المؤلفون: Elizabeth Sara Hecht, Shrenik Mehta, Aaron T. Wecksler, Ben Aguilar, Nathaniel Swanson, Wilson Phung, Ananya Dubey Kelsoe, W. Henry Benner, Devin Tesar, Robert F. Kelley, Wendy Sandoval, Alavattam Sreedhara

المصدر: mAbs, Vol 14, Iss 1 (2022)

مصطلحات موضوعية: protein complex, lipase, polysorbate, antibody, FPOP, native mass spectrometry, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

URL الوصول: https://doaj.org/article/d0847215cccc4d5da45d73cb8db4ce8f

المؤلفون: Arthur J. Schick, Victor Lundin, Justin Low, Kun Peng, Richard Vandlen, Aaron T. Wecksler

المصدر: mAbs, Vol 14, Iss 1 (2022)

مصطلحات موضوعية: anti-drug antibodies, immunogenicity, epitope mapping, hydroxyl radical footprinting-mass spectrometry, fast photochemical oxidation of proteins (fpop), bispecific antibody, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

URL الوصول: https://doaj.org/article/017ae0f680794d8099ba375d40d32078

المؤلفون: Aaron T. Wecksler, Victor Lundin, Ambrose J. Williams, Karthik Veeravalli, Dorothea E. Reilly, Sung-Hye Grieco

المصدر: Antibodies, Vol 12, Iss 1, p 16 (2023)

مصطلحات موضوعية: biotherapeutic proteins, protein isotopic labeling, ambr250 bioreactors, 13C-celtone, 13C-labeled glucose, knob-into-hole, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4468/12/1/16; https://doaj.org/toc/2073-4468

URL الوصول: https://doaj.org/article/bf85dec8ae9d4900b0494e5eb419cd3b

المؤلفون: Yue Sun, Alberto Estevez, Tilman Schlothauer, Aaron T. Wecksler

المصدر: mAbs, Vol 12, Iss 1 (2020)

مصطلحات موضوعية: Immunoglobulin, Fc neonatal receptor, antigen-induced allosteric effects, hydroxyl radical footprinting-mass spectrometry, negative stain electron microscopy, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

URL الوصول: https://doaj.org/article/d273eef8179e4d3f97176988e1a9261c

المؤلفون: Christophe Morisseau, Aaron T. Wecksler, Catherine Deng, Hua Dong, Jun Yang, Kin Sing S. Lee, Sean D. Kodani, Bruce D. Hammock

المصدر: Journal of Lipid Research, Vol 55, Iss 6, Pp 1131-1138 (2014)

مصطلحات موضوعية: epoxy-fatty acids, inflammation, pain, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520352767; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/0a638edbf9e34dc29a305e7cbbd0a1b4

المؤلفون: Charlene Bashore, Sumit Prakash, Matthew C. Johnson, Ryan J. Conrad, Ivy A. Kekessie, Suzie J. Scales, Noriko Ishisoko, Tracy Kleinheinz, Peter S. Liu, Nataliya Popovych, Aaron T. Wecksler, Lijuan Zhou, Christine Tam, Inna Zilberleyb, Rajini Srinivasan, Robert A. Blake, Aimin Song, Steven T. Staben, Yingnan Zhang, David Arnott, Wayne J. Fairbrother, Scott A. Foster, Ingrid E. Wertz, Claudio Ciferri, Erin C. Dueber

المصدر: Nature Chemical Biology. 19:55-63

مصطلحات موضوعية: Ligases, Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Cryoelectron Microscopy, Proteolysis, Nuclear Proteins, Cell Biology, Molecular Biology, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cffe718a8e978d9932a3400ef0703fa
https://doi.org/10.1038/s41589-022-01218-w

المؤلفون: Aaron T. Wecksler, Lawrie Veale, Maria Basanta-Sanchez, Marshall Bern

المصدر: Journal of the American Society for Mass Spectrometry. 33(3)

مصطلحات موضوعية: Structural Biology, Tandem Mass Spectrometry, Tryptophan, Cysteine, Dipeptides, Disulfides, Spectroscopy, Software, Chromatography, Liquid, Workflow

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ff0842a7284d5b33d219554d499a96
https://pubmed.ncbi.nlm.nih.gov/35157447

المؤلفون: Alberto Estevez, Yue Sun, Tilman Schlothauer, Aaron T. Wecksler

المصدر: mAbs
article-version (VoR) Version of Record

مصطلحات موضوعية: Immunology, Receptors, Fc, 03 medical and health sciences, Immunoglobulin Fab Fragments, 0302 clinical medicine, Neonatal Fc receptor, Antigen, Report, Immunoglobulin, negative stain electron microscopy, Immunology and Allergy, Humans, Receptor, Ternary complex, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Histocompatibility Antigens Class I, Fragment crystallizable region, Immune complex, IgG binding, 030220 oncology & carcinogenesis, Immunoglobulin G, Fc neonatal receptor, biology.protein, Biophysics, hydroxyl radical footprinting-mass spectrometry, antigen-induced allosteric effects, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28c9e3c1f555e10dbb76aa39b70d587
https://pubmed.ncbi.nlm.nih.gov/32795110

