المؤلفون: Ahlström, Fredrik H. G., Viisanen, Hanna, Karhinen, Leena, Velagapudi, Vidya, Blomqvist, Kim J., Lilius, Tuomas O., Rauhala, Pekka V., Kalso, Eija A.

المساهمون: Department of Pharmacology, Faculty of Medicine, Medicum, Institute for Molecular Medicine Finland, Research Programs Unit, Division of Pharmacology and Pharmacotherapy, Divisions of Faculty of Pharmacy, HUSLAB, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Clinicum

مصطلحات موضوعية: Neuropathic pain, Cerebrospinal fluid, Dorsal root ganglion, Opioid tolerance, Pharmacy

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10138/578828; 85195321708; 001252371400001

الاتاحة: http://hdl.handle.net/10138/578828

المؤلفون: Ahlström, Fredrik H. G., Viisanen, Hanna, Karhinen, Leena, Mätlik, Kert, Blomqvist, Kim J., Lilius, Tuomas O., Sidorova, Yulia A., Palada, Vinko, Rauhala, Pekka V., Kalso, Eija A.

المساهمون: Department of Pharmacology, Faculty of Medicine, INDIVIDRUG - Individualized Drug Therapy, Medicum, Research Programs Unit, Research Services, Department of Clinical Pharmacology, Clinicum, HUS Emergency Medicine and Services, Divisions of Faculty of Pharmacy, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Department of Physiology, SLEEPWELL Research Program, Pekka Rauhala / Principal Investigator, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Anestesiologian yksikkö

مصطلحات موضوعية: Opioids, Apoptosis, Circadian rhythm, Microglia, Neuroinflammation, Rat, Transcriptomics, Biochemistry, cell and molecular biology, Neurosciences, Neurology and psychiatry

وصف الملف: application/pdf

Relation: Ahlström , F H G , Viisanen , H , Karhinen , L , Mätlik , K , Blomqvist , K J , Lilius , T O , Sidorova , Y A , Palada , V , Rauhala , P V & Kalso , E A 2023 , ' The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord ' , Molecular pain , vol. 19 , 17448069231183902 . https://doi.org/10.1177/17448069231183902; ORCID: /0000-0003-2036-3522/work/139502362; ORCID: /0000-0001-5090-2254/work/139502800; ORCID: /0000-0002-0926-6273/work/139507522; http://hdl.handle.net/10138/563493; 7542f65e-9182-4bf5-88d9-af7d9d12b3bf; 001016767200001

الاتاحة: http://hdl.handle.net/10138/563493

المؤلفون: Blomqvist, Kim J., Skogster, Moritz O. B., Kurkela, Mika J., Rosenholm, Marko P., Ahlström, Fredrik H. G., Airavaara, Mikko T., Backman, Janne T., Rauhala, Pekka V., Kalso, Eija A., Lilius, Tuomas O.

المساهمون: INDIVIDRUG - Individualized Drug Therapy, Department of Pharmacology, Faculty of Medicine, Medicum, Department of Clinical Pharmacology, Helsinki University Hospital Area, Helsinki Institute of Sustainability Science (HELSUS), Drug Research Program, Division of Pharmacology and Pharmacotherapy, Divisions of Faculty of Pharmacy, Neuroscience Center, HUSLAB, Janne Backman / Principal Investigator, Clinicum, Pekka Rauhala / Principal Investigator, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, SLEEPWELL Research Program, HUS Emergency Medicine and Services

مصطلحات موضوعية: Neurosciences, Biomedicine, Glymphatic system, Drug delivery, Spinal cord, Opioids, Analgesia, Osmosis, BLOOD-BRAIN-BARRIER, CEREBROSPINAL-FLUID, RAT-BRAIN, PAIN, PENETRATION, ANESTHESIA, CLEARANCE, INJECTION, DRUGS

وصف الملف: application/pdf

Relation: Blomqvist , K J , Skogster , M O B , Kurkela , M J , Rosenholm , M P , Ahlström , F H G , Airavaara , M T , Backman , J T , Rauhala , P V , Kalso , E A & Lilius , T O 2022 , ' Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine ' , Journal of Controlled Release , vol. 344 , pp. 214–224 . https://doi.org/10.1016/j.jconrel.2022.03.022; ORCID: /0000-0002-9577-2788/work/114604007; ORCID: /0000-0003-2036-3522/work/114604549; ORCID: /0000-0002-2026-1609/work/114604972; ORCID: /0000-0002-5437-8282/work/114607713; ORCID: /0000-0002-0926-6273/work/114608131; http://hdl.handle.net/10138/345181; 6cb3624c-7ae4-4678-8d16-750388507b19; 000802754800001

الاتاحة: http://hdl.handle.net/10138/345181

المؤلفون: Blomqvist, Kim J., Skogster, Moritz O. B., Kurkela, Mika J., Rosenholm, Marko P., Ahlström, Fredrik H. G., Airavaara, Mikko T., Backman, Janne T., Rauhala, Pekka V., Kalso, Eija A., Lilius, Tuomas O.

