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1Academic Journal
المؤلفون: Liu, Xue, Kimmey, Jacqueline M, Matarazzo, Laura, de Bakker, Vincent, Van Maele, Laurye, Sirard, Jean-Claude, Nizet, Victor, Veening, Jan-Willem
المصدر: Cell Host & Microbe. 29(1)
مصطلحات موضوعية: Microbiology, Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Pneumonia, Pneumonia & Influenza, Prevention, Infectious Diseases, Genetics, Human Genome, Lung, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Infection, Adenylosuccinate Synthase, Animals, Clustered Regularly Interspaced Short Palindromic Repeats, Female, Genes, Bacterial, Genetic Fitness, High-Throughput Nucleotide Sequencing, Influenza A virus, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Operon, Orthomyxoviridae Infections, Pneumonia, Pneumococcal, Streptococcus pneumoniae, Superinfection, CRISPRi-seq, bacterial pathogenesis, bottleneck, influenza A virus superinfection, pneumonia, Immunology, Biochemistry and cell biology, Medical microbiology
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/994563kh
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2Academic Journal
المؤلفون: Kaminski, Pierre-Alexandre
المساهمون: Biologie des Bactéries pathogènes à Gram-positif - Biology of Gram-Positive Pathogens, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), This study was funded from the French government’s Investissement d’Avenir program, Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (Grant No. ANR-10-LABX-62-IBEID)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010)
المصدر: ISSN: 1420-682X.
مصطلحات موضوعية: Adenylosuccinate synthase, Aminoadenine, Bacteriophage, DNA, DNA polymerase, Nucleotide phosphohydrolase, MESH: Adenine, MESH: Adenine Nucleotides, MESH: Bacteriophages, MESH: Base Pairing, MESH: DNA, Viral, MESH: Genome, MESH: Hydrogen Bonding, [SDV]Life Sciences [q-bio]
Relation: info:eu-repo/semantics/altIdentifier/pmid/34910247; pasteur-03549987; https://pasteur.hal.science/pasteur-03549987; https://pasteur.hal.science/pasteur-03549987/document; https://pasteur.hal.science/pasteur-03549987/file/Kaminski_CMLs3_merged.pdf; PUBMED: 34910247
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3Academic Journal
المؤلفون: Kano, Tomonori, Ishikawa, Kazuya, Furuta, Kazuyuki, Kaito, Chikara
المصدر: FEMS Microbiology Letters
مصطلحات موضوعية: colistin, adenylosuccinate synthase, de novo purine synthesis, membrane potential, ATP synthesis
Relation: info:pmid/38305138; https://ousar.lib.okayama-u.ac.jp/files/public/6/66699/20240305101044284433/fulltext20240304-05.pdf; https://ousar.lib.okayama-u.ac.jp/66699
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4Academic Journal
المساهمون: Architecture et Dynamique des Macromolécules Biologiques - Architecture and Dynamics of Biological Macromolecules, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Collège Doctoral, Sorbonne Université (SU), Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Institut Pasteur Paris (IP)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Biologie des Bactéries pathogènes à Gram-positif - Biology of Gram-Positive Pathogens, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), The authors acknowledge a DIM1Health 2019 grant from the Région Ile de France to the project EpiK (coordinated by P.B. Arimondo) for the LCMS equipment., We thank the Crystallogenesis and Crystallography Platform (PF6) of Institut Pasteur for help in crystallization and preliminary crystallographic data collection. We thank Marcel Hollenstein and his group for the use of their HPLC system. We also thank staff from PROXIMA−1 and PROXIMA-2 beamlines for help in data collection and SOLEIL (Saint-Aubin, France) and for provision of synchrotron radiation facilities. We thank Pierre Legrand for discussions regarding the structural aspect of this work, as well as Laurent Debarbieux and his group for discussions regarding phages. We also thank Stéphane Decorps-Declere from the Hub de Bioinformatique et Biostatistique (C3BI, Institut Pasteur) for help with the S-2L genome mapping and its deposition.
المصدر: ISSN: 2041-1723.
