المؤلفون: Adam S Darwich, Anne-Marie Boström, Susanne Guidetti, Jayanth Raghothama, Sebastiaan Meijer

المصدر: JMIR Human Factors, Vol 10, p e42283 (2023)

مصطلحات موضوعية: Medical technology, R855-855.5

وصف الملف: electronic resource

Relation: https://humanfactors.jmir.org/2023/1/e42283; https://doaj.org/toc/2292-9495

URL الوصول: https://doaj.org/article/d2311f0dbc1444d1b8ff9013560133e8

المؤلفون: Cevin Zhang, Karin Pukk Härenstam, Adam S Darwich, Sebastiaan Meijer

المصدر: International Journal of Serious Games, Vol 7, Iss 1 (2020)

مصطلحات موضوعية: Serious game, production simulation, pediatric emergency department, strategic management, work, Education, Electronic computers. Computer science, QA75.5-76.95, Computer software, QA76.75-76.765

وصف الملف: electronic resource

Relation: https://journal.seriousgamessociety.org/index.php/IJSG/article/view/334; https://doaj.org/toc/2384-8766

URL الوصول: https://doaj.org/article/f9686c8461d745f898388f64aa7b9231

المؤلفون: Luca Marzano, Adam S. Darwich, Raghothama Jayanth, Lethvall Sven, Nina Falk, Patrik Bodeby, Sebastiaan Meijer

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/ab0156c1b4794f67863b3ac7b95c47d3

المؤلفون: Luca Marzano, Adam S. Darwich, Asaf Dan, Salomon Tendler, Rolf Lewensohn, Luigi De Petris, Jayanth Raghothama, Sebastiaan Meijer

المصدر: Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

URL الوصول: https://doaj.org/article/1b179c89e7a94476879044a3a0369bfe

المؤلفون: Stephanie F. Ling, Kayode Ogungbenro, Adam S. Darwich, Amirah Binti Mohammad Ariff, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant

المصدر: Pharmaceutics, Vol 16, Iss 6, p 702 (2024)

مصطلحات موضوعية: rheumatoid arthritis, pharmacokinetics, population pharmacokinetics, simulation, biologics, biosimilars, Pharmacy and materia medica, RS1-441

Relation: https://www.mdpi.com/1999-4923/16/6/702; https://doaj.org/toc/1999-4923; https://doaj.org/article/a8cfb2e5d9654bdba668ec4bfe031ac5

الاتاحة: https://doi.org/10.3390/pharmaceutics16060702
https://doaj.org/article/a8cfb2e5d9654bdba668ec4bfe031ac5

المؤلفون: Hiroyuki Takita, Adam S. Darwich, Amais Ahmad, Amin Rostami‐Hodjegan

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 11, Pp 617-627 (2020)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/57e0f61b6e3447b79f2c6d634947cd32

المؤلفون: Luca Marzano, Adam S. Darwich, Salomon Tendler, Asaf Dan, Rolf Lewensohn, Luigi De Petris, Jayanth Raghothama, Sebastiaan Meijer

المصدر: Clinical and Translational Science, Vol 15, Iss 10, Pp 2437-2447 (2022)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

Relation: https://doi.org/10.1111/cts.13371; https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062; https://doaj.org/article/3b96a4fe9f5b47afb4e72d9bdf159dff

الاتاحة: https://doi.org/10.1111/cts.13371
https://doaj.org/article/3b96a4fe9f5b47afb4e72d9bdf159dff

المؤلفون: Daniel Scotcher (7440011), Nicola Melillo (11161053), Sirisha Tadimalla (2219440), Adam S. Darwich (11161056), Sabina Ziemian (11161059), Kayode Ogungbenro (11161062), Gunnar Schütz (11161065), Steven Sourbron (9042614), Aleksandra Galetin (3846784)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Physiology, Pharmacology, Biotechnology, Inorganic Chemistry, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, gadoxetate liver data, DCE, PBPK modeling applications, CV, MRP, MRI, OATP, Imaging Biomarker Gadoxetate, PBPK model, liver-imaging data, organic-anion-transporting polypept., refining PBPK transporter IVIVE, Transporter-Mediated Hepatic Dispos., 1B, gadoxetate PBPK model, hepatocyte, uptake, gadoxetate hepatic tDDI, vivo, multidrug resistance-associated pro., PBPK model refinement

Relation: https://figshare.com/articles/journal_contribution/Physiologically_Based_Pharmacokinetic_Modeling_of_Transporter-Mediated_Hepatic_Disposition_of_Imaging_Biomarker_Gadoxetate_in_Rats/15025482

الاتاحة: https://doi.org/10.1021/acs.molpharmaceut.1c00206.s001

المؤلفون: Adam S. Darwich, Oliver J. Hatley, Andrés Olivares‐Morales, Farzaneh Salem, Alison Margolskee, Amin Rostami‐Hodjegan

المصدر: Oral Drug Delivery for Modified Release Formulations. :65-86

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6d02b9cc329eec3100e4d7d4467a458e
https://doi.org/10.1002/9781119772729.ch4

