المؤلفون: Summers, Robert, Pasaje, Charisse, Pisco, Joao, Striepen, Josefine, Luth, Madeline, Kumpornsin, Krittikorn, Carpenter, Emma, Munro, Justin, Lin, De, Plater, Andrew, Punekar, Avinash, Shepherd, Andrew, Shepherd, Sharon, Vanaerschot, Manu, Murithi, James, Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A, Won, Madalyn, Mandt, Rebecca, McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus, Fidock, David, Gilbert, Ian, Wirth, Dyann, Niles, Jacquin, Baragaña, Beatriz, Lukens, Amanda, Winzeler, Elizabeth

المصدر: Cell Chemical Biology. 29(2)

مصطلحات موضوعية: Plasmodium falciparum, acetyl-CoA synthetase, antimalarial, drug development, drug target identification, histone acetylation, malaria, mechanism of action, Acetate-CoA Ligase, Antimalarials, Enzyme Inhibitors, Humans, Malaria, Models, Molecular, Molecular Structure, Parasitic Sensitivity Tests, Plasmodium falciparum

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2t51p0mx
https://escholarship.org/content/qt2t51p0mx/qt2t51p0mx.pdf

المؤلفون: Cowell, Annie N, Istvan, Eva S, Lukens, Amanda K, Gomez-Lorenzo, Maria G, Vanaerschot, Manu, Sakata-Kato, Tomoyo, Flannery, Erika L, Magistrado, Pamela, Owen, Edward, Abraham, Matthew, LaMonte, Gregory, Painter, Heather J, Williams, Roy M, Franco, Virginia, Linares, Maria, Arriaga, Ignacio, Bopp, Selina, Corey, Victoria C, Gnädig, Nina F, Coburn-Flynn, Olivia, Reimer, Christin, Gupta, Purva, Murithi, James M, Moura, Pedro A, Fuchs, Olivia, Sasaki, Erika, Kim, Sang W, Teng, Christine H, Wang, Lawrence T, Akidil, Aslı, Adjalley, Sophie, Willis, Paul A, Siege, Dionicio, Tanaseichuk, Olga, Zhong, Yang, Zhou, Yingyao, Llinás, Manuel, Ottilie, Sabine, Gamo, Francisco-Javier, Lee, Marcus CS, Goldberg, Daniel E, Fidock, David A, Wirth, Dyann F, Winzeler, Elizabeth A

المصدر: Science. 359(6372)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Biotechnology, Emerging Infectious Diseases, Orphan Drug, Infectious Diseases, Malaria, Rare Diseases, Antimicrobial Resistance, Genetics, Vector-Borne Diseases, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Activation, Metabolic, Alleles, Antimalarials, DNA Copy Number Variations, Directed Molecular Evolution, Drug Resistance, Drug Resistance, Multiple, Genes, Protozoan, Genome, Protozoan, Metabolomics, Mutation, Plasmodium falciparum, Selection, Genetic, Transcription Factors, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/46g806c2
https://escholarship.org/content/qt46g806c2/qt46g806c2.pdf

المؤلفون: Summers, Robert L., Pasaje, Charisse Flerida A., Pisco, Joao P., Striepen, Josefine, Luth, Madeline R., Kumpornsin, Krittikorn, Carpenter, Emma F., Munro, Justin T., Lin, De, Plater, Andrew, Punekar, Avinash S., Shepherd, Andrew M., Shepherd, Sharon M., Vanaerschot, Manu, Murithi, James M., Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A. Hazel, Won, Madalyn, Mandt, Rebecca E. K., McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus C. S., Winzeler, Elizabeth A., Fidock, David A., Gilbert, Ian H., Wirth, Dyann F., Niles, Jacquin C., Baragaña, Beatriz, Lukens, Amanda K.

المصدر: Summers , R L , Pasaje , C F A , Pisco , J P , Striepen , J , Luth , M R , Kumpornsin , K , Carpenter , E F , Munro , J T , Lin , D , Plater , A , Punekar , A S , Shepherd , A M , Shepherd , S M , Vanaerschot , M , Murithi , J M , Rubiano , K , Akidil , A , Ottilie , S , Mittal , N , Dilmore , A H , Won , M , Mandt , R ....

مصطلحات موضوعية: malaria, drug target identification, antimalarial, drug development, acetyl-CoA synthetase, Plasmodium falciparum, mechanism of action, histone acetylation, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/a79f3004-0a50-4219-95f6-445e1d5cd4a4
https://doi.org/10.1016/j.chembiol.2021.07.010
https://discovery.dundee.ac.uk/ws/files/65647009/PIIS2451945621003500.pdf
http://www.scopus.com/inward/record.url?scp=85116027729&partnerID=8YFLogxK

المؤلفون: Skinner, William H., Chung, Michael, Mitchell, Stephen, Akidil, Asli, Fabre, Kristin, Goodwin, Richard, Stokes, Adam A., Radacsi, Norbert, Campbell, Colin J.

المساهمون: Engineering and Physical Sciences Research Council

المصدر: Analytical Chemistry ; volume 93, issue 41, page 13844-13851 ; ISSN 0003-2700 1520-6882

الاتاحة: http://dx.doi.org/10.1021/acs.analchem.1c02530
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.1c02530