المؤلفون: Yingxue C. Liu, Adam T. Gates, Priya Kunapuli, Erica M. Stec, Min Xu, Shane D. Marine, Daniel J. Holder, Berta Strulovici, Joseph F. Heyse, Amy S. Espeseth

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://nar.oxfordjournals.org/content/early/2008/07/15/nar.gkn435.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.605.179; http://nar.oxfordjournals.org/content/early/2008/07/15/nar.gkn435.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.605.179
http://nar.oxfordjournals.org/content/early/2008/07/15/nar.gkn435.full.pdf

المؤلفون: Daria J. Hazuda, David M. Margolis, Kara S. Keedy, Nancie M. Archin, Adam T. Gates, A Limited, Group Class, I Histone

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jvi.asm.org/content/83/10/4749.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.540.180; http://jvi.asm.org/content/83/10/4749.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.540.180
http://jvi.asm.org/content/83/10/4749.full.pdf

المؤلفون: Xiaohua Douglas Zhang, Pei Fen Kuan, Marc Ferrer, Xiaohua Shu, Yingxue C. Liu, Adam T. Gates, Priya Kunapuli, Erica M. Stec, Min Xu, Shane D. Marine, Daniel J. Holder, Berta Strulovici, Joseph F. Heyse, Amy S. Espeseth

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/69/a1/Nucleic_Acids_Res_2008_Aug_36(14)_4667-4679.tar.gz

وصف الملف: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.11

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.11

المؤلفون: Baohua Gu, Adam T. Gates, Olaf Isken, Sven-erik Behrens, Robert T. Sarisky

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jvi.asm.org/content/77/9/5352.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.2417; http://jvi.asm.org/content/77/9/5352.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.327.2417
http://jvi.asm.org/content/77/9/5352.full.pdf

المؤلفون: Nannan Liu, Michael N. Zimmerman, Richard M. Keenan, Victor K. Johnston, Deping Chai, Rosanna Tedesco, Duke M. Fitch, Juili Lin-Goerke, Kenneth Wiggall, Antony N. Shaw, Nestor O. Concha, Ramesh Bambal, Michael G. Darcy, Robert T. Sarisky, Dashyant Dhanak, Kevin J. Duffy, Adam T. Gates

المصدر: Bioorganic & Medicinal Chemistry Letters. 19:4350-4353

مصطلحات موضوعية: Chemistry, Pharmaceutical, viruses, Hepatitis C virus, Clinical Biochemistry, Molecular Conformation, Administration, Oral, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Benzothiadiazines, medicine.disease_cause, Antiviral Agents, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Replicon, Molecular Biology, Polymerase, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Organic Chemistry, biochemical phenomena, metabolism, and nutrition, Rats, Enzyme, Models, Chemical, Benzothiadiazine, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2ff5c553e8d62c4eb72b3845398b47
https://doi.org/10.1016/j.bmcl.2009.05.091

المؤلفون: Kaori Ihida-Stansbury, Sandra L. Merklinger, David M. McKean, Anne L. Plant, Peter L. Jones, Rene Chapados, Khotaro Abe, Adam T. Gates, Hiroaki Shimokawa, John T. Elliott, Michael J. Kern

المصدر: Circulation Research. 99:837-844

مصطلحات موضوعية: medicine.medical_specialty, Stress fiber, Vascular smooth muscle, RHOA, Transcription, Genetic, Physiology, Myocytes, Smooth Muscle, In Vitro Techniques, Protein Serine-Threonine Kinases, Pulmonary Artery, Biology, Cell morphology, Muscle, Smooth, Vascular, Extracellular matrix, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Internal medicine, Cell Adhesion, medicine, Animals, Extracellular Signal-Regulated MAP Kinases, Cytoskeleton, Cell Shape, Protein Kinase Inhibitors, Rho-associated protein kinase, Cells, Cultured, rho-Associated Kinases, Monocrotaline, Intracellular Signaling Peptides and Proteins, Tenascin, musculoskeletal system, Actins, Extracellular Matrix, Rats, Cell biology, Endocrinology, Vasoconstriction, Hypertension, Disease Progression, cardiovascular system, biology.protein, Blood Vessels, Stress, Mechanical, rhoA GTP-Binding Protein, Cardiology and Cardiovascular Medicine, Type I collagen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9a975719bb7ef393e13f6ff5b2fba5
https://doi.org/10.1161/01.res.0000246172.77441.f1