المؤلفون: Luca Marzano, Sebastiaan Meijer, Asaf Dan, Salomon Tendler, Luigi De Petris, Rolf Lewensohn, Jayanth Raghothama, Adam S. Darwich

المصدر: Caring is Sharing – Exploiting the Value in Data for Health and Innovation ISBN: 9781643683881

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ea4ecbeff5f2a80b3ae4dfb718a88078
https://doi.org/10.3233/shti230056

المؤلفون: Mohamed Nezar Abourraja, Luca Marzano, Jayanth Raghothama, Arsineh Boodaghian Asl, Adam S. Darwich, Sebastiaan Meijer, Sven Lethvall, Nina Falk

المصدر: 2022 Winter Simulation Conference (WSC).

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e31965a770ba7187ded2a0826a1d6db5
https://doi.org/10.1109/wsc57314.2022.10015465

المؤلفون: Adam S. Darwich, Anne-Marie Boström, Susanne Guidetti, Jayanth Raghothama, Sebastiaan Meijer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9d2db89260c09856c97de724952d8132
https://doi.org/10.2196/preprints.42283

المؤلفون: Arsineh Boodaghian Asl, Adam S. Darwich, Jayanth Raghothama, Sebastiaan Meijer

المصدر: Proceedings of the Design Society. 1:3379-3388

مصطلحات موضوعية: Value (ethics), Computer science, Scale (chemistry), media_common.quotation_subject, Complex network, Data science, Mental health, law.invention, PageRank, law, Well-being, Quality (business), Social network analysis, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f97ccc82d00d970ac83add660cb8f875
https://doi.org/10.1017/pds.2021.599

المؤلفون: Sirisha Tadimalla, Daniel Scotcher, Adam S. Darwich, Steven Sourbron, Kayode Ogungbenro, Gunnar Schütz, Sabina Ziemian, Nicola Melillo, Aleksandra Galetin

المصدر: Molecular Pharmaceutics
Mol. Pharmaceutics

مصطلحات موضوعية: Gadolinium DTPA, Male, Physiologically based pharmacokinetic modelling, Imaging biomarker, quantitative translation, physiologically based pharmacokinetic model, Biological Transport, Active, Contrast Media, Organic Anion Transporters, Pharmaceutical Science, drug transporters, Pharmacology, Article, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, imaging biomarker, Drug Interactions, drug−drug interactions, Cells, Cultured, medicine.diagnostic_test, Chemistry, Multidrug resistance-associated protein 2, Transporter, Magnetic resonance imaging, Magnetic Resonance Imaging, Rats, medicine.anatomical_structure, Liver, gadoxetate, Hepatocyte, Models, Animal, Hepatocytes, Molecular Medicine, hepatobiliary excretion, Rifampin, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8273f7c9644e0d3b1f1acd044719deee
https://doi.org/10.1021/acs.molpharmaceut.1c00206

المؤلفون: Amin Rostami-Hodjegan, Varinder Athwal, Adam S. Darwich, Eman El-Khateeb, Brahim Achour

المصدر: Alimentary Pharmacology & Therapeutics. 54:388-401

مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, Hepatology, Metabolic Clearance Rate, business.industry, Liver Diseases, Hepatic impairment, media_common.quotation_subject, Gastroenterology, Drug Elimination Routes, medicine.disease, Bioinformatics, Review article, Liver disease, Pharmacokinetics, Humans, Medicine, Pharmacology (medical), Dosing, Medical prescription, business, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee1ee475c69d255066907af52099070
https://doi.org/10.1111/apt.16489

المؤلفون: Adam S. Darwich, Nicola Melillo

المصدر: Journal of Pharmacokinetics and Pharmacodynamics

مصطلحات موضوعية: Statistical assumption, media_common.quotation_subject, Inference, Correlated factors, Latent variable, Machine learning, computer.software_genre, Models, Biological, Sensitivity and Specificity, 030226 pharmacology & pharmacy, Correlation, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Sensitivity (control systems), Mathematics, media_common, Interpretability, Pharmacology, Original Paper, Variables, business.industry, Sobol sequence, Physiologically based pharmacokinetic models, Model-informed drug discovery and development, Global sensitivity analysis, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Artificial intelligence, business, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5956828d07ae743086e1d176b9914ce1
https://doi.org/10.1007/s10928-021-09764-x

المؤلفون: Charalampos Orfanidis, Adam S. Darwich, Rachel Cheong, Xenofon Fafoutis

المصدر: Proceedings of the 2022 Workshop on Emerging Devices for Digital Biomarkers.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::382f2b22027c19ed7f43aa3734caf405
https://doi.org/10.1145/3539494.3542755

