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1Academic Journal
المؤلفون: Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Boonlert Cheewatrakoolpong, Jiyan Xue, Daphne Szeto, Gail Forrest, Corin Miller, Michelle Bunzel, Christopher W Plummer, Harry R Chobanian, Michael W Miller, Sarah Souza, Brande S Thomas-Fowlkes, Aimie M Ogawa, Adam B Weinglass, Jerry Di Salvo, Xiaoyan Li, Yue Feng, Daniel A Tatosian, Andrew D Howard, Steven L Colletti, Maria E Trujillo
المصدر: PLoS ONE, Vol 12, Iss 10, p e0186033 (2017)
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Corin Miller, Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Michelle Bunzel, Jin Cao, Sarah Souza, Brande Thomas-Fowlkes, Jerry Di Salvo, Adam B Weinglass, Xiaoyan Li, Robert W Myers, Kevin Knagge, Paul E Carrington, William K Hagmann, Maria E Trujillo
المصدر: PLoS ONE, Vol 12, Iss 5, p e0176182 (2017)
وصف الملف: electronic resource
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3
المؤلفون: Richard Johnstone, Zhao Ren, Myung K. Shin, Maarten Hoek, Haihong Zhou, Anthony Kreamer, Mary-Jo Wildey, Jason E. Imbriglio, Stephen F. Previs, Xi Ai, Andrea M. Peier, Steve Cifelli, Lufei Hu, Ashmita Saigal, Josephine Johnson, Richard Visconti, Yanqing Kan, Lin-Lin Shiao, William T. McElroy, Jonathan W. Choy, Adam B. Weinglass, Ying Lei, Robert Ramos, Andy Liaw, Michelle Chen
المصدر: SLAS Discovery. 26:1225-1237
مصطلحات موضوعية: Apolipoprotein L2, Phenotypic screening, High-throughput screening, Cell, 030232 urology & nephrology, Biochemistry, Analytical Chemistry, law.invention, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, law, Drug Discovery, medicine, Humans, Viability assay, Cytotoxicity, 030304 developmental biology, 0303 health sciences, Podocytes, Chemistry, Drug discovery, Apolipoprotein L1, High-Throughput Screening Assays, Cell biology, medicine.anatomical_structure, Molecular Medicine, Suppressor, Biotechnology
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4
المؤلفون: Barbara Pio, Ravi P. Nargund, Yan Guo, Daniel Kosinski, Josien Hubert B, Michael Wright, Michele Pachanski, Harry R. Chobanian, Xiaoping Zhang, Richard Tschirret-Guth, Melissa Kirkland, Andrew D. Howard, Sarah Souza, Eric R. Ashley, Robert K. Orr, Steven L. Colletti, Joel Mane, Jerry Di Salvo, Michael W. Miller, Boonlert Cheewatrakoolpong, Koppara Samuel, William K. Hagmann, James Lamca, Juliann Ehrhart, Maria E. Trujillo, Jackie Shang, Qing Chen, Adam B. Weinglass, Randal M. Bugianesi
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:1842-1848
مصطلحات موضوعية: Agonist, endocrine system, medicine.drug_class, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Enteroendocrine cell, 01 natural sciences, Biochemistry, Receptors, G-Protein-Coupled, Free fatty acid receptor 1, Drug Discovery, medicine, Humans, Receptor, Mode of action, Molecular Biology, geography, geography.geographical_feature_category, 010405 organic chemistry, Chemistry, Organic Chemistry, Islet, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Mechanism of action, Drug Design, Indans, Molecular Medicine, medicine.symptom
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5
المؤلفون: Xin Gu, Brande Thomas-Fowlkes, Dorothy Levorse, Harry R. Chobanian, Timothy Cutarelli, Alexander Pasternak, Adam B. Weinglass, Ian W. Davies, Martin Koehler, Michael Margulis, Fa-Xiang Ding, Joel B. Yudkovitz, Jinlong Jiang, Haifeng Tang, Lee-Yuh Pai, Barbara Pio, Shuzhi Dong, Mengwei Hu, Kathleen A. Sullivan, Jack Gibson, Thomas Bateman, Koppara Samuel, Xiaoyan Zhou, Caryn Hampton, Reynalda deJesus, Kevin Houle, Emma R. Parmee
المصدر: Journal of medicinal chemistry. 64(11)
