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المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2
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المؤلفون: Yunhan Zhang, Dingchang Zheng, Du Mengqing, Lin Yang, Hongqing Jiang, Xiaoxiao Song, Jin Peng, Dongmei Hao
المصدر: Biocybernetics and Biomedical Engineering
مصطلحات موضوعية: SM, maximum values in signal, Tr, time reversibility, IUPC, intrauterine pressure catheter, LE, Lyapunov exponent, 02 engineering and technology, Random forest (RF), τz, zero-crossing, K-NN, K-nearest, Electrohysterogram (EHG), Gestational Weeks, 0202 electrical engineering, electronic engineering, information engineering, ADASYN, adaptive synthetic sampling approach, QDA, quadratic discriminant analysis, SE, energy values in signal, Obstetrics, AR, auto-regressive model, Area under the curve, MNF, mean frequency, RMS, root mean square, Random forest, RF, random forest, SampEn, sample entropy, Feature extraction, Gestation, TL, term delivery after the 26th week of gestation, 020201 artificial intelligence & image processing, EHG, electrohysterogram, SS, singular values in signal, Gestational week, medicine.medical_specialty, SV, variance values in signal, 0206 medical engineering, Biomedical Engineering, MDF, median frequency, Timely diagnosis, Article, TPEHG, term-preterm electrohysterogram, PE, preterm delivery before the 26th week of gestation, medicine, Preterm delivery, Term delivery, ACC, accuracy, PL, preterm delivery after the 26th week of gestation, SVM, support vector machine, business.industry, CorrDim, correlation dimension, TE, term delivery before the 26th week of gestation, ANN, artificial neural network, PF, peak frequency, 020601 biomedical engineering, AUC, the area under the curve, TOCO, tocodynamometer, ROC, the receiver operating characteristic curve, SD, standard deviation, business, LDA, linear discriminant analysis, DT, decision tree
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المؤلفون: Aayushi Mittal, Riya Sogani, Rishi Raj Jain, Vishesh Agrawal, Prakriti Garg, Tripti Mishra, Ria Gupta, Debarka Sengupta, Harshit Singh Chhabra, Vishakha Gautam, Gaurav Ahuja, Sushant Gupta, Sanjay Kumar Mohanty, Krishan Gupta
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: computation, Web server, Computer science, SMILES, Simplified Molecular-Input Line-Entry System, Sensory system, Olfaction, BiLSTM, Bidirectional Long Short-Term Memory, computer.software_genre, Ligands, Biochemistry, Olfactory Receptor Neurons, computational biology, CSV, comma-separated value, Feature (machine learning), ligand-receptor, Relevance (information retrieval), chemotaxis, Molecular Biology, AUC-ROC, area under the curve receiver operating characteristic, Artificial neural network, business.industry, Cell Biology, PC, principal component, artificial intelligence, neuron, ligand-binding protein, Identification (information), chemosensory, machine learning, OR, odorant receptor, Odorants, Artificial intelligence, Web service, business, computer, psychological phenomena and processes, Research Article, Olfactory, Signal Transduction
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المؤلفون: Shiraki, Kimiyasu, Sato, Noriaki, Sakai, Kaoru, Matsumoto, Shirou, Kaszynski, Richard H., Takemoto, Masaya
المصدر: Pharmacology & Therapeutics