مصطلحات موضوعية: MESH: 2-Aminopurine, MESH: Adenylosuccinate Synthase, MESH: Static Electricity, MESH: Viral Proteins, MESH: Bacteriophages, MESH: Base Pairing, MESH: Crystallography, X-Ray, MESH: DNA, Bacterial, Viral, MESH: Deoxyadenosines, MESH: Escherichia coli, MESH: Genes, MESH: Genome, MESH: Metabolic Networks and Pathways, MESH: Models, Molecular, MESH: Phosphoric Monoester Hydrolases, MESH: Podoviridae, MESH: Protein Conformation, MESH: Recombinant Proteins, MESH: Siphoviridae, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
Relation: info:eu-repo/semantics/altIdentifier/pmid/34354070; pasteur-03327945; https://pasteur.hal.science/pasteur-03327945; https://pasteur.hal.science/pasteur-03327945/document; https://pasteur.hal.science/pasteur-03327945/file/s41467-021-25064-x.pdf; PUBMED: 34354070; PUBMEDCENTRAL: PMC8342488
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5
المؤلفون: Juanjuan Cheng, Lieqiang Xu, Qiuxia Yu, Guoshu Lin, Xingdong Ma, Mengyao Li, Fengkun Guan, Yuhong Liu, Xiaoqi Huang, Jianhui Xie, Jiannan Chen, Ziren Su, Yucui Li
المصدر: European journal of pharmacology. 933
مصطلحات موضوعية: Pharmacology, Metabolic Syndrome, NF-E2-Related Factor 2, Fructose, AMP-Activated Protein Kinases, Adenosine Monophosphate, Antioxidants, Metformin, Diet, Rats, Adenylosuccinate Synthase, Adenosine Triphosphate, Animals, Insulin, Insulin Resistance, Muscle, Skeletal, Purine Nucleotides
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6Academic Journal
المساهمون: College of Medicine, Dept. of Radiology, Hyung Jun Park, Ha Young Shin, Sungjun Kim, Se Hoon Kim, Yunbeom Lee, Jung Hwan Lee, Ji-Man Hong, Seung Min Kim, Kee Duk Park, Byung-Ok Choi, Ji Hyun Lee, Young-Chul Choi, Kim, Sung Jun, Kim, Se Hoon, Kim, Seung Min, Shin, Ha Young, Lee, Jung Hwan, Choi, Young Chul, Hong, Ji Man
مصطلحات موضوعية: Adenylosuccinate Synthase/genetics, Adolescent, Adult, Asian Continental Ancestry Group/genetics, DNA Mutational Analysis, Distal Myopathies/diagnostic imaging, Distal Myopathies/genetics, Distal Myopathies/pathology, Distal Myopathies/physiopathology, Female, Follow-Up Studies, Genetic Association Studies, Humans, Magnetic Resonance Imaging, Male, Muscle, Skeletal/diagnostic imaging, Skeletal/pathology, Mutation, Republic of Korea, Retrospective Studies, Whole Body Imaging, Young Adult, ADSSL1, Diagnosis, Distal myopathy, Muscle MRI, Phenotype�밽enotype correlation
Relation: NEUROMUSCULAR DISORDERS; J02344; OAK-2017-01734; https://ir.ymlib.yonsei.ac.kr/handle/22282913/153907; http://www.sciencedirect.com/science/article/pii/S0960896616310720; T201701125; NEUROMUSCULAR DISORDERS, Vol.27 : 465-472, 2017
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7
المؤلفون: Biao Li, Xiayuan Wu, Ping Wei, Jun Zhou, Xiao-Na Liu, Xiaoyu Yong, Honghua Jia, Zhiying Yan
المصدر: Journal of Biotechnology. 298:1-4
مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Adenosine, Mutant, Guanosine, Bioengineering, Bacillus subtilis, 01 natural sciences, Applied Microbiology and Biotechnology, Adenylosuccinate Synthase, 03 medical and health sciences, chemistry.chemical_compound, Inosine Monophosphate, 010608 biotechnology, medicine, Carbon-Nitrogen Ligases, Inosine, Gene, biology, Chemistry, Adenylosuccinate synthase, General Medicine, biology.organism_classification, Adenosine Monophosphate, 030104 developmental biology, Biochemistry, Fermentation, Gene Targeting, Mutation, Mutagenesis, Site-Directed, biology.protein, Nucleoside, Biotechnology, medicine.drug
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8
المؤلفون: Nidhi Tibrewal, Gregory I. Elliott
المصدر: ChemMedChem. 15:2269-2272
مصطلحات موضوعية: Purine, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Moiety, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, Adenylosuccinate synthase, Purine Nucleosides, Adenosine, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Purine-Nucleoside Phosphorylase, chemistry, Drug Design, biology.protein, Nucleic acid, Molecular Medicine, Linker, Nucleoside, medicine.drug
