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1
المؤلفون: Don T. Fisher, Gillian F. Watt, Ian Churcher, Laurie J. Gordon, Andrea D Gonçalves, Alina Mares, Phoebe Dace, Rakesh Nagilla, Bartholomew J. Votta, Ian Edward David Smith, John D. Harling, Pamela A. Haile, Afjal Hussain Miah, Paul Giffen, Paul Scott-Stevens, Aditya R. Thawani, Mark David Rackham, Jane Denyer
المصدر: Journal of Medicinal Chemistry. 64:12978-13003
مصطلحات موضوعية: Male, Molecular Structure, THP-1 Cells, Kinase, Chemistry, Molecular Pharmacology, Pharmacology, Inhibitor of apoptosis, Rats, Rats, Sprague-Dawley, RIPK2, Serine, Gene Expression Regulation, Receptor-Interacting Protein Serine-Threonine Kinase 2, Drug Design, Drug Discovery, Lipophilicity, Animals, Humans, Molecular Medicine, Rats, Wistar, Threonine, Protein kinase A, Half-Life
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2
المؤلفون: Jenni Cryan, Don T. Fisher, Michael Reilly, Ian Edward David Smith, Anna Vossenkämper, Gillian F. Watt, Ian Churcher, John D. Harling, Allison M. Beal, Thomas T. MacDonald, Alina Mares, Phoebe Dace, Bartholomew J. Votta, Marcus Bantscheff, Jane Denyer, Paul Scott-Stevens, Afjal Hussain Miah, Andrew B. Benowitz, Aditya R. Thawani, Carol A. Capriotti, Mark David Rackham, Nico Zinn, Pamela A. Haile
المصدر: Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biologyمصطلحات موضوعية: Male, THP-1 Cells, Anti-Inflammatory Agents, Medicine (miscellaneous), Medicinal chemistry, Pharmacology, 01 natural sciences, Serine, Rats, Sprague-Dawley, Tissue Culture Techniques, Ubiquitin, Crohn Disease, Enzyme Stability, lcsh:QH301-705.5, 0303 health sciences, biology, medicine.diagnostic_test, Drug discovery, Chemistry, Ubiquitin ligase, Injections, Intravenous, Cytokines, Female, medicine.symptom, Inflammation Mediators, General Agricultural and Biological Sciences, Proteasome Endopeptidase Complex, Proteolysis, Ubiquitin-Protein Ligases, General Biochemistry, Genetics and Molecular Biology, Article, RIPK2, 03 medical and health sciences, Receptor-Interacting Protein Serine-Threonine Kinase 2, medicine, Animals, Humans, Pharmacokinetics, Rats, Wistar, Protein kinase A, 030304 developmental biology, Inflammation, Dose-Response Relationship, Drug, 010405 organic chemistry, Ubiquitination, 0104 chemical sciences, Mechanism of action, Pharmacodynamics, lcsh:Biology (General), Drug Design, biology.protein, Leukocytes, Mononuclear, Colitis, Ulcerative
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المؤلفون: Nigel Deeks, Torquil I. Jack, Jonathan D. Goodacre, Martin Sims, Nigel J. Parr, Martin Brandt, Pamela Thomas, Kevin R. Page, Gordon Bruton, James H. Thorpe, Afjal Hussain Miah, Lena Shukla, Duncan S. Holmes, Matthew J Lindon, Leanne Cutler, Erica Christodoulou, David Jonathan Hirst
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127533
مصطلحات موضوعية: Indoles, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Chemistry, Pharmaceutical, Cellular Assay, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, METAP2, Rapid identification, Structure-Activity Relationship, Orally active, Molecular size, Drug Discovery, Humans, Methionyl Aminopeptidases, Molecular Medicine, Molecule, Distribution (pharmacology), Structure based, Enzyme Inhibitors, Molecular Biology
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المؤلفون: Kirsty E Waddington, Céline Gongora, Lauren C. Davis, Valentino Parravicini, Zuni I. Bassi, Emma J. Roberts, Philip G. Humphreys, Darcy E. Lewis, Abigail L. Macmillan-Jones, Ian Churcher, Afjal Hussain Miah, Claire Maller, Martin Christian Fillmore, David F. Tough, Rab K. Prinjha, Trevor D. Chapman, Nicholas Galwey
