المؤلفون: Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/a5462d8522964b13a5f79a9e1b35250a

المؤلفون: Duncan C. Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J. Cook, Noel Edwards, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Ian Hardcastle, Suzannah J. Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P. Martin, Nick C. Martin, Stephanie Myers, David R. Newell, Richard A. Noble, Nicole Phillips, Laurent Rigoreau, Huw Thomas, Julie A. Tucker, Lan-Zhen Wang, Michael J. Waring, Ai-Ching Wong, Stephen R. Wedge, Martin E. M. Noble, Celine Cano

المصدر: Journal of Medicinal Chemistry. 65:6513-6540

مصطلحات موضوعية: Drug Discovery, Molecular Medicine, Pyrroles, Mitogen-Activated Protein Kinase 7, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a06ab562a276985938cc66414c34c2
https://doi.org/10.1021/acs.jmedchem.1c01756

المؤلفون: Christina Alli, Christopher J. Lord, Marcel Tijsterman, Katherine Ewings, Marco Ranzani, Ai Ching Wong, Claire McWhirter, Martin Swarbrick, Harry Finch, Robert A. Heald, Rachel Brough, Nan Shao, Rebecca Marlow, Shaun Moore, Vera Grinkevich, Ellen Macdonald, Jayne Curry, Helen M. R. Robinson, Graeme Hewitt, Eleanor Knight, Christopher Bot, Syed Haider, Mathew Calder, Theresia A. Schaedler, Hollie McCarron, Luned M. Badder, Aditi Gulati, Martin Stockley, Eeson Rajendra, Sophie Langdon, Stephen J. Pettitt, Simon J. Boulton, Chris Pedder, Elsa Callen, Ed Wheatley, Wojciech Krajewski, André Nussenzweig, Daniela Novo, Peter Blencowe, Jayesh B. Majithiya, Laurent Rigoreau, Lerin Geo, Cameron Bell, Kimberley A. Wiggins, Diana Zatreanu, Geoff S. Higgins, Remko Prevo, Tennyson Ekwuru, Leon Pang, Simon N. Willis, Sandhya Sridhar, Marie Boursier, Diego Grande, Joana F. Neves, Mark Charles, Joost Schimmel, Andrew Tutt, Niall M. B. Martin, Omar Alkhatib, Amanda Ferdinand, Graeme C. M. Smith

المصدر: Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, DNA Repair, DNA polymerase, General Physics and Astronomy, Apoptosis, Cell Cycle Proteins, Synthetic lethality, DNA-Directed DNA Polymerase, Poly (ADP-Ribose) Polymerase Inhibitor, Mice, 0302 clinical medicine, Homologous Recombination, Polymerase, Cancer, Ovarian Neoplasms, Multidisciplinary, Deoxyribonucleases, biology, Drug discovery, Chemistry, BRCA1 Protein, DNA-Binding Proteins, Organoids, 030220 oncology & carcinogenesis, PARP inhibitor, Female, Tumor Suppressor p53-Binding Protein 1, DNA repair, DNA damage, Cell Survival, Science, Poly(ADP-ribose) Polymerase Inhibitors, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Inhibitory Concentration 50, Allosteric Regulation, Cell Line, Tumor, Animals, Humans, Cell Proliferation, Nucleic Acid Synthesis Inhibitors, BRCA2 Protein, General Chemistry, Rats, 030104 developmental biology, Drug Resistance, Neoplasm, biology.protein, Cancer research, Drug Screening Assays, Antitumor, Homologous recombination, Synthetic Lethal Mutations, Biomarkers, DNA Damage

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50fa596497393cd588028cd95531690
https://hdl.handle.net/1887/3213877

المؤلفون: Simon J. Cook, Mathew P. Martin, Julie A. Tucker, Miller Duncan Charles, Timothy J. Blackburn, Stephanie M. Myers, Ai-Ching Wong, Nick C. Martin, Mercedes Arasta, Martin E.M. Noble, Huw D. Thomas, Ruth H. Bawn, Lan-Zhen Wang, Noel Edwards, Pamela A. Lochhead, Celine Cano, Suzannah J. Harnor, Tristan Reuillon, Laurent Rigoreau, Lauren Molyneux, Roger J. Griffin, David R. Newell, Bernard T. Golding, Tim Hammonds, Amy B. Heptinstall, P.J. Owen, Stephen R. Wedge, Ian R. Hardcastle, Leon Pang, Jane A. Endicott

