المؤلفون: Kurki, MI, Karjalainen, J, Palta, P, Sipilä, TP, Kristiansson, K, Donner, KM, Reeve, MP, Laivuori, H, Aavikko, M, Kaunisto, MA, Loukola, A, Lahtela, E, Mattsson, H, Laiho, P, Della Briotta Parolo, P, Lehisto, AA, Kanai, M, Mars, N, Rämö, J, Kiiskinen, T, Heyne, HO, Veerapen, K, Rüeger, S, Lemmelä, S, Zhou, W, Ruotsalainen, S, Pärn, K, Hiekkalinna, T, Koskelainen, S, Paajanen, T, Llorens, V, Gracia-Tabuenca, J, Siirtola, H, Reis, K, Elnahas, AG, Sun, B, Foley, CN, Aalto-Setälä, K, Alasoo, K, Arvas, M, Auro, K, Biswas, S, Bizaki-Vallaskangas, A, Carpen, O, Chen, CY, Dada, OA, Ding, Z, Ehm, MG, Eklund, K, Färkkilä, M, Finucane, H, Ganna, A, Ghazal, A, Graham, RR, Green, EM, Hakanen, A, Hautalahti, M, Hedman, ÅK, Hiltunen, M, Hinttala, R, Hovatta, I, Hu, X, Huertas-Vazquez, A, Huilaja, L, Hunkapiller, J, Jacob, H, Jensen, JN, Joensuu, H, John, S, Julkunen, V, Jung, M, Junttila, J, Kaarniranta, K, Kähönen, M, Kajanne, R, Kallio, L, Kälviäinen, R, Kaprio, J, Kerimov, N, Kettunen, J, Kilpeläinen, E, Kilpi, T, Klinger, K, Kosma, VM, Kuopio, T, Kurra, V, Laisk, T, Laukkanen, J, Lawless, N, Liu, A, Longerich, S, Mägi, R, Mäkelä, J, Mäkitie, A, Malarstig, A, Mannermaa, A, Maranville, J, Matakidou, A, Meretoja, T, Mozaffari, SV, Niemi, MEK, Niemi, M, Niiranen, T, O Donnell, CJ, Obeidat, ME, Okafo, G, Ollila, HM, Palomäki, A, Palotie, T, Partanen, J, Paul, DS, Pelkonen, M, Pendergrass, RK, Petrovski, S, Pitkäranta, A, Platt, A, Pulford, D, Punkka, E, Pussinen, P, Raghavan, N, Rahimov, F, Rajpal, D, Renaud, NA, Riley-Gillis, B, Rodosthenous, R, Saarentaus, E, Salminen, A, Salminen, E, Salomaa, V, Schleutker, J, Serpi, R, Shen, HY, Siegel, R, Silander, K, Siltanen, S, Soini, S, Soininen, H, Sul, JH, Tachmazidou, I, Tasanen, K, Tienari, P, Toppila-Salmi, S, Tukiainen, T, Tuomi, T, Turunen, JA, Ulirsch, JC, Vaura, F, Virolainen, P, Waring, J, Waterworth, D, Yang, R, Nelis, M, Reigo, A, Metspalu, A, Milani, L, Esko, T, Fox, C, Havulinna, AS, Perola, M, Ripatti, S, Jalanko, A, Laitinen, T, Mäkelä, TP, Plenge, R, McCarthy, M, Runz, H, Daly, MJ, Palotie, A

المصدر: Nature. 615(7952):E19

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:236829046

المؤلفون: Pölönen, R. P., Swan, H., Aalto-Setälä, K.