المساهمون: Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
المصدر: ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2018, 13 (10), pp.2862-2867. ⟨10.1021/acschembio.8b00705⟩مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Lipopolysaccharide, Ubiquitin-Protein Ligases, Context (language use), [SDV.CAN]Life Sciences [q-bio]/Cancer, Biochemistry, Benzoates, Monocytes, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Immune system, Piperidines, Protein Domains, Animals, Humans, p300-CBP Transcription Factors, Adaptor Proteins, Signal Transducing, Inflammation, Macrophages, Proteolysis targeting chimera, Signal transducing adaptor protein, Cell Differentiation, Stereoisomerism, General Medicine, Dendritic Cells, 3. Good health, Cell biology, Bromodomain, Pyridazines, enzymes and coenzymes (carbohydrates), 030104 developmental biology, chemistry, PCAF, 030220 oncology & carcinogenesis, Acetyltransferase, Proteolysis, Molecular Medicine, Cytokines, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Peptide Hydrolases
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5
المؤلفون: Natasha Routly, Giovanna Bergamini, Jeffrey L. Gustafson, Ko Eunhwa, Kristoffer Famm, Paola Grandi, John J. Flanagan, Daniel P. Bondeson, Maria Faelth-Savitski, Afjal Hussain Miah, Nico Zinn, Deborah A. Gordon, Craig M. Crews, Laurens Kruidenier, Paul S. Carter, Ian Edward David Smith, Marcus Bantscheff, Alina Mares, Dennis L. Buckley, John D. Harling, Linda N. Casillas, Sebastien Andre Campos, Ryan R. Willard, Bartholomew J. Votta, Willem den Besten, Satoko Shimamura, Carly S. Cox, Ian Churcher, Katie E Mulholland
المصدر: Nature Chemical Biology. 11:611-617
مصطلحات موضوعية: Gene knockdown, biology, Proteolysis targeting chimera, Cell Biology, Plasma protein binding, Small molecule, Article, Ubiquitin ligase, Cell biology, Ubiquitin, Biochemistry, RNA interference, biology.protein, Binding site, Molecular Biology
وصف الملف: application/pdf; application/vnd.ms-excel; application/vnd.ms-powerpoint
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المؤلفون: Rebecca H. Graves, Panayiotis A. Procopiou, Simon Teanby Hodgson, Afjal Hussain Miah, Jonathan M. Percy, Aurelie C. Champigny
المصدر: Bioorganicmedicinal chemistry. 25(20)
مصطلحات موضوعية: 0301 basic medicine, Male, Receptors, CCR4, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Pyrazolopyrimidine, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Solubility, Rats, Wistar, Molecular Biology, chemistry.chemical_classification, Indazole, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Sulfonamide, Rats, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Lipophilicity, Molecular Medicine
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المؤلفون: Alison J. Ford, Panayiotis A. Procopiou, Jonathan M. Percy, Daniel E. O’Flynn, Malcolm Begg, Afjal Hussain Miah, Sally-Anne Rumley, Steve A. Richards, Benjamin J. Marsh, Hossay Abas
المصدر: Bioorganic & Medicinal Chemistry. 22:4298-4311
مصطلحات موضوعية: Indazoles, Receptors, CCR4, Stereochemistry, Clinical Biochemistry, CCR4, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, QD, Solubility, Molecular Biology, Serum Albumin, Alkyl, Whole blood, chemistry.chemical_classification, Aza Compounds, Sulfonamides, Indazole, Aryl, Organic Chemistry, Human serum albumin, chemistry, Molecular Medicine, Benzimidazoles, CC chemokine receptors, Protein Binding, medicine.drug
وصف الملف: application/pdf
