المؤلفون: Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S. Craik, Matthew P. Jacobson, Aimee W. Kao

المصدر: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)

مصطلحات موضوعية: Cathepsin, Protease, α-synuclein, TDP-43, Tau, Lysosome, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1750-1326

URL الوصول: https://doaj.org/article/e9dcb181060f4b0d9dcfbc703faec0a4

المؤلفون: Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson, Aimee W. Kao

المصدر: Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)

مصطلحات موضوعية: Progranulin, Granulin, Frontotemporal lobar degeneration, Lysosome, Protease, pH, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1750-1326

URL الوصول: https://doaj.org/article/2bcbf5d1642d41eea3c3e628a2a7b9be

المؤلفون: Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S. Craik, Matthew P. Jacobson, Aimee W. Kao

المصدر: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)

مصطلحات موضوعية: Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1750-1326

URL الوصول: https://doaj.org/article/54f456d00d3341bd985157eb4b460991

المؤلفون: Celeste M. Karch, Aimee W. Kao, Anna Karydas, Khadijah Onanuga, Rita Martinez, Andrea Argouarch, Chao Wang, Cindy Huang, Peter Dongmin Sohn, Kathryn R. Bowles, Salvatore Spina, M. Catarina Silva, Jacob A. Marsh, Simon Hsu, Derian A. Pugh, Nupur Ghoshal, Joanne Norton, Yadong Huang, Suzee E. Lee, William W. Seeley, Panagiotis Theofilas, Lea T. Grinberg, Fermin Moreno, Kathryn McIlroy, Bradley F. Boeve, Nigel J. Cairns, John F. Crary, Stephen J. Haggarty, Justin K. Ichida, Kenneth S. Kosik, Bruce L. Miller, Li Gan, Alison M. Goate, Sally Temple, Carolina Alquezar, Kathryn Bowles, David Butler, Israel Hernandez, Valerie Hennes, Martin Kampmann

المصدر: Stem Cell Reports, Vol 13, Iss 5, Pp 939-955 (2019)

مصطلحات موضوعية: Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213671119303352; https://doaj.org/toc/2213-6711

URL الوصول: https://doaj.org/article/598d132842794126ace928eb080d817b

المؤلفون: Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P. Simon, Victoria J. Butler, Manfred Jung, Julie Andersen, Aimee W. Kao, Eric Verdin

المصدر: npj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-11 (2019)

مصطلحات موضوعية: Geriatrics, RC952-954.6

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2056-3973

URL الوصول: https://doaj.org/article/fedb936c93fd4ed4a2abe901304bf02a

المؤلفون: Carolina Alquezar, Shruti Arya, Aimee W. Kao

المصدر: Frontiers in Neurology, Vol 11 (2021)

مصطلحات موضوعية: phosphorylation, acetylation, ubiquitination, methylation, sumoylation, glycosylation, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2020.595532/full; https://doaj.org/toc/1664-2295

URL الوصول: https://doaj.org/article/6dd3d1dd45cb4609b7755ad5686e6998

المؤلفون: Sushmitha Gururaj, Paul J. Sampognaro, Andrea R. Argouarch, Aimee W. Kao

المصدر: Frontiers in Neuroscience, Vol 14 (2020)

مصطلحات موضوعية: progranulin, adsorption, neurodegeneration, polypropylene, cathepsins, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2020.602235/full; https://doaj.org/toc/1662-453X

URL الوصول: https://doaj.org/article/b6873566170e451bb63d2a96c6dd715e

المؤلفون: Brianne M. Bettcher, Ryan Fitch, Matthew J. Wynn, Matthew A. Lalli, Jonathan Elofson, Laura Jastrzab, Laura Mitic, Zachary A. Miller, Gil D. Rabinovici, Bruce L. Miller, Aimee W. Kao, Kenneth S. Kosik, Joel H. Kramer

المصدر: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 3, Iss 1, Pp 91-97 (2016)

