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1
المؤلفون: Leon P. Loevenich, Thomas Engleitner, Marlies Michl, Sebastian Vosberg, Matjaz Rokavec, Andreas Jung, Heiko Hermeking, Philipp A. Greif, Jens Neumann, Jörg Kumbrink, Roland Rad, Thomas Kirchner, Peter Jung, Rupert Öllinger, Sophie L. Boos
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 517-540 (2022)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: Colorectal cancer, EdU, 5-ethynyl-2’-deoxyuridine, RNP, ribonucleoprotein, Cetuximab, RC799-869, DMSO, dimethyl sulfoxide, medicine.disease_cause, MEK, mitogen-activated protein/extracellular signal-regulated kinase kinase, eKRAS, clustered regularly interspaced short palindromic repeats/Cas9-generated KRASG12D, PDTO, patient-derived tumor organoid, PCR, polymerase chain reaction, ERK, extracellular signal-regulated kinase, GSEA, gene set enrichment analysis, IC50, half-maximal inhibitory concentration, CT-PDTO, chemotherapy-adapted patient-derived tumor organoid, 5’-FU, 5-fluorouracil, Medicine, E2F1, Epidermal growth factor receptor, ANOVA, analysis of variance, Original Research, Aurora Kinase A, biology, TOC, tumor organoid culture, Liver Neoplasms, Gastroenterology, AfaSel, afatinib + selumetinib, FOLFIRI, folinic acid, Combination chemotherapy, Diseases of the digestive system. Gastroenterology, ADF, advanced Dulbecco’s modified Eagle medium/F12, FFPE, formalin-fixed paraffin-embedded, Organoids, CRISPR, clustered regularly interspaced short palindromic repeats, CRC, colorectal cancer, FOLFIRI, Cas9, CRISPR-associated 9 protein, 5’-FU, irinotecan (or SN-38), KRAS, Colorectal Neoplasms, SN-38, irinotecan active metabolite, Chemoresistance, medicine.drug, AURKA, Aurora kinase A, CRC Organoid, c-MYC, c-MYC oncogene, cDNA, complementary DNA, Cmab, cetuximab, E2F, E2 transcription factor, RAS, rat sarcoma viral oncogene homolog, 3D, 3-dimensional, Humans, MSI, microsatellite instable, UMI, unique molecular identifier, EGF, epidermal growth factor, HER, human epithelial growth factor receptor, Hepatology, business.industry, PARP, poly-adenosine diphosphate ribose polymerase, LMU, Ludwig-Maximilians-University, medicine.disease, digestive system diseases, EGFR, epidermal growth factor receptor, Cancer research, biology.protein, TCGA, The Cancer Genome Atlas, business, MAPK, mitogen-activated protein kinase
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المؤلفون: Melanie Weingart, Robert W. Schnepp, Komal S. Rathi, John M. Maris, Dongdong Chen, Julie Cox, Cara E. Shields, Kristopher R. Bosse, Priya Khurana, Adeiye Pilgrim, Jo Lynne Rokita, Oskar Laur, Jayabhargav Annam, Grace Essien, Daisy Li, Selma M. Cuya
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 6, Pp 231-241 (2020)
Neoplasia (New York, N.Y.)مصطلحات موضوعية: 0301 basic medicine, Original article, Cancer Research, AURKA, Aurora kinase A, LIN28B, RNA-binding protein, Biology, GALNT14, N-acetyl-galactosaminyltransferase, lcsh:RC254-282, PDZ binding kinase, Metastasis, TARGET, Therapeutically Applicable Research to Generate Effective Treatments project, Neuroblastoma, 03 medical and health sciences, 0302 clinical medicine, PBK, PDZ Binding Kinase, medicine, Cell growth, Kinase, Neural crest, Cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Neural stem cell, Let-7, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research
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3