المساهمون: HUS Heart and Lung Center, University of Helsinki, Kardiologian yksikkö

مصطلحات موضوعية: hiPSC, Cardiomyocyte, CPVT, Patch clamp, Contraction, Carvedilol, Flecainide, POLYMORPHIC VENTRICULAR-TACHYCARDIA, CARDIAC RYANODINE RECEPTOR, CALCIUM TRANSIENTS, ACTION-POTENTIALS, COMMON DEFECT, CA2+ RELEASE, MODEL, WAVES, DEPOLARIZATION, REPOLARIZATION, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: The authors thank Henna Lappi and Markus Haponen for assistance in cell culture and Chandra Prajapati and Kim Larsson for technical assistance in patch clamp. RPP carried out the experiments and analyzed the data and wrote the manuscript, HS collected the biopsies, KAS worked the manuscript and designed the study. All authors read and approved the final manuscript. This work was financially supported by Academy of Finland, the Finnish Cultural Foundation, the Finnish Foundation for Cardiovascular Research, Paavo Nurmi foundation and the Pirkanmaa Hospital district. The authors acknowledge Tampere Facility of Electrophysiological Measurements for their service. Abstract of this manuscript has been presented in Europhysiology 2018 conference, London UK, organized by Scandinavian Physiological Society, The Physiological Society and The Deutsche Society of Physiology and The Annual meeting of Finnish Developmental Biologists 2018 at Murikka, Finland. The manuscript has been used in the PhD thesis "Modeling Arrhythmias and Drug Responses in CPVT Patient Specific hiPSC Derived Cardiomyocytes" by Risto-Pekka Polonen, Tampere University, Faculty of Medicine and Health Technology, Finland. The Heart Center, Tampere University Hospital, Tampere, Finland is affiliated to the ethical committee of Pirkanmaa Hospital District and performs research according to the guidelines of this regulatory body.; Pölönen , R P , Swan , H & Aalto-Setälä , K 2020 , ' Mutation-specific differences in arrhythmias and drug responses in CPVT patients : simultaneous patch clamp and video imaging of iPSC derived cardiomyocytes ' , Molecular Biology Reports , vol. 47 , no. 2 , pp. 1067-1077 . https://doi.org/10.1007/s11033-019-05201-y; http://hdl.handle.net/10138/325283; 0db049c6-b6dc-4bc4-b3c0-1c131bbaf8f7; 000499552000002

الاتاحة: http://hdl.handle.net/10138/325283

المؤلفون: Pekkanen-Mattila, Mari, Häkli, M, Pölönen, R, Mansikkala, T, Junnila, Anni, Talvitie, E, Koivisto, JT, Kellomäki, M, Aalto-Setälä, K

المساهمون: Tampere University, BioMediTech, Research group: Biomaterials and Tissue Engineering Group, TAYS Heart Centre

مصطلحات موضوعية: 217 Medical engineering

وصف الملف: fulltext

Relation: 1805; 11; 12; ORCID: /0000-0002-7904-4780/work/58124591; Sole: 49103322; Julki: 201900315; Tutcris: 51a05a9f-532e-4e1f-bc04-6203b6fcb31b; Wos: 000472638600079; ORCID: /0000-0003-4321-1820/work/99264252; https://trepo.tuni.fi/handle/10024/126906; urn:nbn:fi:tuni-201908062823

الاتاحة: https://trepo.tuni.fi/handle/10024/126906
https://doi.org/10.3390/ma12111805

المؤلفون: Jääskeläinen, P, Vangipurapu, J, Raivo, J, Kuulasmaa, T, Heliö, T, Aalto-Setälä, K, Kaartinen, M, Ilveskoski, E, Vanninen, S, Hämäläinen, L, Melin, J, Kokkonen, J, Nieminen, M.S., Laakso, M, Kuusisto, J, The FinHCM Study Group

المساهمون: Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University

مصطلحات موضوعية: Genetics, Hypertrophic cardiomyopathy, Mortality, Mutation, Outcome, Targeted sequencing, Biolääketieteet - Biomedicine, Sisätaudit - Internal medicine

وصف الملف: fulltext; 436-445

Relation: Esc heart failure; https://trepo.tuni.fi//handle/10024/116252; URN:NBN:fi:tuni-201907292764

الاتاحة: https://trepo.tuni.fi//handle/10024/116252

المؤلفون: Viiri, L.E., Rantapero, T., Kiamehr, M., Alexanova, A., Oittinen, M., Viiri, K., Niskanen, H., Nykter, M., Kaikkonen, M.U., Aalto-Setälä, K.