مصطلحات موضوعية: Male, medicine.medical_treatment, Diuresis, Action Potentials, Blood Pressure, Pharmacology, 01 natural sciences, Piperazines, Natriuresis, Excretion, 03 medical and health sciences, Dogs, Rats, Inbred SHR, Drug Discovery, medicine, Potassium Channel Blockers, Animals, Humans, Dosing, Potassium Channels, Inwardly Rectifying, Diuretics, 030304 developmental biology, Benzofurans, 0303 health sciences, Chemistry, Furosemide, Haplorhini, medicine.disease, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Heart failure, ROMK, Potassium, Molecular Medicine, Natriuretic Agents, Diuretic, medicine.drug, Half-Life
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6
المؤلفون: Jerry Di Salvo, Santhosh Satapati, Mark D. Erion, Jin Shang, Stephen F. Previs, Adam B. Weinglass, John S. Debenham, Margaret Wu, Sheng-Ping Wang, Andrew D. Howard, Ying Chen, Aleksandr Petrov, Ge Dai, Yonghua Zhu, Liangsu Wang, David E. Kelley, Ying Qian, Xiaolan Shen, Eric S. Muise, Jason M. Cox, Ping Lan, Vinit Shah, Emanuel Zycband
المصدر: Journal of Lipid Research, Vol 58, Iss 8, Pp 1561-1578 (2017)
مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, endocrine system, medicine.medical_specialty, medicine.drug_class, Lipolysis, medicine.medical_treatment, Adipose tissue, 030209 endocrinology & metabolism, QD415-436, CHO Cells, Biochemistry, Diabetes Mellitus, Experimental, Receptors, G-Protein-Coupled, Islets of Langerhans, Mice, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Endocrinology, Insulin resistance, Cricetinae, Internal medicine, Free fatty acid receptor 1, medicine, Animals, Research Articles, diabetes, Chemistry, Insulin, GPR120, Cell Biology, medicine.disease, lipolysis and fatty acid metabolism, Rats, 030104 developmental biology, Adipose Tissue, Gene Expression Regulation, Mechanism of action, fatty acid, Insulin Resistance, medicine.symptom
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المؤلفون: Judith N. Gorski, Maria E. Trujillo, Brande Thomas-Fowlkes, Adam B. Weinglass, Jerry Di Salvo, Aimie M. Ogawa, Sarah Souza, Christopher W. Plummer, Joel Mane, Michele Pachanski, Boonlert Cheewatrakoolpong, Andrew D. Howard, Steven L. Colletti
المصدر: American Journal of Physiology-Endocrinology and Metabolism. 313:E37-E47
مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, endocrine system, medicine.medical_specialty, Physiology, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Gastric motility, Biology, Partial agonist, Receptors, G-Protein-Coupled, Eating, Mice, 03 medical and health sciences, Glucagon-Like Peptide 1, Weight loss, Physiology (medical), Internal medicine, Free fatty acid receptor 1, Weight Loss, medicine, Animals, Mice, Knockout, Appetite Regulation, Insulin, Body Weight, Glucagon-like peptide-1, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, medicine.symptom, Weight gain
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8
المؤلفون: Adam B Weinglass, Nicholas B Hastings, Bradley S Sherborne, Jennifer M. Johnston, Andrew D Howard, Maria Webb, Steven L. Colletti, Clemens Vonrhein, Kevin J. Lumb, Srivanya Tummala, Frank K Brown, Jennifer Hadix, Hubert Josien, Stephen M. Soisson, Guo Yan, Harry R. Chobanian, John Wang, Michael W. Miller, Brande Thomas-Fowlkes, Dawn L. Hall, Jeffrey D. Hermes, Thu Ho, Barbara Pio, Payal R. Sheth, Sujata Sharma, Maria Kornienko, Samantha J Allen, Sangita B. Patel, Jerry Di Salvo, Sarah Souza, Gérard Bricogne, Christopher W Plummer, Jun Lu, Noel Byrne
المصدر: Nature Structural & Molecular Biology. 24:570-577