مصطلحات موضوعية: TLR, toll like receptor, Antiviral therapy, HZ, herpes zoster, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, TNF-α, tumor necrosis factor-α, Antiviral Agents, Article, COVID-19 Testing, Favipiravir, Influenza, Human, Humans, IFN, interferon, Pharmacology (medical), RdRp, RNA-dependent RNA polymerase, SARS, severe acute respiratory syndrome, SOC, standard of care, FTP, favipiravir-4-ribofuranosyl-5′-triphosphate, CMI, cell-mediated immunity, Pharmacology, SARS-CoV-2, COVID-19, coronavirus disease 2019 caused by SARS-CoV-2 virus, COVID-19, CMV, cytomegalovirus, Amides, RNA dependent RNA polymerase, IL, interleukin, TERT, telomerase reverse transcriptase, COVID-19 Drug Treatment, Innate and adaptive immunity, AUC, the area under the curve, Pyrazines, Cytomegalovirus Infections, EC50, half maximal effective concentration, HSV, herpes simplex virus, VZV, varicella-zoster virus
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المؤلفون: Weili Lu, Cheng Cui, Lu Zhao, Hongyan Ren, Liuyi Song, Yilan Liao, An Zhang
المصدر: Science of The Total Environment
The Science of the Total Environmentمصطلحات موضوعية: China, medicine.medical_specialty, Environmental Engineering, 010504 meteorology & atmospheric sciences, Pneumonia, Viral, Early forecasting, NHC, national health commission, 010501 environmental sciences, 01 natural sciences, Article, Betacoronavirus, China's megacities, Beijing, Environmental health, Pandemic, medicine, Humans, Infection control, Environmental Chemistry, Cities, Pandemics, Socioeconomic status, Waste Management and Disposal, 0105 earth and related environmental sciences, SARS-CoV-2, Risk zones, Public health, COVID-19, Pollution, ROC, receiver operating characteristic, Geography, Megacity, COVID-19, the coronavirus disease 2019, AUC, the area under the curve, Ecological niche model, Scale (social sciences), ENM, ecological niche model, Coronavirus Infections
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المؤلفون: Yanqing Gong, Liqun Zhou, Jianrong Zheng, Shuyuan Guo, Anbang He, Jieshan Chi, Xinliang Zhong, Yonghao Zhan, Zhicong Chen, Xuesong Li
المصدر: EBioMedicine
مصطلحات موضوعية: 95%CI, 95% Confidence interval, 0301 basic medicine, Oncology, ROC curve, receiver operating characteristic curve, NMIBC, non-muscle-invasive bladder cancer, Urologic cancer, T, size or direct extent of the primary tumour, TRIPOD, Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis, TCGA-PRAD, prostate adenocarcinoma in TCGA chort, Metastasis, TCGA-BLCA, bladder cancer in TCGA chort, Prostate cancer, 0302 clinical medicine, miRNA, microRNA, FFPE, formalin fixed paraffin-embedded, Medicine, CHN, Chinese, GEO, Gene Expression Omnibus, TCGA-KICH, kidney chromophobe carcinoma in TCGA chort, DM, distant metastasis, TCGA-KIRP, kidney papillary cell carcinoma in TCGA chort, Hazard ratio, OR, odds ratios, qRT-PCR, quantitative real-time polymerase chain reaction, REMARK, Reporting Recommendations for Tumour Marker Prognostic Studies, General Medicine, G, histology grade, Prognosis, BRISQ, Biospecimen Reporting for Improved Study Quality, AT, advanced T-stage, Prostate-specific antigen, 030220 oncology & carcinogenesis, miRNAs, HG, higher histologic grade, qPCR, quantitative polymerase chain reaction, RFS, relapse free survival, Research Paper, LNM, lymph nodes metastasis, Stage, TNM stage, ISH, in-situ hybridization, miRNA panel, Urologic Neoplasms, medicine.medical_specialty, BCa, bladder cancer, PCa, prostate cancer, Gleason, gleason score, WHO, World Health Organization, General Biochemistry, Genetics and Molecular Biology, OS, overall survival, 03 medical and health sciences, Bioinformatics analysis, TCGA-KIRC, kidney clear cell carcinoma in TCGA chort, Internal medicine, Humans, Progression-free survival, IQR, interquartile range, non-CHN, Non-Chinese, Bladder cancer, BCR-FS, biochemical recurrence free survival, SE, standard error, CSS, cancer/disease specific survival, business.industry, AS, advanced TNM stage, KCa, kidney cancer, Biomarker, Odds ratio, medicine.disease, PRISMA, Preferred Reporting Items for Systematic Review and Meta-analysis, DFS, disease free survival, MicroRNAs, PSA, prostate specific antigen, 030104 developmental biology, NOS, Newcastle-Ottawa quality assessment scale, AUC, the area under the curve, HR, Hazard Ratio, PFS, progression free survival, RNA, ribonucleic acid, TCGA, The Cancer Genome Atlas, business, Kidney cancer