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9
المساهمون: Architecture et Dynamique des Macromolécules Biologiques - Architecture and Dynamics of Biological Macromolecules, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Collège doctoral [Sorbonne universités], Sorbonne Université (SU), Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Biologie des Bactéries pathogènes à Gram-positif - Biology of Gram-Positive Pathogens, The authors acknowledge a DIM1Health 2019 grant from the Région Ile de France to the project EpiK (coordinated by P.B. Arimondo) for the LCMS equipment., We thank the Crystallogenesis and Crystallography Platform (PF6) of Institut Pasteur for help in crystallization and preliminary crystallographic data collection. We thank Marcel Hollenstein and his group for the use of their HPLC system. We also thank staff from PROXIMA−1 and PROXIMA-2 beamlines for help in data collection and SOLEIL (Saint-Aubin, France) and for provision of synchrotron radiation facilities. We thank Pierre Legrand for discussions regarding the structural aspect of this work, as well as Laurent Debarbieux and his group for discussions regarding phages. We also thank Stéphane Decorps-Declere from the Hub de Bioinformatique et Biostatistique (C3BI, Institut Pasteur) for help with the S-2L genome mapping and its deposition., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Collège Doctoral, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4710. ⟨10.1038/s41467-021-25064-x⟩
Nature Communications, 2021, 12 (1), pp.4710. ⟨10.1038/s41467-021-25064-x⟩
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)مصطلحات موضوعية: DNA, Bacterial, Models, Molecular, Genes, Viral, Protein Conformation, Science, Static Electricity, MESH: Base Pairing, Genome, Viral, Siphoviridae, Crystallography, X-Ray, Article, MESH: Recombinant Proteins, Adenylosuccinate Synthase, Viral Proteins, MESH: Protein Conformation, Escherichia coli, DNA metabolism, MESH: 2-Aminopurine, Bacteriophages, MESH: Adenylosuccinate Synthase, MESH: Siphoviridae, MESH: Bacteriophages, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], 2-Aminopurine, Base Pairing, MESH: Static Electricity, X-ray crystallography, MESH: Genes, Viral, Deoxyadenosines, MESH: Escherichia coli, MESH: Podoviridae, MESH: Deoxyadenosines, Podoviridae, MESH: Crystallography, X-Ray, MESH: Viral Proteins, MESH: DNA, Bacterial, Phosphoric Monoester Hydrolases, Recombinant Proteins, MESH: DNA, Viral, MESH: Metabolic Networks and Pathways, DNA, Viral, MESH: Phosphoric Monoester Hydrolases, MESH: Genome, Viral, Structural biology, Metabolic Networks and Pathways, MESH: Models, Molecular
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10Academic Journal
المساهمون: College of Medicine, Dept. of Pathology, Hyung Jun Park, Young Bin Hong, Young-Chul Choi, Jinho Lee, Eun Ja Kim, Ji-Su Lee, Won Min Mo, Soo Mi Ki, Hyo In Kim, Hye Jin Kim, Young Se Hyun, Hyun Dae Hong, Kisoo Nam, Sung Chul Jung, Sang-Beom Kim, Se Hoon Kim, Deok-Ho Kim, Ki-Wook Oh, Seung Hyun Kim, Jeong Hyun Yoo, Ji Eun Lee, Ki Wha Chung, Byung-Ok Choi, Kim, Se Hoon, Choi, Young Chul
مصطلحات موضوعية: Adenylosuccinate Synthase/genetics, Adult, Age of Onset, Animals, Genetically Modified, Disease Models, Animal, Distal Myopathies/enzymology, Distal Myopathies/genetics, Distal Myopathies/physiopathology, Female, Humans, Male, Mice, Mutation, Pedigree, Phenotype, Republic of Korea, Young Adult, Zebrafish, Zebrafish Proteins
وصف الملف: 231~243
Relation: ANNALS OF NEUROLOGY; J00166; OAK-2016-01795; https://ir.ymlib.yonsei.ac.kr/handle/22282913/146712; T201601151; ANNALS OF NEUROLOGY, Vol.79(2) : 231-243, 2016
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المؤلفون: Ivana Leščić Ašler, Elżbieta K. Jagusztyn-Krynicka, Petar Knežević, Verica Aleksic Sabo, Agnieszka Bzowska, Radosław Jaźwiec, Marta Ilona Wojtyś, Saša Kazazić, Marija Luić
المصدر: Applied microbiology and biotechnology