المساهمون: Individualized Drug Therapy, Farmakologian osasto, Lääketieteellinen tiedekunta, Medicum, Kliinisen farmakologian osasto, HYKS-sairaanhoitoalue, Kestävyystieteen instituutti (HELSUS), Drug Research Program, Farmakologian ja lääkehoidon osasto, Farmasian tiedekunnan osastot, Neurotieteen tutkimuskeskus, HUSLAB, Janne Backman / Vastuullinen tutkija, Clinicum, Pekka Rauhala / Vastuullinen tutkija, HUS Leikkaussalit, teho- ja kivunhoito, Eija Kalso / Vastuullinen tutkija, Diagnostis-terapeuttinen osasto, Anestesiologian yksikkö, Sleep and stress in health and in transition from acute to chronic diseases (SLEEPWELL), HUS Akuutti

مصطلحات موضوعية: Neurotieteet, Biolääketieteet, Glymphatic system, Drug delivery, Spinal cord, Opioids, Analgesia, Osmosis, BLOOD-BRAIN-BARRIER, CEREBROSPINAL-FLUID, RAT-BRAIN, PAIN, PENETRATION, ANESTHESIA, CLEARANCE, INJECTION, DRUGS

وصف الملف: application/pdf

Relation: Blomqvist , K J , Skogster , M O B , Kurkela , M J , Rosenholm , M P , Ahlström , F H G , Airavaara , M T , Backman , J T , Rauhala , P V , Kalso , E A & Lilius , T O 2022 , ' Glymfaattinen järjestelmä saattaa intratekaalisen lääkkeen selkäytimeen ' , Duodecim , Vuosikerta. 138 , Nro 10 , Sivut 949 . < https://www.duodecimlehti.fi/lehti/2022/10/duo16806 >; ORCID: /0000-0002-2026-1609/work/152926078; ORCID: /0000-0003-2036-3522/work/152927082; ORCID: /0000-0002-0926-6273/work/152930866; ORCID: /0000-0002-9577-2788/work/152931850; ORCID: /0000-0002-5437-8282/work/152932680; http://hdl.handle.net/10138/570954; 31da3107-beb1-492b-ab06-d42efb1bcf32

الاتاحة: http://hdl.handle.net/10138/570954

المؤلفون: Blomqvist, Kim, Viisanen, Hanna, Ahlström, Fredrik H. G., Jokinen, Viljami, Sidorova, Yulia A., Suleymanova, Ilida, Rauhala, Pekka V., Kalso, Eija A., Lilius, Tuomas O.

المساهمون: Department of Pharmacology, Clinicum, Faculty of Medicine, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, University of Helsinki, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, HUSLAB, Pekka Rauhala / Principal Investigator, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Medicum, Anestesiologian yksikkö, Department of Clinical Pharmacology

مصطلحات موضوعية: Biomedicine, Dose-response relationship, Drug tolerance, Opioid, Morphine, Morphine-3-glucuronide, Substance P, OPIOID-INDUCED HYPERALGESIA, RAT MODEL, MORPHINE-6-GLUCURONIDE, ACTIVATION, PAIN, Pharmacy

وصف الملف: application/pdf

Relation: Blomqvist , K , Viisanen , H , Ahlström , F H G , Jokinen , V , Sidorova , Y A , Suleymanova , I , Rauhala , P V , Kalso , E A & Lilius , T O 2020 , ' Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression ' , European Journal of Pharmacology , vol. 875 , 173021 . https://doi.org/10.1016/j.ejphar.2020.173021; ORCID: /0000-0003-2036-3522/work/73242457; ORCID: /0000-0002-0926-6273/work/73244656; http://hdl.handle.net/10138/321107; c948ef28-2268-48b4-9ccc-a7958c259b78; 000522724900005

الاتاحة: http://hdl.handle.net/10138/321107