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المؤلفون: Xuerong Wang, Tong Sun, Baoan Chen, Hongling Chen, Haibo Wang, Caidong Liu
المصدر: Translational Oncology, Vol 14, Iss 5, Pp 101052-(2021)
Translational Oncologyمصطلحات موضوعية: 0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, Small pulmonary nodule, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Circulating tumor cell, FISH, CEP8, centromere probe 8, EpCAM, epithelial cancer-associated marker, medicine, SPNs, small pulmonary nodules, IA, invasive adenocarcinoma, CD45, Stage (cooking), Liquid biopsy, Lung cancer, pTNM, pathological tumor nodal metastasis, FISH, fluorescence in situ, Original Research, Tumor marker, AFP, alpha-fetoprotein, business.industry, FR, folate receptor, CTCs, circulating tumor cells, MIA, minimally invasive adenocarcinoma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, FDA, Food and Drug Administration, CT, computed tomography, Staining, CKs, cytokeratins, MTD, maximum tumor diameter, 030104 developmental biology, ROC analysis, receiver operating characteristic analysis, Oncology, AUC, the area under the curve, NSCLC, non-small cell lung carcinoma, EpCAM, 030220 oncology & carcinogenesis, Cancer cell, AIS, adenocarcinoma in situ, Histopathology, CEA, carcinoembryonic antigen, business
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المؤلفون: Yao Zhang, Gong-Ping Liu, Hong-Hua Li, Hu-Jun Ren, Dan Ke, Yanchao Liu, Su-Lian Yang, Mengzhu Li, Shi Zhao, Sheng Wei, Qun Wang, Rong-Xi Huang, Hong-Wei Jiang, Pei-Yan Zhan, Xin Wang, Cai-Xia Kong, Lin Fang, Lin Deng, Jing-Rong Li, Na Li, Shujuan Zhang, Jian-Zhi Wang, Zhi-Peng Xu, Cheng-Hong Zheng, Yuan Gao, Qiuzhi Zhou, Jing-Wang Ye, Li-Fang Zhang
المصدر: EBioMedicine, Vol 5, Iss C, Pp 105-113 (2016)
EBioMedicineمصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, CCCRC, Connecticut Chemosensory Clinical Research Center, Male, Glycogen synthase kinase-3β, Apolipoprotein E4, lcsh:Medicine, MMSE, minimum mental state examination, Type 2 diabetes, Bioinformatics, 0302 clinical medicine, ApoE, apolipoprotein E, Olfactory score, lcsh:R5-920, ARMS, amplification refractory mutation system, ROC, receiver operating characteristics, General Medicine, Middle Aged, Alzheimer's disease, MCI, mild cognitive impairment, Female, AD, Alzheimer's disease, lcsh:Medicine (General), Research Paper, Blood Platelets, medicine.medical_specialty, Genotype, Clinical Dementia Rating, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Alzheimer Disease, Internal medicine, Type 2 diabetes mellitus, medicine, Humans, Cognitive Dysfunction, Alleles, Aged, Retrospective Studies, GSK-3β, glycogen synthase kinase-3β, HbA1c, hemoglobin A1c, Glycogen Synthase Kinase 3 beta, Receiver operating characteristic, business.industry, lcsh:R, Case-control study, Mild cognitive impairment, Odds ratio, T2DM, type 2 diabetes mellitus, medicine.disease, CDR, clinical dementia rating, OR, odds ratio, 030104 developmental biology, Diabetes Mellitus, Type 2, CI, confidence intervals, AUC, the area under the curve, Case-Control Studies, Nested case-control study, ApoE gene, business, 030217 neurology & neurosurgery, Biomarkers