المؤلفون: Claus Garbe, Katharina Zittlau, Boris Macek, Marisa Schmitt, Tobias Sinnberg, Katrin Bratl, Nicolas C. Nalpas
المصدر: Molecular & Cellular Proteomics : MCP
مصطلحات موضوعية: NOG, N-ocetylglucoside, Biochemistry, Interactome, WES, whole-exome sequencing, Analytical Chemistry, AURKA, aurora kinase A, ERK, extracellular signal-regulated kinase, A375 S, BRAFi-sensitive A375 cells, A375 R, BRAFi-resistant A375 cells, Vemurafenib, nucleotide sequencing, mass spectrometry, Proteogenomics, Kinase, phosphorylation, AGC, automatic gain control, LC-MS/MS, liquid chromatography–tandem mass spectrometry, Proteome, Core Binding Factor Alpha 2 Subunit, Phosphorylation, RT, room temperature, medicine.drug, RUNX1, runt-related transcription factor 1, Signal Transduction, Proto-Oncogene Proteins B-raf, FDR, false discovery rate, Biology, Serine/Threonine-Protein Kinase B-Raf, FBS, fetal bovine serum, DHB, dihydroxybenzoic acid, Cell Line, Tumor, medicine, melanoma, cancer, Humans, Molecular Biology, Protein Kinase Inhibitors, SNV, single nucleotide variant, Research, AURKAi, AURKA inhibition, BRAFi resistance, BRAF, serine/threonine-protein kinase B-raf, BRAFi, BRAF inhibitor, MS, mass spectrometry, Drug Resistance, Neoplasm, HCD, higher-energy collisional dissociation, Cancer research, Aurora Kinase A, PTM, posttranslational modification, MAPK, mitogen-activated protein kinase
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4Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma1
المصدر: Neoplasia (New York, N.Y.)
مصطلحات موضوعية: Original article, Cell Cycle Proteins, Mice, SCID, Fa, fraction affected, Heterocyclic Compounds, 4 or More Rings, AURKA, aurora kinase A, Neuroblastoma, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, LOH, loss of heterozygosity, neoplasms, Aurora Kinase A, N-Myc Proto-Oncogene Protein, CI, combination index, Nuclear Proteins, 11q, long arm of chromosome 11, Drug Synergism, Azepines, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Survival Rate, p-AURKA, phosphorylated AURKA, specifically at threonine 288, Pyrimidines, Vincristine, BRD4, Bromodomain-containing protein 4, Transcription Factors
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5
المؤلفون: Shang, Yao, Lavender Yuen-Nam, Fan, Eric Wing-Fai, Lam
المصدر: Seminars in Cancer Biology
مصطلحات موضوعية: IGF, insulin growth factor, MRN, MER11-RAD50-NBS1, Skp2, S-phase kinase-associated protein 2, DNA Repair, ER, estrogen receptor, FasL, fas ligand, GICs, glioma-initiating cells, TCF/LEF, T-cell factor/lymphoid enhancer factor, NBS1, Nijmegen breakage syndrome 1, ATM, Ataxia-telangiectasia mutated, FHRE, forkhead response element, AURKA, aurora kinase A, Mst1, macrophage stimulating 1, ERK, extracellular signal-regulated kinase, Bim, B-cell lymphoma 2 interacting mediator, RTKs, receptor tyrosine kinases, Neoplasms, XRCC1, X-ray cross-complementing group 1, Cell Self Renewal, BER, base excision repair, MDR1, multidrug resistance protein 1, AMPK, adenosine monophosphate-activated protein kinase, OTUB1, OUT domain-containing ubiquitin aldehyde-binding protein 1, Forkhead Box Protein O3, Fox, forkhead box, ABCB1, ATP-binding cassette sub-family B member 1, PI3K, phosphatidylinositol 3-kinase, TRAIL, tumour necrosis factor-related apoptosis inducing ligand, TKIs, tyrosine kinase inhibitors, VEGF, vascular endothelial growth factor, Gene Expression Regulation, Neoplastic, PIP3, phosphatidylinositol- 3,4,5-trisphosphate, GADD45, DNA damage-inducible protein 