemical_compound, Tissue factor, Membrane Biology, Cell Line, Tumor, medicine, Humans, Tissue Factor Procoagulant, Enzyme Inhibitors, Endoplasmic Reticulum Chaperone BiP, Molecular Biology, Heat-Shock Proteins, Autoantibodies, Endoplasmic reticulum, Autoantibody, Prostatic Neoplasms, Venous Thromboembolism, Cell Biology, Cell biology, Cytosol, medicine.anatomical_structure, chemistry, Cell culture, Type C Phospholipases, Cancer cell, Immunology, Unfolded protein response, Additions and Corrections, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfbcae83edff54bc57bbc671e554c7d
https://doi.org/10.1074/jbc.m110.119107