المؤلفون: Natalie K. Garcia, Galahad Deperalta, Aaron T. Wecksler

المصدر: Protein & Peptide Letters. 26:35-43

مصطلحات موضوعية: DNA footprinting, Mass spectrometry, 01 natural sciences, Biochemistry, Mass Spectrometry, 03 medical and health sciences, Protein structure, Structural Biology, Protein Interaction Mapping, Protein Footprinting, 030304 developmental biology, 0303 health sciences, Hydroxyl Radical, Protein Stability, Chemistry, Protein footprinting, 010401 analytical chemistry, Antibodies, Monoclonal, General Medicine, Recombinant Proteins, Footprinting, 0104 chemical sciences, Epitope mapping, Covalent bond, Biophysics, Protein quaternary structure

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7931ce78b7ec8a5b6a5d96c04b580aa7
https://doi.org/10.2174/0929866526666181128141953

المؤلفون: Mike Reichelt, Inna Zilberleyb, Hans E. Purkey, Hoangdung Ho, Benjamin D. Sellers, Maureen Beresini, Jian Payandeh, Vishal Verma, Natalie K. Garcia, Yvonne Franke, Yan Lu, Till Maurer, James R. Kiefer, Angela Oh, John G. Quinn, Aaron T. Wecksler, Yiming Xu, Mary Kate Alexander, Man-Wah Tan, Anh Miu, Stephanie Shriver, Christopher M. Koth, Jun Liang, Christine Tam, Mireille Nishiyama, Sharada Labadie, Michael F. T. Koehler, Kevin R Clark, Huiyong Hu, Jian Wang, Lan Wang, Cary D. Austin

المصدر: Nature. 557:196-201

مصطلحات موضوعية: Lipopolysaccharides, Models, Molecular, 0301 basic medicine, Protein family, 030106 microbiology, Allosteric regulation, ATP-binding cassette transporter, Crystallography, X-Ray, 03 medical and health sciences, Allosteric Regulation, Bacterial Proteins, Protein Domains, Escherichia coli, Inner membrane, ABC Transporter Inhibition, Lipid Transport, Binding Sites, Multidisciplinary, Dose-Response Relationship, Drug, Chemistry, Transporter, Hydrocarbons, Transmembrane protein, Anti-Bacterial Agents, 030104 developmental biology, Quinolines, Biophysics, ATP-Binding Cassette Transporters

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdded180233b15f2f4abb1c64264d81
https://doi.org/10.1038/s41586-018-0083-5

المؤلفون: Yue Sun, Galahad Deperalta, Saeed Izadi, Matthew D. Callahan, Aaron T. Wecksler

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Glycosylation, Protein Conformation, DNA Mutational Analysis, Receptors, Fc, Biochemistry, Fragment antigen-binding, Receptor, FA, formic acid, Antibody-dependent cell-mediated cytotoxicity, biology, Chemistry, Editors' Pick, afucosylation, N297, asparagine 297, Fab, fragment antigen-binding, Antibody, mAbs, monoclonal antibodies, Research Article, antibody-dependent cellular cytotoxicity, Protein Binding, Glycan, Fuc, fucose, medicine.drug_class, Fab–Fc receptor interactions, CHO Cells, LC, light chain, Molecular Dynamics Simulation, Immunoglobulin light chain, Monoclonal antibody, CHO, Chinese hamster ovary, fast photochemical oxidation of proteins (FPOP), Immunoglobulin Fab Fragments, 03 medical and health sciences, FcγRIIIa, Cricetulus, nG0-F, normalized G0-F, medicine, Animals, Molecular Biology, Fucose, mAb, IgG1, immunoglobulin G1, ADCC, antibody-dependent cellular cytotoxicity, 030102 biochemistry & molecular biology, Hydroxyl Radical, IgG1, HC, heavy chain, Antibody-Dependent Cell Cytotoxicity, SASA, solvent-accessible surface area, Cell Biology, Fragment crystallizable region, molecular dynamics, 030104 developmental biology, Immunoglobulin G, Mutation, hydroxyl radical footprinting-mass spectrometry, biology.protein, Biophysics, HRF, hydroxyl radical footprint, HDX, hydrogen–deuterium exchange

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1434bc455747921029f61b4b0ee4f0
https://doi.org/10.1016/j.jbc.2021.100826