المؤلفون: Alex Mattinson, David Lindley, Helena Engman, Manthena V.S. Varma, Anh-Thu Nguyen-Trung, Binfeng Xia, Xavier Pepin, Linette Ruston, Wei Zhu, Bill van Osdol, Celine Ollier, David Good, Jonathan Brown, Laurent Boulu, Talia Flanagan, Olivier Nicolas, Staffan Berg, Shanoo Budhdeo, Aarti Patel, Jan Bevernage, Handan He, Sweta Modi, Richard Barker, Claire Jackson, Christer Tannergren, Xiojun Ren, Stephane Beilles, J. Matthew Wood, Johanna Laru, Pierre Daublain, Sara Carlert, Louis Henrion, Jean-Flaubert Nguefack, Gunilla Hanisch, Eva Karlsson, Wen Lin, Shruthi Vaidhyanathan, Robert Carr, Fan Wu, Jin Zhang, Amais Ahmad, James M. Mullin, Sari Pappinen, Andrea Moir, Ke Szeto, Christine Xu, Claire Patterson, David B. Turner, Guillaume Louit, Yuya Wang, Tycho Heimbach, Richard Lloyd, Frans Franek, Masoud Jamei, Christophe Tistaert, Bertil Abrahamsson, Kerstin Julia Schäfer, Leon Aarons, Shriram M. Pathak, Adam S. Darwich, Suet Wong, Dónal Murphy, Amin Rostami-Hodjegan, Timo Korjamo, Helena Thörn, Kartrin Schmid, Michael B. Bolger, Johanna Tuunainen, Mai Anh Nguyen

المصدر: European Journal of Pharmaceutics and Biopharmaceutics. 156:50-63

مصطلحات موضوعية: Data Analysis, Physiologically based pharmacokinetic modelling, Databases, Factual, Administration, Oral, Pharmaceutical Science, 02 engineering and technology, Machine learning, computer.software_genre, Models, Biological, 030226 pharmacology & pharmacy, Biopharmaceutics, Pharmaceutical Sciences, 03 medical and health sciences, 0302 clinical medicine, Software, Pharmacokinetics, Humans, Clinical Trials as Topic, business.industry, Compound specific, General Medicine, Farmaceutiska vetenskaper, 021001 nanoscience & nanotechnology, Bioavailability, Intestinal Absorption, Pharmaceutical Preparations, Drug development, Performance indicator, Artificial intelligence, 0210 nano-technology, business, computer, Forecasting, Biotechnology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bca05a74d852f38ad03c52e9e4fba40
https://doi.org/10.1016/j.ejpb.2020.08.006

المؤلفون: Clive G. Wilson, Leon Aarons, Patrick Augustijns, Joachim Brouwers, Adam S. Darwich, Tom De Waal, Grzegorz Garbacz, Simone Hansmann, Dagmara Hoc, Anela Ivanova, Mirko Koziolek, Christos Reppas, Philipp Schick, Maria Vertzoni, J. Arturo García-Horsman

المساهمون: Regenerative pharmacology group, Division of Pharmacology and Pharmacotherapy

المصدر: Aarons, L 2021, ' Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective ', European Journal of Pharmaceutical Sciences . https://doi.org/10.1016/j.ejps.2021.106100

مصطلحات موضوعية: Male, RM, Pharmaceutical Science, Administration, Oral, Molecular dynamics, Models, Biological, Pharmaceutical Sciences, Gastrointestinal tract, In silico models of absorption, Oral drug product development, Humans, Computer Simulation, In vitro models of absorpt, COVID-19, Farmaceutiska vetenskaper, Pharmacometric modelling, Scintigraphy, Gastrointestinal Tract, Human intestinal fluid, Intestinal Absorption, Pharmaceutical Preparations, Solubility, Gastrointestinal Absorption, 3121 General medicine, internal medicine and other clinical medicine, Nuclear imaging

وصف الملف: application/pdf; Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2539f9583e36cc3176667f2192d6135f
https://doi.org/10.1016/j.ejps.2021.106100

المؤلفون: Amin Rostami-Hodjegan, Adam S. Darwich, Howard Burt

المصدر: Darwich, A S, Burt, H J & Rostami-hodjegan, A 2019, ' The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall ', European Journal of Pharmaceutical Sciences . https://doi.org/10.1016/j.ejps.2019.02.017

مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, Modelling and simulation, Enterocyte, media_common.quotation_subject, Pharmaceutical Science, Special populations, 02 engineering and technology, Computational biology, Disease, Models, Biological, 030226 pharmacology & pharmacy, Physiologically-based pharmacokinetics, Quantitative systems pharmacology, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, Cytochrome P-450 CYP3A, Drug-drug interactions, Intestinal Mucosa, media_common, chemistry.chemical_classification, biology, Cytochrome P450, 021001 nanoscience & nanotechnology, Turnover, Fruit and Vegetable Juices, Intestinal Diseases, Enterocytes, Enzyme, medicine.anatomical_structure, Pharmaceutical Preparations, chemistry, Gut wall metabolism, biology.protein, Cytochrome P-450 CYP3A Inhibitors, 0210 nano-technology, Citrus paradisi, Systems pharmacology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516ac9281fc5923df7f382fc84d9708f
https://doi.org/10.1016/j.ejps.2019.02.017