مصطلحات موضوعية: Inflammation, Neuropsychology, Chemokines, Neuroimaging, Episodic memory, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2352-8729

URL الوصول: https://doaj.org/article/ca18ddfd0c2c49a89d1a08cae026cec8

المؤلفون: Swetha Mohan (2935887), Paul J. Sampognaro (9765293), Andrea R. Argouarch (9765296), Jason C. Maynard (11227654), Mackenzie Welch (10942705), Anand Patwardhan (807166), Emma C. Courtney (11227657), Jiasheng Zhang (2855429), Amanda Mason (4092172), Kathy H. Li (11227660), Eric J. Huang (11227663), William W. Seeley (749329), Bruce L. Miller (8450160), Alma Burlingame (11227666), Mathew P. Jacobson (11227669), Aimee W. Kao (11227672)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Neuroscience, Immunology, Mental Health, Computational Biology, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Progranulin, Granulin, Frontotemporal lobar degeneration, Lysosome, Protease, pH, Asparagine endopeptidase

Relation: https://figshare.com/articles/journal_contribution/Additional_file_1_of_Processing_of_progranulin_into_granulins_involves_multiple_lysosomal_proteases_and_is_affected_in_frontotemporal_lobar_degeneration/15102601

الاتاحة: https://doi.org/10.6084/m9.figshare.15102601.v1

المؤلفون: Marcus Y. Chin (10942699), Anand R. Patwardhan (10942702), Kean-Hooi Ang (694023), Austin L. Wang (6732764), Carolina Alquezar (322310), Mackenzie Welch (10942705), Phi T. Nguyen (10942708), Michael Grabe (48010), Anna V. Molofsky (10942711), Michelle R. Arkin (114394), Aimee W. Kao (7181462)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Inorganic Chemistry, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, p K, Genetically Encoded, V-ATPase inhibitor, Fluorescence Indicator REporting pH, acidic lumenal pH, lysosomal pH, lysosomal pH biosensor, FIRE-pHLy, cyan pH-sensitive FP variant, lysosome-based drug discovery, Lysosomal pH Lysosomes, pH dynamics, protein 1, lumenal pH

Relation: https://figshare.com/articles/journal_contribution/Genetically_Encoded_pH-Sensitive_mTFP1_Biosensor_for_Probing_Lysosomal_pH/14751634

الاتاحة: https://doi.org/10.1021/acssensors.0c02318.s001

المؤلفون: Andrea R. Argouarch, Nina Schultz, Andrew C. Yang, Yeongjun Jang, Kristle Garcia, Celica G. Cosme, Christian I. Corrales, Alissa L. Nana, Anna M. Karydas, Salvatore Spina, Lea T. Grinberg, Bruce Miller, Tony Wyss-Coray, Alexej Abyzov, Hani Goodarzi, William W. Seeley, Aimee W. Kao

المصدر: Stem cell reviews and reports, vol 18, iss 8

مصطلحات موضوعية: Biobanking, Loss of Y chromosome, Cells, Dermal epithelium, Postmortem tissue, Neurodegenerative disease, Human dura mater, Mice, Clinical Research, Genetics, Animals, Humans, 2.1 Biological and endogenous factors, Aetiology, Cultured, Dural cells, Chromosomal karyotype, Mural cells, Neurosciences, Cell Differentiation, General Medicine, Fibroblasts, Dermal fibroblasts, Good Health and Well Being, Dura Mater, Transcriptome

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a19762f36406e2df75505e5a75a499
https://doi.org/10.1007/s12015-022-10416-x

المؤلفون: Apeksha Singh, Frank V Marcoline, Salome Veshaguri, Aimee W Kao, Marcel Bruchez, Joseph A Mindell, Dimitrios Stamou, Michael Grabe

المصدر: PLoS Computational Biology, Vol 15, Iss 12, p e1007539 (2019)

مصطلحات موضوعية: Biology (General), QH301-705.5

Relation: https://doi.org/10.1371/journal.pcbi.1007539; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358; https://doaj.org/article/01d7c71e8534490fad934f619561704f