Applied Microbiology and Biotechnologyمصطلحات موضوعية: Purine, Formycin, Helicobacter pylori, Cells penetration by drug candidates, Salvage pathway enzymes, Hadacidin, Glycine, Purine nucleoside phosphorylase, Applied Microbiology and Biotechnology, Adenylosuccinate Synthase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nucleotide, Enzyme Inhibitors, Purine metabolism, Nucleotide salvage, Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Methods and Protocols, Adenylosuccinate synthase, General Medicine, 3. Good health, Enzyme, Purine-Nucleoside Phosphorylase, chemistry, Biochemistry, biology.protein, 030211 gastroenterology & hepatology, Formycins, DNA, Biotechnology
وصف الملف: application/pdf
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12
المؤلفون: Ahmed Haouz, Simonetta Gribaldo, Pierre Simon Garcia, Najwa Taib, Pascal Röthlisberger, Pierre Alexandre Kaminski, Marion Lagune, Philippe Marliere, Jérôme Loc’h, Dona Sleiman
المساهمون: Biologie des Bactéries pathogènes à Gram-positif - Biology of Gram-Positive Pathogens, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Biologie Evolutive de la Cellule Microbienne - Evolutionary Biology of the Microbial Cell, Adaptation au stress et Métabolisme chez les entérobactéries - Stress adaptation and metabolism in enterobacteria (SAMe), Dynamique structurale des Macromolécules / Structural Dynamics of Macromolecules, Cristallographie (Plateforme) - Crystallography (Platform), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Chimie bioorganique des acides nucléiques - Bioorganic chemistry of nucleic acids, Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), D.S. and P.S.G. were supported by an ERASynBio 'TNA episome' and by an ERACoBioTech 'Iron Plug’n Play' fellowship, respectively. S.G. acknowledges funding from the French National Agency for research grant Archaevol (ANR-16-CE02-0005-01). This study was funded from the French government’s Investissement d’Avenir program, Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases (grant no. ANR-10-LABX-62-IBEID)., ANR-16-CE02-0005,Arch-Evol,Approches phylogenomiques pour étudier l'origine et évolution des Archées(2016), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE)
المصدر: Science
Science, 2021, 372 (6541), pp.516-520. ⟨10.1126/science.abe6494⟩
Science, American Association for the Advancement of Science, 2021, 372 (6541), pp.516-520. ⟨10.1126/science.abe6494⟩مصطلحات موضوعية: Purine, DNA polymerase, Guanine, Genome, Viral, Viral Nonstructural Proteins, Crystallography, X-Ray, Genome, 03 medical and health sciences, chemistry.chemical_compound, Adenylosuccinate Synthase, MESH: 2-Aminopurine, A-DNA, MESH: Adenylosuccinate Synthase, Bacteriophages, MESH: Bacteriophages, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Phylogeny, 2-Aminopurine, Phylogeny, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, biology, ATP synthase, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], 030302 biochemistry & molecular biology, MESH: Crystallography, X-Ray, MESH: DNA, Viral, Biosynthetic Pathways, Enzyme, chemistry, Biochemistry, DNA, Viral, biology.protein, MESH: Viral Nonstructural Proteins, MESH: Biosynthetic Pathways, MESH: Genome, Viral, DNA
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13
مصطلحات موضوعية: Genetics, Physiology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, spontaneous missense mutation, insulin degrading enzyme, extremely wide use, blood components involved, adenylosuccinate synthase 2, >, wd repeat, metabolically important tissues, brown adipose tissue, differentially expressed genes, frequently used substrains, div >< p, build transgenic mice, b6j mice compared, tissue weight, seven tissues, generating transgenic, less expressed, highly expressed, inbred mice, whereby b6j, well studied, vivo <, type 1, two substrains
