المؤلفون: Ardeshir Goliaei, Haley A. Woods, Adriana E. Tron, Matthew A. Belmonte, J. Paul Secrist, Douglas Ferguson, Lisa Drew, Adrian J. Fretland, Bree B. Aldridge, Francis D. Gibbons

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 561-570 (2020)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/07ad18bfe7b84642b234c602cec0a6fa

المؤلفون: Joan Montero, Cécile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R. Cidado, J. Paul Secrist, Adriana E. Tron, Keith Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher, Rizwan Haq

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/f51e8b007adc48feb4f6169ad611de36

المؤلفون: Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9

المؤلفون: Meng Zhang (154027), Angelo Aguilar (573070), Shilin Xu (1884217), Liyue Huang (797169), Krishnapriya Chinnaswamy (843776), Taryn Sleger (11059626), Bo Wang (86769), Stefan Gross (673951), Brandon N. Nicolay (7943810), Sebastien Ronseaux (11059629), Kaitlin Harvey (11059632), Yu Wang (12152), Donna McEachern (573068), Paul D. Kirchhoff (1947619), Zhaomin Liu (824564), Jeanne Stuckey (1334310), Adriana E. Tron (11059635), Tao Liu (10785), Shaomeng Wang (88290)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, M -1121 drives dose-dependent down-., MLLr leukemia, m -1121, HOXA, MEIS 1 gene expression, interaction, MV, leukemia cell lines, MLL binding pocket, Long-Lasting Tumor Regression Targeting, covalent menin inhibitor, findings support development

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_M_1121_as_an_Orally_Active_Covalent_Inhibitor_of_Menin-MLL_Interaction_Capable_of_Achieving_Complete_and_Long-Lasting_Tumor_Regression/14892690

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00789.s001

المؤلفون: Maria R. Baer, Danilo Perrotti, Adriana E. Tron, Dennis Huszar, Manfred Kraus, Eduardo Davila, Rossana Trotta, Mario Scarpa, Trevor J. Mathias, Rena G. Lapidus, Kshama A. Doshi, Patrick R. Baldwin, Karthika Natarajan, Shivani Kapoor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa4dc3b4b50fe54ac11960a14462b2d
https://doi.org/10.1158/1078-0432.22463250.v1

المؤلفون: Maria R. Baer, Danilo Perrotti, Adriana E. Tron, Dennis Huszar, Manfred Kraus, Eduardo Davila, Rossana Trotta, Mario Scarpa, Trevor J. Mathias, Rena G. Lapidus, Kshama A. Doshi, Patrick R. Baldwin, Karthika Natarajan, Shivani Kapoor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be4683261314d8ff2b7e0db830d39d2
https://doi.org/10.1158/1078-0432.c.6525348

المؤلفون: Maria R. Baer, Danilo Perrotti, Adriana E. Tron, Dennis Huszar, Manfred Kraus, Eduardo Davila, Rossana Trotta, Mario Scarpa, Trevor J. Mathias, Rena G. Lapidus, Kshama A. Doshi, Patrick R. Baldwin, Karthika Natarajan, Shivani Kapoor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818d2eda80870822ec22e7393eb8042c
https://doi.org/10.1158/1078-0432.22463238.v1

المؤلفون: Francis D. Gibbons, Haley Woods, Matthew A. Belmonte, Ardeshir Goliaei, Douglas Ferguson, Adriana E. Tron, Bree B. Aldridge, J. Paul Secrist, Adrian J. Fretland, Lisa Drew

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 561-570 (2020)
CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: Myeloid, Macrocyclic Compounds, Cell, Antineoplastic Agents, Apoptosis, Article, Drug Administration Schedule, Mice, Cell Line, Tumor, hemic and lymphatic diseases, Medicine, Animals, Humans, Pharmacology (medical), business.industry, Research, lcsh:RM1-950, Myeloid leukemia, Articles, Cell cycle, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Lymphoma, Leukemia, Leukemia, Myeloid, Acute, medicine.anatomical_structure, lcsh:Therapeutics. Pharmacology, Cell culture, Drug Resistance, Neoplasm, Modeling and Simulation, Models, Animal, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e59c72d486a10dbcaf60a38ec56d943
https://doaj.org/article/07ad18bfe7b84642b234c602cec0a6fa

المؤلفون: Pavlina Chuntova, Akane Yamamichi, Tiffany Chen, Rohini Narayanaswamy, Sebastien Ronseaux, Christine Hudson, Adriana E Tron, Marc L Hyer, Megan Montoya, Abigail L Mende, Takahide Nejo, Kira M Downey, David Diebold, Min Lu, Brandon Nicolay, Hideho Okada

المصدر: Journal for immunotherapy of cancer, vol 10, iss 5

مصطلحات موضوعية: Pharmacology, Cancer Research, Immunology, HLA-DR1 Antigen, Mice, Transgenic, Glioma, Cancer Vaccines, Isocitrate Dehydrogenase, Up-Regulation, Glutarates, Mice, Oncology, HLA-A2 Antigen, Vaccines, Subunit, Tumor Microenvironment, Animals, Humans, Molecular Medicine, Immunology and Allergy, Immune Checkpoint Inhibitors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5327e3311d9f2d9383543f4b19111e8
https://escholarship.org/uc/item/37d5t20s