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المؤلفون: Rebecca H. Graves, Alan P. Hill, David E. Clapham, Steven L. Sollis, Karen M. L. Morriss, Robert J. Slack, Nick Barton, Ashley Paul Hancock, Heather Hobbs, Afjal Hussain Miah, Coline Jumeaux, Alison J. Ford, Claire E. Smith, Deborah Needham, Emma B. Sheriff, Panayiotis A. Procopiou, Simon Teanby Hodgson, John Barrett, Malcolm Begg, David A. Hall, Yannick M. L. Lacroix, Royston C. B. Copley, Hugo Staton
المصدر: Journal of Medicinal Chemistry. 56:1946-1960
مصطلحات موضوعية: Male, chemistry.chemical_classification, Sulfonamides, Indazole, Indazoles, Receptors, CCR4, Stereochemistry, Aryl, Allosteric regulation, Rats, Sulfonamide, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, chemistry, In vivo, Intramolecular force, Drug Discovery, Animals, Humans, Molecular Medicine, Structure–activity relationship, Receptor
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9
المؤلفون: Jonathan M. Percy, Simon Teanby Hodgson, Sean M. Lynn, Brian Evans, Panayiotis A. Procopiou, Rebecca H. Graves, Laura Ajram, Stephen A. Richards, Afjal Hussain Miah, Malcolm Begg, Robert J. Slack, Lena Shukla
مصطلحات موضوعية: 0301 basic medicine, Receptors, CCR4, Stereochemistry, Allosteric regulation, Endocytosis, 03 medical and health sciences, Chemokine receptor, Structure-Activity Relationship, Cell surface receptor, Drug Discovery, Structure–activity relationship, Humans, Spiro Compounds, QD, Receptor, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Ligand binding assay, Organic Chemistry, General Medicine, Molecular biology, Small molecule, 030104 developmental biology, Pyrimidines
وصف الملف: application/pdf
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المؤلفون: Jeffrey L. Gustafson, Ian Edward David Smith, Kanak Raina, Craig M. Crews, John Hines, John D. Harling, Dennis L. Buckley, Afjal Hussain Miah, Nicole Darricarrère
مصطلحات موضوعية: biology, Chemistry, Proteolysis targeting chimera, HEK 293 cells, General Medicine, Plasma protein binding, Protein degradation, Biochemistry, Fusion protein, Combinatorial chemistry, Small molecule, Article, Ubiquitin ligase, Cell biology, biology.protein, Molecular Medicine, Degradation (geology)
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المؤلفون: Daniel E. O’Flynn, Jonathan M. Percy, Afjal Hussain Miah, Panayiotis A. Procopiou, Royston C. B. Copley
المصدر: Organicbiomolecular chemistry. 12(11)
مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, Sulfonamides, Receptors, CCR4, Hydrogen bond, Stereochemistry, Aryl, Organic Chemistry, Molecular Conformation, Pyrazole, Ring (chemistry), Biochemistry, Small molecule, Sulfonamide, chemistry.chemical_compound, Structure-Activity Relationship, chemistry, Allosteric Regulation, Intramolecular force, Moiety, Pyrazoles, QD, Physical and Theoretical Chemistry
وصف الملف: application/pdf
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12Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode
المؤلفون: Jessica L. Schneck, Brian Dombroski, Michael D. Wall, Chris J. Delves, Stuart P. Ballantine, James P. Villa, Jeffrey W. Gross, Afjal Hussain Miah, Michael Kranz, Don O. Somers, Brian Evans, Margarete Neu
المصدر: Bioorganicmedicinal chemistry. 17(14)
مصطلحات موضوعية: Models, Molecular, Molecular model, medicine.drug_class, Stereochemistry, Protein Conformation, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Thiophenes, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, PDE4B, Drug Discovery, Hydrolase, medicine, Humans, Amino Acid Sequence, Binding site, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, Chemistry, Organic Chemistry, Ligand (biochemistry), Cyclic Nucleotide Phosphodiesterases, Type 4, Enzyme, Docking (molecular), Mutation, Molecular Medicine, Phosphodiesterase 4 Inhibitors, Protein Binding