45, AML, acute myeloid leukaemia, SOD-2, superoxide dismutase, IFNɣ, interferon-ɣ, PKB, protein kinase B, CSCs, cancer stem cells, NAMPT, nicotinamide-phosphribosyltransferase, Antineoplastic Agents, BRCA1, breast cancer susceptibility gene product 1, MMR, mismatch repair, mTOR, mammalian target of rapamycin, SSBs, single-strand breaks, ER+ve, estreogen receptor positive, Article, DDR, DNA damage response, DSBs, double strands breaks, ESR1, estrogen receptor alpha gene, EXO1, exonuclease 1, miRs, Micro-RNAs, ROS, reactive oxygen species, NER, nucleotide excision repair, MCL, mantle cell lymphoma, MEK, mitogen-activated protein kinase kinase, Humans, Cks1, cyclin-dependent kinases regulatory subunit 1, SCs, stem cells, Cell Proliferation, CML, chronic myeloid leukaemia, EGF, epidermal growth factor, Forkhead Box Protein M1, EGFR, epidermal growth factor receptor, PA, Psammaplysene A, ChIP-seq, chromatin immunoprecipitation with massively parallel DNA sequencing, Drug Resistance, Neoplasm, BRCA2, breast cancer-associated gene 2, NHEJ, non-homologous end joining, BRIP1, BRCA1-interacting protein-terminal helicase 1, Rb2, retinoblastoma-related p130, HR, homologous recombination, HCC, hepatocellular carcinoma, JNK/SAPK, c-Jun N-terminal kinase/stress activated protein kinase, Sox1, sex determining region Y box 2, PDK, phosphoinositide-dependent kinase
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المؤلفون: Michelle Haber, Glenn M. Marshall, Jennifer A. Byrne, David S. Ziegler, Murray D. Norris, Federica Saletta, Geoffrey McCowage, Carol Wadham
المساهمون: Saletta, Federica, Wadham, Carol, Ziegler, David S, Marshall, Glenn M, Haber, Michelle, McCowage, G, Norris, Murray D, Byrne, Jennifer A
المصدر: BBA Clinical
مصطلحات موضوعية: CAR, chimeric antigen receptor, AURKB, aurora kinase B, PARP, poly(ADP-ribose) polymerase, medicine.medical_treatment, Hsp90, heat shock protein 90, Review, Bioinformatics, Ph +, Philadelphia chromosome-positive, Targeted therapy, SHH, sonic hedgehog, AURKA, aurora kinase A, IGF-1R, insulin-like growth factor type 1 receptor, HDAC, histone deacetylases, Medicine, Profiling (information science), PI3K, phosphatidylinositol 3′-kinase, BET, bromodomain and extra terminal, AML, acute myeloid leukemia, food and beverages, targeted therapy, 3. Good health, PLK1, polo-like kinase 1, AML - Acute myeloid leukemia, Molecular Medicine, RMS, rhabdomyosarcoma, ODC1, ornithine decarboxylase 1, DFMO, difluoromethylornithine, Childhood cancer, mAbs, monoclonal antibodies, mTOR, mammalian target of rapamycin, Pathology and Forensic Medicine, SYK, spleen tyrosine kinase, molecular diagnostics, CML, chronic myeloid leukemia, VEGF/VEGFR, vascular endothelial growth factor/receptor, IGF/IGFR, insulin-like growth factor/receptor, Physiology (medical), NSCLC, non-small cell lung cancer, Molecular diagnostics, childhood cancer, mAb, monoclonal antibody, TRAIL, TNF-related apoptosis-inducing ligand, business.industry, ALK, anaplastic lymphoma kinase, biomarkers, TOP1/TOP2, DNA topoisomerase 1/2, PDGFRA/B, platelet derived growth factor alpha/beta, CAR - Chimeric antigen receptor, ALL, acute lymphoblastic leukemia, EGFR, epidermal growth factor receptor, ERMS, embryonal rhabdomyosarcoma, DIPG, diffuse intrinsic pontine glioma, Non small lung cancer, ARMS, alveolar rhabdomyosarcoma, AT/RT, atypical teratoid/rhabdoid tumor, sense organs, business, ALL - Acute lymphoblastic leukemia, Biomarkers, SMO, smoothened