المؤلفون: Aleksey A. Vatlin (11229042), Egor A. Shitikov (9645296), Mohd Shahbaaz (504871), Dmitry A. Bespiatykh (9645299), Ksenia M. Klimina (9645308), Alan Christoffels (16635), Valery N. Danilenko (836929), Dmitry A. Maslov (11229045)

مصطلحات موضوعية: Microbiology, Microbial Genetics, Microbial Ecology, Mycology, Mycobacterium, drug resistance, imidazo[1, 2-b][1, 5]tetrazine, transcriptome, drug development, tuberculosis, virtual screening

Time: 2, 4

Relation: https://figshare.com/articles/presentation/Presentation_1_Transcriptomic_Profile_of_Mycobacterium_smegmatis_in_Response_to_an_Imidazo_1_2-b_1_2_4_5_tetrazine_Reveals_Its_Possible_Impact_on_Iron_Metabolism_pdf/15103623

الاتاحة: https://doi.org/10.3389/fmicb.2021.724042.s001

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/Potential_energy_of_the_four_systems_of_NRXN2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324483

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s005

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/Clinical_and_demographic_information_on_members_of_South_African_family_ZA253_with_Parkinson_s_disease_/14324471

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s001

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/Summary_of_whole_exome_sequencing_metrics_in_the_three_affected_individuals_/14324474

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s002

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/The_average_temperature_of_the_four_systems_of_NRXN2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324486

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s006

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/Total_energy_of_the_four_systems_of_NRXN2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324480

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s004

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/2D_interaction_diagram_showing_polar_contacts_formed_between_NRXN2_residues_and_sugar_moiety_NAG_/14324489

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s007

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/The_average_temperature_of_the_four_systems_of_repeat_2_NRNX2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324510

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s014

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/Potential_energy_of_the_four_systems_of_repeat_2_of_NRNX2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324507

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s013

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/Total_energy_of_the_four_systems_of_the_repeat_1_of_NRXN2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324492

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s008

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/Total_energy_of_the_four_systems_of_the_repeat_2_of_NRNX2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324504

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s012

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/The_average_temperature_of_the_four_systems_of_repeat_1_NRXN2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324498

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s010

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/RMSD_deviation_of_the_backbone_atoms_for_the_four_systems_of_repeat_2_NRXN2_1_40mm_0_33_1_98mm_0_45_2_15mm_0_51_and_1_29mm_0_29_/14324513

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s015

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/Potential_energy_of_the_four_systems_of_repeat_1_of_NRXN2_WT_noNAG_MUT_noNAG_WT_NAG_and_MUT_NAG_over_100_ns_/14324495

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s009

المؤلفون: Boiketlo Sebate (10475333), Katelyn Cuttler (10475336), Ruben Cloete (173249), Marcell Britz (10475339), Alan Christoffels (16635), Monique Williams (391976), Jonathan Carr (7311947), Soraya Bardien (3500174)

مصطلحات موضوعية: Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, NAG, Mendelian, WES, Next-generation sequencing approaches, CCNF, disorder, CFAP, NRNX, RTF, PD, Parkinson, South, TEP, tool, protein, LNS -6 domain, model quality assessment scores, variant, NRXN 2, analysis

Relation: https://figshare.com/articles/journal_contribution/RMSD_deviation_of_the_backbone_atoms_for_the_four_systems_of_repeat_1_NRXN2_/14324501

الاتاحة: https://doi.org/10.1371/journal.pone.0249324.s011

المؤلفون: Aleksey A. Vatlin (11229042), Egor A. Shitikov (9645296), Mohd Shahbaaz (504871), Dmitry A. Bespiatykh (9645299), Ksenia M. Klimina (9645308), Alan Christoffels (16635), Valery N. Danilenko (836929), Dmitry A. Maslov (11229045)

مصطلحات موضوعية: Microbiology, Microbial Genetics, Microbial Ecology, Mycology, Mycobacterium, drug resistance, imidazo[1, 2-b][1, 5]tetrazine, transcriptome, drug development, tuberculosis, virtual screening

