المؤلفون: Christine F. Gelin, Brice Stenne, Heather Coate, Afton Hiscox, Akinola Soyode-Johnson, Jessica L. Wall, Brian Lord, Jeffrey Schoellerman, Kevin J. Coe, Kai Wang, Jesus Alcázar, Christa C. Chrovian, Curt A. Dvorak, Nicholas I. Carruthers, Tatiana Koudriakova, Bartosz Balana, Michael A. Letavic

المصدر: Journal of Medicinal Chemistry. 66:2877-2892

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e473bb48ba527d136d4062091035bc17
https://doi.org/10.1021/acs.jmedchem.2c01916

المؤلفون: Alexandra S Needham, Akinola Soyode-Johnson, Kevin J. Coe, Bartosz Balana, Freddy Schoetens, Xiaohui Jiang, Daniel J. Pippel, Kia Sepassi, Chungfang Xia, Stenne Brice M, Brian Scott, Leslie Nguyen, Tatiana Koudriakova, Christa C. Chrovian, Brian Lord, Michael A. Letavic, Jeffrey Schoellerman

المصدر: Journal of Medicinal Chemistry. 63:9181-9196

مصطلحات موضوعية: 0303 health sciences, Allosteric regulation, Target engagement, Pharmacology, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Mood disorders, chemistry, Drug Discovery, medicine, Molecular Medicine, Major depressive disorder, Structure–activity relationship, Ionotropic glutamate receptor, Receptor, Lead compound, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::19f1743cefc51ebca30728bea44390f7
https://doi.org/10.1021/acs.jmedchem.9b02113

المؤلفون: Akinola Soyode-Johnson, Michael A. Letavic, Kevin J. Coe, Christa C. Chrovian, Brian Lord, Nicholas I. Carruthers, Wall Jessica L, Bartosz Balana, Xiaohui Jiang, Tatiana Koudriakova, Leslie Nguyen, Jason C. Rech, Jeff Schoellerman

المصدر: ACS Medicinal Chemistry Letters. 10:261-266

مصطلحات موضوعية: biology, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Allosteric regulation, hERG, Cytochrome P450, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Pyridine, biology.protein, Potency, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::614ed6a6c02beecc62fce4553e7a6304
https://doi.org/10.1021/acsmedchemlett.8b00542

المؤلفون: Brian Lord, Brian Scott, Kia Sepassi, Akinola Soyode-Johnson, Anindya Bhattacharya, Alexander A. Peterson, Nicholas I. Carruthers, Leah Aluisio, Tatiana Koudriakova, Freddy Schoetens, Christa C. Chrovian, Curt A. Dvorak, David J. Gallacher, Christine F. Gelin, Xiaohu Deng, Michael A. Letavic, Ian Fraser, Kevin J. Coe

المصدر: Journal of medicinal chemistry. 61(1)

مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Purinergic P2X Receptor Antagonists, Stereochemistry, Pyridines, Molecular Conformation, Stereoisomerism, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Dogs, Drug Discovery, Pyridine, Animals, Humans, Tissue Distribution, P2x7 receptor, Trifluoromethyl, Cycloaddition Reaction, Low dose, Antagonist, Cycloaddition, Rats, 030104 developmental biology, chemistry, Tolerability, Drug Design, Molecular Medicine, Receptors, Purinergic P2X7, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2142bef6b6c3fe0e5f8e32199a2bd514
https://pubmed.ncbi.nlm.nih.gov/29211470

المؤلفون: John R. Atack, Kirsten L. Morton, Emily M. Stocking, Christine Dugovic, Akinola Soyode-Johnson, Anita M. Everson, Ian Fraser, Xiaohui Jiang, Brian Lord, Jonathan Shelton, Chandravadan R. Shah, Leah Aluisio, Pascal Bonaventure, Perry Leung, Kiev S. Ly, Nicholas I. Carruthers, Diane Nepomuceno, Michael A. Letavic

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2755-2760

مصطلحات موضوعية: Pyrrolidines, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Histamine receptor, Dogs, Oral administration, Drug Discovery, Animals, Humans, Receptors, Histamine H3, Molecular Biology, Chemistry, Organic Chemistry, Brain, Azepines, Rat brain, Rats, Molecular Medicine, Histamine H3 receptor, Histamine H3 Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab03e0248fd9c2c1836ef521d115da96
https://doi.org/10.1016/j.bmcl.2010.03.071

المؤلفون: Christa C. Chrovian, Akinola Soyode-Johnson, Genesis M. Bacani, Jason C. Rech, Hong Ao, Leslie Nguyen, Nicholas I. Carruthers, Qi Wang, Brian Lord, Michael A. Letavic, Anindya Bhattacharya

المصدر: ACS chemical neuroscience. 7(4)

مصطلحات موضوعية: 0301 basic medicine, Pyrazine, Purinergic P2X Receptor Antagonists, Physiology, Stereochemistry, Cognitive Neuroscience, In Vitro Techniques, Biochemistry, Binding, Competitive, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, 0302 clinical medicine, Pharmacokinetics, In vivo, Structure–activity relationship, Animals, Humans, ADME, Dose-Response Relationship, Drug, Chemistry, Brain, Cell Biology, General Medicine, In vitro, Rats, 030104 developmental biology, Pyrazines, Autoradiography, 030217 neurology & neurosurgery, Ex vivo, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea37a52d37a3b261539ef262089cf467
https://pubmed.ncbi.nlm.nih.gov/26752113