المساهمون: Myers, Stephanie, Miller, Duncan, Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth, Blackburn, Timothy, Cook, Simon, Edwards, Noel, Endicott, Jane, Golding, Bernard, Griffin, Roger, Hammonds, Tim, Hardcastle, Ian, Harnor, Suzannah, Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew, Martin, Nick, Newell, Herbie, Owen, Paul, Pang, Leon, Reuillon, Tristan, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie, Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin, Wedge, Stephen, Cano, Celine

مصطلحات موضوعية: Angiogenesis, High-throughput screening, Motility, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, Cell Cycle Proteins, 01 natural sciences, Mitogen-Activated Protein Kinase 14, 03 medical and health sciences, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Extracellular, Animals, Humans, IC50, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase 7, 030304 developmental biology, Cell Proliferation, Pharmacology, sub_chemistry, 0303 health sciences, biology, sub_pharmacyandpharmacology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Nuclear Proteins, General Medicine, Neoplasms, Experimental, 0104 chemical sciences, Endothelial stem cell, Biochemistry, Mitogen-activated protein kinase, biology.protein, Female, Drug Screening Assays, Antitumor, Transcription Factors

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b20469b74ddfa9b4388aacc50467a77
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docx

المؤلفون: Michael F. Olson, John Dunn, Ai Ching Wong, Tim Hammonds, Gavin Greenland, Susan M. Boyd, Diane Crighton, Mark Charles, Anne Cheasty, Tennyson Ekwuru, Joanna Brookfield, Martin Stockley, Michelle Riddick, Elisabeth Trivier

المصدر: Journal of Medicinal Chemistry. 58:8309-8313

مصطلحات موضوعية: High-throughput screening, LIMK1, Structure-Activity Relationship, chemistry.chemical_compound, Gentamicin protection assay, Aminothiazole, Drug Discovery, High-Throughput Screening Assays, Animals, Humans, Structure–activity relationship, Neoplasm Invasiveness, Enzyme Inhibitors, Biotransformation, Matrigel, Lim Kinases, Small molecule, Combinatorial chemistry, Thiazoles, Actin Depolymerizing Factors, chemistry, Drug Design, Microsomes, Liver, Cancer research, Molecular Medicine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e14a8dbb31dcadf26449467127f683
https://doi.org/10.1021/acs.jmedchem.5b01242

المؤلفون: Timothy J. Blackburn, Roger J. Griffin, Tim Hammonds, Betty Cottyn, Ian R. Hardcastle, Sandrine Vidot, Lauren Molyneux, Bernard T. Golding, Celine Cano, William Clegg, Ruth H. Bawn, Louise Bisset, Hing Y. Leung, David R. Newell, Ai-Ching Wong, Stephanie M. Myers, Laurent Rigoreau, Ross W. Harrington

المساهمون: Newcastle University [Newcastle]

المصدر: ACS Combinatorial Science
ACS Combinatorial Science, ACS, 2016, 18, pp.444-455. ⟨10.1021/acscombsci.5b00155⟩
ACS Combinatorial Science (18), 444-455. (2016)

مصطلحات موضوعية: 0301 basic medicine, High-throughput screening, [SDV]Life Sciences [q-bio], Antineoplastic Agents, Plasma protein binding, Computational biology, 01 natural sciences, Mitogen-Activated Protein Kinase 14, 03 medical and health sciences, Structure-Activity Relationship, Neoplasms, High-Throughput Screening Assays, Extracellular, Structure–activity relationship, Humans, Pyrroles, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase 7, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, General Chemistry, General Medicine, Combinatorial chemistry, Amides, 3. Good health, 0104 chemical sciences, 030104 developmental biology, Kinase binding, Pharmacophore, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002ffb5033573e80911c966b43ada6d9
https://eprints.gla.ac.uk/139945/1/139945.pdf

المؤلفون: Tim Hammonds, Ai Ching Wong, Margaret Ainger, Mokdad Mezna, Michael F. Olson, Rebecca W. Scott

المصدر: SLAS Discovery. 17:460-468

مصطلحات موضوعية: Drug Evaluation, Preclinical, Biology, Biochemistry, Article, Analytical Chemistry, Lim kinase, Small Molecule Libraries, Substrate-level phosphorylation, chemistry.chemical_compound, Adenosine Triphosphate, Humans, Luciferase, Phosphorylation, Luciferases, Protein Kinase Inhibitors, Kinase, Drug discovery, Lim Kinases, High-Throughput Screening Assays, Adenosine Diphosphate, Enzyme Activation, Actin Depolymerizing Factors, chemistry, Molecular Medicine, Signal transduction, Adenosine triphosphate, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee61bc774fbaac92e736a554196fe4
https://doi.org/10.1177/1087057111430529