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Binding Sites, biology, Protein Conformation, Allosteric regulation, Cooperativity, Crystallography, X-Ray, Partial agonist, Receptors, G-Protein-Coupled, 03 medical and health sciences, Transmembrane domain, 030104 developmental biology, Allosteric Regulation, Allosteric enzyme, Biochemistry, Structural Biology, Free fatty acid receptor 1, biology.protein, Free fatty acid receptor, Biophysics, Humans, Binding site, Molecular Biology, Protein Binding
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9
المؤلفون: Haifeng Tang, Zack Zhiqiang Guo, Lee-Yuh Pai, Adam B. Weinglass, Xin Gu, Shuzhi Dong, Alexander Pasternak, Yang Yu, Kathleen A. Sullivan, Mengwei Hu, Kelsey VanGelder, Gloria J. Zingaro, Sophie Roy, Jessica Liu, Qinghong Fu, Birgit T. Priest, Michael Margulis, Brande Thomas-Fowlkes, Pierre Morissette, Robin E. Haimbach, Zhicai Wu, Juliann Ehrhart, Karen Owens, Caryn Hampton, Zhi-Cai Shi, Jessica Frie, Ron Ferguson, Shiyao Xu, Vincent Tong
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2559-2566
مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Scaffold, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Dogs, 0302 clinical medicine, Thiadiazoles, In vivo, Rats, Inbred SHR, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Structure–activity relationship, Spiro Compounds, Potassium Channels, Inwardly Rectifying, Molecular Biology, biology, Chemistry, Organic Chemistry, Potassium channel blocker, Rats, Disease Models, Animal, Pyrimidines, 030104 developmental biology, 030220 oncology & carcinogenesis, Hypertension, ROMK, biology.protein, Molecular Medicine, Pharmacophore, Half-Life, medicine.drug
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10
المؤلفون: Sarah Souza, Steven Cifelli, Alice Struck, Richard Visconti, Mary Jo Wildey, Adam B. Weinglass, Brande Thomas-Fowlkes
المصدر: SLAS technology. 25(3)
مصطلحات موضوعية: 0303 health sciences, Reproducibility, Drug discovery, Chemistry, High-throughput screening, Cells, In vitro toxicology, Reproducibility of Results, Computational biology, 01 natural sciences, Small molecule, In vitro, 0104 chemical sciences, Computer Science Applications, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Medical Laboratory Technology, Automation, HEK293 Cells, Manual evacuation, Humans, Biological Assay, 030304 developmental biology, Cell based
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11
المؤلفون: Melissa Kirkland, Randal M. Bugianesi, Melodie Christensen, Maria E. Trujillo, Michele Pachanski, Richard Tschirret-Guth, Josien Hubert B, Adam B. Weinglass, Sarah Souza, Ravi P. Nargund, Christopher W. Plummer, Andrew D. Howard, Joel Mane, Louis-Charles Campeau, Robert K. Orr, Daniel Kosinski, Xiaoping Zhang, Boonlert Cheewatrakoolpong, Jerry Di Salvo, Michael W. Miller, William K. Hagmann, Helen Chen, Steven L. Colletti, Andrew Nolting, Michael Wright, Matthew J. Clements, Murali Rajagopalan
المصدر: ACS Medicinal Chemistry Letters. 8:221-226
مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, business.industry, Pancreatic islets, Organic Chemistry, Tachyphylaxis, Hypoglycemia, medicine.disease, Biochemistry, Partial agonist, 03 medical and health sciences, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Tolerability, Internal medicine, Diabetes mellitus, Free fatty acid receptor 1, Drug Discovery, medicine, Receptor, business
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12
المؤلفون: James I. Fells, Michael F.A. Finley, Wen Feng, Graeme L. Fraser, Xi Ai, Adam B. Weinglass, Ying Lei, Hamid R. Hoveyda, Michelle R. Machacek
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127460