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مصطلحات موضوعية: Genetics, Physiology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, spontaneous missense mutation, insulin degrading enzyme, extremely wide use, blood components involved, adenylosuccinate synthase 2, >, wd repeat, metabolically important tissues, brown adipose tissue, differentially expressed genes, frequently used substrains, div >< p, build transgenic mice, b6j mice compared, tissue weight, seven tissues, generating transgenic, less expressed, highly expressed, inbred mice, whereby b6j, well studied, vivo <, type 1, two substrains
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مصطلحات موضوعية: Genetics, Physiology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, spontaneous missense mutation, insulin degrading enzyme, extremely wide use, blood components involved, adenylosuccinate synthase 2, >, wd repeat, metabolically important tissues, brown adipose tissue, differentially expressed genes, frequently used substrains, div >< p, build transgenic mice, b6j mice compared, tissue weight, seven tissues, generating transgenic, less expressed, highly expressed, inbred mice, whereby b6j, well studied, vivo <, type 1, two substrains
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مصطلحات موضوعية: Genetics, Physiology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, spontaneous missense mutation, insulin degrading enzyme, extremely wide use, blood components involved, adenylosuccinate synthase 2, >, wd repeat, metabolically important tissues, brown adipose tissue, differentially expressed genes, frequently used substrains, div >< p, build transgenic mice, b6j mice compared, tissue weight, seven tissues, generating transgenic, less expressed, highly expressed, inbred mice, whereby b6j, well studied, vivo <, type 1, two substrains
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مصطلحات موضوعية: Genetics, Physiology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, spontaneous missense mutation, insulin degrading enzyme, extremely wide use, blood components involved, adenylosuccinate synthase 2, >, wd repeat, metabolically important tissues, brown adipose tissue, differentially expressed genes, frequently used substrains, div >< p, build transgenic mice, b6j mice compared, tissue weight, seven tissues, generating transgenic, less expressed, highly expressed, inbred mice, whereby b6j, well studied, vivo <, type 1, two substrains
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مصطلحات موضوعية: Genetics, Physiology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, spontaneous missense mutation, insulin degrading enzyme, extremely wide use, blood components involved, adenylosuccinate synthase 2, >, wd repeat, metabolically important tissues, brown adipose tissue, differentially expressed genes, frequently used substrains, div >< p, build transgenic mice, b6j mice compared, tissue weight, seven tissues, generating transgenic, less expressed, highly expressed, inbred mice, whereby b6j, well studied, vivo <, type 1, two substrains
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مصطلحات موضوعية: Genetics, Physiology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, spontaneous missense mutation, insulin degrading enzyme, extremely wide use, blood components involved, adenylosuccinate synthase 2, >, wd repeat, metabolically important tissues, brown adipose tissue, differentially expressed genes, frequently used substrains, div >< p, build transgenic mice, b6j mice compared, tissue weight, seven tissues, generating transgenic, less expressed, highly expressed, inbred mice, whereby b6j, well studied, vivo <, type 1, two substrains
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20Image
مصطلحات موضوعية: Genetics, Physiology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, spontaneous missense mutation, insulin degrading enzyme, extremely wide use, blood components involved, adenylosuccinate synthase 2, >, wd repeat, metabolically important tissues, brown adipose tissue, differentially expressed genes, frequently used substrains, div >< p, build transgenic mice, b6j mice compared, tissue weight, seven tissues, generating transgenic, less expressed, highly expressed, inbred mice, whereby b6j, well studied, vivo <, type 1, two substrains