Time: 2, 4

Relation: https://figshare.com/articles/dataset/Table_1_Transcriptomic_Profile_of_Mycobacterium_smegmatis_in_Response_to_an_Imidazo_1_2-b_1_2_4_5_tetrazine_Reveals_Its_Possible_Impact_on_Iron_Metabolism_XLSX/15103626

الاتاحة: https://doi.org/10.3389/fmicb.2021.724042.s002

المؤلفون: Ruben Cloete (173249), Mohd Shahbaaz (504871), Melanie Grobbelaar (11636780), Samantha L. Sampson (7280255), Alan Christoffels (16635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, total interaction energy, prestwick chemical library, potential drug target, nucleotide adenylyl transferase, hydrogen bond interactions, higher binding affinities, drug target nicotinate, div >< p, known human homologs, five compounds based, novobiocin sodium salt, novobiocin salt interacts, rv2421c suggest coumermycin, mycobacterium tuberculosis <, novobiocin (- 379, qsar model validated, 2 , ic50 based 3d, novobiocin salt, novobiocin derivative, vitro <

Relation: https://figshare.com/articles/figure/Multiple_sequence_alignment_between_Rv2421c_probable_nicotinate-nucleotide_adenylyl_transferase_nadD_212AA_in_size_and_two_homologous_templates_/16919549

الاتاحة: https://doi.org/10.1371/journal.pone.0259348.s001

المؤلفون: Ruben Cloete (173249), Mohd Shahbaaz (504871), Melanie Grobbelaar (11636780), Samantha L. Sampson (7280255), Alan Christoffels (16635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, total interaction energy, prestwick chemical library, potential drug target, nucleotide adenylyl transferase, hydrogen bond interactions, higher binding affinities, drug target nicotinate, div >< p, known human homologs, five compounds based, novobiocin sodium salt, novobiocin salt interacts, rv2421c suggest coumermycin, mycobacterium tuberculosis <, novobiocin (- 379, qsar model validated, 2 , ic50 based 3d, novobiocin salt, novobiocin derivative, vitro <

Relation: https://figshare.com/articles/figure/Superimposition_of_the_crystal_structure_of_i_M_tuberculosis_i_Rv2421c_4X0E_and_homologous_templates_3E27_and_2QTN_/16919552

الاتاحة: https://doi.org/10.1371/journal.pone.0259348.s002

المؤلفون: Ruben Cloete (173249), Mohd Shahbaaz (504871), Melanie Grobbelaar (11636780), Samantha L. Sampson (7280255), Alan Christoffels (16635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, total interaction energy, prestwick chemical library, potential drug target, nucleotide adenylyl transferase, hydrogen bond interactions, higher binding affinities, drug target nicotinate, div >< p, known human homologs, five compounds based, novobiocin sodium salt, novobiocin salt interacts, rv2421c suggest coumermycin, mycobacterium tuberculosis <, novobiocin (- 379, qsar model validated, 2 , ic50 based 3d, novobiocin salt, novobiocin derivative, vitro <

Relation: https://figshare.com/articles/figure/Polar_interactions_calculated_for_the_first_four_complex_systems_using_PyMol_/16919555

الاتاحة: https://doi.org/10.1371/journal.pone.0259348.s003

المؤلفون: Ruben Cloete (173249), Mohd Shahbaaz (504871), Melanie Grobbelaar (11636780), Samantha L. Sampson (7280255), Alan Christoffels (16635)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, total interaction energy, prestwick chemical library, potential drug target, nucleotide adenylyl transferase, hydrogen bond interactions, higher binding affinities, drug target nicotinate, div >< p, known human homologs, five compounds based, novobiocin sodium salt, novobiocin salt interacts, rv2421c suggest coumermycin, mycobacterium tuberculosis <, novobiocin (- 379, qsar model validated, 2 , ic50 based 3d, novobiocin salt, novobiocin derivative, vitro <

Relation: https://figshare.com/articles/figure/Polar_interactions_calculated_for_the_last_three_complex_systems_using_PyMol_/16919558

الاتاحة: https://doi.org/10.1371/journal.pone.0259348.s004