المؤلفون: Emily Gruber, Joan So, Alexander C. Lewis, Rheana Franich, Rachel Cole, Luciano G. Martelotto, Amy J. Rogers, Eva Vidacs, Peter Fraser, Kym Stanley, Lisa Jones, Anna Trigos, Niko Thio, Jason Li, Brandon Nicolay, Scott Daigle, Adriana E. Tron, Marc L. Hyer, Jake Shortt, Ricky W. Johnstone, Lev M. Kats

مصطلحات موضوعية: Leukemia, Myeloid, Acute, Mice, Stem Cells, Mutation, Azacitidine, Animals, Enzyme Inhibitors, Isocitrate Dehydrogenase, General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f79e25dc41ea1f27a8047575d542461
https://doi.org/10.1101/2022.04.06.487420

المؤلفون: David E. Fisher, Anthony Letai, F. Stephen Hodi, Daniel J. Kim, Justin Cidado, Dorota Sadowicz, Keith T. Flaherty, Rizwan Haq, Cécile Gstalder, Michael Manos, Joan Montero, Adriana E. Tron, Wayne O. Miles, J. Paul Secrist, Charles H. Yoon

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Proto-Oncogene Proteins B-raf, MRNA destabilization, MAP Kinase Signaling System, Science, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Targeted therapies, hemic and lymphatic diseases, Cytotoxic T cell, Medicine, Humans, lcsh:Science, Melanoma, EGFR inhibitors, Messenger RNA, Multidisciplinary, business.industry, Mechanism (biology), Cancer, General Chemistry, medicine.disease, 3. Good health, Cancer therapeutic resistance, 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, Apoptosis, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, lcsh:Q, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d3fd9b34f5ad82a10765159bc952ab
https://doaj.org/article/f51e8b007adc48feb4f6169ad611de36

المؤلفون: Brandon Nicolay, Liyue Huang, Zhaomin Liu, Shaomeng Wang, Sebastien Ronseaux, Yu Wang, Kaitlin Harvey, Paul D. Kirchhoff, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Shilin Xu, Stefan Gross, Adriana E Tron, Donna McEachern, Taryn Sleger, Bo Wang, Tao Liu, Meng Zhang, Angelo Aguilar

المصدر: J Med Chem

مصطلحات موضوعية: Models, Molecular, Myeloid, Chromosomal translocation, Antineoplastic Agents, Article, Structure-Activity Relationship, In vivo, hemic and lymphatic diseases, Cell Line, Tumor, Proto-Oncogene Proteins, Drug Discovery, medicine, Structure–activity relationship, Humans, neoplasms, Cell Proliferation, Acute leukemia, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, medicine.disease, Leukemia, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Mechanism of action, Cell culture, Cancer research, Molecular Medicine, medicine.symptom, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2462eabb64e84a15ae5d5bf3aa0ed5a
https://europepmc.org/articles/PMC8935478/

المؤلفون: Cécile Gstalder, Dorota Sadowicz, Adriana E. Tron, Keith T. Flaherty, Michael Manos, Daniel J. Kim, Justin Cidado, F. Stephen Hodi, Joan Montero, David E. Fisher, Charles H. Yoon, J. Paul Secrist, Wayne O. Miles, Anthony Letai, Rizwan Haq

المصدر: Cancer Research. 80:62-62

مصطلحات موضوعية: Cancer Research, Oncology, Resistance (ecology), Chemistry, Mechanism (sociology), Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dd788525ebc1eb5df91201e90d9fee4e
https://doi.org/10.1158/1538-7445.am2020-62

المؤلفون: Adriana E. Tron, Alexander Hird

المصدر: Pharmacologytherapeutics. 198

مصطلحات موضوعية: 0301 basic medicine, Protein family, Cancer therapy, Antineoplastic Agents, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Development, Neoplasms, Medicine, Cytotoxic T cell, Animals, Humans, Pharmacology (medical), Pharmacology, business.industry, Venetoclax, Cancer, medicine.disease, 030104 developmental biology, Drug development, chemistry, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, Cancer development, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0b0246b3ec40e9527e26c373e41215
https://pubmed.ncbi.nlm.nih.gov/30790641

المؤلفون: Zhongwu Lai, Adriana E. Tron, Huawei Chen, Dennis Huszar, Minwei Ye, David C. Linch, Asim Khwaja, Keith Dillman, Rosemary E. Gale, Erika Krasnickas Keeton, Chloe Stengel, Matias Casás-Selves, Michael Zinda