المساهمون: Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University

مصطلحات موضوعية: Biolääketieteet - Biomedicine

وصف الملف: fulltext

Relation: 3562; Scientific reports; https://trepo.tuni.fi//handle/10024/116125; URN:NBN:fi:tuni-201907162635

الاتاحة: https://trepo.tuni.fi//handle/10024/116125

المؤلفون: Jääskeläinen, P. (Pertti), Vangipurapu, J. (Jagadish), Raivo, J. (Joose), Kuulasmaa, T. (Teemu), Heliö, T. (Tiina), Aalto-Setälä, K. (Katriina), Kaartinen, M. (Maija), Ilveskoski, E. (Erkki), Vanninen, S. (Sari), Hämäläinen, L. (Liisa), Melin, J. (John), Kokkonen, J. (Jorma), Nieminen, M. S. (Markku S.), T. F. (The FinHCM Study Group), Laakso, M. (Markku), Kuusisto, J. (Johanna)

مصطلحات موضوعية: Genetics, Hypertrophic cardiomyopathy, Mortality, Mutation, Outcome, Targeted sequencing

وصف الملف: application/pdf

الاتاحة: http://urn.fi/urn:nbn:fi-fe202003319810

المؤلفون: Pekkanen-Mattila, M. (Mari), Häkli, M. (Martta), Pölönen, R.-P. (Risto-Pekka), Mansikkala, T. (Tuomas), Junnila, A. (Anni), Talvitie, E. (Elina), Koivisto, J. T. (Janne T.), Kellomäki, M. (Minna), Aalto-Setälä, K. (Katriina)

مصطلحات موضوعية: PET, biomaterials, cardiomyocytes, gene expression, iPS-cells, maturation, textile

وصف الملف: application/pdf

الاتاحة: http://urn.fi/urn:nbn:fi-fe2019101032188

المؤلفون: Pölönen, R. P., Swan, H., Aalto-Setälä, K.

المساهمون: Suomen Kulttuurirahasto, Paavo Nurmen Säätiö, Academy of Finland, Pirkanmaan Sairaanhoitopiiri, Sydäntutkimussäätiö

المصدر: Molecular Biology Reports ; volume 47, issue 2, page 1067-1077 ; ISSN 0301-4851 1573-4978

الاتاحة: http://dx.doi.org/10.1007/s11033-019-05201-y
http://link.springer.com/content/pdf/10.1007/s11033-019-05201-y.pdf
http://link.springer.com/article/10.1007/s11033-019-05201-y/fulltext.html

المؤلفون: Rynänen, T, Pekka-Mattila, M, Shah, D, Kreutzer, J., Kallio, P., Lekkala, Jukka, Aalto-Setälä, K

المساهمون: Tampere University, Faculty of Biomedical Sciences and Engineering, Faculty of Medicine and Life Sciences, Research group: Micro and Nanosystems Research Group, Research group: Sensor Technology and Biomeasurements (STB), TAYS Heart Centre

مصطلحات موضوعية: 220 Industrial biotechnology

وصف الملف: fulltext

Relation: 117001; 11; 57; Sole: 45844719; Julki: 201801235; Tutcris: 0aadd141-94ff-40d5-a7cd-64d24dd8922e; ORCID: /0000-0002-2890-6782/work/70736388; https://trepo.tuni.fi/handle/10024/126730; urn:nbn:fi:uta-201811132820

الاتاحة: https://trepo.tuni.fi/handle/10024/126730
https://doi.org/10.7567/jjap.57.117001

المؤلفون: Paci, M, Pölönen, RP, Cori, D, Penttinen, K., Aalto-Setälä, K, Severi, S., Hyttinen, J.