الاتاحة: https://doi.org/10.1371/journal.pcbi.1007539
https://doaj.org/article/01d7c71e8534490fad934f619561704f

المؤلفون: Victoria J Butler, Fuying Gao, Christian I Corrales, Wilian A Cortopassi, Benjamin Caballero, Mihir Vohra, Kaveh Ashrafi, Ana Maria Cuervo, Matthew P Jacobson, Giovanni Coppola, Aimee W Kao

المصدر: PLoS Genetics, Vol 15, Iss 8, p e1008295 (2019)

مصطلحات موضوعية: Genetics, QH426-470

Relation: https://doi.org/10.1371/journal.pgen.1008295; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404; https://doaj.org/article/28ae161b4c77481f8ab396351dac3ed4

الاتاحة: https://doi.org/10.1371/journal.pgen.1008295
https://doaj.org/article/28ae161b4c77481f8ab396351dac3ed4

المؤلفون: Ji-Hye L. Hwang, Olga S. Perloff, Stephanie E. Gaus, Camila Benitez, Carolina Alquezar, Celica Q. Cosme, Alissa L. Nana, Sarat C. Vatsavayai, Eliana M. Ramos, Daniel H. Geschwind, Bruce L. Miller, Aimee W. Kao, William W. Seeley

المصدر: Acta Neuropathol
Acta neuropathologica, vol 145, iss 1

مصطلحات موضوعية: Adult, Aging, Intellectual and Developmental Disabilities (IDD), Clinical Sciences, Neurodegenerative, Alzheimer's Disease, Article, Pathology and Forensic Medicine, Neurofibrillary tangle, Cellular and Molecular Neuroscience, Rare Diseases, Tuberous Sclerosis, Clinical Research, Acquired Cognitive Impairment, Humans, 2.1 Biological and endogenous factors, Aetiology, Alzheimer's Disease Related Dementias (ADRD), Epilepsy, Amyloid beta-Peptides, Neurology & Neurosurgery, Tumor Suppressor Proteins, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acetylation, TSC2, TSC1, Brain Disorders, Tauopathy, Frontotemporal Dementia (FTD), Tauopathies, Tuberous sclerosis complex, Mutation, Neurological, Dementia, Neurology (clinical), Tau

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2ccbd5a1be1a194149fd8dcce8994c
https://europepmc.org/articles/PMC10244026/

المؤلفون: Aimee W. Kao, Austin L Wang, Anand Patwardhan, Michael Grabe, Phi T. Nguyen, Kean-Hooi Ang, Anna V. Molofsky, Carolina Alquezar, Michelle R. Arkin, Marcus Y. Chin, Mackenzie Welch

المصدر: ACS Sensors
ACS sensors, vol 6, iss 6

مصطلحات موضوعية: Green Fluorescent Proteins, Biomedical Engineering, neurons, Bioengineering, Biosensing Techniques, macromolecular substances, 02 engineering and technology, 01 natural sciences, Article, Analytical Chemistry, chemistry.chemical_compound, lysosomes, ratiometric imaging, Lysosome, medicine, Nanotechnology, Instrumentation, Fluid Flow and Transfer Processes, LAMP1, Chemistry, Process Chemistry and Technology, 010401 analytical chemistry, Bafilomycin, high-content analysis, Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, Fluorescence, pH biosensor, 0104 chemical sciences, medicine.anatomical_structure, Membrane protein, Biochemistry, High-content screening, Generic health relevance, 0210 nano-technology, mCherry, Biosensor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2415b35c8d9c812672f8372fce4396ee
https://doi.org/10.1021/acssensors.0c02318

المؤلفون: Marcus Y. Chin, Kean-Hooi Ang, Julia Davies, Carolina Alquezar, Virginia G. Garda, Brendan Rooney, Kun Leng, Martin Kampmann, Michelle R. Arkin, Aimee W. Kao