مصطلحات موضوعية: Nearest neighbor search, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Receptors, Cell Surface, Computational biology, Ligands, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Statistical quality, Drug Discovery, Humans, Molecular Biology, Virtual screening, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Docking (molecular), Molecular Medicine
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13
المؤلفون: Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey
المصدر: ACS Medicinal Chemistry Letters. 6:747-752
مصطلحات موضوعية: Pharmacokinetics, Chemistry, Pharmacodynamics, Organic Chemistry, Drug Discovery, ROMK, Pharmacology, Biochemistry
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14
المؤلفون: Birgitte Holst, Jerry Di Salvo, Michael Lückmann, Marie A. Vestmar, Maja S. Engelstoft, Andrew D. Howard, Michael W. Miller, Thue W. Schwartz, Adam B. Weinglass, Thomas M. Frimurer, Andreas N. Madsen, Maria E. Trujillo, Michael Wright, Anna Sofie Husted, Jeppe P. Ekberg, Maria Hauge
المصدر: Molecular Metabolism
مصطلحات موضوعية: Agonist, endocrine system, medicine.medical_specialty, Ago-allosteric agonist, medicine.drug_class, Incretin, Pharmacology, In vivo, Internal medicine, Free fatty acid receptor 1, medicine, Secretion, G protein-coupled receptor, Receptor, Molecular Biology, Glucagon like peptide 1 (GLP-1), Long chain fatty acids (LCFAs), business.industry, digestive, oral, and skin physiology, Cell Biology, Biased signaling, Endocrinology, Original Article, Secretagogue, business, hormones, hormone substitutes, and hormone antagonists, Ex vivo
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15
المؤلفون: Daniel Kosinski, Melissa Kirkland, Michelle Bunzel, Jin Cao, Robert W. Myers, Adam B. Weinglass, Kevin Knagge, Michele Pachanski, Sarah Souza, William K. Hagmann, Joel Mane, Xiaoyan Li, Maria E. Trujillo, Corin O. Miller, Paul E. Carrington, Jerry Di Salvo, Brande Thomas-Fowlkes
المصدر: PLoS ONE, Vol 12, Iss 5, p e0176182 (2017)
PLoS ONEمصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, Partial Agonists, Time Factors, Physiology, medicine.medical_treatment, Drug Evaluation, Preclinical, lcsh:Medicine, Spectrum analysis techniques, Biochemistry, Receptors, G-Protein-Coupled, Tissue Culture Techniques, 0302 clinical medicine, Endocrinology, Glucose Metabolism, Medicine and Health Sciences, Glucose homeostasis, Insulin, lcsh:Science, Mice, Knockout, Multidisciplinary, Chemistry, Organic Compounds, Monosaccharides, Drugs, Fasting, Blood Sugar, Body Fluids, Blood, Liver, Physical Sciences, Carbohydrate Metabolism, Anatomy, Research Article, medicine.medical_specialty, endocrine system, Endocrine Disorders, Carbohydrates, Blood sugar, 030209 endocrinology & metabolism, CHO Cells, Carbohydrate metabolism, Partial agonist, Blood Plasma, Diabetes Mellitus, Experimental, 03 medical and health sciences, Cricetulus, NMR spectroscopy, Internal medicine, Free fatty acid receptor 1, Diabetes mellitus, medicine, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Benzopyrans, Rats, Wistar, Pharmacology, Diabetic Endocrinology, Organic Chemistry, lcsh:R, Chemical Compounds, Biology and Life Sciences, medicine.disease, Hormones, Rats, Research and analysis methods, 030104 developmental biology, Glucose, HEK293 Cells, Metabolism, Gluconeogenesis, Metabolic Disorders, Thiazolidinediones, lcsh:Q
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المؤلفون: Christopher Joseph Sinz, Sarah Souza, Aimie M. Ogawa, Dennis Leung, Eric R. Ashley, Brande Thomas-Fowlkes, Maria Madeira, Mary Ann Powles, Effie Tozzo, Hong D. Chu, Feroze Ujjainwalla, Melissa Kirkland, Matthew Lombardo, Clare London, Jerry Di Salvo, Keith Eagen, John S. Debenham, Jason M. Cox, Ping Lan, Alejandro Crespo, Adam B. Weinglass, Taro E. Akiyama, Nengxue Wang, Henry M. Vaccaro, Michele Pachanski, Shah Unmesh G, Zhongxiang Sun, Mariappan V. Chelliah, James R. Tata, Michael A. Plotkin, Candice Alleyne, Takao Suzuki, Srikanth Venkatraman