المساهمون: Tampere University, Faculty of Biomedical Sciences and Engineering, Faculty of Medicine and Life Sciences, TAYS Heart Centre, Research group: Computational Biophysics and Imaging Group

مصطلحات موضوعية: 217 Medical engineering

وصف الملف: fulltext

Relation: 709; JUN; Sole: 43623527; Julki: 201801149; Tutcris: 971f6f9d-2057-4827-b454-fc5c8c550dcf; Wos: 000436318100001; ORCID: /0000-0003-1850-3055/work/46974863; ORCID: /0000-0003-0510-1444/work/46974867; https://trepo.tuni.fi/handle/10024/126588; urn:nbn:fi:uta-201807102303

الاتاحة: https://trepo.tuni.fi/handle/10024/126588
https://doi.org/10.3389/fphys.2018.00709

المؤلفون: Mäki, A, Verho, J, Kreutzer, J, Ryynänen, T., Rajan, D., Pekkanen-Mattila, Mari, Ahola, A., Hyttinen, J., Aalto-Setälä, K, Lekkala, Jukka, Kallio, P.

المساهمون: Tampere University, Faculty of Biomedical Sciences and Engineering, Faculty of Medicine and Life Sciences, Research group: Computational Biophysics and Imaging Group, TAYS Heart Centre, Research group: Sensor Technology and Biomeasurements (STB), Research group: Micro and Nanosystems Research Group

مصطلحات موضوعية: 217 Medical engineering, 3121 Internal medicine, 3111 Biomedicine

وصف الملف: fulltext

Relation: 23; Sole: 42975613; Julki: 201800700; Tutcris: 8a2a04fb-5468-4df5-978c-a0d540840bbe; Wos: 000452285600008; ORCID: /0000-0003-1850-3055/work/48035585; ORCID: /0000-0001-9210-9481/work/50481388; ORCID: /0000-0001-7565-3530/work/48035761; ORCID: /0000-0003-2588-4343/work/48035672; ORCID: /0000-0002-2890-6782/work/70736383; https://trepo.tuni.fi/handle/10024/126536; URN:NBN:fi:tty-201809052273

الاتاحة: https://trepo.tuni.fi/handle/10024/126536
https://doi.org/10.1177/2472630318768710

المؤلفون: Vanninen, S U M, Leivo, K, Seppälä, E H, Aalto-Setälä, K, Pitkänen, O, Suursalmi, P, Annala, A-P, Anttila, I, Alastalo, T-P, Myllykangas, S, Heliö, T M, Koskenvuo, J W

المساهمون: Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere

مصطلحات موضوعية: Biolääketieteet - Biomedicine, Sisätaudit - Internal medicine

وصف الملف: fulltext

Relation: e0203422; Plos One; 13; https://trepo.tuni.fi/handle/10024/104366; URN:NBN:fi:uta-201810052633

الاتاحة: https://trepo.tuni.fi/handle/10024/104366

المؤلفون: Pölönen, R-P, Penttinen, K, Swan, H, Aalto-Setälä, K

المساهمون: Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere

مصطلحات موضوعية: Biolääketieteet - Biomedicine, Sisätaudit - Internal medicine

وصف الملف: fulltext

Relation: 9109503; Stem cells international; 2018; https://trepo.tuni.fi/handle/10024/103405; URN:NBN:fi:uta-201805151695

الاتاحة: https://trepo.tuni.fi/handle/10024/103405

المؤلفون: Polonen, R. P., Penttinen, K., Swan, H., Aalto-Setälä, K.

المساهمون: Clinicum, Kardiologian yksikkö, Department of Medicine, HUS Heart and Lung Center

مصطلحات موضوعية: CARDIAC RYANODINE RECEPTOR, INDUCED CA2+ RELEASE, MECHANISM, MODEL, RYR2, THRESHOLD, THERAPY, TRIAL, WAVES, CPVT, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: The authors thank Henna Lappi and Markus Haponen for the assistance in cell culture, Marisa Ojala and Kim Larsson in the Ca 2+ data analysis, and Heini Huhtala for the assistance in statistical analysis. This work was financially supported by the Academy of Finland, the Finnish Cultural Foundation, the Finnish Foundation for Cardiovascular Research, the Finnish Funding Agency for Innovation (TEKES), the Pirkanmaa Hospital District, and the Paavo Nurmi Foundation. The authors acknowledge the Tampere Facility of Electrophysiological Measurements for their service.; Polonen , R P , Penttinen , K , Swan , H & Aalto-Setälä , K 2018 , ' Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients ' , Stem Cells International . https://doi.org/10.1155/2018/9109503; http://hdl.handle.net/10138/235312; f49da50a-6711-449e-959d-397223c0a96b; 85050515682; 000430664700001