المصدر: Leukemia & Lymphoma. 57:2927-2929

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Oncogene Proteins, Fusion, Chromosomal translocation, macromolecular substances, Biology, ELAV-Like Protein 1, Fusion gene, 03 medical and health sciences, 0302 clinical medicine, TYK2 Kinase, Cell Line, Tumor, hemic and lymphatic diseases, medicine, Humans, Protein Kinase Inhibitors, Genetics, Regulation of gene expression, Gene Expression Regulation, Leukemic, Biphenyl Compounds, High-Throughput Nucleotide Sequencing, Hematology, medicine.disease, Lymphoma, Biphenyl compound, Leukemia, Myeloid, Acute, Leukemia, 030104 developmental biology, Oncology, Drug Resistance, Neoplasm, Tyrosine kinase 2, 030220 oncology & carcinogenesis, Cancer research, Thiazolidines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24a9d0d20844160184a5aba3a9b17ed
https://doi.org/10.3109/10428194.2016.1171861

المؤلفون: Rossana Trotta, Manfred Kraus, Maria R. Baer, Karthika Natarajan, Eduardo Davila, Dennis Huszar, Patrick R. Baldwin, Kshama A. Doshi, Rena G. Lapidus, Mario Scarpa, Trevor J. Mathias, Shivani Kapoor, Adriana E. Tron, Danilo Perrotti

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Proteome, Cell Survival, Apoptosis, Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, fluids and secretions, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Cell Line, Tumor, Gene Duplication, MG132, medicine, Animals, Humans, Benzothiazoles, Protein Kinase Inhibitors, Quizartinib, Cell Proliferation, Membrane Potential, Mitochondrial, Phenylurea Compounds, Myeloid leukemia, hemic and immune systems, medicine.disease, Myeloid Cell Leukemia Sequence 1 Protein, Leukemia, Leukemia, Myeloid, Acute, 030104 developmental biology, Oncology, chemistry, fms-Like Tyrosine Kinase 3, 030220 oncology & carcinogenesis, Fms-Like Tyrosine Kinase 3, Immunology, embryonic structures, Proteolysis, Cancer research, Proteasome inhibitor, Female, FLT3 Inhibitor, Reactive Oxygen Species, Protein Processing, Post-Translational, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e820063b3bfac9e171485cfa0e7870
https://europepmc.org/articles/PMC6444348/

المؤلفون: Kathleen A. Burke, Tyler Faits, Adriana E. Tron, Jay Mettetal, Andrew Bloecher, Zhongwu Lai, Jonathan Dry, Bolan Linghu

المصدر: Cancer Research. 79:2462-2462

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bc7d7360698814e0bb48ffb1387e446f
https://doi.org/10.1158/1538-7445.am2019-2462

المؤلفون: Maria R. Baer, Karthika Natarajan, Feyruz V. Rassool, Dennis Huszar, Adriana E. Tron, Danilo Perrotti, Kshama A. Doshi, Rossana Trotta

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, FLT3-ITD, Daunorubicin, Apoptosis, acute myeloid leukemia, chemotherapy, 03 medical and health sciences, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Medicine, Humans, Topoisomerase II Inhibitors, Protein Kinase Inhibitors, Etoposide, Serine/threonine-specific protein kinase, reactive oxygen species, Mitoxantrone, Pim kinase, business.industry, Biphenyl Compounds, Cytarabine, Myeloid leukemia, hemic and immune systems, Drug Synergism, 3. Good health, Leukemia, Myeloid, Acute, Oxidative Stress, 030104 developmental biology, Oncology, fms-Like Tyrosine Kinase 3, 030220 oncology & carcinogenesis, Fms-Like Tyrosine Kinase 3, Immunology, embryonic structures, Cancer research, Thiazolidines, Topoisomerase-II Inhibitor, business, psychological phenomena and processes, medicine.drug, DNA Damage, Signal Transduction, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcbaa55a2ddbbe078a3a2b085cc36ee
https://pubmed.ncbi.nlm.nih.gov/27374090

المؤلفون: Tanja Mittag, Lester J. Lambert, James A. DeCaprio, Brenda A. Schulman, Jennifer L. Olszewski, Adriana E. Tron, David M. Duda, Michal Hammel, M. Brett Waddell

المصدر: Molecular Cell. 47(3):371-382

مصطلحات موضوعية: 0303 health sciences, biology, Cullin Proteins, Ubiquitin-Protein Ligases, Plasma protein binding, Cell Biology, Ubiquitin-conjugating enzyme, Ubiquitin ligase, Cell biology, 03 medical and health sciences, 0302 clinical medicine, biology.protein, CUL1, Protein folding, Binding site, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabbda6cb1a474d5aa1bf61ea41c5215

المؤلفون: Jennifer L. Olszewski, Adriana E. Tron, David M. Duda, Hiroshi Kuwabara, Brittany Bahamon, Takehiro Arai, Yuko Fujiwara, James A. DeCaprio, Sabina Signoretti, Brenda A. Schulman

المصدر: Molecular Cell. 46(1):67-78

مصطلحات موضوعية: Cyclin E, Cullin Proteins, RBX1, Signal transducing adaptor protein, Cell Biology, Biology, F-box protein, Molecular biology, Article, Glomuvenous malformation, Ubiquitin ligase, Cell biology, Ubiquitin, biology.protein, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b14ff5f93852d5990ac0b5eb1364459