المؤلفون: Aaron T. Wecksler, Michael L. Gross, Patricia Molina, Weidong Cui, Galahad Deperalta, Ying Zhang, Hao Zhang

المصدر: Journal of the American Society for Mass Spectrometry. 27:1139-1142

مصطلحات موضوعية: 0301 basic medicine, Dimer, Analytical chemistry, Electrons, Mass spectrometry, Proteomics, 01 natural sciences, Mass Spectrometry, Article, Fourier transform ion cyclotron resonance, Dissociation (chemistry), law.invention, Immunoglobulin Fab Fragments, 03 medical and health sciences, chemistry.chemical_compound, X-Ray Diffraction, Structural Biology, law, Infrared multiphoton dissociation, Crystallization, Spectroscopy, Chemistry, 010401 analytical chemistry, Proteins, 0104 chemical sciences, 3. Good health, Crystallography, 030104 developmental biology, Stoichiometry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d154e48633673d0ce5cf4db036f4e6
https://doi.org/10.1007/s13361-016-1398-9

المؤلفون: Kelly M, Storek, Marcy R, Auerbach, Handuo, Shi, Natalie K, Garcia, Dawei, Sun, Nicholas N, Nickerson, Rajesh, Vij, Zhonghua, Lin, Nancy, Chiang, Kellen, Schneider, Aaron T, Wecksler, Elizabeth, Skippington, Gerald, Nakamura, Dhaya, Seshasayee, James T, Koerber, Jian, Payandeh, Peter A, Smith, Steven T, Rutherford

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 115(14)

مصطلحات موضوعية: Models, Molecular, Protein Folding, Membrane Fluidity, Protein Conformation, Escherichia coli Proteins, Cell Membrane, Escherichia coli, Antibodies, Monoclonal, Antibodies, Bacterial, Anti-Bacterial Agents, Bacterial Outer Membrane Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::0722df3b236dc0506826ddb05eefe2cf
https://pubmed.ncbi.nlm.nih.gov/29903418

المؤلفون: Paula Lee Tao, Aaron T. Wecksler, Alavattam Sreedhara, Galahad Deperalta, Jian Yin, Bruce Kabakoff

المصدر: Molecular pharmaceutics. 15(4)

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Stereochemistry, Size-exclusion chromatography, Population, Acrylic Resins, Pharmaceutical Science, Monoclonal antibody, 030226 pharmacology & pharmacy, Mass Spectrometry, 03 medical and health sciences, Electron transfer, 0302 clinical medicine, Drug Discovery, medicine, Amino Acid Sequence, Cysteine, Disulfides, Photodegradation, education, education.field_of_study, Photolysis, Chemistry, Disulfide bond, Tryptophan, Antibodies, Monoclonal, Dipeptides, 030104 developmental biology, Immunoglobulin G, Molecular Medicine, Photochemical degradation, Oxidation-Reduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeeba7e1e7ac037d0ed672b65d27a8d1
https://pubmed.ncbi.nlm.nih.gov/29502420

المؤلفون: Mark R. Chance, Aaron T. Wecksler, Sara E. Tomechko, Wuxian Shi, Janna Kiselar, Galahad Deperalta, Parminder Kaur, Victor Ling, Giridharan Gokulrangan

المصدر: mAbs. 7:540-552

مصطلحات موضوعية: Circular dichroism, Glycosylation, medicine.drug_class, Immunology, Size-exclusion chromatography, DNA footprinting, Glutamic acid, Monoclonal antibody, Footprinting, Antibodies, Monoclonal, Murine-Derived, Mice, chemistry.chemical_compound, chemistry, Biochemistry, Aspartic acid, medicine, Animals, Immunology and Allergy, 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide, Peptides, Reports

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dcfbacbd79834bece90508eedd1293
https://doi.org/10.1080/19420862.2015.1023683

المؤلفون: Galahad Deperalta, Aaron T. Wecksler, Matthew D. Callahan, Margaret S. Lin, Denise C. Krawitz

المصدر: Journal of the American Society for Mass Spectrometry. 29(5)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Glycan, medicine.drug_class, Enzyme-Linked Immunosorbent Assay, CHO Cells, Monoclonal antibody, Negative Staining, Epitope, Mass Spectrometry, 03 medical and health sciences, Mice, Cricetulus, Western blot, Antigen, Microscopy, Electron, Transmission, Structural Biology, medicine, Animals, Protein Footprinting, Spectroscopy, medicine.diagnostic_test, biology, Chemistry, Antibodies, Monoclonal, Negative stain, Footprinting, Molecular Docking Simulation, 030104 developmental biology, Epitope mapping, Biochemistry, biology.protein, Lysophospholipase, Epitope Mapping

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c984c3fd577b35be9da856c5fc0c6e0
https://pubmed.ncbi.nlm.nih.gov/29512051