المؤلفون: Chao Han, Warren W. Gerhardt, Dashyant Dhanak, Kevin J. Duffy, Nestor O. Concha, Adam T. Gates, Richard M. Keenan, Victor K. Johnston, Glenn A. Hofmann, Duke M. Fitch, Nannan Liu, Kenneth Wiggall, Antony N. Shaw, Dina L. Halegoua, Robert T. Sarisky, Michael N. Zimmerman, Ramesh Bambal, Michael G. Darcy, Arun C. Kaura, Juili Lin-Goerke, Deping Chai, Rosanna Tedesco

المصدر: Journal of Medicinal Chemistry. 49:971-983

مصطلحات موضوعية: Models, Molecular, Genotype, Stereochemistry, Hepatitis C virus, High-throughput screening, Biological Availability, RNA-dependent RNA polymerase, Hepacivirus, Quinolones, Benzothiadiazines, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, RNA polymerase, Drug Discovery, medicine, Animals, Polymerase, Subgenomic mRNA, chemistry.chemical_classification, Molecular Structure, Thiadiazines, biology, Blood Proteins, RNA-Dependent RNA Polymerase, Rats, Macaca fascicularis, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Mutation, biology.protein, Molecular Medicine, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cae20df8f691062dcbdf7b76d9840b9
https://doi.org/10.1021/jm050855s

المؤلفون: Adam T. Gates, Baohua Gu, Robert T. Sarisky

المصدر: Virus Research. 100:213-222

مصطلحات موضوعية: Cancer Research, Carcinoma, Hepatocellular, viruses, Molecular Sequence Data, Genome, Viral, Hepacivirus, Virus Replication, Polymerase Chain Reaction, Virus, chemistry.chemical_compound, Chimera (genetics), Cell Line, Tumor, Virology, Humans, Coding region, Replicon, 3' Untranslated Regions, NS5B, Gene, Polymerase, DNA Primers, Subgenomic mRNA, Genetics, Base Sequence, biology, Chimera, Liver Neoplasms, Reproducibility of Results, Electroporation, Infectious Diseases, chemistry, Mutagenesis, Site-Directed, biology.protein, RNA, Viral

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5508b35100849159ad1d87e8efea0d
https://doi.org/10.1016/j.virusres.2003.12.029

المؤلفون: Baohua Gu, Robert T. Sarisky, Kevin J. Duffy, Adam T. Gates, Lester L. Gutshall, Tammy T. Nguyen, Victor K. Johnston

المصدر: Antimicrobial Agents and Chemotherapy. 47:3525-3530

مصطلحات موضوعية: DNA, Complementary, viruses, Hepatitis C virus, RNA-dependent RNA polymerase, Hepacivirus, Benzothiadiazines, medicine.disease_cause, Antiviral Agents, Cell Line, Viral Proteins, chemistry.chemical_compound, RNA polymerase, Drug Resistance, Viral, medicine, Humans, Pharmacology (medical), Replicon, Enzyme Inhibitors, Polymerase Gene, Gene, NS5B, Polymerase, Pharmacology, biology, biochemical phenomena, metabolism, and nutrition, RNA-Dependent RNA Polymerase, Virology, Molecular biology, Infectious Diseases, chemistry, Mutagenesis, Site-Directed, biology.protein, RNA, Viral

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfd6bc297392e4a33ee0229da99c35f
https://doi.org/10.1128/aac.47.11.3525-3530.2003

المؤلفون: Summa V, Steven W Ludmerer, John A McCauley, Christine Fandozzi, Christine Burlein, Giuliano Claudio, Paul J Coleman, Jillian M DiMuzio, Marco Ferrara, Marcello Di Filippo, Adam T Gates, Donald J Graham, Steven Harper, Daria J Hazuda, Qian Huang, Carolyn McHale, Edith Monteagudo, Vincenzo Pucci, Michael Rowley, Michael T Rudd, Aileen Soriano, Mark W Stahlhut, Joseph P Vacca, David B Olsen, Nigel J Liverton, Steven S Carroll