المؤلفون: Siobhan M. Hughes, Patricia Haus, Vanessa Petrucci, Thomas Leiser, Matthew J. Fuchter, S.S. Samlal, Andrew J. P. White, Robert J.K. Wood, Stephen Neidle, Fabrice Turlais, Matthias G. J. Baud, Ai Ching Wong, Lakjaya Buluwela, Franz-Josef Meyer-Almes, Mekala Gunaratnam

المصدر: Journal of medicinal chemistry. 55(4)

مصطلحات موضوعية: Models, Molecular, Methyltransferase, Antineoplastic Agents, Crystallography, X-Ray, DNA methyltransferase, Epigenesis, Genetic, Histones, Structure-Activity Relationship, Tubulin, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Humans, Prodrugs, DNA (Cytosine-5-)-Methyltransferases, Disulfides, Cytotoxicity, biology, Chemistry, HDAC8, Acetylation, Histone Deacetylase Inhibitors, Isoenzymes, Histone, Mechanism of action, Biochemistry, biology.protein, Molecular Medicine, Tyrosine, medicine.symptom, Drug Screening Assays, Antitumor, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746e44178705daaa043dcd345e13d517
https://pubmed.ncbi.nlm.nih.gov/22280363

المؤلفون: Jenny McKelvie, Kelly A. Holmes, Julie Stock, Aurore Lejeune, Stephen S. Myatt, Michelle Barnard, Jon Roffey, Ai Ching Wong, Jason S. Carroll

المصدر: Cancer Research. 75:LB-125

مصطلحات موضوعية: Cancer Research, biology, medicine.drug_class, Cell, Pioneer factor, Pharmacology, medicine.disease, Breast cancer, medicine.anatomical_structure, Oncology, Estrogen, Selective estrogen receptor modulator, medicine, biology.protein, Cancer research, Aromatase, FOXA1, Estrogen receptor alpha

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d422f558b848479e216769e27726aa08
https://doi.org/10.1158/1538-7445.am2015-lb-125

المؤلفون: Myers, Stephanie M., Bawn, Ruth H., Bisset, Louise C., Blackburn, Timothy J., Cottyn, Betty, Molyneux, Lauren, Ai-Ching Wong, Cano, Celine, Clegg, William, Harrington, Ross. W., Hing Leung, Rigoreau, Laurent, Vidot, Sandrine, Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Newell, David R., Hardcastle, Ian R.

المصدر: ACS Combinatorial Science; 8/8/2016, Vol. 18 Issue 8, p444-455, 12p

المؤلفون: Siobhan M. Hughes, Thomas Leiser, Mekala Gunaratnam, S.S. Samlal, Franz-Josef Meyer-Almes, Fabrice Turlais, Ai Ching Wong, Robert J.K. Wood, Stephen Neidle, Matthias G. J. Baud, Lakjaya Buluwela, Matthew J. Fuchter

المصدر: Molecular Cancer Therapeutics. 10:B166-B166

مصطلحات موضوعية: Cancer Research, Natural product, biology, Topoisomerase, Chemical biology, HDAC8, Prodrug, DNA methyltransferase, Small molecule, chemistry.chemical_compound, Oncology, chemistry, Biochemistry, biology.protein, Histone deacetylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e19b546df9e0869de1d670de99e2b238
https://doi.org/10.1158/1535-7163.targ-11-b166

المؤلفون: Brad E. Sleebs, Ian P. Street, Jonathan B. Baell, Mark Charles, Ai Ching Wong, Alla Levit, Timothy Robin Hammonds, Hendrik Falk, Michael F. Olson

المصدر: MedChemComm. 2:977

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Pyrimidine, Bicyclic molecule, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Biology, Biochemistry, Combinatorial chemistry, Chemical screening, chemistry.chemical_compound, chemistry, Drug Discovery, Actin dynamics, Pyridine, Molecular Medicine, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9200250dce3f48ea1ed05d9f16902d9e
https://doi.org/10.1039/c1md00137j

المؤلفون: Mark D. Charles, JoannaL. Brookfield, TennysonC. Ekwuru, Martin Stockley, John Dunn, Michelle Riddick, Tim Hammonds, Elisabeth Trivier, Gavin Greenland, Ai Ching Wong, Anne Cheasty, Susan Boyd, Diane Crighton, MichaelF. Olson

المصدر: Journal of Medicinal Chemistry; Oct2015, Vol. 58 Issue 20, p8309-8313, 5p