المصدر: ACS medicinal chemistry letters. 8(1)
مصطلحات موضوعية: 0301 basic medicine, Agonist, medicine.medical_specialty, medicine.drug_class, Insulin, medicine.medical_treatment, Organic Chemistry, Type 2 Diabetes Mellitus, GPR120, Type 2 diabetes, Biology, medicine.disease, Biochemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Insulin resistance, Endocrinology, 030220 oncology & carcinogenesis, Diabetes mellitus, Internal medicine, Drug Discovery, medicine, Receptor
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المؤلفون: Maria L. Garcia, Adam B. Weinglass, Gregory L Kaczorowski
المصدر: Channels. 2:312-321
مصطلحات موضوعية: Technology, Drug Delivery Systems, Drug discovery, Drug Discovery, Biophysics, Humans, Membrane Transport Proteins, Transporter, Disease, Biology, Bioinformatics, Biochemistry, High-Throughput Screening Assays
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18
المؤلفون: Kelly Bleasby, Yui Sing Tang, Emmanuel O. Nketiah, Lauren Smith, Margaret E. McCann, Feroze Ujjainwalla, Brande S. Williams, Michael J. Hafey, Jessica Aijia Liu, Gregory J. Kaczorowski, William A. Schmalhofer, Joseph F. Leone, Matthew P. Braun, Lindsey Beers, Anu Thomas, Martin Köhler, Maria L. Garcia, Adam B. Weinglass
المصدر: Molecular Pharmacology. 73:1072-1084
مصطلحات موضوعية: medicine.drug_class, Pharmacology, Transfection, Tritium, beta-Lactams, Cell Line, chemistry.chemical_compound, Dogs, Ezetimibe, medicine, Animals, Humans, Cholesterol absorption inhibitor, Cloning, Molecular, Sulfonamides, biology, Cholesterol, Membrane Proteins, Membrane Transport Proteins, Reproducibility of Results, Sitosterols, Biochemistry, chemistry, Caco-2, Cell culture, HMG-CoA reductase, biology.protein, Azetidines, Molecular Medicine, Lovastatin, Caco-2 Cells, medicine.drug
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19
المؤلفون: Aiwu Zhang, Ronald E. Painter, Stephen F. Previs, Shuo Quan, Heather Zhou, Adam B. Weinglass, Anka G. Ehrhardt, Daphne Szeto, Michael Kavana, Sheng-Ping Wang, Dan Xie, Marina Ichetovkin, Brian K. Hubbard, Larissa Wilsie, Karen O. Akinsanya, Thomas P. Roddy, Oksana C Palyha, Jing Xiao, Mark Rosenbach, Alison M. Strack, Donald Chu, Weihua Ni, Douglas Wisniewski, Douglas G. Johns, Jim Milligan, Paul A. Fischer, Sookhee Ha, Xi Ai, George H. Addona, Thomas F. Vogt, Gail Forrest, Jennifer Baysarowich
المصدر: Biochemistry & Molecular Biology Journal.
مصطلحات موضوعية: biology, Cholesterol, PCSK9, General Medicine, Phenotype, In vitro, Terminal loop, Cell biology, chemistry.chemical_compound, chemistry, LDL receptor, biology.protein, Secretion, Calreticulin
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20
المؤلفون: Maria L. Garcia, Gregory J. Kaczorowski, Jessica Liu, Birgit T. Priest, William A. Schmalhofer, Stephanie Kinkel, John P. Felix, Timothy Bailey, Martin Köhler, Maria A. Bednarek, Adam B. Weinglass
المصدر: Biochemistry. 45:10129-10139
مصطلحات موضوعية: Time Factors, Peptide, Peptide binding, Plasma protein binding, Biology, Kidney, Biochemistry, Cell Physiological Phenomena, Iodine Radioisotopes, chemistry.chemical_compound, Animals, Humans, Potassium Channels, Inwardly Rectifying, Cells, Cultured, chemistry.chemical_classification, Tertiapin, Base Sequence, Inward-rectifier potassium ion channel, Biological activity, Potassium channel, Rats, Electrophysiology, Bee Venoms, chemistry, Linker, Protein Binding