المساهمون: Summa, V, Steven, W Ludmerer, John, A McCauley, Christine, Fandozzi, Christine, Burlein, Giuliano, Claudio, Paul, J Coleman, Jillian, M DiMuzio, Marco, Ferrara, Marcello Di, Filippo, Adam, T Gate, Donald, J Graham, Steven, Harper, Daria, J Hazuda, Qian, Huang, Carolyn, Mchale, Edith, Monteagudo, Vincenzo, Pucci, Michael, Rowley, Michael, T Rudd, Aileen, Soriano, Mark, W Stahlhut, Joseph, P Vacca, David, B Olsen, Nigel, J Liverton, Steven, S Carroll

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000306826300016; volume:56; issue:8; firstpage:4161; lastpage:4167; numberofpages:7; journal:ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; http://hdl.handle.net/11588/771084; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84864387126

الاتاحة: http://hdl.handle.net/11588/771084
https://doi.org/10.1128/AAC.00324-12

المؤلفون: Vincenzo Summa, Steven W. Ludmerer, John A. McCauley, Christine Fandozzi, Christine Burlein, Giuliano Claudio, Paul J. Coleman, Jillian M. DiMuzio, Marco Ferrara, Marcello Di Filippo, Adam T. Gates, Donald J. Graham, Steven Harper, Daria J. Hazuda, Qian Huang, Carolyn McHale, Edith Monteagudo, Vincenzo Pucci, Michael Rowley, Michael T. Rudd, Aileen Soriano, Mark W. Stahlhut, Joseph P. Vacca, David B. Olsen, Nigel J. Liverton, Steven S. Carroll

المساهمون: Summa, V, Steven, W Ludmerer, John, A McCauley, Christine, Fandozzi, Christine, Burlein, Giuliano, Claudio, Paul, J Coleman, Jillian, M DiMuzio, Marco, Ferrara, Marcello Di, Filippo, Adam, T Gate, Donald, J Graham, Steven, Harper, Daria, J Hazuda, Qian, Huang, Carolyn, Mchale, Edith, Monteagudo, Vincenzo, Pucci, Michael, Rowley, Michael, T Rudd, Aileen, Soriano, Mark, W Stahlhut, Joseph, P Vacca, David, B Olsen, Nigel, J Liverton, Steven, S Carroll

مصطلحات موضوعية: Cyclopropanes, Elbasvir, Genotype, Pan troglodytes, Hepatitis C virus, Hepacivirus, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Telaprevir, chemistry.chemical_compound, Dogs, Interferon, Pegylated interferon, Boceprevir, Quinoxalines, Drug Resistance, Viral, medicine, Animals, Protease inhibitor (pharmacology), Protease Inhibitors, Pharmacology (medical), Author Correction, Pharmacology, Sulfonamides, Hepatitis C, Chronic, Viral Load, Virology, Amides, Rats, Infectious Diseases, chemistry, Liver, Carbamates, Viral load, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64682d798f2e752e5f8cca964cb3aeb8
http://hdl.handle.net/11588/771084

المؤلفون: Rosanna Tedesco, Duke M. Fitch, Robert T. Sarisky, Antony N. Shaw, Michael N. Zimmerman, Kevin J. Duffy, Michael G. Darcy, Dashyant Dhanak, Juili Lin-Goerke, Richard M. Keenan, Adam T. Gates, Victor K. Johnston, Deping Chai, Kenneth Wiggall, Klára Valkó

المصدر: Bioorganicmedicinal chemistry letters. 19(15)

مصطلحات موضوعية: Genotype, Stereochemistry, Hepatitis C virus, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Quinolones, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Chemical synthesis, Antiviral Agents, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Humans, Molecular Biology, chemistry.chemical_classification, Bicyclic molecule, biology, Molecular Structure, Organic Chemistry, Biological activity, Enzyme, chemistry, Models, Chemical, Enzyme inhibitor, Drug Design, Lactam, biology.protein, Molecular Medicine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11408964cf7b6803b2d1e72c0055aa0d
https://pubmed.ncbi.nlm.nih.gov/19505821