المؤلفون: Galahad Deperalta, Aaron T. Wecksler, Patricia Molina, Michael L. Gross, Ying Zhang

مصطلحات موضوعية: 0301 basic medicine, Vascular Endothelial Growth Factor A, medicine.drug_class, Protein Conformation, Plasma protein binding, Monoclonal antibody, Photochemistry, Proteomics, Mass spectrometry, 01 natural sciences, Epitope, Article, Mass Spectrometry, Fragment antigen-binding, 03 medical and health sciences, Epitopes, Immunoglobulin Fab Fragments, Structural Biology, medicine, Humans, Amino Acid Sequence, Spectroscopy, Chemistry, 010401 analytical chemistry, Footprinting, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Epitope mapping, Binding Sites, Antibody, Oxidation-Reduction, Epitope Mapping

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26f33a97e3efd0ee2b90369666307eb
https://europepmc.org/articles/PMC5624547/

المؤلفون: Sung H ee Hwang, Aaron T. Wecksler, Jian Wu, Jun-Yan Liu, Bruce D. Hammock, Robert H. Weiss, Hiromi I. Wettersten, Christophe Morisseau

المصدر: Cancer Chemotherapy and Pharmacology. 75:161-171

مصطلحات موضوعية: Male, Niacinamide, Epoxide hydrolase 2, Sorafenib, Cancer Research, Cell Survival, medicine.medical_treatment, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Antineoplastic Agents, Apoptosis, Pharmacology, Biology, urologic and male genital diseases, Toxicology, Resting Phase, Cell Cycle, Article, Targeted therapy, Mice, Cell Line, Tumor, Neoplasms, Animals, Outbred Strains, medicine, Animals, Humans, heterocyclic compounds, Pharmacology (medical), Cytotoxicity, Protein Kinase Inhibitors, neoplasms, Membrane Potential, Mitochondrial, Kinase, Phenylurea Compounds, Drugs, Investigational, medicine.disease, Vascular Endothelial Growth Factor Receptor-2, Small molecule, female genital diseases and pregnancy complications, digestive system diseases, Neoplasm Proteins, Oncology, Hepatocellular carcinoma, raf Kinases, Half-Life, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762e86e21e95e10c343032036edb919e
https://doi.org/10.1007/s00280-014-2626-2

المؤلفون: Keith Baar, Aaron T. Wecksler, Kermit L. Carraway, Leonardo J. Leon, Bruce D. Hammock, Aldrin V. Gomes, Hiromi I. Wettersten, Jennifer E. Gilda, Amy Patton, Robert H. Weiss, Sung Hee Hwang

المصدر: Anti-cancer drugs, vol 25, iss 4

مصطلحات موضوعية: Cancer Research, Adamantane, Apoptosis, mTORC1, Medical Biochemistry and Metabolomics, Drug Screening Assays, Urea, oxidative stress, Pharmacology (medical), Caspase, Cancer, Tumor, biology, Cell Cycle, Apoptosis Inducing Factor, Pharmacology and Pharmaceutical Sciences, Sorafenib, Cell cycle, Cell biology, Oncology, Caspases, Benzamides, Mitochondrial Membranes, kinase selectivity profiling, Apoptosis-inducing factor, medicine.drug, Niacinamide, Proteasome Endopeptidase Complex, autophagy, 1.1 Normal biological development and functioning, Antineoplastic Agents, P70-S6 Kinase 1, Article, sorafenib analogues, Cell Line, Medicinal and Biomolecular Chemistry, Underpinning research, Cell Line, Tumor, Autophagy, medicine, Humans, Oncology & Carcinogenesis, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Pharmacology, Phenylurea Compounds, Antitumor, Oxidative Stress, biology.protein, Generic health relevance, Drug Screening Assays, Antitumor, hepatoma cells

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c706bc2f01d938a230bd64abafd7c88
https://doi.org/10.1097/cad.0000000000000079

المؤلفون: Karen Wagner, Bruce D. Hammock, Sung-Hee Hwang, Aaron T. Wecksler

المصدر: Current Medicinal Chemistry. 20:1783-1799

مصطلحات موضوعية: Lipoxygenase, Pain, Inflammation, Pharmacology, Biochemistry, Article, Cytochrome P-450 Enzyme System, Drug Discovery, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Cyclooxygenase Inhibitors, Lipoxygenase Inhibitors, Molecular Targeted Therapy, Adverse effect, Arachidonic Acid, biology, Chemistry, Organic Chemistry, Cytochrome P450, Biological activity, Eicosanoid, Prostaglandin-Endoperoxide Synthases, Drug Design, biology.protein, Molecular Medicine, Cyclooxygenase, medicine.symptom, Signal transduction, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a418a75901556b103397d35ae3d7097
https://doi.org/10.2174/0929867311320130013