المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/journal_contribution/Structure_Activity_Relationship_of_USP5_Inhibitors/16811665

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s001

المؤلفون: Yudao Shen (1476319), Fengling Li (176389), Magdalena M. Szewczyk (3119427), Levon Halabelian (710679), Irene Chau (2276365), Mohammad S. Eram (1399684), Carlo Dela Seña (10151727), Kwang-Su Park (10151730), Fanye Meng (8299767), He Chen (104732), Hong Zeng (24161), Aiping Dong (141147), Hong Wu (105254), Viacheslav V. Trush (10429365), David McLeod (2086192), Carlos A. Zepeda-Velázquez (8805626), Robert M. Campbell (2443825), Mary M. Mader (1398535), Brian M. Watson (2521252), Matthieu Schapira (51934), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Dalia Barsyte-Lovejoy (1399687), H. Ümit Kaniskan (1476325), Peter J. Brown (499896), Masoud Vedadi (210076), Jian Jin (351142)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, PRMT 6 functions, Protein Arginine Methyltransferase ., well-characterized PRMT 6 chemical ., PRMT 6, 6870N, PRMT 6 inhibitor, Cell-Active Allosteric Inhibitor, SGC, IC

Relation: https://figshare.com/articles/journal_contribution/A_First-in-Class_Highly_Selective_and_Cell-Active_Allosteric_Inhibitor_of_Protein_Arginine_Methyltransferase_6/14043573

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02160.s001

المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_of_USP5_Inhibitors/16811677

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s005

المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_of_USP5_Inhibitors/16811668

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s002

المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_of_USP5_Inhibitors/16811671

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s003

المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_of_USP5_Inhibitors/16811674

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s004

المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_of_USP5_Inhibitors/16811680

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s006

المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_of_USP5_Inhibitors/16811686

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s007

المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_of_USP5_Inhibitors/16811695

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s009

المؤلفون: Mandeep K. Mann (11564635), Carlos A. Zepeda-Velázquez (8805626), Héctor González-Álvarez (11564638), Aiping Dong (141147), Taira Kiyota (2507788), Ahmed M. Aman (1884958), Peter Loppnau (273605), Yanjun Li (46396), Brian Wilson (2144590), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Rachel J. Harding (7847774), Matthieu Schapira (51934)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, poorly characterized zinc, delineate usp5 function, usp5 inhibitors usp5, usp5 catalytic cleavage, targeting chemical probe, 64 , chemical probe, catalytic activity, vitro <, k <, , usp5 znf, ubiquitin substrate, terminal ubiquitin, study provides, structural framework, multiple ligands, including cancer, crystallographic characterization, chemical series, binding site, >< sub, 8 μm

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationship_of_USP5_Inhibitors/16811698

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00889.s010