المؤلفون: Cynthia M. Pruss, Adam T. Gates, Sanjay S. Khandekar, Baohua Gu

المصدر: Protein and peptide letters. 12(4)

مصطلحات موضوعية: viruses, medicine.medical_treatment, Hepatitis C virus, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Structural Biology, medicine, Escherichia coli, NS3, Protease, biology, Serine Endopeptidases, virus diseases, Helicase, RNA, General Medicine, biochemical phenomena, metabolism, and nutrition, RNA Helicase A, Small molecule, Molecular biology, digestive system diseases, Recombinant Proteins, Protein Structure, Tertiary, NS2-3 protease, biology.protein, Chromatography, Gel, Baculoviridae, RNA Helicases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f969c64454b391b02441c52dce043ac
https://pubmed.ncbi.nlm.nih.gov/15907174

المؤلفون: Victor K. Johnston, Carol Silverman, Ricardo Macarron, Arun C. Kaura, George M. Chan, Kevin J. Duffy, Alfred DelVecchio, Adam T. Gates, Hung-Yuan Cheng, Sanjay S. Khandekar, Derrick Maley, Baohua Gu, Lester L. Gutshall, Zaid Alnoah, Dashyant Dhanak, Antony N. Shaw, Robert T. Sarisky, Glenn A. Hofmann, Cathy Greenwood, David J. Casper, Richard M. Keenan, David L. Earnshaw, Michael R. Nonnemacher, Michael G. Darcy, Juili Lin-Goerke, Audrey Baker

المصدر: The Journal of biological chemistry. 277(41)

مصطلحات موضوعية: Protein Denaturation, viruses, Hepatitis C virus, Drug Evaluation, Preclinical, RNA-dependent RNA polymerase, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Cell Line, chemistry.chemical_compound, Transcription (biology), RNA polymerase, Enzyme Stability, medicine, Humans, Enzyme Inhibitors, Molecular Biology, NS5B, Polymerase, biology, Molecular Structure, Thiadiazines, Circular Dichroism, Temperature, RNA, Cell Biology, RNA-Dependent RNA Polymerase, Molecular biology, Recombinant Proteins, NS2-3 protease, chemistry, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f7b630323027328a40134cf9e21149
https://pubmed.ncbi.nlm.nih.gov/12167642

المؤلفون: Rene Chapados, Khotaro Abe, Kaori Ihida-stansbury, David Mckean, Adam T. Gates, Ra Merklinger, John Elliott, Anne Plant, Hiroaki Shimokawa, Peter Lloyd Jones, Michael Kern

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://circres.ahajournals.org/content/99/8/837.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.255; http://circres.ahajournals.org/content/99/8/837.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.255
http://circres.ahajournals.org/content/99/8/837.full.pdf

المؤلفون: T. Sarisky, Victor K. Johnston, Baohua Gu, Kevin J. Duffy, Tammy T. Nguyen, Adam T. Gates, Lester L. Gutshall, Rna-dependent Rna Polymerase

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://aac.asm.org/content/47/11/3525.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.573.5772; http://aac.asm.org/content/47/11/3525.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.573.5772
http://aac.asm.org/content/47/11/3525.full.pdf

المؤلفون: Cell Host, Honglin Zhou, Min Xu, Qian Huang, Adam T. Gates, Xiaohua D. Zhang, John C. Castle, Erica Stec, Marc Ferrer, Berta Strulovici, Daria J. Hazuda, Amy S. Espeseth

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://download.cell.com/cell-host-microbe/mmcs/journals/1931-3128/piis1931312808003302.mmc1.pdf.

مصطلحات موضوعية: Cell viability Assay, Following incubation for either 48 or 96 hours, an alamar blue- based assay was used to measure cell viability. Cell growth media wa

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.560.1393; http://download.cell.com/cell-host-microbe/mmcs/journals/1931-3128/piis1931312808003302.mmc1.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.560.1393
http://download.cell.com/cell-host-microbe/mmcs/journals/1931-3128/piis1931312808003302.mmc1.pdf