المصدر: ACS chemical neuroscience, vol 13, iss 10

مصطلحات موضوعية: Neurons, lysosomal pH, Physiology, Cognitive Neuroscience, phenotypic screening, Neurosciences, Neurodegenerative Diseases, high-content analysis, Cell Biology, General Medicine, Neurodegenerative, Hydrogen-Ion Concentration, Biochemistry, pH biosensor, Medicinal and Biomolecular Chemistry, lysosomes, Rare Diseases, Orphan Drug, 5.1 Pharmaceuticals, Autophagy, Humans, Development of treatments and therapeutic interventions, Lysosomes, Biotechnology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932a175ca48bd59781d99e7e7f40d25d
https://pubmed.ncbi.nlm.nih.gov/35522480

المؤلفون: Dennis W. Dickson, Jennifer S. Yokoyama, Alma L. Burlingame, Eliana Marisa Ramos, Carolina Alquezar, Gerard D. Schellenberg, Beth A. Dombroski, Ana Maria Cuervo, Kathleen M. Schoch, Aimee W. Kao, Aurora Scrivo, Elisabeth E. Mlynarski, Ethan G. Geier, Michael DeTure, Bruce L. Miller, Andrea R. Argouarch, Kathy H. Li, Timothy M. Miller

المصدر: Science Advances

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Mutation, Multidisciplinary, Chemistry, SciAdv r-articles, medicine.disease, medicine.disease_cause, Cell biology, medicine.anatomical_structure, Chaperone-mediated autophagy, Acetylation, Cellular Neuroscience, mental disorders, medicine, TSC1, Tauopathy, Gene, Intracellular, Research Article, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2971ddfc3f38684396c55b5251cbb38
https://doi.org/10.1126/sciadv.abg3897

المؤلفون: Manuel D. Leonetti, Saeed Fathi, Aimee W. Kao, Kari A. Herrington, Sophie Bax, Martin Kampmann, Kun Leng, Marcus Y. Chin, Joshua E. Elias, Frank McCarthy, Indigo V.L. Rose, Brendan Rooney

مصطلحات موضوعية: medicine.anatomical_structure, Chemistry, Lysosome, Cell, Regulator, medicine, Neurotoxicity, medicine.disease, PI3K/AKT/mTOR pathway, Exocytosis, Homeostasis, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cf62582038ac0c543128bc3b8140882f
https://doi.org/10.1101/2021.09.11.459904

المؤلفون: Austin L Wang, Wilian A. Cortopassi, Matthew P. Jacobson, Victoria J. Butler, Aimee W. Kao, Sushmitha Gururaj, Olivia M Pierce

المصدر: Biochemistry

مصطلحات موضوعية: chemistry.chemical_classification, Enzyme Precursors, Protein Conformation, Protein Stability, Chemistry, Neurodegeneration, Cathepsin D, Granulin, Plasma protein binding, medicine.disease, Biochemistry, Article, In vitro, Cell biology, Protein structure, medicine.anatomical_structure, Lysosome, medicine, Humans, Transition Temperature, Glycoprotein, Granulins, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6024f73ee9e6ad06204ca85f1cc3090
https://doi.org/10.1021/acs.biochem.9b00275

المؤلفون: Aimee W. Kao, Andrea R. Argouarch, Alissa L. Nana, Bruce L. Miller, Salvatore Spina, Anna Karydas, Christian I. Corrales, William W. Seeley, Kristle Garcia, Hani Goodarzi, Celica Cosme, Lea T. Grinberg

مصطلحات موضوعية: musculoskeletal diseases, Pathology, medicine.medical_specialty, integumentary system, Dura mater, Biology, musculoskeletal system, In vitro, Epithelium, medicine.anatomical_structure, nervous system, Dermis, Cell culture, Gene expression, medicine, Fibroblast, Reprogramming

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fc127e6dcf0295022882090700da2c56
https://doi.org/10.1101/2021.05.17.444554