الاتاحة: http://hdl.handle.net/10138/235312

المؤلفون: Kiviaho, A.L., Ahola, A., Larsson, K., Penttinen, K., Swan, H., Pekkanen-Mattila, M., Venäläinen, H., Paavola, K., Hyttinen, J., Aalto-Setälä, K.

المساهمون: Clinicum, Department of Medicine, Kardiologian yksikkö

مصطلحات موضوعية: General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: Kiviaho , A L , Ahola , A , Larsson , K , Penttinen , K , Swan , H , Pekkanen-Mattila , M , Venäläinen , H , Paavola , K , Hyttinen , J & Aalto-Setälä , K 2015 , ' Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations ' , International journal of cardiology. Heart & vasculature , vol. 8 , pp. 19-31 . https://doi.org/10.1016/j.ijcha.2015.04.008; Bibtex: urn:9ec71d21818eff6245ec2925625aa145; http://hdl.handle.net/10138/176054; 45605626-9a71-41bc-bfbc-a90abf0b1099; 84934929449

الاتاحة: http://hdl.handle.net/10138/176054

المؤلفون: Ahola, A., Pölönen, R.-P., Aalto-Setälä, K., Hyttinen, J.

المساهمون: Pirkanmaan Rahasto, Paavo Nurmen Säätiö, Tekes

المصدر: Annals of Biomedical Engineering ; volume 46, issue 1, page 148-158 ; ISSN 0090-6964 1573-9686

الاتاحة: http://dx.doi.org/10.1007/s10439-017-1933-2
http://link.springer.com/article/10.1007/s10439-017-1933-2/fulltext.html
http://link.springer.com/content/pdf/10.1007/s10439-017-1933-2.pdf

المؤلفون: Alexanova, A., Valtonen, J., Viiri, L., Kiamehr, M., Aalto-Setälä, K.

المصدر: Atherosclerosis ; volume 331, page e220 ; ISSN 0021-9150

الاتاحة: http://dx.doi.org/10.1016/j.atherosclerosis.2021.06.675
https://api.elsevier.com/content/article/PII:S0021915021009473?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021915021009473?httpAccept=text/plain

المؤلفون: Straessler, E.T., Aalto-Setälä, K., Kiamehr, M., Kraenkel, N., Landmesser, U.

المساهمون: ACS

المصدر: Atherosclerosis ; volume 315, page e88-e89 ; ISSN 0021-9150

الاتاحة: http://dx.doi.org/10.1016/j.atherosclerosis.2020.10.272
https://api.elsevier.com/content/article/PII:S0021915020308546?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021915020308546?httpAccept=text/plain

المؤلفون: Alexanova, A., Viiri, L., Laaksonen, R., Kiamehr, M., Aalto-Setälä, K.

المصدر: Atherosclerosis ; volume 287, page e118-e119 ; ISSN 0021-9150

الاتاحة: http://dx.doi.org/10.1016/j.atherosclerosis.2019.06.344
https://api.elsevier.com/content/article/PII:S0021915019308019?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0021915019308019?httpAccept=text/plain

المؤلفون: Aalto-Setälä, K, Weinstock, P H, Bisgaier, C L, Wu, L, Smith, J D, Breslow, J L

المصدر: Journal of Lipid Research ; volume 37, issue 8, page 1802-1811 ; ISSN 0022-2275

الاتاحة: http://dx.doi.org/10.1016/s0022-2275(20)39123-9
https://api.elsevier.com/content/article/PII:S0022227520391239?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0022227520391239?httpAccept=text/plain