المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/journal_contribution/Real-time_qPCR_and_ChIP_primer_sequences_/17301897

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s010

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/journal_contribution/Glossary_of_mutant_mouse_lines_/17301900

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s011

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_induces_phospho-histone_H3_/17301873

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s003

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_the_posterior_limb_bud_mesenchyme_does_not_induce_PPD_/17301870

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s002

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/Removal_of_i_Hes1_i_in_a_Gli3_sup_xt_sup_background_rescues_anterior_i_Pax9_i_limb_bud_expression_without_altering_elevated_levels_of_i_Ptch1_i_/17301891

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s008

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_results_in_defects_in_carpal_joint_formation_/17301867

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s001

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_posterior_mesenchyme_does_not_affect_cell_cycle_regulators_and_SHH_GLI_target_genes_/17301876

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s004

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/HES1_binding_sites_within_the_i_Cdkn1b_i_i_Col2a1_i_i_Pax9_i_i_and_Hes1_i_promoter_enhancer_regions_/17301879

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s005

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/HES1_over-expression_within_limb_bud_mesenchyme_restores_normal_levels_of_i_Bcl2_i_expression_in_SHH_LOF_background_and_HES1_over-expression_does_not_affect_limb_bud_mesenchyme_apoptosis_/17301885

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s006

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/GLI3_binds_specific_regions_of_the_i_Hes1_i_promoter_/17301894

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s009

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_promotes_cell_proliferation_/17301909

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g002

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/dataset/Raw_Data_and_Statistics_/17301903

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.s012

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_alters_the_expression_of_digit_patterning_factors_/17301915

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g004

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_induces_preaxial_polydactyly_/17301906

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g001

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/Proposed_model_for_SHH_GLI3_HES1_regulation_of_digit_number_/17301930

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g009

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/HES1_is_a_critical_effector_of_SHH-induced_PPD_/17301927

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g008

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/HES1_and_SHH_GLI3_signaling_cooperatively_regulate_digit_number_/17301924

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g007

المؤلفون: Deepika Sharma (599458), Anthony J. Mirando (11859177), Abigail Leinroth (11859180), Jason T. Long (11859183), Courtney M. Karner (11859186), Matthew J. Hilton (7548629)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Computational Biology, digit number reductions, regulating digit number, ppd ), required, inhibiting chondrogenic genes, gli signaling target, novel downstream modifier, inducing preaxial polydactyly, findings establish hes1, div >< p, critical downstream effector, downstream modifier, simultaneously regulating, deficient ppd, additional genes, gli3 signaling, utilizing genetic, sonic hedgehog, pax9 <, molecular approaches, induced chondrogenesis, identified hes1

Relation: https://figshare.com/articles/figure/_i_Hes1_i_over-expression_within_limb_bud_mesenchyme_is_sufficient_to_overcome_the_digit_loss_observed_in_SHH_LOF_limbs_/17301921

الاتاحة: https://doi.org/10.1371/journal.pgen.1009982.g006